Ocean scientists work to forecast huge plankton blooms in Arabian Sea
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03698-0
Author: Jeff Tollefson
An operational forecast could help countries prepare for booms in these tiny marine creatures. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Jeff Tollefson Tags: News Source Type: research
Four-in-one 3D printer paves way for custom-made robots and phones
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03446-4
Author: Mark Zastrow
Experimental device is a route to printing smartphones and other electronics. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Mark Zastrow Tags: News Source Type: research
Pioneering Alzheimer ’s study in Colombia zeroes in on enigmatic protein
Pioneering Alzheimer’s study in Colombia zeroes in on enigmatic protein
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03848-4
Author: Sara Reardon
Researchers tracking a genetic mutation that causes an early-onset form of the disease hope to uncover new drug targets. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Sara Reardon Tags: News Source Type: research
Athlete brain bank, costly weather and science on social media
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03772-7
Author:
The week in science: 23–29 March 2018. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Tags: Seven Days Source Type: research
Drug executives should take a Hippocratic oath
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03230-4
Author: Bob More
The industry must earn patients’ trust that new medicines really are worth the price, says Bob More. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Bob More Tags: Column Source Type: research
Mushrooms: coming soon to a burger near you
Nature 555, 7698 (2018). doi:10.1038/d41586-018-03855-5
Author:
Mushroom–beef blends can tackle expanding waistlines and carbon footprints. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Tags: Editorial Source Type: research
Cambridge Analytica controversy must spur researchers to update data ethics
Nature 555, 7698 (2018). doi:10.1038/d41586-018-03856-4
Author:
A scandal over an academic’s use of Facebook data highlights the need for research scrutiny. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Tags: Editorial Source Type: research
On the use and abuse of ancient DNA
Nature 555, 7698 (2018). doi:10.1038/d41586-018-03857-3
Author:
Researchers in several disciplines need to tread carefully over shared landscapes of the past. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Tags: Editorial Source Type: research
Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis
; Andrew C. Kruse
The shape, elongation, division and sporulation (SEDS) proteins are a large family of ubiquitous and essential transmembrane enzymes with critical roles in bacterial cell wall biology. The exact function of SEDS proteins was for a long time poorly understood, but recent work has revealed that the prototypical SEDS family member RodA is a peptidoglycan polymerase—a role previously attributed exclusively to members of the penicillin-binding protein family. This discovery has made RodA and other SEDS proteins promising targets for the development of next-generation antibiotics. However, little is know...
Source: Nature - March 28, 2018 Category: Research Authors: Megan Sjodt Kelly Brock Genevieve Dobihal Patricia D. A. Rohs Anna G. Green Thomas A. Hopf Alexander J. Meeske Veerasak Srisuknimit Daniel Kahne Suzanne Walker Debora S. Marks Thomas G. Bernhardt David Z. Rudner Andrew C. Kruse Tags: Letter Source Type: research
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
We describe the use of a new cell-permeable itaconate derivative, 4-octyl itaconate, which is protective against lipopolysaccharide-induced lethality in vivo and decreases cytokine production. We show that type I interferons boost the expression of Irg1 (also known as Acod1) and itaconate production. Furthermore, we find that itaconate production limits the type I interferon response, indicating a negative feedback loop that involves interferons and itaconate. Our findings demonstrate that itaconate is a crucial anti-inflammatory metabolite that acts via Nrf2 to limit inflammation and modulate type I interferons. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Evanna L. Mills Dylan G. Ryan Hiran A. Prag Dina Dikovskaya Deepthi Menon Zbigniew Zaslona Mark P. Jedrychowski Ana S. H. Costa Maureen Higgins Emily Hams John Szpyt Marah C. Runtsch Martin S. King Joanna F. McGouran Roman Fischer Benedikt M. Kessler Anne Tags: Letter Source Type: research
Whole-organism clone tracing using single-cell sequencing
naarden
Embryonic development is a crucial period in the life of a multicellular organism, during which limited sets of embryonic progenitors produce all cells in the adult body. Determining which fate these progenitors acquire in adult tissues requires the simultaneous measurement of clonal history and cell identity at single-cell resolution, which has been a major challenge. Clonal history has traditionally been investigated by microscopically tracking cells during development, monitoring the heritable expression of genetically encoded fluorescent proteins and, more recently, using next-generation sequencing technol...
