A new vaccine for tuberculosis in rhesus macaques
Nature Medicine 24, 124 (2018).
doi:10.1038/nm.4488
Authors: Stephen M Carpenter & Samuel M Behar
In a recent study using cytomegalovirus (CMV)-vectored vaccines in rhesus macaques, prevention of tuberculosis in over 40% of vaccinated animals is shown and is attributed to reprogrammed innate immunity and CMV's maintenance of vaccine-elicited effector memory T cells. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Stephen M Carpenter Samuel M Behar Tags: News and Views Source Type: research
A potential biomarker for anti-PD-1 immunotherapy
Nature Medicine 24, 123 (2018).
doi:10.1038/nm.4489
Authors: Sangeeta Goswami, Sreyashi Basu & Padmanee Sharma
A recent study identifies an immune cell type known as classical monocytes in the peripheral blood as a potential biomarker for response to anti-PD-1 immune checkpoint therapy in metastatic melanoma. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Sangeeta Goswami Sreyashi Basu Padmanee Sharma Tags: News and Views Source Type: research
Gene therapies for hemophilia hit the mark in clinical trials
Nature Medicine 24, 121 (2018).
doi:10.1038/nm.4492
Authors: Adrian K Pickar & Charles A Gersbach
Two recent studies describe clinical successes for single-dose gene therapy in trials for two forms of hemophilia. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Adrian K Pickar Charles A Gersbach Tags: News and Views Source Type: research
A shot at contraception: In India, a nonagenarian renews testing of a birth control vaccine
Nature Medicine 24, 118 (2018).
doi:10.1038/nm0218-118
Author: Killugudi Jayaraman (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Killugudi Jayaraman Tags: News Source Type: research
Correction
Nature Medicine 24, 117 (2018).
doi:10.1038/nm0218-117 (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Tags: News Source Type: research
Animals on the verge: What different species can teach us about human puberty
Nature Medicine 24, 114 (2018).
doi:10.1038/nm0218-114
Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
Taking personalized medicine to heart
Nature Medicine 24, 113 (2018).
doi:10.1038/nm.4495
Tailoring treatment to the individual patient has revolutionized cancer therapy, but
personalized medicine has yet to make much headway in the treatment of cardiovascular disease. With
emerging insight into disease mechanisms and new treatment options, the time is now ripe for the cardiovascular field to adopt a more personalized approach to therapy. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Tags: Editorial Source Type: research
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain
Nature Medicine 24, 368 (2018).
doi:10.1038/nm.4485
Authors: Kristina M Adams Waldorf, Branden R Nelson, Jennifer E Stencel-Baerenwald, Colin Studholme, Raj P Kapur, Blair Armistead, Christie L Walker, Sean Merillat, Jay Vornhagen, Jennifer Tisoncik-Go, Audrey Baldessari, Michelle Coleman, Manjiri K Dighe, Dennis W W Shaw, Justin A Roby, Veronica Santana-Ufret, Erica Boldenow, Junwei Li, Xiaohu Gao, Michael A Davis, Jesica A Swanstrom, Kara Jensen, Douglas G Widman, Ralph S Baric, Joseph T Medwid, Kathryn A Hanley, Jason Ogle, G Michael Gough, Wonsok Lee, Chris English, W McIntyre Durning, Jeff Thiel, Chris Gatenby...
Source: Nature Medicine - February 5, 2018 Category: General Medicine Authors: Kristina M Adams Waldorf Branden R Nelson Jennifer E Stencel-Baerenwald Colin Studholme Raj P Kapur Blair Armistead Christie L Walker Sean Merillat Jay Vornhagen Jennifer Tisoncik-Go Audrey Baldessari Michelle Coleman Manjiri K Dighe Dennis W W Shaw Justi Tags: Letter Source Type: research
A novel chimeric antigen receptor containing a JAK – STAT signaling domain mediates superior antitumor effects
Nature Medicine 24, 352 (2018).
doi:10.1038/nm.4478
Authors: Yuki Kagoya, Shinya Tanaka, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Kayoko Saso, Marcus O Butler, Mark D Minden & Naoto Hirano
The adoptive transfer of T cells engineered with a chimeric antigen receptor (CAR) (hereafter referred to as CAR-T cells) specific for the B lymphocyte antigen CD19 has shown impressive clinical responses in patients with refractory B cell malignancies. However, the therapeutic effects of CAR-T cells that target other malignancies have not yet resulted in significant clinical benefit. Although inefficient tumor trafficki...
