Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation
Nature Genetics 49, 959 (2017).
doi:10.1038/ng.3845
Authors: Punna Ramu, Williams Esuma, Robert Kawuki, Ismail Y Rabbi, Chiedozie Egesi, Jessen V Bredeson, Rebecca S Bart, Janu Verma, Edward S Buckler & Fei Lu
Cassava (Manihot esculenta Crantz) is an important staple food crop in Africa and South America; however, ubiquitous deleterious mutations may severely decrease its fitness. To evaluate these deleterious mutations, we constructed a cassava haplotype map through deep sequencing 241 diverse accessions and identified >28 million segregating variants. We found that (i) although domestication has modified s...
Source: Nature Genetics - April 17, 2017 Category: Genetics & Stem Cells Authors: Punna Ramu Williams Esuma Robert Kawuki Ismail Y Rabbi Chiedozie Egesi Jessen V Bredeson Rebecca S Bart Janu Verma Edward S Buckler Fei Lu Tags: Letter Source Type: research
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population
Nature Genetics 49, 953 (2017).
doi:10.1038/ng.3842
Authors: Siew-Kee Low, Atsushi Takahashi, Yusuke Ebana, Kouichi Ozaki, Ingrid E Christophersen, Patrick T Ellinor, Soichi Ogishima, Masayuki Yamamoto, Mamoru Satoh, Makoto Sasaki, Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane, Keitaro Tanaka, Mariko Naito, Kenji Wakai, Hideo Tanaka, Tetsushi Furukawa, Michiaki Kubo, Kaoru Ito, Yoichiro Kamatani & Toshihiro Tanaka
Atrial fibrillation is the most common cardiac arrhythmia and leads to stroke. To investigate genetic loci associated with atrial fibrillation in the Japanese population, we performed a genome-wide ...
Source: Nature Genetics - April 17, 2017 Category: Genetics & Stem Cells Authors: Siew-Kee Low Atsushi Takahashi Yusuke Ebana Kouichi Ozaki Ingrid E Christophersen Patrick T Ellinor Soichi Ogishima Masayuki Yamamoto Mamoru Satoh Makoto Sasaki Taiki Yamaji Motoki Iwasaki Shoichiro Tsugane Keitaro Tanaka Mariko Naito Kenji Wakai Hideo Ta Tags: Letter Source Type: research
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
Nature Genetics 49, 946 (2017).
doi:10.1038/ng.3843
Authors: Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E Arking, Albert V Smith, Christine M Albert, Mark Chaffin, Nathan R Tucker, Molong Li, Derek Klarin, Nathan A Bihlmeyer, Siew-Kee Low, Peter E Weeke, Martina Müller-Nurasyid, J Gustav Smith, Jennifer A Brody, Maartje N Niemeijer, Marcus Dörr, Stella Trompet, Jennifer Huffman, Stefan Gustafsson, Claudia Schurmann, Marcus E Kleber, Leo-Pekka Lyytikäinen, Ilkka Seppälä, Rainer Malik, Andrea R V R Horimoto, Ma...
Source: Nature Genetics - April 17, 2017 Category: Genetics & Stem Cells Authors: Ingrid E Christophersen Michiel Rienstra Carolina Roselli Xiaoyan Yin Bastiaan Geelhoed John Barnard Honghuang Lin Dan E Arking Albert V Smith Christine M Albert Mark Chaffin Nathan R Tucker Molong Li Derek Klarin Nathan A Bihlmeyer Siew-Kee Low Peter E W Tags: Letter Source Type: research
Contrasting evolutionary genome dynamics between domesticated and wild yeasts
Nature Genetics 49, 913 (2017).
doi:10.1038/ng.3847
Authors: Jia-Xing Yue, Jing Li, Louise Aigrain, Johan Hallin, Karl Persson, Karen Oliver, Anders Bergström, Paul Coupland, Jonas Warringer, Marco Cosentino Lagomarsino, Gilles Fischer, Richard Durbin & Gianni Liti (Source: Nature Genetics)
Source: Nature Genetics - April 17, 2017 Category: Genetics & Stem Cells Authors: Jia-Xing Yue Jing Li Louise Aigrain Johan Hallin Karl Persson Karen Oliver Anders Bergstr ö m Paul Coupland Jonas Warringer Marco Cosentino Lagomarsino Gilles Fischer Richard Durbin Gianni Liti Tags: Article Source Type: research
Pathogenic variants that alter protein code often disrupt splicing
Nature Genetics 49, 848 (2017).
