A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
Nature Genetics 49, 1511 (2017).
doi:10.1038/ng.3955
Authors: Diana Chang, Mike A Nalls, Ingileif B Hallgrímsdóttir, Julie Hunkapiller, Marcel van der Brug, Fang Cai, Geoffrey A Kerchner, Gai Ayalon, Baris Bingol, Morgan Sheng, David Hinds, Timothy W Behrens, Andrew B Singleton, Tushar R Bhangale & Robert R Graham
Common variant genome-wide association studies (GWASs) have, to date, identified >24 risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS comparing 6,476 PD cases with 302,042 controls, followed by a meta-analysis with a recent study of over 13,000 PD...
Source: Nature Genetics - September 11, 2017 Category: Genetics & Stem Cells Authors: Diana Chang Mike A Nalls Ingileif B Hallgr í msd ó ttir Julie Hunkapiller Marcel van der Brug Fang Cai Geoffrey A Kerchner Gai Ayalon Baris Bingol Morgan Sheng David Hinds Timothy W Behrens Andrew B Singleton Tushar R Bhangale Robert R Graham Tags: Letter Source Type: research
Interpreting short tandem repeat variations in humans using mutational constraint
Nature Genetics 49, 1495 (2017).
doi:10.1038/ng.3952
Authors: Melissa Gymrek, Thomas Willems, David Reich & Yaniv Erlich (Source: Nature Genetics)
Source: Nature Genetics - September 11, 2017 Category: Genetics & Stem Cells Authors: Melissa Gymrek Thomas Willems David Reich Yaniv Erlich Tags: Article Source Type: research
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
Nature Genetics 49, 1458 (2017).
doi:10.1038/ng.3951
Authors: Masato Akiyama, Yukinori Okada, Masahiro Kanai, Atsushi Takahashi, Yukihide Momozawa, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Makoto Hirata, Koichi Matsuda, Motoki Iwasaki, Taiki Yamaji, Norie Sawada, Tsuyoshi Hachiya, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Naoko Minegishi, Shoichiro Tsugane, Masayuki Yamamoto, Michiaki Kubo & Yoichiro Kamatani (Source: Nature Genetics)
Source: Nature Genetics - September 11, 2017 Category: Genetics & Stem Cells Authors: Masato Akiyama Yukinori Okada Masahiro Kanai Atsushi Takahashi Yukihide Momozawa Masashi Ikeda Nakao Iwata Shiro Ikegawa Makoto Hirata Koichi Matsuda Motoki Iwasaki Taiki Yamaji Norie Sawada Tsuyoshi Hachiya Kozo Tanno Atsushi Shimizu Atsushi Hozawa Naoko Tags: Article Source Type: research
A functional genomics predictive network model identifies regulators of inflammatory bowel disease
Nature Genetics 49, 1437 (2017).
doi:10.1038/ng.3947
Authors: Lauren A Peters, Jacqueline Perrigoue, Arthur Mortha, Alina Iuga, Won-min Song, Eric M Neiman, Sean R Llewellyn, Antonio Di Narzo, Brian A Kidd, Shannon E Telesco, Yongzhong Zhao, Aleksandar Stojmirovic, Jocelyn Sendecki, Khader Shameer, Riccardo Miotto, Bojan Losic, Hardik Shah, Eunjee Lee, Minghui Wang, Jeremiah J Faith, Andrew Kasarskis, Carrie Brodmerkel, Mark Curran, Anuk Das, Joshua R Friedman, Yoshinori Fukui, Mary Beth Humphrey, Brian M Iritani, Nicholas Sibinga, Teresa K Tarrant, Carmen Argmann, Ke Hao, Panos Roussos, Jun Zhu, Bin Zhang, Radu Do...
