Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Nature Cell Biology 19, 1061 (2017).
doi:10.1038/ncb3586
Authors: Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender & Andrea Ablasser (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 31, 2017 Category: Cytology Authors: Selene Gl ü ck Baptiste Guey Muhammet Fatih Gulen Katharina Wolter Tae-Won Kang Niklas Arndt Schmacke Anne Bridgeman Jan Rehwinkel Lars Zender Andrea Ablasser Tags: Article Source Type: research
Corrigendum: Pulsatile cell-autonomous contractility drives compaction in the mouse embryo
Nature Cell Biology 19, 1003 (2017).
doi:10.1038/ncb3587
Author: Jean-Léon Maître, Ritsuya Niwayama, Hervé Turlier, François Nédélec & Takashi Hiiragi (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Jean-L é on Ma î tre Ritsuya Niwayama Herv é Turlier Fran ç ois N é d é lec Takashi Hiiragi Tags: Corrigendum Source Type: research
Corrigendum: Pramel7 mediates ground-state pluripotency through proteasomal – epigenetic combined pathways
Nature Cell Biology 19, 1003 (2017).
doi:10.1038/ncb3572
Author: Urs Graf, Elisa A. Casanova, Sarah Wyck, Damian Dalcher, Marco Gatti, Eva Vollenweider, Michal J. Okoniewski, Fabienne A. Weber, Sameera S. Patel, Marc W. Schmid, Jiwen Li, Jafar Sharif, Guido A. Wanner, Haruhiko Koseki, Jiemin Wong, Pawel Pelczar, Lorenza Penengo, Raffaella Santoro & Paolo Cinelli (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Urs Graf Elisa A. Casanova Sarah Wyck Damian Dalcher Marco Gatti Eva Vollenweider Michal J. Okoniewski Fabienne A. Weber Sameera S. Patel Marc W. Schmid Jiwen Li Jafar Sharif Guido A. Wanner Haruhiko Koseki Jiemin Wong Pawel Pelczar Lorenza Penengo Raffae Tags: Corrigendum Source Type: research
Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation
Nature Cell Biology 19, 996 (2017).
doi:10.1038/ncb3581
Authors: Kimberly C. Lin, Toshiro Moroishi, Zhipeng Meng, Han-Sol Jeong, Steven W. Plouffe, Yoshitaka Sekido, Jiahuai Han, Hyun Woo Park & Kun-Liang Guan
The Hippo pathway controls organ size and tissue homeostasis, with deregulation leading to cancer. The core Hippo components in mammals are composed of the upstream serine/threonine kinases Mst1/2, MAPK4Ks and Lats1/2. Inactivation of these upstream kinases leads to dephosphorylation, stabilization, nuclear translocation and thus activation of the major functional transducers of the Hippo pathway, YAP and...
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Kimberly C. Lin Toshiro Moroishi Zhipeng Meng Han-Sol Jeong Steven W. Plouffe Yoshitaka Sekido Jiahuai Han Hyun Woo Park Kun-Liang Guan Tags: Letter Source Type: research
A key HDAC6 dependency of ARID1A-mutated ovarian cancer
Nature Cell Biology 19, 889 (2017).
doi:10.1038/ncb3588
Author: Lucia Altucci
Mutations in AT rich interactive domain 1A (ARID1A) are common in ovarian cancers. A study now shows that HDAC6 activity is required for survival of ovarian cancer cells bearing ARID1A mutations. HDAC6 inhibition selectively promotes apoptosis of ARID1A-inactivated cells, supporting the use of HDAC6 inhibition in the treatment of clear cell ovarian cancer. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Lucia Altucci Tags: News and Views Source Type: research
The skinny on obesity and cancer
Nature Cell Biology 19, 887 (2017).
doi:10.1038/ncb3583
Authors: Jaclyn Sceneay & Sandra S. McAllister
Obesity now rivals smoking as one of the leading preventable causes of cancer. Obesity-associated neutrophilia is now shown to enhance breast cancer metastasis and to be reversible through dietary modification and weight loss. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Jaclyn Sceneay Sandra S. McAllister Tags: News and Views Source Type: research
Origin and regulation of a lung repair kit
Nature Cell Biology 19, 885 (2017).
doi:10.1038/ncb3585
Author: Jichao Chen
The lung undergoes a striking repair process in response to severe injuries such as influenza infection. A study now demonstrates that associated stem/progenitor cells are heterogeneous in nature and comprise subpopulations dominated by hypoxia/Notch or Wnt signalling. Modulation of this heterogeneity in favour of functional repair may have therapeutic value. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Jichao Chen Tags: News and Views Source Type: research
CTCF fences make good neighbours
Nature Cell Biology 19, 883 (2017).
doi:10.1038/ncb3584
Authors: Ivan Krivega & Ann Dean
CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Ivan Krivega Ann Dean Tags: News and Views Source Type: research
Journal metrics: what's in a number?
