Reforms spell optimism for biological research in China
Nature Cell Biology 19, 1297 (2017).
doi:10.1038/ncb3639
A series of government reforms aim to enhance basic research efforts in China with a shift in focus from quantity to quality. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 31, 2017 Category: Cytology Tags: Editorial Source Type: research
Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis
Nature Cell Biology 19, 1433 (2017).
doi:10.1038/ncb3634
Authors: Jamin B. Hein, Emil P. T. Hertz, Dimitriya H. Garvanska, Thomas Kruse & Jakob Nilsson
Protein phosphatase 2A (PP2A) in complex with B55 regulatory subunits reverses cyclin-dependent kinase 1 (Cdk1) phosphorylations at mitotic exit. Interestingly, threonine and serine residues phosphorylated by Cdk1 display distinct phosphorylation dynamics, but the biological significance remains unexplored. Here we demonstrate that the phosphothreonine preference of PP2A–B55 provides an essential regulatory element of mitotic exit. To allow rapid activatio...
Source: Nature Cell Biology - October 30, 2017 Category: Cytology Authors: Jamin B. Hein Emil P. T. Hertz Dimitriya H. Garvanska Thomas Kruse Jakob Nilsson Tags: Letter Source Type: research
TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi
Nature Cell Biology 19, 1424 (2017).
doi:10.1038/ncb3627
Authors: John J. H. Shin, Alison K. Gillingham, Farida Begum, Jessica Chadwick & Sean Munro
The specificity of membrane traffic involves tethers at destination organelles that selectively capture incoming transport vesicles to allow SNAREs on opposing membranes to then assemble and drive fusion. Tethers include both protein complexes and long coiled-coil proteins, although how they contribute to specificity remains unclear. The golgin coiled-coil proteins at the Golgi apparatus capture vesicles from different origins, but the vesicle-specific molecular cu...
Source: Nature Cell Biology - October 30, 2017 Category: Cytology Authors: John J. H. Shin Alison K. Gillingham Farida Begum Jessica Chadwick Sean Munro Tags: Letter Source Type: research
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
Nature Cell Biology 19, 1412 (2017).
doi:10.1038/ncb3631
Authors: Fergal O’Farrell, Viola Hélène Lobert, Marte Sneeggen, Ashish Jain, Nadja Sandra Katheder, Eva Maria Wenzel, Sebastian Wolfgang Schultz, Kia Wee Tan, Andreas Brech, Harald Stenmark & Tor Erik Rusten (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 30, 2017 Category: Cytology Authors: Fergal O ’ Farrell Viola H é l è ne Lobert Marte Sneeggen Ashish Jain Nadja Sandra Katheder Eva Maria Wenzel Sebastian Wolfgang Schultz Kia Wee Tan Andreas Brech Harald Stenmark Tor Erik Rusten Tags: Article Source Type: research
PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Nature Cell Biology 19, 1358 (2017).
doi:10.1038/ncb3630
Authors: Fabao Liu, Fengfei Ma, Yuyuan Wang, Ling Hao, Hao Zeng, Chenxi Jia, Yidan Wang, Peng Liu, Irene M. Ong, Baobin Li, Guojun Chen, Jiaoyang Jiang, Shaoqin Gong, Lingjun Li & Wei Xu (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 23, 2017 Category: Cytology Authors: Fabao Liu Fengfei Ma Yuyuan Wang Ling Hao Hao Zeng Chenxi Jia Yidan Wang Peng Liu Irene M. Ong Baobin Li Guojun Chen Jiaoyang Jiang Shaoqin Gong Lingjun Li Wei Xu Tags: Article Source Type: research
Synthetic hydrogels for human intestinal organoid generation and colonic wound repair
Nature Cell Biology 19, 1326 (2017).
doi:10.1038/ncb3632
Authors: Ricardo Cruz-Acuña, Miguel Quirós, Attila E. Farkas, Priya H. Dedhia, Sha Huang, Dorothée Siuda, Vicky García-Hernández, Alyssa J. Miller, Jason R. Spence, Asma Nusrat & Andrés J. García (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 23, 2017 Category: Cytology Authors: Ricardo Cruz-Acu ñ a Miguel Quir ó s Attila E. Farkas Priya H. Dedhia Sha Huang Doroth é e Siuda Vicky Garc í a-Hern á ndez Alyssa J. Miller Jason R. Spence Asma Nusrat Andr é s J. Garc í a Tags: Article Source Type: research
EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity
Nature Cell Biology 19, 1313 (2017).
doi:10.1038/ncb3628
Authors: Zarah M. Löf-Öhlin, Pia Nyeng, Matthew E. Bechard, Katja Hess, Eric Bankaitis, Thomas U. Greiner, Jacqueline Ameri, Christopher V. Wright & Henrik Semb (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 23, 2017 Category: Cytology Authors: Zarah M. L ö f- Ö hlin Pia Nyeng Matthew E. Bechard Katja Hess Eric Bankaitis Thomas U. Greiner Jacqueline Ameri Christopher V. Wright Henrik Semb Tags: Article Source Type: research
The impact of cellular metabolism on chromatin dynamics and epigenetics
Nature Cell Biology 19, 1298 (2017).
