Glucagon-like peptide 1(GLP-1) receptor agonists in the management of the patient with type 2diabetes mellitus and chronic kidney disease: an approach for the nephrologist
Nefrologia (Engl Ed). 2023 Oct 7:S2013-2514(23)00147-5. doi: 10.1016/j.nefroe.2023.09.003. Online ahead of print.ABSTRACTDiabetic kidney disease, a common complication in patients with type 2 diabetes mellitus, is associated with a markedly increased morbidity and mortality, especially of cardiovascular origin, and faster progression to end-stage renal disease. To date, reducing cardiovascular and renal risk in this population was based on strict control of cardiovascular risk factors and the renin-angiotensin system blockade. More recently, sodium-glucose cotransporter type 2 inhibitors have demonstrated to offer cardiova...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - October 9, 2023 Category: Urology & Nephrology Authors: Aleix Cases Source Type: research

¿Which peritransplant features can predict graft survival in donor after circulatory death kidney transplantation?
Nefrologia (Engl Ed). 2023 Oct 7:S2013-2514(23)00135-9. doi: 10.1016/j.nefroe.2021.04.019. Online ahead of print.NO ABSTRACTPMID:37813742 | DOI:10.1016/j.nefroe.2021.04.019 (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - October 9, 2023 Category: Urology & Nephrology Authors: Iris Coello Ana Isabel Mart ínez Maria Peraire Laura Aizpiri Camila Andrea Vega Miquel Amer Ricardo Jos é Guldris Jos é L Bauzà Quetglas Enrique Carmelo Pieras Source Type: research

Finerenone: towards a holistic therapeutic approach to patients with diabetic kidney disease
Nefrologia (Engl Ed). 2023 Oct 7:S2013-2514(23)00146-3. doi: 10.1016/j.nefroe.2023.09.002. Online ahead of print.ABSTRACTDespite current treatments, that include renin angiotensin system blockers and SGLT2 inhibitors, the risk of renal disease progression among patients with diabetes and chronic kidney disease (CKD) remains unacceptably high. The pathogenesis of CKD in patients with diabetes is complex and includes hemodynamic and metabolic factors, as well as inflammation and fibrosis. Finerenone is a nonsteroidal highly selective mineralocorticoid antagonist that, in contrast to current therapies, may directly reduce inf...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - October 9, 2023 Category: Urology & Nephrology Authors: Jose Luis G órriz Jos é Ramón González-Juanatey Lorenzo Facila Maria Jose Soler Alfonso Valle Alberto Ortiz Source Type: research

Autosomal dominant distal renal tubular acidosis in two pediatric patients with mutations in the SLC4A1 gene. Can the maximum urinary pCO < sub > 2 < /sub > test be normal?
We present a family with autosomal dominant dRTA produced by a heterozygous mutation in the SLC4A1 gene in which the two paediatric members showed a test of normal maximum urinary pCO2. Our hypothesis is that since the H + -ATPase is intact, at least initially, the stimulation induced by intratubular electronegativity to secrete H + could be effective, which would allow the maximum urinary pCO2 to be paradoxically normal, which could explain the onset, moderate presentation of symptoms and late diagnosis in patients with this mutation. This is the first documented case of a dominant dRTA in Mexico.PMID:37775346 | DOI:10.10...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - September 29, 2023 Category: Urology & Nephrology Authors: Norma E Guerra Hern ández Circe G ómez Tenorio Laura Paloma M éndez Silva Teresa Moraleda Mesa Laura I Escobar Carolina Salvador Rosa Vargas Poussou V íctor M García Nieto Source Type: research

Meta-regression analysis to determine the effect of knowledge of the concept of brain death on the attitude towards organ donation among medical students
Nefrologia (Engl Ed). 2023 Sep 23:S2013-2514(23)00140-2. doi: 10.1016/j.nefroe.2021.04.020. Online ahead of print.NO ABSTRACTPMID:37748961 | DOI:10.1016/j.nefroe.2021.04.020 (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - September 25, 2023 Category: Urology & Nephrology Authors: Antonio R íos Marina Iniesta-Sep úlveda Pablo Ram írez Ana Isabel L ópez-Navas Source Type: research