The activated conformation of integrin β 7 is a novel multiple myeloma – specific target for CAR T cell therapy
Nature Medicine 23, 1436 (2017).
doi:10.1038/nm.4431
Authors: Naoki Hosen, Yukiko Matsunaga, Kana Hasegawa, Hiroshi Matsuno, Yuki Nakamura, Mio Makita, Kouki Watanabe, Mikako Yoshida, Kei Satoh, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Masahiro Manabe, Hiroyoshi Ichihara, Yasutaka Aoyama, Atsuko Mugitani, Takafumi Nakao, Masayuki Hino, Ryosuke Uchibori, Keiya Ozawa, Yoshihiro Baba, Seitaro Terakura, Naoki Wada, Eiichi Morii, Junichi Nishimura, Kiyoshi Takeda, Yusuke Oji, Haruo Sugiyama, Junichi Takagi & Atsushi Kumanogoh (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2017 Category: General Medicine Authors: Naoki Hosen Yukiko Matsunaga Kana Hasegawa Hiroshi Matsuno Yuki Nakamura Mio Makita Kouki Watanabe Mikako Yoshida Kei Satoh Soyoko Morimoto Fumihiro Fujiki Hiroko Nakajima Jun Nakata Sumiyuki Nishida Akihiro Tsuboi Yoshihiro Oka Masahiro Manabe Hiroyoshi Tags: Article Source Type: research
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Nature Medicine 23, 1405 (2017).
doi:10.1038/nm.4419
Authors: David Lagares, Parisa Ghassemi-Kakroodi, Caroline Tremblay, Alba Santos, Clemens K Probst, Alicia Franklin, Daniela M Santos, Paula Grasberger, Neil Ahluwalia, Sydney B Montesi, Barry S Shea, Katharine E Black, Rachel Knipe, Meryem Blati, Murray Baron, Brian Wu, Hassan Fahmi, Rajiv Gandhi, Annie Pardo, Moisés Selman, Jiangping Wu, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Andrew M Tager & Mohit Kapoor (Source: Nature Medicine)
Source: Nature Medicine - October 23, 2017 Category: General Medicine Authors: David Lagares Parisa Ghassemi-Kakroodi Caroline Tremblay Alba Santos Clemens K Probst Alicia Franklin Daniela M Santos Paula Grasberger Neil Ahluwalia Sydney B Montesi Barry S Shea Katharine E Black Rachel Knipe Meryem Blati Murray Baron Brian Wu Hassan F Tags: Article Source Type: research
Epigenetic suppression of hippocampal calbindin-D28k by Δ FosB drives seizure-related cognitive deficits
Nature Medicine 23, 1377 (2017).
doi:10.1038/nm.4413
Authors: Jason C You, Kavitha Muralidharan, Jin W Park, Iraklis Petrof, Mark S Pyfer, Brian F Corbett, John J LaFrancois, Yi Zheng, Xiaohong Zhang, Carrie A Mohila, Daniel Yoshor, Robert A Rissman, Eric J Nestler, Helen E Scharfman & Jeannie Chin
The calcium-binding protein calbindin-D28k is critical for hippocampal function and cognition, but its expression is markedly decreased in various neurological disorders associated with epileptiform activity and seizures. In Alzheimer's disease (AD) and epilepsy, both of which are accompanied by recurrent seizures, t...
Source: Nature Medicine - October 16, 2017 Category: General Medicine Authors: Jason C You Kavitha Muralidharan Jin W Park Iraklis Petrof Mark S Pyfer Brian F Corbett John J LaFrancois Yi Zheng Xiaohong Zhang Carrie A Mohila Daniel Yoshor Robert A Rissman Eric J Nestler Helen E Scharfman Jeannie Chin Tags: Letter Source Type: research
lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/ β -catenin signaling
Nature Medicine 23, 1331 (2017).
doi:10.1038/nm.4424
Authors: Yuanyuan Lu, Xiaodi Zhao, Qi Liu, Cunxi Li, Ramona Graves-Deal, Zheng Cao, Bhuminder Singh, Jeffrey L Franklin, Jing Wang, Huaying Hu, Tianying Wei, Mingli Yang, Timothy J Yeatman, Ethan Lee, Kenyi Saito-Diaz, Scott Hinger, James G Patton, Christine H Chung, Stephan Emmrich, Jan-Henning Klusmann, Daiming Fan & Robert J Coffey (Source: Nature Medicine)
Source: Nature Medicine - October 16, 2017 Category: General Medicine Authors: Yuanyuan Lu Xiaodi Zhao Qi Liu Cunxi Li Ramona Graves-Deal Zheng Cao Bhuminder Singh Jeffrey L Franklin Jing Wang Huaying Hu Tianying Wei Mingli Yang Timothy J Yeatman Ethan Lee Kenyi Saito-Diaz Scott Hinger James G Patton Christine H Chung Stephan Emmric Tags: Article Source Type: research
Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys
Nature Medicine 23, 1277 (2017).