doi:10.1038/ng.3837
Authors: Rachel Soemedi, Kamil J Cygan, Christy L Rhine, Jing Wang, Charlston Bulacan, John Yang, Pinar Bayrak-Toydemir, Jamie McDonald & William G Fairbrother (Source: Nature Genetics)
Source: Nature Genetics - April 17, 2017 Category: Genetics & Stem Cells Authors: Rachel Soemedi Kamil J Cygan Christy L Rhine Jing Wang Charlston Bulacan John Yang Pinar Bayrak-Toydemir Jamie McDonald William G Fairbrother Tags: Article Source Type: research
IFN- λ 3, not IFN- λ 4, likely mediates IFNL3 – IFNL4 haplotype – dependent hepatic inflammation and fibrosis
Nature Genetics 49, 795 (2017).
doi:10.1038/ng.3836
Authors: Mohammed Eslam, Duncan McLeod, Kebitsaone Simon Kelaeng, Alessandra Mangia, Thomas Berg, Khaled Thabet, William L Irving, Gregory J Dore, David Sheridan, Henning Grønbæk, Maria Lorena Abate, Rune Hartmann, Elisabetta Bugianesi, Ulrich Spengler, Angela Rojas, David R Booth, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Hema Mahajan, Janett Fischer, Jacob Nattermann, Mark W Douglas, Christopher Liddle, Elizabeth Powell, Manuel Romero-Gomez & Jacob George
Genetic variation in the IFNL3–IFNL4 (interferon-λ3–int...
Source: Nature Genetics - April 10, 2017 Category: Genetics & Stem Cells Authors: Mohammed Eslam Duncan McLeod Kebitsaone Simon Kelaeng Alessandra Mangia Thomas Berg Khaled Thabet William L Irving Gregory J Dore David Sheridan Henning Gr ø nb æ k Maria Lorena Abate Rune Hartmann Elisabetta Bugianesi Ulrich Spengler Angela Rojas David Tags: Letter Source Type: research
Spatial heterogeneity in medulloblastoma
Nature Genetics 49, 780 (2017).
doi:10.1038/ng.3838
Authors: A Sorana Morrissy, Florence M G Cavalli, Marc Remke, Vijay Ramaswamy, David J H Shih, Borja L Holgado, Hamza Farooq, Laura K Donovan, Livia Garzia, Sameer Agnihotri, Erin N Kiehna, Eloi Mercier, Chelsea Mayoh, Simon Papillon-Cavanagh, Hamid Nikbakht, Tenzin Gayden, Jonathon Torchia, Daniel Picard, Diana M Merino, Maria Vladoiu, Betty Luu, Xiaochong Wu, Craig Daniels, Stuart Horswell, Yuan Yao Thompson, Volker Hovestadt, Paul A Northcott, David T W Jones, John Peacock, Xin Wang, Stephen C Mack, Jüri Reimand, Steffen Albrecht, Adam M Fontebasso, Nina T...
Source: Nature Genetics - April 10, 2017 Category: Genetics & Stem Cells Authors: A Sorana Morrissy Florence M G Cavalli Marc Remke Vijay Ramaswamy David J H Shih Borja L Holgado Hamza Farooq Laura K Donovan Livia Garzia Sameer Agnihotri Erin N Kiehna Eloi Mercier Chelsea Mayoh Simon Papillon-Cavanagh Hamid Nikbakht Tenzin Gayden Jonat Tags: Letter Source Type: research
Genomic analyses of primitive, wild and cultivated citrus provide insights into asexual reproduction
Nature Genetics 49, 765 (2017).
doi:10.1038/ng.3839
Authors: Xia Wang, Yuantao Xu, Siqi Zhang, Li Cao, Yue Huang, Junfeng Cheng, Guizhi Wu, Shilin Tian, Chunli Chen, Yan Liu, Huiwen Yu, Xiaoming Yang, Hong Lan, Nan Wang, Lun Wang, Jidi Xu, Xiaolin Jiang, Zongzhou Xie, Meilian Tan, Robert M Larkin, Ling-Ling Chen, Bin-Guang Ma, Yijun Ruan, Xiuxin Deng & Qiang Xu (Source: Nature Genetics)
Source: Nature Genetics - April 10, 2017 Category: Genetics & Stem Cells Authors: Xia Wang Yuantao Xu Siqi Zhang Li Cao Yue Huang Junfeng Cheng Guizhi Wu Shilin Tian Chunli Chen Yan Liu Huiwen Yu Xiaoming Yang Hong Lan Nan Wang Lun Wang Jidi Xu Xiaolin Jiang Zongzhou Xie Meilian Tan Robert M Larkin Ling-Ling Chen Bin-Guang Ma Yijun Rua Tags: Article Source Type: research
Population- and individual-specific regulatory variation in Sardinia
Nature Genetics 49, 700 (2017).
