Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4
Nature Medicine 23, 1220 (2017).
doi:10.1038/nm.4395
Authors: Samarchith P Kurup, Nyamekye Obeng-Adjei, Scott M Anthony, Boubacar Traore, Ogobara K Doumbo, Noah S Butler, Peter D Crompton & John T Harty
Malaria, caused by the protozoan Plasmodium, is a devastating mosquito-borne disease with the potential to affect nearly half the world's population. Despite mounting substantial T and B cell responses, humans fail to efficiently control blood-stage malaria or develop sterilizing immunity to reinfections. Although forkhead box P3 (FOXP3)+CD4+ regulatory T (Treg) cells form a part of these responses, their influe...
Source: Nature Medicine - September 11, 2017 Category: General Medicine Authors: Samarchith P Kurup Nyamekye Obeng-Adjei Scott M Anthony Boubacar Traore Ogobara K Doumbo Noah S Butler Peter D Crompton John T Harty Tags: Letter Source Type: research
A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors
Nature Medicine 23, 1191 (2017).
doi:10.1038/nm.4402
Authors: Julia E Neumann, Annika K Wefers, Sander Lambo, Edoardo Bianchi, Marie Bockstaller, Mario M Dorostkar, Valerie Meister, Pia Schindler, Andrey Korshunov, Katja von Hoff, Johannes Nowak, Monika Warmuth-Metz, Marlon R Schneider, Ingrid Renner-Müller, Daniel J Merk, Mehdi Shakarami, Tanvi Sharma, Lukas Chavez, Rainer Glass, Jennifer A Chan, M Mark Taketo, Philipp Neumann, Marcel Kool & Ulrich Schüller (Source: Nature Medicine)
Source: Nature Medicine - September 11, 2017 Category: General Medicine Authors: Julia E Neumann Annika K Wefers Sander Lambo Edoardo Bianchi Marie Bockstaller Mario M Dorostkar Valerie Meister Pia Schindler Andrey Korshunov Katja von Hoff Johannes Nowak Monika Warmuth-Metz Marlon R Schneider Ingrid Renner-M ü ller Daniel J Merk Mehd Tags: Article Source Type: research
Functional precision cancer medicine — moving beyond pure genomics
Nature Medicine 23, 1028 (2017).
doi:10.1038/nm.4389
Author: Anthony Letai (Source: Nature Medicine)
Source: Nature Medicine - September 8, 2017 Category: General Medicine Authors: Anthony Letai Tags: Perspective Source Type: research
Microglia emerge as central players in brain disease
Nature Medicine 23, 1018 (2017).
doi:10.1038/nm.4397
Authors: Michael W Salter & Beth Stevens (Source: Nature Medicine)
Source: Nature Medicine - September 8, 2017 Category: General Medicine Authors: Michael W Salter Beth Stevens Tags: Review Source Type: research
Sex-specific disease-associated modules for depression
Nature Medicine 23, 1015 (2017).
doi:10.1038/nm.4391
Author: Ronald S Duman
A recent study reveals sexually dimorphic disease-associated gene-expression modules and hub genes in postmortem brains from female and male individuals with depression. These modules are conserved in mouse models of depression. (Source: Nature Medicine)
Source: Nature Medicine - September 8, 2017 Category: General Medicine Authors: Ronald S Duman Tags: News and Views Source Type: research
SPOP tips the balance of BETs in cancer
Nature Medicine 23, 1014 (2017).
doi:10.1038/nm.4398
Authors: Katie A Fennell & Mark A Dawson
Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal inhibitors in prostate and endometrial cancer. (Source: Nature Medicine)
Source: Nature Medicine - September 8, 2017 Category: General Medicine Authors: Katie A Fennell Mark A Dawson Tags: News and Views Source Type: research
The enteric virome in hematopoietic stem cell transplantation: ready for its close-up
Nature Medicine 23, 1012 (2017).
doi:10.1038/nm.4403
Authors: Shuichiro Takashima & Alan M Hanash
A new study highlights dynamic changes in the enteric virome after hematopoietic stem cell transplantation in humans, pointing to a correlation between these changes and graft-versus-host disease. (Source: Nature Medicine)
Source: Nature Medicine - September 8, 2017 Category: General Medicine Authors: Shuichiro Takashima Alan M Hanash Tags: News and Views Source Type: research
Correction
Nature Medicine 23, 1011 (2017).
doi:10.1038/nm0917-1011 (Source: Nature Medicine)
Source: Nature Medicine - September 8, 2017 Category: General Medicine Tags: Correction Source Type: research
Inflammatory illness: Why the next wave of antidepressants may target the immune system
Nature Medicine 23, 1009 (2017).
doi:10.1038/nm0917-1009
Author: Nicole Wetsman (Source: Nature Medicine)
Source: Nature Medicine - September 8, 2017 Category: General Medicine Authors: Nicole Wetsman Tags: News Source Type: research
Uncovering cancer: How enlisting T cells can boost the power of immunotherapy
Nature Medicine 23, 1006 (2017).
doi:10.1038/nm0917-1006
Author: Amanda B. Keener (Source: Nature Medicine)
Source: Nature Medicine - September 8, 2017 Category: General Medicine Authors: Amanda B. Keener Tags: News Source Type: research
Children first
Nature Medicine 23, 1005 (2017).
