The missing pieces: Lack of Zika data from Africa complicates search for answers
Nature Medicine 23, 904 (2017).
doi:10.1038/nm0817-904
Author: Nicole Wetsman (Source: Nature Medicine)
Source: Nature Medicine - August 4, 2017 Category: General Medicine Authors: Nicole Wetsman Tags: News Source Type: research
The epigenome editors: How tools such as CRISPR offer new details about epigenetics
Nature Medicine 23, 900 (2017).
doi:10.1038/nm0817-900
Author: Cassandra Willyard (Source: Nature Medicine)
Source: Nature Medicine - August 4, 2017 Category: General Medicine Authors: Cassandra Willyard Tags: News Source Type: research
Lessons from reservoirs
Nature Medicine 23, 899 (2017).
doi:10.1038/nm.4387 (Source: Nature Medicine)
Source: Nature Medicine - August 4, 2017 Category: General Medicine Tags: Editorial Source Type: research
Implications of human genetic variation in CRISPR-based therapeutic genome editing
Nature Medicine 23, 1095 (2017).
doi:10.1038/nm.4377
Authors: David A Scott & Feng Zhang (Source: Nature Medicine)
Source: Nature Medicine - July 31, 2017 Category: General Medicine Authors: David A Scott Feng Zhang Tags: Analysis Source Type: research
The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease
Nature Medicine 23, 1080 (2017).
doi:10.1038/nm.4380
Authors: Jérôme Legoff, Matthieu Resche-Rigon, Jerome Bouquet, Marie Robin, Samia N Naccache, Séverine Mercier-Delarue, Scot Federman, Erik Samayoa, Clotilde Rousseau, Prescillia Piron, Nathalie Kapel, François Simon, Gérard Socié & Charles Y Chiu
Much attention has been focused on the role of the bacterial microbiome in human health, but the virome is understudied. Although previously investigated in individuals with inflammatory bowel diseases or solid-organ transplants, virome dynamics in allogeneic hematopoietic stem cell tra...
Source: Nature Medicine - July 31, 2017 Category: General Medicine Authors: J é r ô me Legoff Matthieu Resche-Rigon Jerome Bouquet Marie Robin Samia N Naccache S é verine Mercier-Delarue Scot Federman Erik Samayoa Clotilde Rousseau Prescillia Piron Nathalie Kapel Fran ç ois Simon G é rard Soci é Charles Y Chiu Tags: Letter Source Type: research
D-mannose induces regulatory T cells and suppresses immunopathology
Nature Medicine 23, 1036 (2017).
doi:10.1038/nm.4375
Authors: Dunfang Zhang, Cheryl Chia, Xue Jiao, Wenwen Jin, Shimpei Kasagi, Ruiqing Wu, Joanne E Konkel, Hiroko Nakatsukasa, Peter Zanvit, Nathan Goldberg, Qianming Chen, Lingyun Sun, Zi-Jiang Chen & WanJun Chen (Source: Nature Medicine)
Source: Nature Medicine - July 24, 2017 Category: General Medicine Authors: Dunfang Zhang Cheryl Chia Xue Jiao Wenwen Jin Shimpei Kasagi Ruiqing Wu Joanne E Konkel Hiroko Nakatsukasa Peter Zanvit Nathan Goldberg Qianming Chen Lingyun Sun Zi-Jiang Chen WanJun Chen Tags: Article Source Type: research
Correction of a splicing defect in a mouse model of congenital muscular dystrophy type 1A using a homology-directed-repair-independent mechanism
Nature Medicine 23, 984 (2017).
doi:10.1038/nm.4367
Authors: Dwi U Kemaladewi, Eleonora Maino, Elzbieta Hyatt, Huayun Hou, Maylynn Ding, Kara M Place, Xinyi Zhu, Prabhpreet Bassi, Zahra Baghestani, Amit G Deshwar, Daniele Merico, Hui Y Xiong, Brendan J Frey, Michael D Wilson, Evgueni A Ivakine & Ronald D Cohn
Splice-site defects account for about 10% of pathogenic mutations that cause Mendelian diseases. Prevalence is higher in neuromuscular disorders (NMDs), owing to the unusually large size and multi-exonic nature of genes encoding muscle structural proteins. Therapeutic genome editing to correct disease-caus...