Source: Nature Genetics - September 11, 2017 Category: Genetics & Stem Cells Authors: Lauren A Peters Jacqueline Perrigoue Arthur Mortha Alina Iuga Won-min Song Eric M Neiman Sean R Llewellyn Antonio Di Narzo Brian A Kidd Shannon E Telesco Yongzhong Zhao Aleksandar Stojmirovic Jocelyn Sendecki Khader Shameer Riccardo Miotto Bojan Losic Har Tags: Article Source Type: research
Linkage disequilibrium – dependent architecture of human complex traits shows action of negative selection
Nature Genetics 49, 1421 (2017).
doi:10.1038/ng.3954
Authors: Steven Gazal, Hilary K Finucane, Nicholas A Furlotte, Po-Ru Loh, Pier Francesco Palamara, Xuanyao Liu, Armin Schoech, Brendan Bulik-Sullivan, Benjamin M Neale, Alexander Gusev & Alkes L Price (Source: Nature Genetics)
Source: Nature Genetics - September 11, 2017 Category: Genetics & Stem Cells Authors: Steven Gazal Hilary K Finucane Nicholas A Furlotte Po-Ru Loh Pier Francesco Palamara Xuanyao Liu Armin Schoech Brendan Bulik-Sullivan Benjamin M Neale Alexander Gusev Alkes L Price Tags: Analysis Source Type: research
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
Nature Genetics 49, 1468 (2017).
doi:10.1038/ng.3949
Authors: John P Kemp, John A Morris, Carolina Medina-Gomez, Vincenzo Forgetta, Nicole M Warrington, Scott E Youlten, Jie Zheng, Celia L Gregson, Elin Grundberg, Katerina Trajanoska, John G Logan, Andrea S Pollard, Penny C Sparkes, Elena J Ghirardello, Rebecca Allen, Victoria D Leitch, Natalie C Butterfield, Davide Komla-Ebri, Anne-Tounsia Adoum, Katharine F Curry, Jacqueline K White, Fiona Kussy, Keelin M Greenlaw, Changjiang Xu, Nicholas C Harvey, Cyrus Cooper, David J Adams, Celia M T Greenwood, Matthew T Maurano, Stephen Kaptoge, Fernando Rivadeneira, Jonathan...
Source: Nature Genetics - September 4, 2017 Category: Genetics & Stem Cells Authors: John P Kemp John A Morris Carolina Medina-Gomez Vincenzo Forgetta Nicole M Warrington Scott E Youlten Jie Zheng Celia L Gregson Elin Grundberg Katerina Trajanoska John G Logan Andrea S Pollard Penny C Sparkes Elena J Ghirardello Rebecca Allen Victoria D L Tags: Article Source Type: research
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Nature Genetics 49, 1450 (2017).
doi:10.1038/ng.3943
Authors: Wei Zhao, Asif Rasheed, Emmi Tikkanen, Jung-Jin Lee, Adam S Butterworth, Joanna M M Howson, Themistocles L Assimes, Rajiv Chowdhury, Marju Orho-Melander, Scott Damrauer, Aeron Small, Senay Asma, Minako Imamura, Toshimasa Yamauch, John C Chambers, Peng Chen, Bishwa R Sapkota, Nabi Shah, Sehrish Jabeen, Praveen Surendran, Yingchang Lu, Weihua Zhang, Atif Imran, Shahid Abbas, Faisal Majeed, Kevin Trindade, Nadeem Qamar, Nadeem Hayyat Mallick, Zia Yaqoob, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Khalid Meh...
Source: Nature Genetics - September 4, 2017 Category: Genetics & Stem Cells Authors: Wei Zhao Asif Rasheed Emmi Tikkanen Jung-Jin Lee Adam S Butterworth Joanna M M Howson Themistocles L Assimes Rajiv Chowdhury Marju Orho-Melander Scott Damrauer Aeron Small Senay Asma Minako Imamura Toshimasa Yamauch John C Chambers Peng Chen Bishwa R Sapk Tags: Article Source Type: research
Reconstruction of enhancer – target networks in 935 samples of human primary cells, tissues and cell lines
Nature Genetics 49, 1428 (2017).
doi:10.1038/ng.3950
Authors: Qin Cao, Christine Anyansi, Xihao Hu, Liangliang Xu, Lei Xiong, Wenshu Tang, Myth T S Mok, Chao Cheng, Xiaodan Fan, Mark Gerstein, Alfred S L Cheng & Kevin Y Yip (Source: Nature Genetics)
Source: Nature Genetics - September 4, 2017 Category: Genetics & Stem Cells Authors: Qin Cao Christine Anyansi Xihao Hu Liangliang Xu Lei Xiong Wenshu Tang Myth T S Mok Chao Cheng Xiaodan Fan Mark Gerstein Alfred S L Cheng Kevin Y Yip Tags: Analysis Source Type: research
Concepts, estimation and interpretation of SNP-based heritability
Nature Genetics 49, 1304 (2017).