doi:10.1038/ng.3840
Authors: Mauro Pala, Zachary Zappala, Mara Marongiu, Xin Li, Joe R Davis, Roberto Cusano, Francesca Crobu, Kimberly R Kukurba, Michael J Gloudemans, Frederic Reinier, Riccardo Berutti, Maria G Piras, Antonella Mulas, Magdalena Zoledziewska, Michele Marongiu, Elena P Sorokin, Gaelen T Hess, Kevin S Smith, Fabio Busonero, Andrea Maschio, Maristella Steri, Carlo Sidore, Serena Sanna, Edoardo Fiorillo, Michael C Bassik, Stephen J Sawcer, Alexis Battle, John Novembre, Chris Jones, Andrea Angius, Gonçalo R Abecasis, David Schlessinger, Francesco Cucca & Stephen...
Source: Nature Genetics - April 10, 2017 Category: Genetics & Stem Cells Authors: Mauro Pala Zachary Zappala Mara Marongiu Xin Li Joe R Davis Roberto Cusano Francesca Crobu Kimberly R Kukurba Michael J Gloudemans Frederic Reinier Riccardo Berutti Maria G Piras Antonella Mulas Magdalena Zoledziewska Michele Marongiu Elena P Sorokin Gael Tags: Article Source Type: research
Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus
Nature Genetics 49, 666 (2017).
doi:10.1038/ng.3835
Authors: M Azim Ansari, Vincent Pedergnana, Camilla L C Ip, Andrea Magri, Annette Von Delft, David Bonsall, Nimisha Chaturvedi, Istvan Bartha, David Smith, George Nicholson, Gilean McVean, Amy Trebes, Paolo Piazza, Jacques Fellay, Graham Cooke, Graham R Foster, Emma Hudson, John McLauchlan, Peter Simmonds, Rory Bowden, Paul Klenerman, Eleanor Barnes & Chris C A Spencer (Source: Nature Genetics)
Source: Nature Genetics - April 10, 2017 Category: Genetics & Stem Cells Authors: M Azim Ansari Vincent Pedergnana Camilla L C Ip Andrea Magri Annette Von Delft David Bonsall Nimisha Chaturvedi Istvan Bartha David Smith George Nicholson Gilean McVean Amy Trebes Paolo Piazza Jacques Fellay Graham Cooke Graham R Foster Emma Hudson John M Tags: Article Source Type: research
IFN- λ3, not IFN-λ4, likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis
Nature Genetics 49, 795 (2017).
doi:10.1038/ng.3836
Authors: Mohammed Eslam, Duncan McLeod, Kebitsaone Simon Kelaeng, Alessandra Mangia, Thomas Berg, Khaled Thabet, William L Irving, Gregory J Dore, David Sheridan, Henning Grønbæk, Maria Lorena Abate, Rune Hartmann, Elisabetta Bugianesi, Ulrich Spengler, Angela Rojas, David R Booth, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Hema Mahajan, Janett Fischer, Jacob Nattermann, Mark W Douglas, Christopher Liddle, Elizabeth Powell, Manuel Romero-Gomez & Jacob George
Genetic variation in the IFNL3–IFNL4 (interferon-λ3–int...
Source: Nature Genetics - April 10, 2017 Category: Genetics & Stem Cells Authors: Mohammed Eslam Duncan McLeod Kebitsaone Simon Kelaeng Alessandra Mangia Thomas Berg Khaled Thabet William L Irving Gregory J Dore David Sheridan Henning Gr ønbæk Maria Lorena Abate Rune Hartmann Elisabetta Bugianesi Ulrich Spengler Angela Rojas David R Tags: Letter Source Type: research
Spatial heterogeneity in medulloblastoma
Nature Genetics 49, 780 (2017).
doi:10.1038/ng.3838
Authors: A Sorana Morrissy, Florence M G Cavalli, Marc Remke, Vijay Ramaswamy, David J H Shih, Borja L Holgado, Hamza Farooq, Laura K Donovan, Livia Garzia, Sameer Agnihotri, Erin N Kiehna, Eloi Mercier, Chelsea Mayoh, Simon Papillon-Cavanagh, Hamid Nikbakht, Tenzin Gayden, Jonathon Torchia, Daniel Picard, Diana M Merino, Maria Vladoiu, Betty Luu, Xiaochong Wu, Craig Daniels, Stuart Horswell, Yuan Yao Thompson, Volker Hovestadt, Paul A Northcott, David T W Jones, John Peacock, Xin Wang, Stephen C Mack, Jüri Reimand, Steffen Albrecht, Adam M Fontebasso, Nina T...