doi:10.1038/nm.4421
Authors: Nicolas Huot, Beatrice Jacquelin, Thalia Garcia-Tellez, Philippe Rascle, Mickaël J Ploquin, Yoann Madec, R Keith Reeves, Nathalie Derreudre-Bosquet & Michaela Müller-Trutwin (Source: Nature Medicine)
Source: Nature Medicine - October 16, 2017 Category: General Medicine Authors: Nicolas Huot Beatrice Jacquelin Thalia Garcia-Tellez Philippe Rascle Micka ë l J Ploquin Yoann Madec R Keith Reeves Nathalie Derreudre-Bosquet Michaela M ü ller-Trutwin Tags: Article Source Type: research
Targeting glioma stem cells through combined BMI1 and EZH2 inhibition
Nature Medicine 23, 1352 (2017).
doi:10.1038/nm.4415
Authors: Xun Jin, Leo J Y Kim, Qiulian Wu, Lisa C Wallace, Briana C Prager, Tanwarat Sanvoranart, Ryan C Gimple, Xiuxing Wang, Stephen C Mack, Tyler E Miller, Ping Huang, Claudia L Valentim, Qi-gang Zhou, Jill S Barnholtz-Sloan, Shideng Bao, Andrew E Sloan & Jeremy N Rich (Source: Nature Medicine)
Source: Nature Medicine - October 9, 2017 Category: General Medicine Authors: Xun Jin Leo J Y Kim Qiulian Wu Lisa C Wallace Briana C Prager Tanwarat Sanvoranart Ryan C Gimple Xiuxing Wang Stephen C Mack Tyler E Miller Ping Huang Claudia L Valentim Qi-gang Zhou Jill S Barnholtz-Sloan Shideng Bao Andrew E Sloan Jeremy N Rich Tags: Article Source Type: research
Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma
Nature Medicine 23, 1342 (2017).
doi:10.1038/nm.4418
Authors: Wilson X Mai, Laura Gosa, Veerle W Daniels, Lisa Ta, Jonathan E Tsang, Brian Higgins, W Blake Gilmore, Nicholas A Bayley, Mitra Dehghan Harati, Jason T Lee, William H Yong, Harley I Kornblum, Steven J Bensinger, Paul S Mischel, P Nagesh Rao, Peter M Clark, Timothy F Cloughesy, Anthony Letai & David A Nathanson (Source: Nature Medicine)
Source: Nature Medicine - October 9, 2017 Category: General Medicine Authors: Wilson X Mai Laura Gosa Veerle W Daniels Lisa Ta Jonathan E Tsang Brian Higgins W Blake Gilmore Nicholas A Bayley Mitra Dehghan Harati Jason T Lee William H Yong Harley I Kornblum Steven J Bensinger Paul S Mischel P Nagesh Rao Peter M Clark Timothy F Clou Tags: Article Source Type: research
Sympathetic neuron – associated macrophages contribute to obesity by importing and metabolizing norepinephrine
Nature Medicine 23, 1309 (2017).
doi:10.1038/nm.4422
Authors: Roksana M Pirzgalska, Elsa Seixas, Jason S Seidman, Verena M Link, Noelia Martínez Sánchez, Inês Mahú, Raquel Mendes, Vitka Gres, Nadiya Kubasova, Imogen Morris, Bernardo A Arús, Chelsea M Larabee, Miguel Vasques, Francisco Tortosa, Ana L Sousa, Sathyavathy Anandan, Erin Tranfield, Maureen K Hahn, Matteo Iannacone, Nathanael J Spann, Christopher K Glass & Ana I Domingos (Source: Nature Medicine)
Source: Nature Medicine - October 9, 2017 Category: General Medicine Authors: Roksana M Pirzgalska Elsa Seixas Jason S Seidman Verena M Link Noelia Mart í nez S á nchez In ê s Mah ú Raquel Mendes Vitka Gres Nadiya Kubasova Imogen Morris Bernardo A Ar ú s Chelsea M Larabee Miguel Vasques Francisco Tortosa Ana L Sousa Sathyavath Tags: Article Source Type: research
Activation of intestinal hypoxia-inducible factor 2 α during obesity contributes to hepatic steatosis
Nature Medicine 23, 1298 (2017).
doi:10.1038/nm.4412
Authors: Cen Xie, Tomoki Yagai, Yuhong Luo, Xianyi Liang, Tao Chen, Qiong Wang, Dongxue Sun, Jie Zhao, Sadeesh K Ramakrishnan, Lulu Sun, Chunmei Jiang, Xiang Xue, Yuan Tian, Kristopher W Krausz, Andrew D Patterson, Yatrik M Shah, Yue Wu, Changtao Jiang & Frank J Gonzalez (Source: Nature Medicine)
Source: Nature Medicine - October 9, 2017 Category: General Medicine Authors: Cen Xie Tomoki Yagai Yuhong Luo Xianyi Liang Tao Chen Qiong Wang Dongxue Sun Jie Zhao Sadeesh K Ramakrishnan Lulu Sun Chunmei Jiang Xiang Xue Yuan Tian Kristopher W Krausz Andrew D Patterson Yatrik M Shah Yue Wu Changtao Jiang Frank J Gonzalez Tags: Article Source Type: research
Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation
Nature Medicine 23, 1287 (2017).