doi:10.1038/ncb3629
Authors: Michael A. Reid, Ziwei Dai & Jason W. Locasale (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 23, 2017 Category: Cytology Authors: Michael A. Reid Ziwei Dai Jason W. Locasale Tags: Review Source Type: research
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
Nature Cell Biology 19, 1371 (2017).
doi:10.1038/ncb3626
Authors: Beatrice Rondinelli, Ewa Gogola, Hatice Yücel, Alexandra A. Duarte, Marieke van de Ven, Roxanne van der Sluijs, Panagiotis A. Konstantinopoulos, Jos Jonkers, Raphaël Ceccaldi, Sven Rottenberg & Alan D. D’Andrea
The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes genomic stability in BRCA1/2-deficient cancers. Dissect...
Source: Nature Cell Biology - October 16, 2017 Category: Cytology Authors: Beatrice Rondinelli Ewa Gogola Hatice Y ü cel Alexandra A. Duarte Marieke van de Ven Roxanne van der Sluijs Panagiotis A. Konstantinopoulos Jos Jonkers Rapha ë l Ceccaldi Sven Rottenberg Alan D. D ’ Andrea Tags: Letter Source Type: research
Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche
Nature Cell Biology 19, 1336 (2017).
doi:10.1038/ncb3625
Authors: Allison L. Boyd, Jennifer C. Reid, Kyle R. Salci, Lili Aslostovar, Yannick D. Benoit, Zoya Shapovalova, Mio Nakanishi, Deanna P. Porras, Mohammed Almakadi, Clinton J. V. Campbell, Michael F. Jackson, Catherine A. Ross, Ronan Foley, Brian Leber, David S. Allan, Mitchell Sabloff, Anargyros Xenocostas, Tony J. Collins & Mickie Bhatia (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 16, 2017 Category: Cytology Authors: Allison L. Boyd Jennifer C. Reid Kyle R. Salci Lili Aslostovar Yannick D. Benoit Zoya Shapovalova Mio Nakanishi Deanna P. Porras Mohammed Almakadi Clinton J. V. Campbell Michael F. Jackson Catherine A. Ross Ronan Foley Brian Leber David S. Allan Mitchell Tags: Article Source Type: research
A non-coding function of TYRP1 mRNA promotes melanoma growth
Nature Cell Biology 19, 1348 (2017).
doi:10.1038/ncb3623
Authors: David Gilot, Mélodie Migault, Laura Bachelot, Fabrice Journé, Aljosja Rogiers, Emmanuelle Donnou-Fournet, Ariane Mogha, Nicolas Mouchet, Marie-Laure Pinel-Marie, Bernard Mari, Tristan Montier, Sébastien Corre, Arthur Gautron, Florian Rambow, Petra El Hajj, Rania Ben Jouira, Sophie Tartare-Deckert, Jean-Christophe Marine, Brice Felden, Ghanem Ghanem & Marie-Dominique Galibert (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 9, 2017 Category: Cytology Authors: David Gilot M é lodie Migault Laura Bachelot Fabrice Journ é Aljosja Rogiers Emmanuelle Donnou-Fournet Ariane Mogha Nicolas Mouchet Marie-Laure Pinel-Marie Bernard Mari Tristan Montier S é bastien Corre Arthur Gautron Florian Rambow Petra El Hajj Rania Tags: Article Source Type: research
MK2 balances inflammation and cell death
Nature Cell Biology 19, 1150 (2017).
doi:10.1038/ncb3619
Author: Andrew Oberst
The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in response to TNF and TLR signalling. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 29, 2017 Category: Cytology Authors: Andrew Oberst Tags: News and Views Source Type: research
Myofibrils put the squeeze on nuclei
Nature Cell Biology 19, 1148 (2017).
doi:10.1038/ncb3618
Authors: Jonathan N. Rosen & Mary K. Baylies
During muscle development, nuclei travel from the centre of the myofibre to the periphery, a process defective in certain diseases. A new study reveals that this movement is due to centripetal forces imposed on nuclei by the crosslinking and contraction of myofibrils. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 29, 2017 Category: Cytology Authors: Jonathan N. Rosen Mary K. Baylies Tags: News and Views Source Type: research
What DKKtates where to metastasize
Nature Cell Biology 19, 1146 (2017).
doi:10.1038/ncb3621
Authors: Wei Zheng & Jeffrey W. Pollard
Cancer cells preferentially metastasize to certain organs. A study in mouse models of breast cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the lung, but enhances tropism to the bone due to the differential regulation of canonical and non-canonical WNT signalling in the two microenvironments. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 29, 2017 Category: Cytology Authors: Wei Zheng Jeffrey W. Pollard Tags: News and Views Source Type: research
Retriever fetches integrins from endosomes
Nature Cell Biology 19, 1144 (2017).
doi:10.1038/ncb3612
Author: Catherine Rabouille
Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for. Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of α5β1 integrins. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 29, 2017 Category: Cytology Authors: Catherine Rabouille Tags: News and Views Source Type: research
