Is autoimmunity the Achilles' heel of cancer immunotherapy?
Nature Medicine 23, 540 (2017).
doi:10.1038/nm.4321
Authors: Carl H June, Jeremy T Warshauer & Jeffrey A Bluestone (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: Journals (General) Authors: Carl H June Jeremy T Warshauer Jeffrey A Bluestone Tags: Perspective Source Type: research
HIV persistence in macrophages
Nature Medicine 23, 538 (2017).
doi:10.1038/nm.4337
Author: Mario Stevenson
A recent study using a humanized mouse model shows that HIV-1 can persist in macrophages during antiretroviral therapy (ART), and suggests that macrophages may represent an obstacle to efforts to cure HIV-1 infection. (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: Journals (General) Authors: Mario Stevenson Tags: News and Views Source Type: research
Thymosin α1: a single drug with multiple targets in cystic fibrosis
Nature Medicine 23, 536 (2017).
doi:10.1038/nm.4339
Authors: André M Cantin & John W Hanrahan
A new study in mice suggests that a single drug, thymosin α1, may simultaneously rectify the impaired trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in cystic fibrosis (CF) and reduce inflammation, offering new hope for CF treatment. (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: Journals (General) Authors: Andr é M Cantin John W Hanrahan Tags: News and Views Source Type: research
A role for oncostatin M in inflammatory bowel disease
Nature Medicine 23, 535 (2017).
doi:10.1038/nm.4338
Authors: Walter M Kim, Arthur Kaser & Richard S Blumberg
A new study identifies oncostatin M (OSM) as a potential biomarker and therapeutic target for anti-tumor necrosis factor (TNF)-refractory inflammatory bowel disease (IBD), and pinpoints mucosal stromal cells as key players in OSM-mediated inflammation. (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: Journals (General) Authors: Walter M Kim Arthur Kaser Richard S Blumberg Tags: News and Views Source Type: research
Correction
Nature Medicine 23, 534 (2017).
doi:10.1038/nm0517-534 (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: Journals (General) Tags: Correction Source Type: research
Bringing RNA into the fold: Small molecules find new targets in RNA to combat disease
Nature Medicine 23, 532 (2017).
doi:10.1038/nm0517-532
Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: Journals (General) Authors: Shraddha Chakradhar Tags: News Source Type: research
Host with the most: Targeting host cells instead of pathogens to fight infectious disease
Nature Medicine 23, 528 (2017).
doi:10.1038/nm0517-528
Author: Amanda B. Keener (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: Journals (General) Authors: Amanda B. Keener Tags: News Source Type: research
The curse of uncertainty
Nature Medicine 23, 527 (2017).
doi:10.1038/nm.4342
Proposed US budget cuts and the impending exit of the UK from the European Union have the potential to destabilize the global biomedical-research enterprise. In the meantime, the uncertainty of not knowing just how bad the effects will be will inflict its own damage. (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: Journals (General) Tags: Editorial Source Type: research
Pericytes impair capillary blood flow and motor function after chronic spinal cord injury
Nature Medicine 23, 733 (2017).
doi:10.1038/nm.4331
Authors: Yaqing Li, Ana M Lucas-Osma, Sophie Black, Mischa V Bandet, Marilee J Stephens, Romana Vavrek, Leo Sanelli, Keith K Fenrich, Antonio F Di Narzo, Stella Dracheva, Ian R Winship, Karim Fouad & David J Bennett (Source: Nature Medicine)
Source: Nature Medicine - May 1, 2017 Category: General Medicine Authors: Yaqing Li Ana M Lucas-Osma Sophie Black Mischa V Bandet Marilee J Stephens Romana Vavrek Leo Sanelli Keith K Fenrich Antonio F Di Narzo Stella Dracheva Ian R Winship Karim Fouad David J Bennett Tags: Article Source Type: research
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation
Nature Medicine 23, 681 (2017).
doi:10.1038/nm.4332
Authors: Marie Toussaint, David J Jackson, Dawid Swieboda, Anabel Guedán, Theodora-Dorita Tsourouktsoglou, Yee Man Ching, Coraline Radermecker, Heidi Makrinioti, Julia Aniscenko, Michael R Edwards, Roberto Solari, Frédéric Farnir, Venizelos Papayannopoulos, Fabrice Bureau, Thomas Marichal & Sebastian L Johnston (Source: Nature Medicine)
Source: Nature Medicine - May 1, 2017 Category: General Medicine Authors: Marie Toussaint David J Jackson Dawid Swieboda Anabel Gued á n Theodora-Dorita Tsourouktsoglou Yee Man Ching Coraline Radermecker Heidi Makrinioti Julia Aniscenko Michael R Edwards Roberto Solari Fr é d é ric Farnir Venizelos Papayannopoulos Fabrice Bu Tags: Article Source Type: research
Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease
Nature Medicine 23, 678 (2017).
doi:10.1038/nm.4330
Authors: Alice D Lam, Gina Deck, Alica Goldman, Emad N Eskandar, Jeffrey Noebels & Andrew J Cole
We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperex...