Source: Nature - March 28, 2018 Category: Research Authors: Anna Alemany Maria Florescu Chlo é S. Baron Josi Peterson-Maduro Alexander van Oudenaarden Tags: Letter Source Type: research
A new class of synthetic retinoid antibiotics effective against bacterial persisters
l S. Gilmore, Huajian Gao, Frederick M. Ausubel & Eleftherios Mylonakis
A challenge in the treatment of Staphylococcus aureus infections is the high prevalence of methicillin-resistant S. aureus (MRSA) strains and the formation of non-growing, dormant ‘persister’ subpopulations that exhibit high levels of tolerance to antibiotics and have a role in chronic or recurrent infections. As conventional antibiotics are not effective in the treatment of infections caused by such bacteria, novel antibacterial therapeutics are urgently required. Here we used a Caenorhabditis elegans–MRSA infection screen to identify t...
Source: Nature - March 28, 2018 Category: Research Authors: Wooseong Kim Wenpeng Zhu Gabriel Lambert Hendricks Daria Van Tyne Andrew D. Steele Colleen E. Keohane Nico Fricke Annie L. Conery Steven Shen Wen Pan Kiho Lee Rajmohan Rajamuthiah Beth Burgwyn Fuchs Petia M. Vlahovska William M. Wuest Michael S. Gilmore H Tags: Letter Source Type: research
Quantized Majorana conductance
Daniel J. Pennachio, Borzoyeh Shojaei, Joon Sue Lee, Chris J. Palmstrøm, Erik P. A. M. Bakkers, S. Das Sarma & Leo P. Kouwenhoven
Majorana zero-modes—a type of localized quasiparticle—hold great promise for topological quantum computing. Tunnelling spectroscopy in electrical transport is the primary tool for identifying the presence of Majorana zero-modes, for instance as a zero-bias peak in differential conductance. The height of the Majorana zero-bias peak is predicted to be quantized at the universal conductance value of 2e2/h at zero temperature (where e is the charge of an electron and h is the Planck c...
Source: Nature - March 28, 2018 Category: Research Authors: Hao Zhang Chun-Xiao Liu Sasa Gazibegovic Di Xu John A. Logan Guanzhong Wang Nick van Loo Jouri D. S. Bommer Michiel W. A. de Moor Diana Car Roy L. M. Op het Veld Petrus J. van Veldhoven Sebastian Koelling Marcel A. Verheijen Mihir Pendharkar Daniel J. Pen Tags: Letter Source Type: research
Architecture of the human GATOR1 and GATOR1 –Rag GTPases complexes
Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
Nature 556, 7699 (2018). doi:10.1038/nature26158
Authors: Kuang Shen, Rick K. Huang, Edward J. Brignole, Kendall J. Condon, Max L. Valenstein, Lynne Chantranupong, Aimaiti Bomaliyamu, Abigail Choe, Chuan Hong, Zhiheng Yu & David M. Sabatini
Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex—comprising DEPDC5, NPRL2 and NPRL3—regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrien...
Source: Nature - March 28, 2018 Category: Research Authors: Kuang Shen Rick K. Huang Edward J. Brignole Kendall J. Condon Max L. Valenstein Lynne Chantranupong Aimaiti Bomaliyamu Abigail Choe Chuan Hong Zhiheng Yu David M. Sabatini Tags: Article Source Type: research
The logic of single-cell projections from visual cortex
sic-Flogel
Neocortical areas communicate through extensive axonal projections, but the logic of information transfer remains poorly understood, because the projections of individual neurons have not been systematically characterized. It is not known whether individual neurons send projections only to single cortical areas or distribute signals across (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Yunyun Han Justus M. Kebschull Robert A. A. Campbell Devon Cowan Fabia Imhof Anthony M. Zador Thomas D. Mrsic-Flogel Tags: Article Source Type: research