Source: Nature Medicine - July 17, 2017 Category: General Medicine Authors: Dwi U Kemaladewi Eleonora Maino Elzbieta Hyatt Huayun Hou Maylynn Ding Kara M Place Xinyi Zhu Prabhpreet Bassi Zahra Baghestani Amit G Deshwar Daniele Merico Hui Y Xiong Brendan J Frey Michael D Wilson Evgueni A Ivakine Ronald D Cohn Tags: Letter Source Type: research
SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans
Nature Medicine 23, 975 (2017).
doi:10.1038/nm.4370
Authors: E Kaitlynn Allen, Adrienne G Randolph, Tushar Bhangale, Pranay Dogra, Maikke Ohlson, Christine M Oshansky, Anthony E Zamora, John P Shannon, David Finkelstein, Amy Dressen, John DeVincenzo, Miguela Caniza, Ben Youngblood, Carrie M Rosenberger & Paul G Thomas (Source: Nature Medicine)
Source: Nature Medicine - July 17, 2017 Category: General Medicine Authors: E Kaitlynn Allen Adrienne G Randolph Tushar Bhangale Pranay Dogra Maikke Ohlson Christine M Oshansky Anthony E Zamora John P Shannon David Finkelstein Amy Dressen John DeVincenzo Miguela Caniza Ben Youngblood Carrie M Rosenberger Paul G Thomas Tags: Article Source Type: research
Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells
Nature Medicine 23, 938 (2017).
doi:10.1038/nm.4373
Authors: Simon Rauber, Markus Luber, Stefanie Weber, Lisa Maul, Alina Soare, Thomas Wohlfahrt, Neng-Yu Lin, Katharina Dietel, Aline Bozec, Martin Herrmann, Mark H Kaplan, Benno Weigmann, Mario M Zaiss, Ursula Fearon, Douglas J Veale, Juan D Cañete, Oliver Distler, Felice Rivellese, Costantino Pitzalis, Markus F Neurath, Andrew N J McKenzie, Stefan Wirtz, Georg Schett, Jörg H W Distler & Andreas Ramming (Source: Nature Medicine)
Source: Nature Medicine - July 17, 2017 Category: General Medicine Authors: Simon Rauber Markus Luber Stefanie Weber Lisa Maul Alina Soare Thomas Wohlfahrt Neng-Yu Lin Katharina Dietel Aline Bozec Martin Herrmann Mark H Kaplan Benno Weigmann Mario M Zaiss Ursula Fearon Douglas J Veale Juan D Ca ñ ete Oliver Distler Felice Rivell Tags: Article Source Type: research
An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer
Nature Medicine 23, 929 (2017).
doi:10.1038/nm.4369
Authors: Yaohua Xue, Luciano Martelotto, Timour Baslan, Alberto Vides, Martha Solomon, Trang Thi Mai, Neelam Chaudhary, Greg J Riely, Bob T Li, Kerry Scott, Fabiola Cechhi, Ulrika Stierner, Kalyani Chadalavada, Elisa de Stanchina, Sarit Schwartz, Todd Hembrough, Gouri Nanjangud, Michael F Berger, Jonas Nilsson, Scott W Lowe, Jorge S Reis-Filho, Neal Rosen & Piro Lito (Source: Nature Medicine)
Source: Nature Medicine - July 17, 2017 Category: General Medicine Authors: Yaohua Xue Luciano Martelotto Timour Baslan Alberto Vides Martha Solomon Trang Thi Mai Neelam Chaudhary Greg J Riely Bob T Li Kerry Scott Fabiola Cechhi Ulrika Stierner Kalyani Chadalavada Elisa de Stanchina Sarit Schwartz Todd Hembrough Gouri Nanjangud M Tags: Article Source Type: research
Insulin action and resistance in obesity and type 2 diabetes
Nature Medicine 23, 804 (2017).
doi:10.1038/nm.4350
Author: Michael P Czech (Source: Nature Medicine)
Source: Nature Medicine - July 11, 2017 Category: General Medicine Authors: Michael P Czech Tags: Perspective Source Type: research
A mouse model of renal cell carcinoma
Nature Medicine 23, 802 (2017).
doi:10.1038/nm.4366
Authors: Laura S Schmidt & W Marston Linehan
A mouse model with combined renal epithelium-specific deletion of Vhl, Trp53 and Rb1 that develops clear-cell renal cell carcinoma provides a research tool for investigating the mechanisms that drive this cancer, and for evaluating the efficacy of novel therapeutic agents. (Source: Nature Medicine)
Source: Nature Medicine - July 11, 2017 Category: General Medicine Authors: Laura S Schmidt W Marston Linehan Tags: News and Views Source Type: research
An unexpected role for bile acid synthesis in adaptation to low temperature
Nature Medicine 23, 800 (2017).
doi:10.1038/nm.4365
Authors: Folkert Kuipers & Albert K Groen
Enhanced conversion of dietary cholesterol to bile acids through the alternative pathway leads to cold-associated, metabolically beneficial changes in the intestinal microbiome and to elevated bile acid levels that contribute to adaptive thermogenesis. (Source: Nature Medicine)
Source: Nature Medicine - July 11, 2017 Category: General Medicine Authors: Folkert Kuipers Albert K Groen Tags: News and Views Source Type: research
Correction
Nature Medicine 23, 799 (2017).
doi:10.1038/nm0717-799 (Source: Nature Medicine)
Source: Nature Medicine - July 11, 2017 Category: General Medicine Tags: Correction Source Type: research
Put to the test: Organoid-based testing becomes a clinical tool
Nature Medicine 23, 796 (2017).
doi:10.1038/nm0717-796
Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - July 11, 2017 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
