Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice
Nature Medicine 23, 1384 (2017).
doi:10.1038/nm1117-1384c
Authors: Joshua N Farr, Ming Xu, Megan M Weivoda, David G Monroe, Daniel G Fraser, Jennifer L Onken, Brittany A Negley, Jad G Sfeir, Mikolaj B Ogrodnik, Christine M Hachfeld, Nathan K LeBrasseur, Matthew T Drake, Robert J Pignolo, Tamar Pirtskhalava, Tamara Tchkonia, Merry Jo Oursler, James L Kirkland & Sundeep Khosla (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Joshua N Farr Ming Xu Megan M Weivoda David G Monroe Daniel G Fraser Jennifer L Onken Brittany A Negley Jad G Sfeir Mikolaj B Ogrodnik Christine M Hachfeld Nathan K LeBrasseur Matthew T Drake Robert J Pignolo Tamar Pirtskhalava Tamara Tchkonia Merry Jo Ou Tags: Corrigendum Source Type: research
Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
Nature Medicine 23, 1384 (2017).
doi:10.1038/nm1117-1384b
Authors: Matthew D Lynes, Luiz O Leiria, Morten Lundh, Alexander Bartelt, Farnaz Shamsi, Tian Lian Huang, Hirokazu Takahashi, Michael F Hirshman, Christian Schlein, Alexandra Lee, Lisa A Baer, Francis J May, Fei Gao, Niven R Narain, Emily Y Chen, Michael A Kiebish, Aaron M Cypess, Matthias Blüher, Laurie J Goodyear, Gökhan S Hotamisligil, Kristin I Stanford & Yu-Hua Tseng (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Matthew D Lynes Luiz O Leiria Morten Lundh Alexander Bartelt Farnaz Shamsi Tian Lian Huang Hirokazu Takahashi Michael F Hirshman Christian Schlein Alexandra Lee Lisa A Baer Francis J May Fei Gao Niven R Narain Emily Y Chen Michael A Kiebish Aaron M Cypess Tags: Corrigendum Source Type: research
Corrigendum: Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation
Nature Medicine 23, 1384 (2017).
doi:10.1038/nm1117-1384a
Authors: Marie Toussaint, David J Jackson, Dawid Swieboda, Anabel Guedán, Theodora-Dorita Tsourouktsoglou, Yee Man Ching, Coraline Radermecker, Heidi Makrinioti, Julia Aniscenko, Michael R Edwards, Roberto Solari, Frédéric Farnir, Venizelos Papayannopoulos, Fabrice Bureau, Thomas Marichal & Sebastian L Johnston (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Marie Toussaint David J Jackson Dawid Swieboda Anabel Gued á n Theodora-Dorita Tsourouktsoglou Yee Man Ching Coraline Radermecker Heidi Makrinioti Julia Aniscenko Michael R Edwards Roberto Solari Fr é d é ric Farnir Venizelos Papayannopoulos Fabrice Bu Tags: Corrigendum Source Type: research
Barrier-tissue macrophages: functional adaptation to environmental challenges
Nature Medicine 23, 1258 (2017).
doi:10.1038/nm.4430
Authors: Allan McI Mowat, Charlotte L Scott & Calum C Bain (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Allan McI Mowat Charlotte L Scott Calum C Bain Tags: Review Source Type: research
Macrophages dispose of catecholamines in adipose tissue
Nature Medicine 23, 1255 (2017).
doi:10.1038/nm.4440
Author: Michael P Czech
Recent research has identified sympathetic neuron–associated macrophages in adipose tissue that take up and degrade catecholamines released from neurons. Obesity and aging enhance this system, decreasing responses to cold stress and starvation. (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Michael P Czech Tags: News and Views Source Type: research
Can NK cells purge HIV sanctuaries?
Nature Medicine 23, 1254 (2017).
doi:10.1038/nm.4434
Authors: Madeleine J Bunders & Marcus Altfeld
A recent study identifies a population of CXCR5+ natural killer (NK) cells patrolling B cell follicles in simian immunodeficiency virus (SIV)-infected African green monkeys that might contribute to the lack of disease progression in this nonpathogenic model. (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Madeleine J Bunders Marcus Altfeld Tags: News and Views Source Type: research
An epitranscriptomic vulnerability in myeloid malignancies
Nature Medicine 23, 1252 (2017).
doi:10.1038/nm.4435
Authors: Alexandra C Schmiechen & Pedro J Batista
A recent study finds that the N6-methyladenosine (m6A) modifier METTL3 regulates proliferation and differentiation in myeloid cells and acute myeloid leukemia (AML). (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Alexandra C Schmiechen Pedro J Batista Tags: News and Views Source Type: research
Long-range hypoxia signaling in NAFLD
Nature Medicine 23, 1251 (2017).
doi:10.1038/nm.4436
Authors: Edward L LaGory & Amato J Giaccia
A recent study describes a role for hypoxic signaling in the small intestine in the etiology of nonalcoholic fatty liver disease (NAFLD) and suggests that HIF-2α inhibitors may be an effective option for the treatment of this disease. (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Edward L LaGory Amato J Giaccia Tags: News and Views Source Type: research
Stalking new vaccines: Methods that target the stems of viral proteins could put universal vaccines within reach
Nature Medicine 23, 1248 (2017).