Source: Nature Medicine - February 5, 2018 Category: General Medicine Authors: Yuki Kagoya Shinya Tanaka Tingxi Guo Mark Anczurowski Chung-Hsi Wang Kayoko Saso Marcus O Butler Mark D Minden Naoto Hirano Tags: Letter Source Type: research
Pericyte degeneration causes white matter dysfunction in the mouse central nervous system
Nature Medicine 24, 326 (2018).
doi:10.1038/nm.4482
Authors: Axel Montagne, Angeliki M Nikolakopoulou, Zhen Zhao, Abhay P Sagare, Gabriel Si, Divna Lazic, Samuel R Barnes, Madelaine Daianu, Anita Ramanathan, Ariel Go, Erica J Lawson, Yaoming Wang, William J Mack, Paul M Thompson, Julie A Schneider, Jobin Varkey, Ralf Langen, Eric Mullins, Russell E Jacobs & Berislav V Zlokovic (Source: Nature Medicine)
Source: Nature Medicine - February 5, 2018 Category: General Medicine Authors: Axel Montagne Angeliki M Nikolakopoulou Zhen Zhao Abhay P Sagare Gabriel Si Divna Lazic Samuel R Barnes Madelaine Daianu Anita Ramanathan Ariel Go Erica J Lawson Yaoming Wang William J Mack Paul M Thompson Julie A Schneider Jobin Varkey Ralf Langen Eric M Tags: Article Source Type: research
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
Nature Medicine 24, 313 (2018).
doi:10.1038/nm.4490
Authors: Yingxiao Shi, Shaoyu Lin, Kim A Staats, Yichen Li, Wen-Hsuan Chang, Shu-Ting Hung, Eric Hendricks, Gabriel R Linares, Yaoming Wang, Esther Y Son, Xinmei Wen, Kassandra Kisler, Brent Wilkinson, Louise Menendez, Tohru Sugawara, Phillip Woolwine, Mickey Huang, Michael J Cowan, Brandon Ge, Nicole Koutsodendris, Kaitlin P Sandor, Jacob Komberg, Vamshidhar R Vangoor, Ketharini Senthilkumar, Valerie Hennes, Carina Seah, Amy R Nelson, Tze-Yuan Cheng, Shih-Jong J Lee, Paul R August, Jason A Chen, Nicholas Wisniewski, Victor Hanson-Smith, T Grant Belgard, Alice Zha...
Source: Nature Medicine - February 5, 2018 Category: General Medicine Authors: Yingxiao Shi Shaoyu Lin Kim A Staats Yichen Li Wen-Hsuan Chang Shu-Ting Hung Eric Hendricks Gabriel R Linares Yaoming Wang Esther Y Son Xinmei Wen Kassandra Kisler Brent Wilkinson Louise Menendez Tohru Sugawara Phillip Woolwine Mickey Huang Michael J Cowa Tags: Article Source Type: research
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
Nature Medicine 24, 292 (2018).
