Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
Nature Genetics 49, 1113 (2017).
doi:10.1038/ng.3874
Authors: Joanna M M Howson, Wei Zhao, Daniel R Barnes, Weang-Kee Ho, Robin Young, Dirk S Paul, Lindsay L Waite, Daniel F Freitag, Eric B Fauman, Elias L Salfati, Benjamin B Sun, John D Eicher, Andrew D Johnson, Wayne H H Sheu, Sune F Nielsen, Wei-Yu Lin, Praveen Surendran, Anders Malarstig, Jemma B Wilk, Anne Tybjærg-Hansen, Katrine L Rasmussen, Pia R Kamstrup, Panos Deloukas, Jeanette Erdmann, Sekar Kathiresan, Nilesh J Samani, Heribert Schunkert, Hugh Watkins, Ron Do, Daniel J Rader, Julie A Johnson, Stanley L Hazen, Arshed A Quyyumi, John A Spertus, Carl ...
Source: Nature Genetics - May 22, 2017 Category: Genetics & Stem Cells Authors: Joanna M M Howson Wei Zhao Daniel R Barnes Weang-Kee Ho Robin Young Dirk S Paul Lindsay L Waite Daniel F Freitag Eric B Fauman Elias L Salfati Benjamin B Sun John D Eicher Andrew D Johnson Wayne H H Sheu Sune F Nielsen Wei-Yu Lin Praveen Surendran Anders Tags: Letter Source Type: research
Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Nature Genetics 49, 1107 (2017).
doi:10.1038/ng.3869
Authors: Suzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R Jansen, Jonathan R I Coleman, Eva Krapohl, Erdogan Taskesen, Anke R Hammerschlag, Aysu Okbay, Delilah Zabaneh, Najaf Amin, Gerome Breen, David Cesarini, Christopher F Chabris, William G Iacono, M Arfan Ikram, Magnus Johannesson, Philipp Koellinger, James J Lee, Patrik K E Magnusson, Matt McGue, Mike B Miller, William E R Ollier, Antony Payton, Neil Pendleton, Robert Plomin, Cornelius A Rietveld, Henning Tiemeier, Cornelia M van Duijn & Danielle Posthuma
Intelligence is associated with importan...
Source: Nature Genetics - May 22, 2017 Category: Genetics & Stem Cells Authors: Suzanne Sniekers Sven Stringer Kyoko Watanabe Philip R Jansen Jonathan R I Coleman Eva Krapohl Erdogan Taskesen Anke R Hammerschlag Aysu Okbay Delilah Zabaneh Najaf Amin Gerome Breen David Cesarini Christopher F Chabris William G Iacono M Arfan Ikram Magn Tags: Letter Source Type: research
Whole-genome resequencing of 292 pigeonpea accessions identifies genomic regions associated with domestication and agronomic traits
Nature Genetics 49, 1082 (2017).
doi:10.1038/ng.3872
Authors: Rajeev K Varshney, Rachit K Saxena, Hari D Upadhyaya, Aamir W Khan, Yue Yu, Changhoon Kim, Abhishek Rathore, Dongseon Kim, Jihun Kim, Shaun An, Vinay Kumar, Ghanta Anuradha, Kalinati Narasimhan Yamini, Wei Zhang, Sonnappa Muniswamy, Jong-So Kim, R Varma Penmetsa, Eric von Wettberg & Swapan K Datta (Source: Nature Genetics)
Source: Nature Genetics - May 22, 2017 Category: Genetics & Stem Cells Authors: Rajeev K Varshney Rachit K Saxena Hari D Upadhyaya Aamir W Khan Yue Yu Changhoon Kim Abhishek Rathore Dongseon Kim Jihun Kim Shaun An Vinay Kumar Ghanta Anuradha Kalinati Narasimhan Yamini Wei Zhang Sonnappa Muniswamy Jong-So Kim R Varma Penmetsa Eric von Tags: Article Source Type: research
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease
Nature Genetics 49, 1025 (2017).
