Nephrology Dialysis Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Lipoprotein(a) concentrations, apolipoprotein(a) isoforms and clinical endpoints in haemodialysis patients with type 2 diabetes mellitus: results from the 4D Study
Conclusions High Lp(a) concentrations and LMW apo(a) isoforms are risk predictors for all-cause mortality and death due to infection in haemodialysis patients with diabetes mellitus. These associations are modified by age. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Kollerits, B., Drechsler, C., Krane, V., Lamina, C., März, W., Dieplinger, H., Ritz, E., Wanner, C., Kronenberg, F., for the German Diabetes and Dialysis Study Investigators Tags: Chronic Kidney Disease Source Type: research

Albuminuria and tolvaptan in autosomal-dominant polycystic kidney disease: results of the TEMPO 3:4 Trial
Conclusions In ADPKD, higher baseline albuminuria was associated with more eGFR loss. Tolvaptan decreased albuminuria compared with placebo, independent of blood pressure. Treatment efficacy of tolvaptan on changes in TKV and eGFR was more readily detected in patients with higher albuminuria. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Gansevoort, R. T., Meijer, E., Chapman, A. B., Czerwiec, F. S., Devuyst, O., Grantham, J. J., Higashihara, E., Krasa, H. B., Ouyang, J., Perrone, R. D., Torres, V. E., for the TEMPO 3:4 Investigators Tags: Chronic Kidney Disease Source Type: research

Development and initial validation of prescribing quality indicators for patients with chronic kidney disease
Conclusions We developed a set of 16 PQIs for measuring the quality of treatment in CKD patients, which had sufficient content and face validity as well as operational feasibility. These PQIs can be used to point out priority areas for improvement. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Smits, K. P. J., Sidorenkov, G., Bilo, H. J. G., Bouma, M., van Ittersum, F. J., Voorham, J., Navis, G., Denig, P. Tags: Chronic Kidney Disease Source Type: research

Selective screening for distal renal tubular acidosis in recurrent kidney stone formers: initial experience and comparison of the simultaneous furosemide and fludrocortisone test with the short ammonium chloride test
Conclusions The F+F test is characterized by an excellent sensitivity and negative predictive value, and the diagnosis of incomplete dRTA can be excluded reliably in a patient who acidifies their urine normally with this test. However, its lack of specificity is a drawback, and if there is any doubt, an abnormal F+F test may need to be confirmed by a follow-up NH4Cl test. Ideally, a prospective blinded study in unselected KSFs is needed to accurately assess the reliability of the F+F test in diagnosing, rather than excluding, dRTA. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Shavit, L., Chen, L., Ahmed, F., Ferraro, P. M., Moochhala, S., Walsh, S. B., Unwin, R. Tags: Chronic Kidney Disease Source Type: research

Primary care physicians perceived barriers, facilitators and strategies to enhance conservative care for older adults with chronic kidney disease: a qualitative descriptive study
Conclusions PCPs identified important barriers and facilitators to conservative care for their older patients with Stage 5 CKD. Further investigation of potential strategies that address barriers and enable facilitators is required to improve the quality of conservative care for older adults in the community. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Tam-Tham, H., Hemmelgarn, B. R., Campbell, D. J. T., Thomas, C. M., Fruetel, K., Quinn, R. R., King-Shier, K. M. Tags: Chronic Kidney Disease Source Type: research

Atherosclerotic renal artery stenosis is associated with elevated cell cycle arrest markers related to reduced renal blood flow and postcontrast hypoxia
Conclusion These data demonstrate elevated IGFBP-7 and TIMP-2 levels in ARAS as a function of the degree of reduced RBF. Elevated baseline IGFBP-7 levels were associated with protection against postimaging hypoxia, consistent with ‘ischemic preconditioning’. Despite contrast injection and stenting, AKI in these high-risk ARAS subjects with elevated IGFBP-7/TIMP-2 was rare and did not affect long-term kidney function. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Saad, A., Wang, W., Herrmann, S. M. S., Glockner, J. F., Mckusick, M. A., Misra, S., Bjarnason, H., Lerman, L. O., Textor, S. C. Tags: Acute Kidney Injury Source Type: research

A simple care bundle for use in acute kidney injury: a propensity score-matched cohort study
Conclusions Compliance with an AKI-CB was associated with lower mortality and reduced progression of AKI to higher stages. The AKI-CB is simple and inexpensive, and could therefore be applied in all healthcare settings to improve outcomes. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Kolhe, N. V., Reilly, T., Leung, J., Fluck, R. J., Swinscoe, K. E., Selby, N. M., Taal, M. W. Tags: Acute Kidney Injury Source Type: research