doi:10.1038/nm.4481
Authors: Alexander Bartelt, Scott B Widenmaier, Christian Schlein, Kornelia Johann, Renata L S Goncalves, Kosei Eguchi, Alexander W Fischer, Günes Parlakgül, Nicole A Snyder, Truc B Nguyen, Oliver T Bruns, Daniel Franke, Moungi G Bawendi, Matthew D Lynes, Luiz O Leiria, Yu-Hua Tseng, Karen E Inouye, Ana Paula Arruda & Gökhan S Hotamisligil (Source: Nature Medicine)
Source: Nature Medicine - February 5, 2018 Category: General Medicine Authors: Alexander Bartelt Scott B Widenmaier Christian Schlein Kornelia Johann Renata L S Goncalves Kosei Eguchi Alexander W Fischer G ü nes Parlakg ü l Nicole A Snyder Truc B Nguyen Oliver T Bruns Daniel Franke Moungi G Bawendi Matthew D Lynes Luiz O Leiria Yu Tags: Article Source Type: research
Noncanonical hedgehog pathway activation through SRF – MKL1 promotes drug resistance in basal cell carcinomas
Nature Medicine 24, 271 (2018).
doi:10.1038/nm.4476
Authors: Ramon J Whitson, Alex Lee, Nicole M Urman, Amar Mirza, Catherine Y Yao, Alexander S Brown, Jiang R Li, Gautam Shankar, Micah A Fry, Scott X Atwood, Eunice Y Lee, S Tyler Hollmig, Sumaira Z Aasi, Kavita Y Sarin, Matthew P Scott, Ervin H Epstein, Jean Y Tang & Anthony E Oro (Source: Nature Medicine)
Source: Nature Medicine - February 5, 2018 Category: General Medicine Authors: Ramon J Whitson Alex Lee Nicole M Urman Amar Mirza Catherine Y Yao Alexander S Brown Jiang R Li Gautam Shankar Micah A Fry Scott X Atwood Eunice Y Lee S Tyler Hollmig Sumaira Z Aasi Kavita Y Sarin Matthew P Scott Ervin H Epstein Jean Y Tang Anthony E Oro Tags: Article Source Type: research
Antagonism of PPAR- γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis
Nature Medicine 24, 360 (2018).
doi:10.1038/nm.4477
Authors: Bin Guo, Xinxin Huang, Man Ryul Lee, Sang A Lee & Hal E Broxmeyer
Hematopoietic stem cells (HSCs) quiescently reside in bone marrow niches and have the capacity to self-renew or differentiate to form all of the blood cells throughout the lifespan of an animal. Allogeneic HSC transplantation is a life-saving treatment for malignant and nonmalignant disorders. HSCs isolated from umbilical cord blood (CB) are used for hematopoietic cell transplantation (HCT), but due to the limited numbers of HSCs in single units of umbilical CB, a number of methods have...
Source: Nature Medicine - January 29, 2018 Category: General Medicine Authors: Bin Guo Xinxin Huang Man Ryul Lee Sang A Lee Hal E Broxmeyer Tags: Letter Source Type: research
Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation
Nature Medicine 24, 224 (2018).
doi:10.1038/nm.4467
Authors: Yu-Mei He, Xing Li, Michela Perego, Yulia Nefedova, Andrew V Kossenkov, Erik A Jensen, Valerian Kagan, Yu-Feng Liu, Shu-Yu Fu, Qing-Jian Ye, Yan-Hong Zhou, Lai Wei, Dmitry I Gabrilovich & Jie Zhou
Myeloid-derived suppressor cells (MDSCs) are pathologically activated and relatively immature myeloid cells that have been implicated in the immunological regulation of many pathologic conditions. Phenotypically and morphologically, MDSCs are similar to neutrophils (PMN-MDSCs) and monocytes (M-MDSCs). However, they have potent suppressive activity and distin...
Source: Nature Medicine - January 15, 2018 Category: General Medicine Authors: Yu-Mei He Xing Li Michela Perego Yulia Nefedova Andrew V Kossenkov Erik A Jensen Valerian Kagan Yu-Feng Liu Shu-Yu Fu Qing-Jian Ye Yan-Hong Zhou Lai Wei Dmitry I Gabrilovich Jie Zhou Tags: Letter Source Type: research