doi:10.1038/ng.3871
Authors: Hao Lu, Maria C Rondón Galeano, Elisabeth Ott, Geraldine Kaeslin, P Jaya Kausalya, Carina Kramer, Nadina Ortiz-Brüchle, Nadescha Hilger, Vicki Metzis, Milan Hiersche, Shang Yew Tay, Robert Tunningley, Shubha Vij, Andrew D Courtney, Belinda Whittle, Elke Wühl, Udo Vester, Björn Hartleben, Steffen Neuber, Valeska Frank, Melissa H Little, Daniel Epting, Peter Papathanasiou, Andrew C Perkins, Graham D Wright, Walter Hunziker, Heon Yung Gee, Edgar A Otto, Klaus Zerres, Friedhelm Hildebrandt, Sudipto Roy, Carol Wicking & Carsten Bergman...
Source: Nature Genetics - May 22, 2017 Category: Genetics & Stem Cells Authors: Hao Lu Maria C Rond ó n Galeano Elisabeth Ott Geraldine Kaeslin P Jaya Kausalya Carina Kramer Nadina Ortiz-Br ü chle Nadescha Hilger Vicki Metzis Milan Hiersche Shang Yew Tay Robert Tunningley Shubha Vij Andrew D Courtney Belinda Whittle Elke W ü hl Ud Tags: Article Source Type: research
Reevaluation of SNP heritability in complex human traits
Nature Genetics 49, 986 (2017).
doi:10.1038/ng.3865
Authors: Doug Speed, Na Cai, Michael R Johnson, Sergey Nejentsev & David J Balding (Source: Nature Genetics)
Source: Nature Genetics - May 22, 2017 Category: Genetics & Stem Cells Authors: Doug Speed Na Cai Michael R Johnson Sergey Nejentsev David J Balding Tags: Article Source Type: research
Lineage-specific functions of TET1 in the postimplantation mouse embryo
Nature Genetics 49, 1061 (2017).
doi:10.1038/ng.3868
Authors: Rita Khoueiry, Abhishek Sohni, Bernard Thienpont, Xinlong Luo, Joris Vande Velde, Michela Bartoccetti, Bram Boeckx, An Zwijsen, Anjana Rao, Diether Lambrechts & Kian Peng Koh (Source: Nature Genetics)
Source: Nature Genetics - May 15, 2017 Category: Genetics & Stem Cells Authors: Rita Khoueiry Abhishek Sohni Bernard Thienpont Xinlong Luo Joris Vande Velde Michela Bartoccetti Bram Boeckx An Zwijsen Anjana Rao Diether Lambrechts Kian Peng Koh Tags: Article Source Type: research
Paused RNA polymerase II inhibits new transcriptional initiation
Nature Genetics 49, 1045 (2017).
doi:10.1038/ng.3867
Authors: Wanqing Shao & Julia Zeitlinger (Source: Nature Genetics)
Source: Nature Genetics - May 15, 2017 Category: Genetics & Stem Cells Authors: Wanqing Shao Julia Zeitlinger Tags: Article Source Type: research
PGBD5 promotes site-specific oncogenic mutations in human tumors
Nature Genetics 49, 1005 (2017).
doi:10.1038/ng.3866
Authors: Anton G Henssen, Richard Koche, Jiali Zhuang, Eileen Jiang, Casie Reed, Amy Eisenberg, Eric Still, Ian C MacArthur, Elias Rodríguez-Fos, Santiago Gonzalez, Montserrat Puiggròs, Andrew N Blackford, Christopher E Mason, Elisa de Stanchina, Mithat Gönen, Anne-Katrin Emde, Minita Shah, Kanika Arora, Catherine Reeves, Nicholas D Socci, Elizabeth Perlman, Cristina R Antonescu, Charles W M Roberts, Hanno Steen, Elizabeth Mullen, Stephen P Jackson, David Torrents, Zhiping Weng, Scott A Armstrong & Alex Kentsis (Source: Nature Genetics)
Source: Nature Genetics - May 15, 2017 Category: Genetics & Stem Cells Authors: Anton G Henssen Richard Koche Jiali Zhuang Eileen Jiang Casie Reed Amy Eisenberg Eric Still Ian C MacArthur Elias Rodr í guez-Fos Santiago Gonzalez Montserrat Puiggr ò s Andrew N Blackford Christopher E Mason Elisa de Stanchina Mithat G ö nen Anne-Katr Tags: Article Source Type: research
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Nature Genetics 49, 978 (2017).
