Signatures of adaptation in the weedy rice genome
Nature Genetics 49, 811 (2017). doi:10.1038/ng.3825 Authors: Lin-Feng Li, Ya-Ling Li, Yulin Jia, Ana L Caicedo & Kenneth M Olsen Crop domestication provided the calories that fueled the rise of civilization. For many crop species, domestication was accompanied by the evolution of weedy crop relatives, which aggressively outcompete crops and reduce harvests. Understanding the genetic mechanisms that underlie the evolution of weedy crop relatives is critical for agricultural weed management and food security. Here we use whole-genome sequences to examine the origin and adaptation of the two major strains of weedy...
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Lin-Feng Li Ya-Ling Li Yulin Jia Ana L Caicedo Kenneth M Olsen Tags: Letter Source Type: research

Estimating the selective effects of heterozygous protein-truncating variants from human exome data
Nature Genetics 49, 806 (2017). doi:10.1038/ng.3831 Authors: Christopher A Cassa, Donate Weghorn, Daniel J Balick, Daniel M Jordan, David Nusinow, Kaitlin E Samocha, Anne O'Donnell-Luria, Daniel G MacArthur, Mark J Daly, David R Beier & Shamil R Sunyaev The evolutionary cost of gene loss is a central question in genetics and has been investigated in model organisms and human cell lines. In humans, tolerance of the loss of one or both functional copies of a gene is related to the gene's causal role in disease. However, estimates of the selection and dominance coefficients in humans have been elusive. Here we ana...
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Christopher A Cassa Donate Weghorn Daniel J Balick Daniel M Jordan David Nusinow Kaitlin E Samocha Anne O'Donnell-Luria Daniel G MacArthur Mark J Daly David R Beier Shamil R Sunyaev Tags: Letter Source Type: research

SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBP ɛ dependent mechanism
Nature Genetics 49, 753 (2017). doi:10.1038/ng.3812 Authors: Pierre Priam, Veneta Krasteva, Philippe Rousseau, Giovanni D'Angelo, Louis Gaboury, Guy Sauvageau & Julie A Lessard (Source: Nature Genetics)
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Pierre Priam Veneta Krasteva Philippe Rousseau Giovanni D'Angelo Louis Gaboury Guy Sauvageau Julie A Lessard Tags: Article Source Type: research

Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes
Nature Genetics 49, 742 (2017). doi:10.1038/ng.3833 Authors: Maximilian Witzel, Daniel Petersheim, Yanxin Fan, Ehsan Bahrami, Tomas Racek, Meino Rohlfs, Jacek Puchałka, Christian Mertes, Julien Gagneur, Christoph Ziegenhain, Wolfgang Enard, Asbjørg Stray-Pedersen, Peter D Arkwright, Miguel R Abboud, Vahid Pazhakh, Graham J Lieschke, Peter M Krawitz, Maik Dahlhoff, Marlon R Schneider, Eckhard Wolf, Hans-Peter Horny, Heinrich Schmidt, Alejandro A Schäffer & Christoph Klein (Source: Nature Genetics)
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Maximilian Witzel Daniel Petersheim Yanxin Fan Ehsan Bahrami Tomas Racek Meino Rohlfs Jacek Pucha ł ka Christian Mertes Julien Gagneur Christoph Ziegenhain Wolfgang Enard Asbj ø rg Stray-Pedersen Peter D Arkwright Miguel R Abboud Vahid Pazhakh Graham J Tags: Article Source Type: research

The impact of structural variation on human gene expression
Nature Genetics 49, 692 (2017). doi:10.1038/ng.3834 Authors: Colby Chiang, Alexandra J Scott, Joe R Davis, Emily K Tsang, Xin Li, Yungil Kim, Tarik Hadzic, Farhan N Damani, Liron Ganel, Stephen B Montgomery, Alexis Battle, Donald F Conrad & Ira M Hall (Source: Nature Genetics)
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Colby Chiang Alexandra J Scott Joe R Davis Emily K Tsang Xin Li Yungil Kim Tarik Hadzic Farhan N Damani Liron Ganel Stephen B Montgomery Alexis Battle Donald F Conrad Ira M Hall Tags: Article Source Type: research

Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire
Nature Genetics 49, 659 (2017). doi:10.1038/ng.3822 Authors: Ryan O Emerson, William S DeWitt, Marissa Vignali, Jenna Gravley, Joyce K Hu, Edward J Osborne, Cindy Desmarais, Mark Klinger, Christopher S Carlson, John A Hansen, Mark Rieder & Harlan S Robins (Source: Nature Genetics)
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Ryan O Emerson William S DeWitt Marissa Vignali Jenna Gravley Joyce K Hu Edward J Osborne Cindy Desmarais Mark Klinger Christopher S Carlson John A Hansen Mark Rieder Harlan S Robins Tags: Article Source Type: research

Signatures of adaptation in the weedy rice genome
Nature Genetics 49, 811 (2017). doi:10.1038/ng.3825 Authors: Lin-Feng Li, Ya-Ling Li, Yulin Jia, Ana L Caicedo & Kenneth M Olsen Crop domestication provided the calories that fueled the rise of civilization. For many crop species, domestication was accompanied by the evolution of weedy crop relatives, which aggressively outcompete crops and reduce harvests. Understanding the genetic mechanisms that underlie the evolution of weedy crop relatives is critical for agricultural weed management and food security. Here we use whole-genome sequences to examine the origin and adaptation of the two major strains of weedy...
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Lin-Feng Li Ya-Ling Li Yulin Jia Ana L Caicedo Kenneth M Olsen Tags: Letter Source Type: research

Estimating the selective effects of heterozygous protein-truncating variants from human exome data
Nature Genetics 49, 806 (2017). doi:10.1038/ng.3831 Authors: Christopher A Cassa, Donate Weghorn, Daniel J Balick, Daniel M Jordan, David Nusinow, Kaitlin E Samocha, Anne O'Donnell-Luria, Daniel G MacArthur, Mark J Daly, David R Beier & Shamil R Sunyaev The evolutionary cost of gene loss is a central question in genetics and has been investigated in model organisms and human cell lines. In humans, tolerance of the loss of one or both functional copies of a gene is related to the gene's causal role in disease. However, estimates of the selection and dominance coefficients in humans have been elusive. Here we ana...
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Christopher A Cassa Donate Weghorn Daniel J Balick Daniel M Jordan David Nusinow Kaitlin E Samocha Anne O'Donnell-Luria Daniel G MacArthur Mark J Daly David R Beier Shamil R Sunyaev Tags: Letter Source Type: research

SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBP ɛ dependent mechanism
Nature Genetics 49, 753 (2017). doi:10.1038/ng.3812 Authors: Pierre Priam, Veneta Krasteva, Philippe Rousseau, Giovanni D'Angelo, Louis Gaboury, Guy Sauvageau & Julie A Lessard (Source: Nature Genetics)
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Pierre Priam Veneta Krasteva Philippe Rousseau Giovanni D'Angelo Louis Gaboury Guy Sauvageau Julie A Lessard Tags: Article Source Type: research

Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes
Nature Genetics 49, 742 (2017). doi:10.1038/ng.3833 Authors: Maximilian Witzel, Daniel Petersheim, Yanxin Fan, Ehsan Bahrami, Tomas Racek, Meino Rohlfs, Jacek Puchałka, Christian Mertes, Julien Gagneur, Christoph Ziegenhain, Wolfgang Enard, Asbjørg Stray-Pedersen, Peter D Arkwright, Miguel R Abboud, Vahid Pazhakh, Graham J Lieschke, Peter M Krawitz, Maik Dahlhoff, Marlon R Schneider, Eckhard Wolf, Hans-Peter Horny, Heinrich Schmidt, Alejandro A Schäffer & Christoph Klein (Source: Nature Genetics)
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Maximilian Witzel Daniel Petersheim Yanxin Fan Ehsan Bahrami Tomas Racek Meino Rohlfs Jacek Pucha łka Christian Mertes Julien Gagneur Christoph Ziegenhain Wolfgang Enard Asbj ørg Stray-Pedersen Peter D Arkwright Miguel R Abboud Vahid Pazhakh Graham J Li Tags: Article Source Type: research