Source: Nature Medicine - May 1, 2017 Category: General Medicine Authors: Alice D Lam Gina Deck Alica Goldman Emad N Eskandar Jeffrey Noebels Andrew J Cole Tags: Brief Communication Source Type: research
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Nature Medicine 23, 775 (2017).
doi:10.1038/nm.4324
Authors: Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge, Marco Demaria, Sona Rathod, Alain P Vasserot, Jae Wook Chung, Do Hun Kim, Yan Poon, Nathaniel David, Darren J Baker, Jan M van Deursen, Judith Campisi & Jennifer H Elisseeff
Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to age-related pathologies, presumably through their secretion of factors contributing to the senescence-associated secretory phenotype (SASP). Removal of SnCs delays several pathologies and increases healthy lifespan. Aging and trauma are risk factor...
Source: Nature Medicine - April 24, 2017 Category: General Medicine Authors: Ok Hee Jeon Chaekyu Kim Remi-Martin Laberge Marco Demaria Sona Rathod Alain P Vasserot Jae Wook Chung Do Hun Kim Yan Poon Nathaniel David Darren J Baker Jan M van Deursen Judith Campisi Jennifer H Elisseeff Tags: Letter Source Type: research
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction
Nature Medicine 23, 753 (2017).
doi:10.1038/nm.4328
Authors: Weier Qi, Hillary A Keenan, Qian Li, Atsushi Ishikado, Aimo Kannt, Thorsten Sadowski, Mark A Yorek, I-Hsien Wu, Samuel Lockhart, Lawrence J Coppey, Anja Pfenninger, Chong Wee Liew, Guifen Qiang, Alison M Burkart, Stephanie Hastings, David Pober, Christopher Cahill, Monika A Niewczas, William J Israelsen, Liane Tinsley, Isaac E Stillman, Peter S Amenta, Edward P Feener, Matthew G Vander Heiden, Robert C Stanton & George L King (Source: Nature Medicine)
Source: Nature Medicine - April 24, 2017 Category: General Medicine Authors: Weier Qi Hillary A Keenan Qian Li Atsushi Ishikado Aimo Kannt Thorsten Sadowski Mark A Yorek I-Hsien Wu Samuel Lockhart Lawrence J Coppey Anja Pfenninger Chong Wee Liew Guifen Qiang Alison M Burkart Stephanie Hastings David Pober Christopher Cahill Monika Tags: Article Source Type: research
HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy
Nature Medicine 23, 638 (2017).
doi:10.1038/nm.4319
Authors: Jenna B Honeycutt, William O Thayer, Caroline E Baker, Ruy M Ribeiro, Steven M Lada, Youfang Cao, Rachel A Cleary, Michael G Hudgens, Douglas D Richman & J Victor Garcia
Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is never eradicated. One major barrier to eradication is that the virus infects multiple cell types that may individually contribute to HIV persistence. Tissue macrophages are critical contributors to HIV pathogenesis; however, their specific role in HIV persistence during long-term suppress...
Source: Nature Medicine - April 17, 2017 Category: General Medicine Authors: Jenna B Honeycutt William O Thayer Caroline E Baker Ruy M Ribeiro Steven M Lada Youfang Cao Rachel A Cleary Michael G Hudgens Douglas D Richman J Victor Garcia Tags: Letter Source Type: research
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis
Nature Medicine 23, 623 (2017).
doi:10.1038/nm.4316
Authors: Katrin Fischer, Henry H Ruiz, Kevin Jhun, Brian Finan, Douglas J Oberlin, Verena van der Heide, Anastasia V Kalinovich, Natasa Petrovic, Yochai Wolf, Christoffer Clemmensen, Andrew C Shin, Senad Divanovic, Frank Brombacher, Elke Glasmacher, Susanne Keipert, Martin Jastroch, Joachim Nagler, Karl-Werner Schramm, Dasa Medrikova, Gustav Collden, Stephen C Woods, Stephan Herzig, Dirk Homann, Steffen Jung, Jan Nedergaard, Barbara Cannon, Matthias H Tschöp, Timo D Müller & Christoph Buettner (Source: Nature Medicine)
Source: Nature Medicine - April 17, 2017 Category: General Medicine Authors: Katrin Fischer Henry H Ruiz Kevin Jhun Brian Finan Douglas J Oberlin Verena van der Heide Anastasia V Kalinovich Natasa Petrovic Yochai Wolf Christoffer Clemmensen Andrew C Shin Senad Divanovic Frank Brombacher Elke Glasmacher Susanne Keipert Martin Jastr Tags: Article Source Type: research