doi:10.1038/ng.3863
Authors: Daniel J Weiner, Emilie M Wigdor, Stephan Ripke, Raymond K Walters, Jack A Kosmicki, Jakob Grove, Kaitlin E Samocha, Jacqueline I Goldstein, Aysu Okbay, Jonas Bybjerg-Grauholm, Thomas Werge, David M Hougaard, Jacob Taylor, David Skuse, Bernie Devlin, Richard Anney, Stephan J Sanders, Somer Bishop, Preben Bo Mortensen, Anders D Børglum, George Davey Smith, Mark J Daly & Elise B Robinson (Source: Nature Genetics)
Source: Nature Genetics - May 15, 2017 Category: Genetics & Stem Cells Authors: Daniel J Weiner Emilie M Wigdor Stephan Ripke Raymond K Walters Jack A Kosmicki Jakob Grove Kaitlin E Samocha Jacqueline I Goldstein Aysu Okbay Jonas Bybjerg-Grauholm Thomas Werge David M Hougaard Jacob Taylor David Skuse Bernie Devlin Richard Anney Steph Tags: Analysis Source Type: research
Widespread adenine N6-methylation of active genes in fungi
Nature Genetics 49, 964 (2017).
doi:10.1038/ng.3859
Authors: Stephen J Mondo, Richard O Dannebaum, Rita C Kuo, Katherine B Louie, Adam J Bewick, Kurt LaButti, Sajeet Haridas, Alan Kuo, Asaf Salamov, Steven R Ahrendt, Rebecca Lau, Benjamin P Bowen, Anna Lipzen, William Sullivan, Bill B Andreopoulos, Alicia Clum, Erika Lindquist, Christopher Daum, Trent R Northen, Govindarajan Kunde-Ramamoorthy, Robert J Schmitz, Andrii Gryganskyi, David Culley, Jon Magnuson, Timothy Y James, Michelle A O'Malley, Jason E Stajich, Joseph W Spatafora, Axel Visel & Igor V Grigoriev
N6-methyldeoxyadenine (6mA) is a noncanonical DNA b...
Source: Nature Genetics - May 8, 2017 Category: Genetics & Stem Cells Authors: Stephen J Mondo Richard O Dannebaum Rita C Kuo Katherine B Louie Adam J Bewick Kurt LaButti Sajeet Haridas Alan Kuo Asaf Salamov Steven R Ahrendt Rebecca Lau Benjamin P Bowen Anna Lipzen William Sullivan Bill B Andreopoulos Alicia Clum Erika Lindquist Chr Tags: Letter Source Type: research
Genome sequencing and population genomic analyses provide insights into the adaptive landscape of silver birch
Nature Genetics 49, 904 (2017).
doi:10.1038/ng.3862
Authors: Jarkko Salojärvi, Olli-Pekka Smolander, Kaisa Nieminen, Sitaram Rajaraman, Omid Safronov, Pezhman Safdari, Airi Lamminmäki, Juha Immanen, Tianying Lan, Jaakko Tanskanen, Pasi Rastas, Ali Amiryousefi, Balamuralikrishna Jayaprakash, Juhana I Kammonen, Risto Hagqvist, Gugan Eswaran, Viivi Helena Ahonen, Juan Alonso Serra, Fred O Asiegbu, Juan de Dios Barajas-Lopez, Daniel Blande, Olga Blokhina, Tiina Blomster, Suvi Broholm, Mikael Brosché, Fuqiang Cui, Chris Dardick, Sanna E Ehonen, Paula Elomaa, Sacha Escamez, Kurt V Fagerstedt, Hiroaki Fujii...
