Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers
Nature Genetics 49, 1661 (2017).
doi:10.1038/ng1117-1661a
Author: Dominik Glodzik, Sandro Morganella, Helen Davies, Peter T Simpson, Yilong Li, Xueqing Zou, Javier Diez-Perez, Johan Staaf, Ludmil B Alexandrov, Marcel Smid, Arie B Brinkman, Inga Hansine Rye, Hege Russnes, Keiran Raine, Colin A Purdie, Sunil R Lakhani, Alastair M Thompson, Ewan Birney, Hendrik G Stunnenberg, Marc J van de Vijver, John W M Martens, Anne-Lise Børresen-Dale, Andrea L Richardson, Gu Kong, Alain Viari, Douglas Easton, Gerard Evan, Peter J Campbell, Michael R Stratton & Serena Nik-Zainal (Source: Nature Genetics)
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: Dominik Glodzik Sandro Morganella Helen Davies Peter T Simpson Yilong Li Xueqing Zou Javier Diez-Perez Johan Staaf Ludmil B Alexandrov Marcel Smid Arie B Brinkman Inga Hansine Rye Hege Russnes Keiran Raine Colin A Purdie Sunil R Lakhani Alastair M Thompso Tags: Corrigendum Source Type: research
Erratum: DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats
Nature Genetics 49, 1661 (2017).
doi:10.1038/ng1117-1661c
Author: David Brocks, Christopher R Schmidt, Michael Daskalakis, Hyo Sik Jang, Nakul M Shah, Daofeng Li, Jing Li, Bo Zhang, Yiran Hou, Sara Laudato, Daniel B Lipka, Johanna Schott, Holger Bierhoff, Yassen Assenov, Monika Helf, Alzbeta Ressnerova, Md Saiful Islam, Anders M Lindroth, Simon Haas, Marieke Essers, Charles D Imbusch, Benedikt Brors, Ina Oehme, Olaf Witt, Michael Lübbert, Jan-Philipp Mallm, Karsten Rippe, Rainer Will, Dieter Weichenhan, Georg Stoecklin, Clarissa Gerhäuser, Christopher C Oakes, Ting Wang & Christoph Plass (Source: Nature Genetics)
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: David Brocks Christopher R Schmidt Michael Daskalakis Hyo Sik Jang Nakul M Shah Daofeng Li Jing Li Bo Zhang Yiran Hou Sara Laudato Daniel B Lipka Johanna Schott Holger Bierhoff Yassen Assenov Monika Helf Alzbeta Ressnerova Md Saiful Islam Anders M Lindrot Tags: Erratum Source Type: research
Divergent evolutionary trajectories in transplanted tumor models
Nature Genetics 49, 1565 (2017).
doi:10.1038/ng.3983
Authors: Carlos Villacorta-Martin, Amanda J Craig & Augusto Villanueva
Human-derived tumor models are becoming popular in the context of personalized medicine, but a new study shows that these models could be less representative of primary tumors than previously thought, particularly when using late passages. (Source: Nature Genetics)
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: Carlos Villacorta-Martin Amanda J Craig Augusto Villanueva Tags: News and Views Source Type: research
Enhancers looping to target genes
Nature Genetics 49, 1564 (2017).
doi:10.1038/ng.3982
Author: Gosia Trynka
High-resolution maps of enhancer–promoter interactions in rare primary human T cell subsets and coronary artery smooth muscle cells link variants associated with autoimmune and cardiovascular diseases to target genes. This represents an important step forward for mapping genes involved in complex diseases. (Source: Nature Genetics)
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: Gosia Trynka Tags: News and Views Source Type: research
Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology
Nature Genetics 49, 1560 (2017).
doi:10.1038/ng.3968
Authors: Jennifer A Brody, Alanna C Morrison, Joshua C Bis, Jeffrey R O'Connell, Michael R Brown, Jennifer E Huffman, Darren C Ames, Andrew Carroll, Matthew P Conomos, Stacey Gabriel, Richard A Gibbs, Stephanie M Gogarten, Namrata Gupta, Cashell E Jaquish, Andrew D Johnson, Joshua P Lewis, Xiaoming Liu, Alisa K Manning, George J Papanicolaou, Achilleas N Pitsillides, Kenneth M Rice, William Salerno, Colleen M Sitlani, Nicholas L Smith, Susan R Heckbert, Cathy C Laurie, Braxton D Mitchell, Ramachandran S Vasan, Stephen S Rich, Jerome I Rotter, James G Wilson, Eric...