Nature Cell Biology 19, 875 (2017).
doi:10.1038/ncb3589
Metrics of research assessment should be applied with judgment and clarity to avoid undermining scientific efforts. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 28, 2017 Category: Cytology Tags: Editorial Source Type: research
Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization
Nature Cell Biology 19, 988 (2017).
doi:10.1038/ncb3577
Authors: Shyi-Chyi Wang, Tricia Yu Feng Low, Yukako Nishimura, Laurent Gole, Weimiao Yu & Fumio Motegi
Cell polarization enables zygotes to acquire spatial asymmetry, which in turn patterns cellular and tissue axes during development. Local modification in the actomyosin cytoskeleton mediates spatial segregation of partitioning-defective (PAR) proteins at the cortex, but how mechanical changes in the cytoskeleton are transmitted to PAR proteins remains elusive. Here we uncover a role of actomyosin contractility in the remodelling of PAR proteins through co...
Source: Nature Cell Biology - July 24, 2017 Category: Cytology Authors: Shyi-Chyi Wang Tricia Yu Feng Low Yukako Nishimura Laurent Gole Weimiao Yu Fumio Motegi Tags: Letter Source Type: research
Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF
Nature Cell Biology 19, 974 (2017).
doi:10.1038/ncb3578
Authors: Daniela F. Quail, Oakley C. Olson, Priya Bhardwaj, Logan A. Walsh, Leila Akkari, Marsha L. Quick, I-Chun Chen, Nils Wendel, Nir Ben-Chetrit, Jeanne Walker, Peter R. Holt, Andrew J. Dannenberg & Johanna A. Joyce (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 24, 2017 Category: Cytology Authors: Daniela F. Quail Oakley C. Olson Priya Bhardwaj Logan A. Walsh Leila Akkari Marsha L. Quick I-Chun Chen Nils Wendel Nir Ben-Chetrit Jeanne Walker Peter R. Holt Andrew J. Dannenberg Johanna A. Joyce Tags: Article Source Type: research
ARID1A-mutated ovarian cancers depend on HDAC6 activity
Nature Cell Biology 19, 962 (2017).
doi:10.1038/ncb3582
Authors: Benjamin G. Bitler, Shuai Wu, Pyoung Hwa Park, Yang Hai, Katherine M. Aird, Yemin Wang, Yali Zhai, Andrew V. Kossenkov, Ana Vara-Ailor, Frank J. Rauscher III, Weiping Zou, David W. Speicher, David G. Huntsman, Jose R. Conejo-Garcia, Kathleen R. Cho, David W. Christianson & Rugang Zhang (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 24, 2017 Category: Cytology Authors: Benjamin G. Bitler Shuai Wu Pyoung Hwa Park Yang Hai Katherine M. Aird Yemin Wang Yali Zhai Andrew V. Kossenkov Ana Vara-Ailor Frank J. Rauscher III Weiping Zou David W. Speicher David G. Huntsman Jose R. Conejo-Garcia Kathleen R. Cho David W. Christia Tags: Article Source Type: research
Tissue-specific CTCF – cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo
Nature Cell Biology 19, 952 (2017).
doi:10.1038/ncb3573
Authors: Lars L. P. Hanssen, Mira T. Kassouf, A. Marieke Oudelaar, Daniel Biggs, Chris Preece, Damien J. Downes, Matthew Gosden, Jacqueline A. Sharpe, Jacqueline A. Sloane-Stanley, Jim R. Hughes, Benjamin Davies & Douglas R. Higgs (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 24, 2017 Category: Cytology Authors: Lars L. P. Hanssen Mira T. Kassouf A. Marieke Oudelaar Daniel Biggs Chris Preece Damien J. Downes Matthew Gosden Jacqueline A. Sharpe Jacqueline A. Sloane-Stanley Jim R. Hughes Benjamin Davies Douglas R. Higgs Tags: Article Source Type: research
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration
Nature Cell Biology 19, 904 (2017).
doi:10.1038/ncb3580
Authors: Ying Xi, Thomas Kim, Alexis N. Brumwell, Ian H. Driver, Ying Wei, Victor Tan, Julia R. Jackson, Jianming Xu, Dong-Kee Lee, Jeffrey E. Gotts, Michael A. Matthay, John M. Shannon, Harold A. Chapman & Andrew E. Vaughan (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 24, 2017 Category: Cytology Authors: Ying Xi Thomas Kim Alexis N. Brumwell Ian H. Driver Ying Wei Victor Tan Julia R. Jackson Jianming Xu Dong-Kee Lee Jeffrey E. Gotts Michael A. Matthay John M. Shannon Harold A. Chapman Andrew E. Vaughan Tags: Article Source Type: research
Budding yeast Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation
Nature Cell Biology 19, 941 (2017).
doi:10.1038/ncb3576
Authors: Jette Lengefeld, Manuel Hotz, Meaghen Rollins, Kristin Baetz & Yves Barral (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 17, 2017 Category: Cytology Authors: Jette Lengefeld Manuel Hotz Meaghen Rollins Kristin Baetz Yves Barral Tags: Article Source Type: research
