Medicine's movable feast: What jumping genes can teach us about treating disease
Nature Medicine 23, 791 (2017).
doi:10.1038/nm0717-791
Author: Roxanne Khamsi (Source: Nature Medicine)
Source: Nature Medicine - July 11, 2017 Category: General Medicine Authors: Roxanne Khamsi Tags: News Source Type: research
Battling the biology of opioid addiction
Nature Medicine 23, 790 (2017).
doi:10.1038/nm.4374
Deaths from drug overdose are rising worldwide, in part owing to the growing epidemic of opioid addiction. Efforts to combat opioid addiction will benefit from stronger collaboration between preclinical researchers who are studying addiction and those studying chronic pain. (Source: Nature Medicine)
Source: Nature Medicine - July 11, 2017 Category: General Medicine Tags: Editorial Source Type: research
A prescription for cancer diagnostics
Nature Medicine 23, 789 (2017).
doi:10.1038/nm.4371
Cancer research has made great strides in identifying effective therapies for treating advanced-stage tumors. The next challenge is moving the battle to earlier stages of disease. (Source: Nature Medicine)
Source: Nature Medicine - July 11, 2017 Category: General Medicine Tags: Editorial Source Type: research
Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus
Nature Medicine 23, 997 (2017).
doi:10.1038/nm.4361
Authors: Jason K Karimy, Jinwei Zhang, David B Kurland, Brianna Carusillo Theriault, Daniel Duran, Jesse A Stokum, Charuta Gavankar Furey, Xu Zhou, M Shahid Mansuri, Julio Montejo, Alberto Vera, Michael L DiLuna, Eric Delpire, Seth L Alper, Murat Gunel, Volodymyr Gerzanich, Ruslan Medzhitov, J Marc Simard & Kristopher T Kahle
The choroid plexus epithelium (CPE) secretes higher volumes of fluid (cerebrospinal fluid, CSF) than any other epithelium and simultaneously functions as the blood–CSF barrier to gate immune cell entry into the central nervous syste...
Source: Nature Medicine - July 10, 2017 Category: General Medicine Authors: Jason K Karimy Jinwei Zhang David B Kurland Brianna Carusillo Theriault Daniel Duran Jesse A Stokum Charuta Gavankar Furey Xu Zhou M Shahid Mansuri Julio Montejo Alberto Vera Michael L DiLuna Eric Delpire Seth L Alper Murat Gunel Volodymyr Gerzanich Rusla Tags: Letter Source Type: research
Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis
Nature Medicine 23, 964 (2017).
doi:10.1038/nm.4364
Authors: Guillermo de Cárcer, Paulina Wachowicz, Sara Martínez-Martínez, Jorge Oller, Nerea Méndez-Barbero, Beatriz Escobar, Alejandra González-Loyola, Tohru Takaki, Aicha El Bakkali, Juan A Cámara, Luis J Jiménez-Borreguero, Xosé R Bustelo, Marta Cañamero, Francisca Mulero, María de los Ángeles Sevilla, María Jose Montero, Juan Miguel Redondo & Marcos Malumbres (Source: Nature Medicine)
Source: Nature Medicine - July 10, 2017 Category: General Medicine Authors: Guillermo de C á rcer Paulina Wachowicz Sara Mart à nez-Mart à nez Jorge Oller Nerea M é ndez-Barbero Beatriz Escobar Alejandra Gonz á lez-Loyola Tohru Takaki Aicha El Bakkali Juan A C á mara Luis J Jim é nez-Borreguero Xos é R Bustelo Marta Ca à Tags: Article Source Type: research
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids
Nature Medicine 23, 954 (2017).
doi:10.1038/nm.4360
Authors: Fotios Sampaziotis, Alexander W Justin, Olivia C Tysoe, Stephen Sawiak, Edmund M Godfrey, Sara S Upponi, Richard L Gieseck, Miguel Cardoso de Brito, Natalie Lie Berntsen, María J Gómez-Vázquez, Daniel Ortmann, Loukia Yiangou, Alexander Ross, Johannes Bargehr, Alessandro Bertero, Mariëlle C F Zonneveld, Marianne T Pedersen, Matthias Pawlowski, Laura Valestrand, Pedro Madrigal, Nikitas Georgakopoulos, Negar Pirmadjid, Gregor M Skeldon, John Casey, Wenmiao Shu, Paulina M Materek, Kirsten E Snijders, Stephanie E Brown, Casey A Rimland, Ing...