Source: Nature Genetics - April 10, 2017 Category: Genetics & Stem Cells Authors: A Sorana Morrissy Florence M G Cavalli Marc Remke Vijay Ramaswamy David J H Shih Borja L Holgado Hamza Farooq Laura K Donovan Livia Garzia Sameer Agnihotri Erin N Kiehna Eloi Mercier Chelsea Mayoh Simon Papillon-Cavanagh Hamid Nikbakht Tenzin Gayden Jonat Tags: Letter Source Type: research
Genomic analyses of primitive, wild and cultivated citrus provide insights into asexual reproduction
Nature Genetics 49, 765 (2017).
doi:10.1038/ng.3839
Authors: Xia Wang, Yuantao Xu, Siqi Zhang, Li Cao, Yue Huang, Junfeng Cheng, Guizhi Wu, Shilin Tian, Chunli Chen, Yan Liu, Huiwen Yu, Xiaoming Yang, Hong Lan, Nan Wang, Lun Wang, Jidi Xu, Xiaolin Jiang, Zongzhou Xie, Meilian Tan, Robert M Larkin, Ling-Ling Chen, Bin-Guang Ma, Yijun Ruan, Xiuxin Deng & Qiang Xu (Source: Nature Genetics)
Source: Nature Genetics - April 10, 2017 Category: Genetics & Stem Cells Authors: Xia Wang Yuantao Xu Siqi Zhang Li Cao Yue Huang Junfeng Cheng Guizhi Wu Shilin Tian Chunli Chen Yan Liu Huiwen Yu Xiaoming Yang Hong Lan Nan Wang Lun Wang Jidi Xu Xiaolin Jiang Zongzhou Xie Meilian Tan Robert M Larkin Ling-Ling Chen Bin-Guang Ma Yijun Rua Tags: Article Source Type: research
Population- and individual-specific regulatory variation in Sardinia
Nature Genetics 49, 700 (2017).
doi:10.1038/ng.3840
Authors: Mauro Pala, Zachary Zappala, Mara Marongiu, Xin Li, Joe R Davis, Roberto Cusano, Francesca Crobu, Kimberly R Kukurba, Michael J Gloudemans, Frederic Reinier, Riccardo Berutti, Maria G Piras, Antonella Mulas, Magdalena Zoledziewska, Michele Marongiu, Elena P Sorokin, Gaelen T Hess, Kevin S Smith, Fabio Busonero, Andrea Maschio, Maristella Steri, Carlo Sidore, Serena Sanna, Edoardo Fiorillo, Michael C Bassik, Stephen J Sawcer, Alexis Battle, John Novembre, Chris Jones, Andrea Angius, Gonçalo R Abecasis, David Schlessinger, Francesco Cucca & Stephen...
Source: Nature Genetics - April 10, 2017 Category: Genetics & Stem Cells Authors: Mauro Pala Zachary Zappala Mara Marongiu Xin Li Joe R Davis Roberto Cusano Francesca Crobu Kimberly R Kukurba Michael J Gloudemans Frederic Reinier Riccardo Berutti Maria G Piras Antonella Mulas Magdalena Zoledziewska Michele Marongiu Elena P Sorokin Gael Tags: Article Source Type: research
Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus
Nature Genetics 49, 666 (2017).
doi:10.1038/ng.3835
Authors: M Azim Ansari, Vincent Pedergnana, Camilla L C Ip, Andrea Magri, Annette Von Delft, David Bonsall, Nimisha Chaturvedi, Istvan Bartha, David Smith, George Nicholson, Gilean McVean, Amy Trebes, Paolo Piazza, Jacques Fellay, Graham Cooke, Graham R Foster, Emma Hudson, John McLauchlan, Peter Simmonds, Rory Bowden, Paul Klenerman, Eleanor Barnes & Chris C A Spencer (Source: Nature Genetics)
Source: Nature Genetics - April 10, 2017 Category: Genetics & Stem Cells Authors: M Azim Ansari Vincent Pedergnana Camilla L C Ip Andrea Magri Annette Von Delft David Bonsall Nimisha Chaturvedi Istvan Bartha David Smith George Nicholson Gilean McVean Amy Trebes Paolo Piazza Jacques Fellay Graham Cooke Graham R Foster Emma Hudson John M Tags: Article Source Type: research