doi:10.1038/ng.3941
Authors: Jian Yang, Jian Zeng, Michael E Goddard, Naomi R Wray & Peter M Visscher (Source: Nature Genetics)
Source: Nature Genetics - August 30, 2017 Category: Genetics & Stem Cells Authors: Jian Yang Jian Zeng Michael E Goddard Naomi R Wray Peter M Visscher Tags: Perspective Source Type: research
Genomic prediction unifies animal and plant breeding programs to form platforms for biological discovery
Nature Genetics 49, 1297 (2017).
doi:10.1038/ng.3920
Authors: John M Hickey, Tinashe Chiurugwi, Ian Mackay & Wayne Powell (Source: Nature Genetics)
Source: Nature Genetics - August 30, 2017 Category: Genetics & Stem Cells Authors: John M Hickey Tinashe Chiurugwi Ian Mackay Wayne Powell Tags: Perspective Source Type: research
Reaching for the next branch on the biobank tree of knowledge
Nature Genetics 49, 1295 (2017).
doi:10.1038/ng.3946
Author: Nancy J Cox
An innovative study analyzing genetic association across tree-structured routine healthcare data in the UK Biobank represents a new branch on a tree that is poised to grow rapidly and offer new kinds of insights on how genome variation relates to human health and disease. Indeed, this tree is likely to offer new kinds of insights into the very nature of human disease. (Source: Nature Genetics)
Source: Nature Genetics - August 30, 2017 Category: Genetics & Stem Cells Authors: Nancy J Cox Tags: News and Views Source Type: research
Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer
Nature Genetics 49, 1294 (2017).
doi:10.1038/ng.3944
Authors: Deepak Babu & Melissa J Fullwood
ERG overexpression in prostate cancers promotes the development of widespread changes in gene expression and chromatin landscapes, leading to redistribution of key transcription factors in prostate cancers positive for the TMPRSS2-ERG fusion gene. The overexpression of ERG is further assisted by the development of a super-enhancer in the ERG locus. (Source: Nature Genetics)
Source: Nature Genetics - August 30, 2017 Category: Genetics & Stem Cells Authors: Deepak Babu Melissa J Fullwood Tags: News and Views Source Type: research
Genetic insights into mammalian heart regeneration
Nature Genetics 49, 1292 (2017).
doi:10.1038/ng.3942
Authors: Ana Vujic, Vinícius Bassaneze & Richard T Lee
Genetic and functional analyses of 120 mouse strains have identified a heart regeneration candidate gene that modulates the contractile sarcomeric apparatus. This gene, Tnni3k, controls the frequency of the mononuclear, diploid cardiomyocyte population, which affects cardiomyocyte proliferative potential after injury. (Source: Nature Genetics)
Source: Nature Genetics - August 30, 2017 Category: Genetics & Stem Cells Authors: Ana Vujic Vin í cius Bassaneze Richard T Lee Tags: News and Views Source Type: research
Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures
Nature Genetics 49, 1289 (2017).
doi:10.1038/ng.3877
Authors: Marc J Williams, Benjamin Werner, Chris P Barnes, Trevor A Graham & Andrea Sottoriva (Source: Nature Genetics)
Source: Nature Genetics - August 30, 2017 Category: Genetics & Stem Cells Authors: Marc J Williams Benjamin Werner Chris P Barnes Trevor A Graham Andrea Sottoriva Tags: Correspondence Source Type: research
Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures
Nature Genetics 49, 1288 (2017).
doi:10.1038/ng.3876
Authors: Javad Noorbakhsh & Jeffrey H Chuang (Source: Nature Genetics)
Source: Nature Genetics - August 30, 2017 Category: Genetics & Stem Cells Authors: Javad Noorbakhsh Jeffrey H Chuang Tags: Correspondence Source Type: research