Source: Nature Medicine - July 3, 2017 Category: General Medicine Authors: Fotios Sampaziotis Alexander W Justin Olivia C Tysoe Stephen Sawiak Edmund M Godfrey Sara S Upponi Richard L Gieseck Miguel Cardoso de Brito Natalie Lie Berntsen Mar à a J G ó mez-V á zquez Daniel Ortmann Loukia Yiangou Alexander Ross Johannes Bargehr Tags: Article Source Type: research
Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice
Nature Medicine 23, 990 (2017).
doi:10.1038/nm.4363
Authors: Bérengère Benoit, Emmanuelle Meugnier, Martina Castelli, Stéphanie Chanon, Aurélie Vieille-Marchiset, Christine Durand, Nadia Bendridi, Sandra Pesenti, Pierre-Axel Monternier, Anne-Cécile Durieux, Damien Freyssenet, Jennifer Rieusset, Etienne Lefai, Hubert Vidal & Jérôme Ruzzin
The endocrine-derived hormone fibroblast growth factor (FGF) 19 has recently emerged as a potential target for treating metabolic disease. Given that skeletal muscle is a key metabolic organ, we explored the role of FGF19 in that tissue. Here ...
Source: Nature Medicine - June 26, 2017 Category: General Medicine Authors: B é reng è re Benoit Emmanuelle Meugnier Martina Castelli St é phanie Chanon Aur é lie Vieille-Marchiset Christine Durand Nadia Bendridi Sandra Pesenti Pierre-Axel Monternier Anne-C é cile Durieux Damien Freyssenet Jennifer Rieusset Etienne Lefai Hub Tags: Letter Source Type: research
A tripartite complex of suPAR, APOL1 risk variants and α v β 3 integrin on podocytes mediates chronic kidney disease
Nature Medicine 23, 945 (2017).
doi:10.1038/nm.4362
Authors: Salim S Hayek, Kwi Hye Koh, Morgan E Grams, Changli Wei, Yi-An Ko, Jing Li, Beata Samelko, Hyun Lee, Ranadheer R Dande, Ha Won Lee, Eunsil Hahm, Vasil Peev, Melissa Tracy, Nicholas J Tardi, Vineet Gupta, Mehmet M Altintas, Garrett Garborcauskas, Nikolina Stojanovic, Cheryl A Winkler, Michael S Lipkowitz, Adrienne Tin, Lesley A Inker, Andrew S Levey, Martin Zeier, Barry I Freedman, Jeffrey B Kopp, Karl Skorecki, Josef Coresh, Arshed A Quyyumi, Sanja Sever & Jochen Reiser (Source: Nature Medicine)
Source: Nature Medicine - June 26, 2017 Category: General Medicine Authors: Salim S Hayek Kwi Hye Koh Morgan E Grams Changli Wei Yi-An Ko Jing Li Beata Samelko Hyun Lee Ranadheer R Dande Ha Won Lee Eunsil Hahm Vasil Peev Melissa Tracy Nicholas J Tardi Vineet Gupta Mehmet M Altintas Garrett Garborcauskas Nikolina Stojanovic Cheryl Tags: Article Source Type: research
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing
Nature Medicine 23, 878 (2017).
doi:10.1038/nm.4355
Authors: Miguel Crespo, Eduardo Vilar, Su-Yi Tsai, Kyle Chang, Sadaf Amin, Tara Srinivasan, Tuo Zhang, Nina H Pipalia, Huanhuan Joyce Chen, Mavee Witherspoon, Miriam Gordillo, Jenny Zhaoying Xiang, Frederick R Maxfield, Steven Lipkin, Todd Evans & Shuibing Chen
With the goal of modeling human disease of the large intestine, we sought to develop an effective protocol for deriving colonic organoids (COs) from differentiated human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs). Extensive gene and immunohistochemical profiling confirmed tha...
Source: Nature Medicine - June 19, 2017 Category: General Medicine Authors: Miguel Crespo Eduardo Vilar Su-Yi Tsai Kyle Chang Sadaf Amin Tara Srinivasan Tuo Zhang Nina H Pipalia Huanhuan Joyce Chen Mavee Witherspoon Miriam Gordillo Jenny Zhaoying Xiang Frederick R Maxfield Steven Lipkin Todd Evans Shuibing Chen Tags: Letter Source Type: research
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
Nature Medicine 23, 859 (2017).
doi:10.1038/nm.4358
Authors: Ruixin Liu, Jie Hong, Xiaoqiang Xu, Qiang Feng, Dongya Zhang, Yanyun Gu, Juan Shi, Shaoqian Zhao, Wen Liu, Xiaokai Wang, Huihua Xia, Zhipeng Liu, Bin Cui, Peiwen Liang, Liuqing Xi, Jiabin Jin, Xiayang Ying, Xiaolin Wang, Xinjie Zhao, Wanyu Li, Huijue Jia, Zhou Lan, Fengyu Li, Rui Wang, Yingkai Sun, Minglan Yang, Yuxin Shen, Zhuye Jie, Junhua Li, Xiaomin Chen, Huanzi Zhong, Hailiang Xie, Yifei Zhang, Weiqiong Gu, Xiaxing Deng, Baiyong Shen, Xun Xu, Huanming Yang, Guowang Xu, Yufang Bi, Shenghan Lai, Jian Wang, Lu Qi, Lise Madsen, Jiqiu Wang, Guang Ning, Ka...