Source: Nature Genetics - May 8, 2017 Category: Genetics & Stem Cells Authors: Jarkko Saloj ä rvi Olli-Pekka Smolander Kaisa Nieminen Sitaram Rajaraman Omid Safronov Pezhman Safdari Airi Lamminm ä ki Juha Immanen Tianying Lan Jaakko Tanskanen Pasi Rastas Ali Amiryousefi Balamuralikrishna Jayaprakash Juhana I Kammonen Risto Hagqvis Tags: Article Source Type: research
Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma
Nature Genetics 49, 825 (2017).
doi:10.1038/ng.3861
Authors: Michael E Feigin, Tyler Garvin, Peter Bailey, Nicola Waddell, David K Chang, David R Kelley, Shimin Shuai, Steven Gallinger, John D McPherson, Sean M Grimmond, Ekta Khurana, Lincoln D Stein, Andrew V Biankin, Michael C Schatz & David A Tuveson (Source: Nature Genetics)
Source: Nature Genetics - May 8, 2017 Category: Genetics & Stem Cells Authors: Michael E Feigin Tyler Garvin Peter Bailey Nicola Waddell David K Chang David R Kelley Shimin Shuai Steven Gallinger John D McPherson Sean M Grimmond Ekta Khurana Lincoln D Stein Andrew V Biankin Michael C Schatz David A Tuveson Tags: Analysis Source Type: research
DUX-family transcription factors regulate zygotic genome activation in placental mammals
Nature Genetics 49, 941 (2017).
doi:10.1038/ng.3858
Authors: Alberto De Iaco, Evarist Planet, Andrea Coluccio, Sonia Verp, Julien Duc & Didier Trono
In animal embryos, transcription is mostly silent for several cell divisions, until the release of the first major wave of embryonic transcripts through so-called zygotic genome activation (ZGA). Maternally provided ZGA-triggering factors have been identified in Drosophila melanogaster and Danio rerio, but their mammalian homologs are still undefined. Here, we provide evidence that the DUX family of transcription factors is essential to this process in mice and pot...
Source: Nature Genetics - May 1, 2017 Category: Genetics & Stem Cells Authors: Alberto De Iaco Evarist Planet Andrea Coluccio Sonia Verp Julien Duc Didier Trono Tags: Letter Source Type: research
Conservation and innovation in the DUX4-family gene network
Nature Genetics 49, 935 (2017).
doi:10.1038/ng.3846
Authors: Jennifer L Whiddon, Ashlee T Langford, Chao-Jen Wong, Jun Wen Zhong & Stephen J Tapscott
Facioscapulohumeral dystrophy (FSHD; MIM158900, MIM158901) is caused by misexpression of the DUX4 transcription factor in skeletal muscle. Animal models of FSHD are hindered by incomplete knowledge regarding the conservation of the DUX4 transcriptional program in other species. Despite the divergence of their binding motifs, both mouse DUX and human DUX4 in mouse and human muscle cells, respectively, activate genes associated with cleavage-stage embryos, including...
Source: Nature Genetics - May 1, 2017 Category: Genetics & Stem Cells Authors: Jennifer L Whiddon Ashlee T Langford Chao-Jen Wong Jun Wen Zhong Stephen J Tapscott Tags: Letter Source Type: research
Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons
Nature Genetics 49, 925 (2017).
doi:10.1038/ng.3844
Authors: Peter G Hendrickson, Jessie A Doráis, Edward J Grow, Jennifer L Whiddon, Jong-Won Lim, Candice L Wike, Bradley D Weaver, Christian Pflueger, Benjamin R Emery, Aaron L Wilcox, David A Nix, C Matthew Peterson, Stephen J Tapscott, Douglas T Carrell & Bradley R Cairns (Source: Nature Genetics)
Source: Nature Genetics - May 1, 2017 Category: Genetics & Stem Cells Authors: Peter G Hendrickson Jessie A Dor á is Edward J Grow Jennifer L Whiddon Jong-Won Lim Candice L Wike Bradley D Weaver Christian Pflueger Benjamin R Emery Aaron L Wilcox David A Nix C Matthew Peterson Stephen J Tapscott Douglas T Carrell Bradley R Cairns Tags: Article Source Type: research