The impact of structural variation on human gene expression
Nature Genetics 49, 692 (2017). doi:10.1038/ng.3834 Authors: Colby Chiang, Alexandra J Scott, Joe R Davis, Emily K Tsang, Xin Li, Yungil Kim, Tarik Hadzic, Farhan N Damani, Liron Ganel, Stephen B Montgomery, Alexis Battle, Donald F Conrad & Ira M Hall (Source: Nature Genetics)
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Colby Chiang Alexandra J Scott Joe R Davis Emily K Tsang Xin Li Yungil Kim Tarik Hadzic Farhan N Damani Liron Ganel Stephen B Montgomery Alexis Battle Donald F Conrad Ira M Hall Tags: Article Source Type: research

Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire
Nature Genetics 49, 659 (2017). doi:10.1038/ng.3822 Authors: Ryan O Emerson, William S DeWitt, Marissa Vignali, Jenna Gravley, Joyce K Hu, Edward J Osborne, Cindy Desmarais, Mark Klinger, Christopher S Carlson, John A Hansen, Mark Rieder & Harlan S Robins (Source: Nature Genetics)
Source: Nature Genetics - April 3, 2017 Category: Genetics & Stem Cells Authors: Ryan O Emerson William S DeWitt Marissa Vignali Jenna Gravley Joyce K Hu Edward J Osborne Cindy Desmarais Mark Klinger Christopher S Carlson John A Hansen Mark Rieder Harlan S Robins Tags: Article Source Type: research

Corrigendum: Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity
Nature Genetics 49, 651 (2017). doi:10.1038/ng0417-651b Author: Mylène M Maury, Yu-Huan Tsai, Caroline Charlier, Marie Touchon, Viviane Chenal-Francisque, Alexandre Leclercq, Alexis Criscuolo, Charlotte Gaultier, Sophie Roussel, Anne Brisabois, Olivier Disson, Eduardo P C Rocha, Sylvain Brisse & Marc Lecuit (Source: Nature Genetics)
Source: Nature Genetics - March 30, 2017 Category: Genetics & Stem Cells Authors: Myl ène M Maury Yu-Huan Tsai Caroline Charlier Marie Touchon Viviane Chenal-Francisque Alexandre Leclercq Alexis Criscuolo Charlotte Gaultier Sophie Roussel Anne Brisabois Olivier Disson Eduardo P C Rocha Sylvain Brisse Marc Lecuit Tags: Corrigendum Source Type: research

Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
Nature Genetics 49, 651 (2017). doi:10.1038/ng0417-651a Author: Yufei Wang, James D McKay, Thorunn Rafnar, Zhaoming Wang, Maria N Timofeeva, Peter Broderick, Xuchen Zong, Marina Laplana, Yongyue Wei, Younghun Han, Amy Lloyd, Manon Delahaye-Sourdeix, Daniel Chubb, Valerie Gaborieau, William Wheeler, Nilanjan Chatterjee, Gudmar Thorleifsson, Patrick Sulem, Geoffrey Liu, Rudolf Kaaks, Marc Henrion, Ben Kinnersley, Maxime Vallée, Florence Le Calvez-Kelm, Victoria L Stevens, Susan M Gapstur, Wei V Chen, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vla...
Source: Nature Genetics - March 30, 2017 Category: Genetics & Stem Cells Authors: Yufei Wang James D McKay Thorunn Rafnar Zhaoming Wang Maria N Timofeeva Peter Broderick Xuchen Zong Marina Laplana Yongyue Wei Younghun Han Amy Lloyd Manon Delahaye-Sourdeix Daniel Chubb Valerie Gaborieau William Wheeler Nilanjan Chatterjee Gudmar Thorlei Tags: Corrigendum Source Type: research

Erratum: Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Nature Genetics 49, 651 (2017). doi:10.1038/ng0417-651d Author: (Source: Nature Genetics)
Source: Nature Genetics - March 30, 2017 Category: Genetics & Stem Cells Tags: Erratum Source Type: research