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Authors: Jennifer A Brody Alanna C Morrison Joshua C Bis Jeffrey R O'Connell Michael R Brown Jennifer E Huffman Darren C Ames Andrew Carroll Matthew P Conomos Stacey Gabriel Richard A Gibbs Stephanie M Gogarten Namrata Gupta Cashell E Jaquish Andrew D Johnson Josh Tags: Commentary Source Type: research
Neutral citation is poor scholarship
Nature Genetics 49, 1559 (2017).
doi:10.1038/ng.3989
Citation of prior publications is essential both to claim that knowledge is needed in your area of research and to establish that you have indeed advanced understanding substantially in that area. The journal deplores and will decline to consider manuscripts that fail to identify the key findings of published articles and that—deliberately or inadvertently—omit the reason the prior work is cited. (Source: Nature Genetics)
Source: Nature Genetics - October 27, 2017 Category: Genetics & Stem Cells Tags: Editorial Source Type: research
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Nature Genetics 49, 1767 (2017).
doi:10.1038/ng.3785
Authors: Roger L Milne, Karoline B Kuchenbaecker, Kyriaki Michailidou, Jonathan Beesley, Siddhartha Kar, Sara Lindström, Shirley Hui, Audrey Lemaçon, Penny Soucy, Joe Dennis, Xia Jiang, Asha Rostamianfar, Hilary Finucane, Manjeet K Bolla, Lesley McGuffog, Qin Wang, Cora M Aalfs, Marcia Adams, Julian Adlard, Simona Agata, Shahana Ahmed, Habibul Ahsan, Kristiina Aittomäki, Fares Al-Ejeh, Jamie Allen, Christine B Ambrosone, Christopher I Amos, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Norbert Arnold, Kristan J Aronson, ...
Source: Nature Genetics - October 23, 2017 Category: Genetics & Stem Cells Authors: Roger L Milne Karoline B Kuchenbaecker Kyriaki Michailidou Jonathan Beesley Siddhartha Kar Sara Lindstr ö m Shirley Hui Audrey Lema ç on Penny Soucy Joe Dennis Xia Jiang Asha Rostamianfar Hilary Finucane Manjeet K Bolla Lesley McGuffog Qin Wang Cora M A Tags: Letter Source Type: research
Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues
Nature Genetics 49, 1747 (2017).
doi:10.1038/ng.3979
Authors: Andrew Anand Brown, Ana Viñuela, Olivier Delaneau, Tim D Spector, Kerrin S Small & Emmanouil T Dermitzakis
Genetic association mapping produces statistical links between phenotypes and genomic regions, but identifying causal variants remains difficult. Whole-genome sequencing (WGS) can help by providing complete knowledge of all genetic variants, but it is financially prohibitive for well-powered GWAS studies. We performed mapping of expression quantitative trait loci (eQTLs) with WGS and RNA-seq, and found that lead eQTL variants called with WG...
Source: Nature Genetics - October 23, 2017 Category: Genetics & Stem Cells Authors: Andrew Anand Brown Ana Vi ñ uela Olivier Delaneau Tim D Spector Kerrin S Small Emmanouil T Dermitzakis Tags: Letter Source Type: research
Estimating the causal tissues for complex traits and diseases
Nature Genetics 49, 1676 (2017).
doi:10.1038/ng.3981
Authors: Halit Ongen, Andrew A Brown, Olivier Delaneau, Nikolaos I Panousis, Alexandra C Nica & Emmanouil T Dermitzakis (Source: Nature Genetics)
Source: Nature Genetics - October 23, 2017 Category: Genetics & Stem Cells Authors: Halit Ongen Andrew A Brown Olivier Delaneau Nikolaos I Panousis Alexandra C Nica Emmanouil T Dermitzakis Tags: Analysis Source Type: research
Covariate selection for association screening in multiphenotype genetic studies
Nature Genetics 49, 1789 (2017).
doi:10.1038/ng.3975
Authors: Hugues Aschard, Vincent Guillemot, Bjarni Vilhjalmsson, Chirag J Patel, David Skurnik, Chun J Ye, Brian Wolpin, Peter Kraft & Noah Zaitlen (Source: Nature Genetics)
Source: Nature Genetics - October 16, 2017 Category: Genetics & Stem Cells Authors: Hugues Aschard Vincent Guillemot Bjarni Vilhjalmsson Chirag J Patel David Skurnik Chun J Ye Brian Wolpin Peter Kraft Noah Zaitlen Tags: Technical Report Source Type: research
A quantitative genetic framework highlights the role of epistatic effects for grain-yield heterosis in bread wheat
Nature Genetics 49, 1741 (2017).
doi:10.1038/ng.3974
Authors: Yong Jiang, Renate H Schmidt, Yusheng Zhao & Jochen C Reif (Source: Nature Genetics)
Source: Nature Genetics - October 16, 2017 Category: Genetics & Stem Cells Authors: Yong Jiang Renate H Schmidt Yusheng Zhao Jochen C Reif Tags: Article Source Type: research
Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease
Nature Genetics 49, 1664 (2017).
doi:10.1038/ng.3969
Authors:
Genetic variants have been associated with myriad molecular phenotypes that provide new insight into the range of mechanisms underlying genetic traits and diseases. Identifying any particular genetic variant's cascade of effects, from molecule to individual, requires assaying multiple layers of molecular complexity. We introduce the Enhancing GTEx (eGTEx) project that extends the GTEx project to combine gene expression with additional intermediate molecular measurements on the same tissues to provide a resource for studying how genetic differences casca...