Impact of individual intravenous iron preparations on the differentiation of monocytes towards macrophages and dendritic cells
Conclusions This study demonstrates that less stable i.v. iron preparations specifically affect monocyte differentiation towards macrophages and mDCs. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Fell, L. H., Seiler-Mussler, S., Sellier, A. B., Rotter, B., Winter, P., Sester, M., Fliser, D., Heine, G. H., Zawada, A. M. Tags: BASIC SCIENCE Source Type: research

Resveratrol delays polycystic kidney disease progression through attenuation of nuclear factor {kappa}B-induced inflammation
Conclusions The NF-B signaling pathway is activated and partly responsible for inflammation in polycystic kidney tissues. Targeting inflammation through resveratrol could be a new strategy for PKD treatment in the future. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Wu, M., Gu, J., Mei, S., Xu, D., Jing, Y., Yao, Q., Chen, M., Yang, M., Chen, S., Yang, B., Qi, N., Hu, H., Wüthrich, R. P., Mei, C. Tags: BASIC SCIENCE Source Type: research

Four seasons for reflecting: autumn, hearing
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Ruff, D., Giuva, D., Finnel, S., Sandrone family, Cattaneo, G., Ronco, R., Kourilsky, O., Piccoli, G. B. Tags: HUMANITIES IN NEPHROLOGY Source Type: research

Innate immunity in CKD-associated vascular diseases
Chronic kidney disease (CKD) is associated with an increased risk for cardiovascular events. Therefore, the activation of the innate immune system plays an important role. In contrast to the adaptive immunity, unspecific recognition of conserved endogenous and exogenous structures by pattern recognition receptors (PRRs) represents a key feature of the innate immunity. Of these PRRs, Toll-like receptors (TLRs) as well as the inflammasome complex have been documented to be involved in the pathogenesis of cardiovascular diseases (CVDs). They are not only expressed in leukocytes but also in a variety of cell types such as endo...
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Zewinger, S., Schumann, T., Fliser, D., Speer, T. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Genetic testing in steroid-resistant nephrotic syndrome: when and how?
Steroid-resistant nephrotic syndrome (SRNS) represents the second most frequent cause of chronic kidney disease in the first three decades of life. It manifests histologically as focal segmental glomerulosclerosis (FSGS) and carries a 33% risk of relapse in a renal transplant. No efficient treatment exists. Identification of single-gene (monogenic) causes of SRNS has moved the glomerular epithelial cell (podocyte) to the center of its pathogenesis. Recently, mutations in >30 recessive or dominant genes were identified as causing monogenic forms of SRNS, thereby revealing the encoded proteins as essential for glomerular ...
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Lovric, S., Ashraf, S., Tan, W., Hildebrandt, F. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Should chronic metabolic acidosis be treated in older people with chronic kidney disease?
Metabolic acidosis is common in advanced chronic kidney disease and has been associated with a range of physiological derangements of importance to the health of older people. These include associations with skeletal muscle weakness, cardiovascular risk factors, and bone and mineral disorders that may lead to fragility fractures. Although metabolic acidosis is associated with accelerated decline in kidney function, end-stage renal failure is a much less common outcome in older, frail patients than cardiovascular death. Correction of metabolic acidosis using bicarbonate therapy is commonly employed, but the existing evidenc...
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Witham, M. D., Lamb, E. J. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Sex hormones in women with kidney disease
Menstrual disorders, infertility and premature menopause are common but often underrecognized phenomena among women with chronic kidney disease. Hypothalamic, rather than ovarian dysfunction, may be the cause of the abnormal reproductive milieu, which can be at least partially reversed by kidney transplantation and increased intensity of hemodialysis. Endogenous sex hormones, and specifically estradiol, appear to be renoprotective in women, although the effects of exogenous estradiol (as an oral contraceptive and postmenopausal hormone therapy) on kidney function are more controversial. Treatment with postmenopausal hormon...
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Ahmed, S. B., Ramesh, S. Tags: REVIEWS - BASIC SCIENCE AND TRANSLATIONAL NEPHROLOGY Source Type: research

Midkine, a heparin-binding growth factor, and its roles in atherogenesis and inflammatory kidney diseases
The heparin-binding protein midkine is a potent growth factor with emerging roles in numerous inflammatory diseases. Beyond its characterization in embryogenesis and organ development, ample insights into its function have been collected from experimental disease models using knockout animals or knockdown intervention strategies. Here a comprehensive overview on midkine and its functions in atherogenesis and kidney diseases is provided. Molecular clues to key signalling pathways (Akt, ERK, HIF1α) and key events in atherosclerotic vessels link midkine expression with vascular smooth muscle proliferation and (neo)angio...
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Salaru, D. L., Arsenescu-Georgescu, C., Chatzikyrkou, C., Karagiannis, J., Fischer, A., Mertens, P. R. Tags: REVIEWS - BASIC SCIENCE AND TRANSLATIONAL NEPHROLOGY Source Type: research