Source: Nature Medicine - June 19, 2017 Category: General Medicine Authors: Ruixin Liu Jie Hong Xiaoqiang Xu Qiang Feng Dongya Zhang Yanyun Gu Juan Shi Shaoqian Zhao Wen Liu Xiaokai Wang Huihua Xia Zhipeng Liu Bin Cui Peiwen Liang Liuqing Xi Jiabin Jin Xiayang Ying Xiaolin Wang Xinjie Zhao Wanyu Li Huijue Jia Zhou Lan Fengyu Li R Tags: Article Source Type: research
Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin – N-cadherin pathway after spinal cord injury
Nature Medicine 23, 818 (2017).
doi:10.1038/nm.4354
Authors: Masamitsu Hara, Kazu Kobayakawa, Yasuyuki Ohkawa, Hiromi Kumamaru, Kazuya Yokota, Takeyuki Saito, Ken Kijima, Shingo Yoshizaki, Katsumi Harimaya, Yasuharu Nakashima & Seiji Okada (Source: Nature Medicine)
Source: Nature Medicine - June 19, 2017 Category: General Medicine Authors: Masamitsu Hara Kazu Kobayakawa Yasuyuki Ohkawa Hiromi Kumamaru Kazuya Yokota Takeyuki Saito Ken Kijima Shingo Yoshizaki Katsumi Harimaya Yasuharu Nakashima Seiji Okada Tags: Article Source Type: research
ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix
Nature Medicine 23, 890 (2017).
doi:10.1038/nm.4352
Authors: Alejandro E Mayorca-Guiliani, Chris D Madsen, Thomas R Cox, Edward R Horton, Freja A Venning & Janine T Erler (Source: Nature Medicine)
Source: Nature Medicine - June 12, 2017 Category: General Medicine Authors: Alejandro E Mayorca-Guiliani Chris D Madsen Thomas R Cox Edward R Horton Freja A Venning Janine T Erler Tags: Technical Report Source Type: research
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
Nature Medicine 23, 839 (2017).
doi:10.1038/nm.4357
Authors: Anna Worthmann, Clara John, Malte C Rühlemann, Miriam Baguhl, Femke-Anouska Heinsen, Nicola Schaltenberg, Markus Heine, Christian Schlein, Ioannis Evangelakos, Chieko Mineo, Markus Fischer, Maura Dandri, Claus Kremoser, Ludger Scheja, Andre Franke, Philip W Shaul & Joerg Heeren (Source: Nature Medicine)
Source: Nature Medicine - June 12, 2017 Category: General Medicine Authors: Anna Worthmann Clara John Malte C R ü hlemann Miriam Baguhl Femke-Anouska Heinsen Nicola Schaltenberg Markus Heine Christian Schlein Ioannis Evangelakos Chieko Mineo Markus Fischer Maura Dandri Claus Kremoser Ludger Scheja Andre Franke Philip W Shaul Joe Tags: Article Source Type: research
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling
Nature Medicine 23, 829 (2017).
doi:10.1038/nm.4346
Authors: Daniel A Giles, Maria E Moreno-Fernandez, Traci E Stankiewicz, Simon Graspeuntner, Monica Cappelletti, David Wu, Rajib Mukherjee, Calvin C Chan, Matthew J Lawson, Jared Klarquist, Annika Sünderhauf, Samir Softic, C Ronald Kahn, Kerstin Stemmer, Yoichiro Iwakura, Bruce J Aronow, Rebekah Karns, Kris A Steinbrecher, Christopher L Karp, Rachel Sheridan, Shiva K Shanmukhappa, Damien Reynaud, David B Haslam, Christian Sina, Jan Rupp, Simon P Hogan & Senad Divanovic (Source: Nature Medicine)
Source: Nature Medicine - June 12, 2017 Category: General Medicine Authors: Daniel A Giles Maria E Moreno-Fernandez Traci E Stankiewicz Simon Graspeuntner Monica Cappelletti David Wu Rajib Mukherjee Calvin C Chan Matthew J Lawson Jared Klarquist Annika S ü nderhauf Samir Softic C Ronald Kahn Kerstin Stemmer Yoichiro Iwakura Bruc Tags: Article Source Type: research
Elimination of large tumors in mice by mRNA-encoded bispecific antibodies
Nature Medicine 23, 815 (2017).
doi:10.1038/nm.4356
Authors: Christiane R Stadler, Hayat Bähr-Mahmud, Leyla Celik, Bernhard Hebich, Alexandra S Roth, René P Roth, Katalin Karikó, Özlem Türeci & Ugur Sahin
The potential of bispecific T cell–engaging antibodies is hindered by manufacturing challenges and short serum half-life. We circumvented these limitations by treating mice with in vitro–transcribed pharmacologically optimized, nucleoside-modified mRNA encoding the antibody. We achieved sustained endogenous synthesis of the antibody, which eliminated advanced tumors as effe...
Source: Nature Medicine - June 12, 2017 Category: General Medicine Authors: Christiane R Stadler Hayat B ä hr-Mahmud Leyla Celik Bernhard Hebich Alexandra S Roth Ren é P Roth Katalin Karik ó Ö zlem T ü reci Ugur Sahin Tags: Brief Communication Source Type: research