Source: Nature Genetics - October 11, 2017 Category: Genetics & Stem Cells Tags: Commentary Source Type: research
The draft genome of tropical fruit durian (Durio zibethinus)
Nature Genetics 49, 1633 (2017).
doi:10.1038/ng.3972
Authors: Bin Tean Teh, Kevin Lim, Chern Han Yong, Cedric Chuan Young Ng, Sushma Ramesh Rao, Vikneswari Rajasegaran, Weng Khong Lim, Choon Kiat Ong, Ki Chan, Vincent Kin Yuen Cheng, Poh Sheng Soh, Sanjay Swarup, Steven G Rozen, Niranjan Nagarajan & Patrick Tan (Source: Nature Genetics)
Source: Nature Genetics - October 9, 2017 Category: Genetics & Stem Cells Authors: Bin Tean Teh Kevin Lim Chern Han Yong Cedric Chuan Young Ng Sushma Ramesh Rao Vikneswari Rajasegaran Weng Khong Lim Choon Kiat Ong Ki Chan Vincent Kin Yuen Cheng Poh Sheng Soh Sanjay Swarup Steven G Rozen Niranjan Nagarajan Patrick Tan Tags: Article Source Type: research
Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands
Nature Genetics 49, 1593 (2017).
doi:10.1038/ng.3970
Authors: Sheng Chih Jin, Jason Homsy, Samir Zaidi, Qiongshi Lu, Sarah Morton, Steven R DePalma, Xue Zeng, Hongjian Qi, Weni Chang, Michael C Sierant, Wei-Chien Hung, Shozeb Haider, Junhui Zhang, James Knight, Robert D Bjornson, Christopher Castaldi, Irina R Tikhonoa, Kaya Bilguvar, Shrikant M Mane, Stephan J Sanders, Seema Mital, Mark W Russell, J William Gaynor, John Deanfield, Alessandro Giardini, George A Porter, Deepak Srivastava, Cecelia W Lo, Yufeng Shen, W Scott Watkins, Mark Yandell, H Joseph Yost, Martin Tristani-Firouzi, Jane W Newburger, Amy E Roberts,...
Source: Nature Genetics - October 9, 2017 Category: Genetics & Stem Cells Authors: Sheng Chih Jin Jason Homsy Samir Zaidi Qiongshi Lu Sarah Morton Steven R DePalma Xue Zeng Hongjian Qi Weni Chang Michael C Sierant Wei-Chien Hung Shozeb Haider Junhui Zhang James Knight Robert D Bjornson Christopher Castaldi Irina R Tikhonoa Kaya Bilguvar Tags: Article Source Type: research
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
Nature Genetics 49, 1576 (2017).
doi:10.1038/ng.3973
Authors: Zhiqiang Li, Jianhua Chen, Hao Yu, Lin He, Yifeng Xu, Dai Zhang, Qizhong Yi, Changgui Li, Xingwang Li, Jiawei Shen, Zhijian Song, Weidong Ji, Meng Wang, Juan Zhou, Boyu Chen, Yahui Liu, Jiqiang Wang, Peng Wang, Ping Yang, Qingzhong Wang, Guoyin Feng, Benxiu Liu, Wensheng Sun, Baojie Li, Guang He, Weidong Li, Chunling Wan, Qi Xu, Wenjin Li, Zujia Wen, Ke Liu, Fang Huang, Jue Ji, Stephan Ripke, Weihua Yue, Patrick F Sullivan, Michael C O'Donovan & Yongyong Shi (Source: Nature Genetics)
Source: Nature Genetics - October 9, 2017 Category: Genetics & Stem Cells Authors: Zhiqiang Li Jianhua Chen Hao Yu Lin He Yifeng Xu Dai Zhang Qizhong Yi Changgui Li Xingwang Li Jiawei Shen Zhijian Song Weidong Ji Meng Wang Juan Zhou Boyu Chen Yahui Liu Jiqiang Wang Peng Wang Ping Yang Qingzhong Wang Guoyin Feng Benxiu Liu Wensheng Sun B Tags: Article Source Type: research