doi:10.1038/nm.4417
Authors: Yuta Shimanaka, Nozomu Kono, Yoshitaka Taketomi, Makoto Arita, Yoshimichi Okayama, Yuki Tanaka, Yasumasa Nishito, Tatsuki Mochizuki, Hiroyuki Kusuhara, Alexander Adibekian, Benjamin F Cravatt, Makoto Murakami & Hiroyuki Arai (Source: Nature Medicine)
Source: Nature Medicine - October 9, 2017 Category: General Medicine Authors: Yuta Shimanaka Nozomu Kono Yoshitaka Taketomi Makoto Arita Yoshimichi Okayama Yuki Tanaka Yasumasa Nishito Tatsuki Mochizuki Hiroyuki Kusuhara Alexander Adibekian Benjamin F Cravatt Makoto Murakami Hiroyuki Arai Tags: Article Source Type: research
Erratum: Elimination of large tumors in mice by mRNA-encoded bispecific antibodies
Nature Medicine 23, 1241 (2017).
doi:10.1038/nm1017-1241d
Authors: Christiane R Stadler, Hayat Bähr-Mahmud, Leyla Celik, Bernhard Hebich, Alexandra S Roth, René P Roth, Katalin Karikó, Özlem Türeci & Ugur Sahin (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Christiane R Stadler Hayat B ä hr-Mahmud Leyla Celik Bernhard Hebich Alexandra S Roth Ren é P Roth Katalin Karik ó Ö zlem T ü reci Ugur Sahin Tags: Erratum Source Type: research
Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling
Nature Medicine 23, 1241 (2017).
doi:10.1038/nm1017-1241c
Authors: Daniel A Giles, Maria E Moreno-Fernandez, Traci E Stankiewicz, Simon Graspeuntner, Monica Cappelletti, David Wu, Rajib Mukherjee, Calvin C Chan, Matthew J Lawson, Jared Klarquist, Annika Sünderhauf, Samir Softic, C Ronald Kahn, Kerstin Stemmer, Yoichiro Iwakura, Bruce J Aronow, Rebekah Karns, Kris A Steinbrecher, Christopher L Karp, Rachel Sheridan, Shiva K Shanmukhappa, Damien Reynaud, David B Haslam, Christian Sina, Jan Rupp, Simon P Hogan & Senad Divanovic (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Daniel A Giles Maria E Moreno-Fernandez Traci E Stankiewicz Simon Graspeuntner Monica Cappelletti David Wu Rajib Mukherjee Calvin C Chan Matthew J Lawson Jared Klarquist Annika S ü nderhauf Samir Softic C Ronald Kahn Kerstin Stemmer Yoichiro Iwakura Bruc Tags: Erratum Source Type: research
Corrigendum: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates
Nature Medicine 23, 1241 (2017).
doi:10.1038/nm1017-1241b
Authors: Pi-Xiao Wang, Yan-Xiao Ji, Xiao-Jing Zhang, Ling-Ping Zhao, Zhen-Zhen Yan, Peng Zhang, Li-Jun Shen, Xia Yang, Jing Fang, Song Tian, Xue-Yong Zhu, Jun Gong, Xin Zhang, Qiao-Fang Wei, Yong Wang, Jing Li, Lu Wan, Qingguo Xie, Zhi-Gang She, Zhihua Wang, Zan Huang & Hongliang Li (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Pi-Xiao Wang Yan-Xiao Ji Xiao-Jing Zhang Ling-Ping Zhao Zhen-Zhen Yan Peng Zhang Li-Jun Shen Xia Yang Jing Fang Song Tian Xue-Yong Zhu Jun Gong Xin Zhang Qiao-Fang Wei Yong Wang Jing Li Lu Wan Qingguo Xie Zhi-Gang She Zhihua Wang Zan Huang Hongliang Li Tags: Corrigendum Source Type: research
Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types
Nature Medicine 23, 1241 (2017).
doi:10.1038/nm1017-1241a
Authors: Ronald J Hause, Colin C Pritchard, Jay Shendure & Stephen J Salipante (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Ronald J Hause Colin C Pritchard Jay Shendure Stephen J Salipante Tags: Corrigendum Source Type: research
Clonal evolution in leukemia
Nature Medicine 23, 1135 (2017).
doi:10.1038/nm.4410
Authors: Adolfo A Ferrando & Carlos López-Otín (Source: Nature Medicine)
Source: Nature Medicine - October 6, 2017 Category: General Medicine Authors: Adolfo A Ferrando Carlos L ó pez-Ot í n Tags: Review Source Type: research