doi:10.1038/nm1117-1248
Author: Carrie Arnold (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Carrie Arnold Tags: News Source Type: research
Predictable response: Finding optimal drugs and doses using artificial intelligence
Nature Medicine 23, 1244 (2017).
doi:10.1038/nm1117-1244
Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
Accounting for sex in the genome
Nature Medicine 23, 1243 (2017).
doi:10.1038/nm.4445 (Source: Nature Medicine)
Source: Nature Medicine - November 7, 2017 Category: General Medicine Tags: Editorial Source Type: research
IRF3 and type I interferons fuel a fatal response to myocardial infarction
Nature Medicine 23, 1481 (2017).
doi:10.1038/nm.4428
Authors: Kevin R King, Aaron D Aguirre, Yu-Xiang Ye, Yuan Sun, Jason D Roh, Richard P Ng, Rainer H Kohler, Sean P Arlauckas, Yoshiko Iwamoto, Andrej Savol, Ruslan I Sadreyev, Mark Kelly, Timothy P Fitzgibbons, Katherine A Fitzgerald, Timothy Mitchison, Peter Libby, Matthias Nahrendorf & Ralph Weissleder
Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against infections and cancer, but excessive IRF3 activation and type I IFN production cause autoinflammatory conditions such as Aicardi–Goutières syndrome and STING-associa...
Source: Nature Medicine - November 6, 2017 Category: General Medicine Authors: Kevin R King Aaron D Aguirre Yu-Xiang Ye Yuan Sun Jason D Roh Richard P Ng Rainer H Kohler Sean P Arlauckas Yoshiko Iwamoto Andrej Savol Ruslan I Sadreyev Mark Kelly Timothy P Fitzgibbons Katherine A Fitzgerald Timothy Mitchison Peter Libby Matthias Nahre Tags: Letter Source Type: research
Selective neuronal lapses precede human cognitive lapses following sleep deprivation
Nature Medicine 23, 1474 (2017).
doi:10.1038/nm.4433
Authors: Yuval Nir, Thomas Andrillon, Amit Marmelshtein, Nanthia Suthana, Chiara Cirelli, Giulio Tononi & Itzhak Fried
Sleep deprivation is a major source of morbidity with widespread health effects, including increased risk of hypertension, diabetes, obesity, heart attack, and stroke. Moreover, sleep deprivation brings about vehicle accidents and medical errors and is therefore an urgent topic of investigation. During sleep deprivation, homeostatic and circadian processes interact to build up sleep pressure, which results in slow behavioral performance (cogn...
Source: Nature Medicine - November 6, 2017 Category: General Medicine Authors: Yuval Nir Thomas Andrillon Amit Marmelshtein Nanthia Suthana Chiara Cirelli Giulio Tononi Itzhak Fried Tags: Letter Source Type: research
A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle
Nature Medicine 23, 1466 (2017).
doi:10.1038/nm.4420
Authors: Motoharu Awazawa, Paula Gabel, Eva Tsaousidou, Hendrik Nolte, Marcus Krüger, Joel Schmitz, P Justus Ackermann, Claus Brandt, Janine Altmüller, Susanne Motameny, F Thomas Wunderlich, Jan-Wilhelm Kornfeld, Matthias Blüher & Jens C Brüning
Over 40% of microRNAs (miRNAs) are located in introns of protein-coding genes, and many of these intronic miRNAs are co-regulated with their host genes. In such cases of co-regulation, the products of host genes and their intronic miRNAs can cooperate to coordinately regulate biologically important...
Source: Nature Medicine - November 6, 2017 Category: General Medicine Authors: Motoharu Awazawa Paula Gabel Eva Tsaousidou Hendrik Nolte Marcus Kr ü ger Joel Schmitz P Justus Ackermann Claus Brandt Janine Altm ü ller Susanne Motameny F Thomas Wunderlich Jan-Wilhelm Kornfeld Matthias Bl ü her Jens C Br ü ning Tags: Letter Source Type: research
Asprosin is a centrally acting orexigenic hormone
Nature Medicine 23, 1444 (2017).
doi:10.1038/nm.4432
Authors: Clemens Duerrschmid, Yanlin He, Chunmei Wang, Chia Li, Juan C Bournat, Chase Romere, Pradip K Saha, Mark E Lee, Kevin J Phillips, Mahim Jain, Peilin Jia, Zhongming Zhao, Monica Farias, Qi Wu, Dianna M Milewicz, V Reid Sutton, David D Moore, Nancy F Butte, Michael J Krashes, Yong Xu & Atul R Chopra (Source: Nature Medicine)
Source: Nature Medicine - November 6, 2017 Category: General Medicine Authors: Clemens Duerrschmid Yanlin He Chunmei Wang Chia Li Juan C Bournat Chase Romere Pradip K Saha Mark E Lee Kevin J Phillips Mahim Jain Peilin Jia Zhongming Zhao Monica Farias Qi Wu Dianna M Milewicz V Reid Sutton David D Moore Nancy F Butte Michael J Krashes Tags: Article Source Type: research