doi:10.1038/nm.4404
Drugs administered to children with cancer were typically developed under the assumption that childhood cancers are similar to their tissue-matched adult counterparts. Focusing on identifying and targeting alterations present specifically in childhood tumors will accelerate the development of tailored therapies and improve the prognosis of children with cancer. (Source: Nature Medicine)
Source: Nature Medicine - September 8, 2017 Category: General Medicine Tags: Editorial Source Type: research
Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas
Nature Medicine 23, 1226 (2017).
doi:10.1038/nm.4368
Authors: Elodie Bal, Hyun-Sook Park, Zakia Belaid-Choucair, Hülya Kayserili, Magali Naville, Marine Madrange, Elena Chiticariu, Smail Hadj-Rabia, Nicolas Cagnard, Francois Kuonen, Daniel Bachmann, Marcel Huber, Cindy Le Gall, Francine Côté, Sylvain Hanein, Rasim Özgür Rosti, Ayca Dilruba Aslanger, Quinten Waisfisz, Christine Bodemer, Olivier Hermine, Fanny Morice-Picard, Bruno Labeille, Frédéric Caux, Juliette Mazereeuw-Hautier, Nicole Philip, Nicolas Levy, Alain Taieb, Marie-Françoise Avril, Denis J Headon, Gabor Gyapay, T...
Source: Nature Medicine - September 4, 2017 Category: General Medicine Authors: Elodie Bal Hyun-Sook Park Zakia Belaid-Choucair H ü lya Kayserili Magali Naville Marine Madrange Elena Chiticariu Smail Hadj-Rabia Nicolas Cagnard Francois Kuonen Daniel Bachmann Marcel Huber Cindy Le Gall Francine C ô t é Sylvain Hanein Rasim Ö zg ü Tags: Letter Source Type: research
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever
Nature Medicine 23, 1146 (2017).
doi:10.1038/nm.4396
Authors: Chad E Mire, Robert W Cross, Joan B Geisbert, Viktoriya Borisevich, Krystle N Agans, Daniel J Deer, Megan L Heinrich, Megan M Rowland, Augustine Goba, Mambu Momoh, Mathew L Boisen, Donald S Grant, Mohamed Fullah, Sheik Humarr Khan, Karla A Fenton, James E Robinson, Luis M Branco, Robert F Garry & Thomas W Geisbert
There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoprot...
Source: Nature Medicine - September 4, 2017 Category: General Medicine Authors: Chad E Mire Robert W Cross Joan B Geisbert Viktoriya Borisevich Krystle N Agans Daniel J Deer Megan L Heinrich Megan M Rowland Augustine Goba Mambu Momoh Mathew L Boisen Donald S Grant Mohamed Fullah Sheik Humarr Khan Karla A Fenton James E Robinson Luis Tags: Brief Communication Source Type: research
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
Nature Medicine 23, 1215 (2017).
doi:10.1038/nm.4393
Authors: Paul J Emmerson, Feng Wang, Yong Du, Qian Liu, Richard T Pickard, Malgorzata D Gonciarz, Tamer Coskun, Matthew J Hamang, Dana K Sindelar, Kimberly K Ballman, Lisa A Foltz, Avinash Muppidi, Jorge Alsina-Fernandez, Gavin C Barnard, Jason X Tang, Xilin Liu, Xudong Mao, Robert Siegel, John H Sloan, Pamela J Mitchell, Bei B Zhang, Ruth E Gimeno, Bei Shan & Xinle Wu
Growth/differentiation factor 15 (GDF15), also known as MIC-1, is a distant member of the transforming growth factor-β (TGF-β) superfamily and has been implicated in various biologica...
Source: Nature Medicine - August 28, 2017 Category: General Medicine Authors: Paul J Emmerson Feng Wang Yong Du Qian Liu Richard T Pickard Malgorzata D Gonciarz Tamer Coskun Matthew J Hamang Dana K Sindelar Kimberly K Ballman Lisa A Foltz Avinash Muppidi Jorge Alsina-Fernandez Gavin C Barnard Jason X Tang Xilin Liu Xudong Mao Rober Tags: Letter Source Type: research
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
Nature Medicine 23, 1158 (2017).
doi:10.1038/nm.4394
Authors: Linda Yang, Chih-Chuan Chang, Zhe Sun, Dennis Madsen, Haisun Zhu, Søren B Padkjær, Xiaoai Wu, Tao Huang, Karin Hultman, Sarah J Paulsen, Jishu Wang, Anne Bugge, Jane Boesen Frantzen, Per Nørgaard, Jacob Fuglsbjerg Jeppesen, Zhiru Yang, Anna Secher, Haibin Chen, Xun Li, Linu Mary John, Bing Shan, Zhenhua He, Xiang Gao, Jing Su, Kristian T Hansen, Wei Yang & Sebastian Beck Jørgensen (Source: Nature Medicine)
Source: Nature Medicine - August 28, 2017 Category: General Medicine Authors: Linda Yang Chih-Chuan Chang Zhe Sun Dennis Madsen Haisun Zhu S ø ren B Padkj æ r Xiaoai Wu Tao Huang Karin Hultman Sarah J Paulsen Jishu Wang Anne Bugge Jane Boesen Frantzen Per N ø rgaard Jacob Fuglsbjerg Jeppesen Zhiru Yang Anna Secher Haibin Chen Xu Tags: Article Source Type: research
