Nephrology Dialysis Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Regression of asymptomatic cardiomyopathy and clinical outcome of renal transplant recipients: a long-term prospective cohort study
Conclusions This is the first study to demonstrate that LVH regression, regardless of the therapeutic strategy adopted to achieve it, portends better long-term clinical outcome in RTRs. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Paoletti, E., Bellino, D., Signori, A., Pieracci, L., Marsano, L., Russo, R., Massarino, F., Ravera, M., Fontana, I., Carta, A., Cassottana, P., Garibotto, G. Tags: Renal Transplantation Source Type: research

Differences in survival on chronic dialysis treatment between ethnic groups in Denmark: a population-wide, national cohort study
Conclusions Incident chronic dialysis patients in Denmark originating from countries other than Denmark have a better survival compared with native Danes. For Western immigrants, this survival benefit declines among those who have lived in Denmark longer. For non-Western immigrants, the survival benefit largely remains over time. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: van den Beukel, T. O., Hommel, K., Kamper, A.-L., Heaf, J. G., Siegert, C. E. H., Honig, A., Jager, K. J., Dekker, F. W., Norredam, M. Tags: Intra- and extracorporeal treatments of kidney failure Source Type: research

Comparison of oral versus intravenous vitamin D receptor activator in reducing infection-related mortality in hemodialysis patients: the Q-Cohort Study
Conclusions Treatment with intravenous VDRA more effectively reduces the incidence of mortality from infection than oral VDRA in hemodialysis patients. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Tanaka, S., Ninomiya, T., Taniguchi, M., Fujisaki, K., Tokumoto, M., Hirakata, H., Ooboshi, H., Kitazono, T., Tsuruya, K. Tags: Intra- and extracorporeal treatments of kidney failure Source Type: research

Traditional and non-traditional risk factors for incident peripheral arterial disease among patients with chronic kidney disease
Conclusions Among patients with CKD, inflammation, prothrombotic state, oxidative stress, glycated hemoglobin, insulin resistance and alkaline phosphatase are associated with an increased risk of PAD, independent of traditional risk factors. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Chen, J., Mohler, E. R., Xie, D., Shlipak, M., Townsend, R. R., Appel, L. J., Ojo, A., Schreiber, M., Nessel, L., Zhang, X., Raj, D., Strauss, L., Lora, C. M., Rahman, M., Hamm, L. L., He, J., for the CRIC Study Investigators, for the CRIC Study Investiga Tags: Chronic Kidney Disease Source Type: research

Caveolin-1 single-nucleotide polymorphism and arterial stiffness in non-dialysis chronic kidney disease
Conclusions This replicated study suggests potential utility of the studied CAV1 SNP as a genetic biomarker in CKD and a role for CAV1 in the development of arteriosclerosis in this setting. Further studies are warranted to further explore the basic science driving these clinical observations. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Chand, S., Edwards, N. C., Chue, C. D., Jesky, M., Stringer, S., Simmonds, M. J., Duff, C. E., Cockwell, P., Harper, L., Steeds, R. P., Townend, J. N., Ferro, C. J., Borrows, R. Tags: Chronic Kidney Disease Source Type: research

Increased psychosocial risk, depression and reduced quality of life living with autosomal dominant polycystic kidney disease
Conclusions Our results reveal a significantly poorer QOL and increasing psychosocial risk with markers of disease progression in patients, particularly women, with ADPKD prior to starting RRT. The future management strategy of ADPKD should address these issues and provide for better individual and family support throughout the patient journey. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Simms, R. J., Thong, K. M., Dworschak, G. C., Ong, A. C. M. Tags: Chronic Kidney Disease Source Type: research

Progression to Stage 4 chronic kidney disease and death, acute kidney injury and hospitalization risk: a retrospective cohort study
Conclusions Progression from Stage 3 to Stage 4 CKD is associated with increased risks of death, AKI and hospitalization prior to ESRD. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Sud, M., Tangri, N., Pintilie, M., Levey, A. S., Naimark, D. M. J. Tags: Chronic Kidney Disease Source Type: research

Systemic complement activation and complement gene analysis in enterohaemorrhagic Escherichia coli-associated paediatric haemolytic uraemic syndrome
Conclusions Complement activation at the acute phase of EHEC-HUS, indicated by increased levels of sC5b-9, predicts a poor outcome. Complement alterations appear to be more frequent in patients with EHEC-HUS than previously thought and are suspected to have a role in the severity of the disease. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Ahlenstiel-Grunow, T., Hachmeister, S., Bange, F. C., Wehling, C., Kirschfink, M., Bergmann, C., Pape, L. Tags: Acute Kidney Injury Source Type: research

Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models
Conclusions In summary, the pharmacological activation of HIFs by 3,4-DHB administration, although it showed renoprotective effects in sepsis-related kidney injury, induced more severe problems in other organs such as the liver during sepsis, leading to increased mortality. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Schindler, K., Bondeva, T., Schindler, C., Claus, R. A., Franke, S., Wolf, G. Tags: BASIC SCIENCE Source Type: research

Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease
Conclusions Our results indicate a strong association between LVH and enhanced expression levels of FGF23, FGFR4 and calcineurin, activation of NFAT and reduced levels of soluble Klotho in the myocardium of patients with CKD. These alterations are not observed in kidney transplant patients. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Leifheit-Nestler, M., grosse Siemer, R., Flasbart, K., Richter, B., Kirchhoff, F., Ziegler, W. H., Klintschar, M., Becker, J. U., Erbersdobler, A., Aufricht, C., Seeman, T., Fischer, D.-C., Faul, C., Haffner, D. Tags: BASIC SCIENCE Source Type: research

Vitamin D receptor activator and dietary sodium restriction to reduce residual urinary albumin excretion in chronic kidney disease (ViRTUE study): rationale and study protocol
Optimal albuminuria reduction is considered essential to halting chronic kidney disease (CKD) progression. Both vitamin D receptor activator (VDRA) treatment and dietary sodium restriction potentiate the efficacy of renin–angiotensin–aldosterone-system (RAAS) blockade to reduce albuminuria. The ViRTUE study addresses whether a VDRA in combination with dietary sodium restriction provides further albuminuria reduction in non-diabetic CKD patients on top of RAAS blockade. The ViRTUE study is an investigator-initiated, prospective, multi-centre, randomized, double-blind (paricalcitol versus placebo), placebo-contro...
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Keyzer, C. A., de Jong, M. A., Fenna van Breda, G., Vervloet, M. G., Laverman, G. D., Hemmelder, M., Janssen, W. M., Lambers Heerspink, H. J., Navis, G., de Borst, M. H., for the Holland Nephrology Study (HONEST) Network, for the Holland Nephrology Study Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Balancing wobbles in the body sodium
Sodium balance is achieved within a matter of days and everything that enters should come out; sodium stores are of questionable relevance and sodium accumulation is accompanied by weight gain. Careful balance studies oftentimes conflicted with this view, and long-term studies suggested that total body sodium (TBNa) fluctuates independent of intake or body weight. We recently performed the opposite experiment in that we fixed sodium intake for weeks at three levels of sodium intake and collected all urine made. We found weekly (circaseptan) patterns in sodium excretion that were inversely related to aldosterone and directl...
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Titze, J., Rakova, N., Kopp, C., Dahlmann, A., Jantsch, J., Luft, F. C. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Muscle wasting in end-stage renal disease promulgates premature death: established, emerging and potential novel treatment strategies
Muscle wasting (or sarcopenia) is a common feature of the uremic phenotype and predisposes this vulnerable patient population to increased risk of comorbid complications, poor quality of life, frailty and premature death. The old age of dialysis patients is in addition a likely contributor to loss of muscle mass. As recent evidence suggests that assessment of muscle strength (i.e. function) is a better predictor of outcome and comorbidities than muscle mass, this opens new screening, assessment and therapeutic opportunities. Among established treatment strategies, the benefit of resistance exercise and endurance training a...
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Stenvinkel, P., Carrero, J. J., von Walden, F., Ikizler, T. A., Nader, G. A. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Mitochondria: a therapeutic target in acute kidney injury
Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and morbidity. It is a risk factor for the development and progression of chronic kidney disease. Presently, no effective treatment for AKI is available, and novel therapeutic approaches are desperately needed. Accumulating evidence highlights mitochondrial dysfunction as an important factor in the pathogenesis of AKI. Recent advances in our understanding of the molecules involved in mitochondrial biogenesis, fusion/fission, mitophagy and their pathophysiological roles will lead to the development of drugs that target mitochondria ...
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Ishimoto, Y., Inagi, R. Tags: REVIEWS - BASIC SCIENCE AND TRANSLATIONAL NEPHROLOGY Source Type: research

Moderator's view: Cyclophosphamide in lupus nephritis
Mycophenolate mofetil was recently accepted as the effective induction treatment of lupus nephritis, with the potential to replace cyclophosphamide or at least expand our therapeutic armamentarium in patients with this lifelong disease often requiring repeated induction treatment of its relapses. Compared with cyclophosphamide, mycophenolate may be more effective in black patients, and the risk of gonadotoxicity may be significantly lower in mycophenolate-treated subjects. However, experience with mycophenolate in severe lupus nephritis is still limited and we also have insufficient data on the long-term outcome of mycophe...
Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Tesar, V. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research