The persistent dynamic secrets of senescence
Nature Cell Biology 18, 913 (2016).
doi:10.1038/ncb3403
Author: Clemens A. Schmitt
While the beneficial versus detrimental implications of the senescence-associated secretome remain an issue of debate, time-resolved analyses of its composition, regulatory mechanisms and functional consequences have been largely missing. The dynamic activity of NOTCH is now shown to direct two distinct senescence phenotypes, by first promoting a pro-senescent TGF-β1-dependent secretome, followed by a second wave of pro-inflammatory, senescence-clearing cytokines. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 29, 2016 Category: Cytology Authors: Clemens A. Schmitt Tags: News and Views Source Type: research
Melanosomes foster a tumour niche by activating CAFs
Nature Cell Biology 18, 911 (2016).
doi:10.1038/ncb3404
Authors: Susana García-Silva & Héctor Peinado
Extracellular vesicles, such as exosomes, are important effectors in the formation of tumour-fostering niches. Pigmented melanosomes are now shown to have a relevant role in establishing a tumour niche in primary melanoma by reprogramming dermal fibroblasts into cancer-associated fibroblasts through the transfer of miR-211. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 29, 2016 Category: Cytology Authors: Susana Garc ía-Silva H éctor Peinado Tags: News and Views Source Type: research
Melanoma miRNA trafficking controls tumour primary niche formation
Nature Cell Biology 18, 1006 (2016).
doi:10.1038/ncb3399
Authors: Shani Dror, Laureen Sander, Hila Schwartz, Danna Sheinboim, Aviv Barzilai, Yuval Dishon, Sebastien Apcher, Tamar Golan, Shoshana Greenberger, Iris Barshack, Hagar Malcov, Alona Zilberberg, Lotan Levin, Michelle Nessling, Yael Friedmann, Vivien Igras, Ohad Barzilay, Hananya Vaknine, Ronen Brenner, Assaf Zinger, Avi Schroeder, Pinchas Gonen, Mehdi Khaled, Neta Erez, Jörg D. Hoheisel & Carmit Levy (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2016 Category: Cytology Authors: Shani Dror Laureen Sander Hila Schwartz Danna Sheinboim Aviv Barzilai Yuval Dishon Sebastien Apcher Tamar Golan Shoshana Greenberger Iris Barshack Hagar Malcov Alona Zilberberg Lotan Levin Michelle Nessling Yael Friedmann Vivien Igras Ohad Barzilay Hanany Tags: Article Source Type: research
A single dividing cell population with imbalanced fate drives oesophageal tumour growth
Nature Cell Biology 18, 967 (2016).
doi:10.1038/ncb3400
Authors: Julia Frede, Philip Greulich, Tibor Nagy, Benjamin D. Simons & Philip H. Jones (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2016 Category: Cytology Authors: Julia Frede Philip Greulich Tibor Nagy Benjamin D. Simons Philip H. Jones Tags: Article Source Type: research
Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation
Nature Cell Biology 18, 941 (2016).
doi:10.1038/ncb3402
Authors: Zhiqi Sun, Hui-Yuan Tseng, Steven Tan, Fabrice Senger, Laetitia Kurzawa, Dirk Dedden, Naoko Mizuno, Anita A. Wasik, Manuel Thery, Alexander R. Dunn & Reinhard Fässler (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2016 Category: Cytology Authors: Zhiqi Sun Hui-Yuan Tseng Steven Tan Fabrice Senger Laetitia Kurzawa Dirk Dedden Naoko Mizuno Anita A. Wasik Manuel Thery Alexander R. Dunn Reinhard F ässler Tags: Article Source Type: research
Sex hormones establish a reserve pool of adult muscle stem cells
Nature Cell Biology 18, 930 (2016).
doi:10.1038/ncb3401
Authors: Ji-Hoon Kim, Gi-Chan Han, Ji-Yun Seo, Inkuk Park, Wookjin Park, Hyun-Woo Jeong, Su Hyeon Lee, Sung-hwan Bae, Jinwoo Seong, Min-Kyu Yum, Sang-Hyeon Hann, Young-Guen Kwon, Daekwan Seo, Man Ho Choi & Young-Yun Kong (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2016 Category: Cytology Authors: Ji-Hoon Kim Gi-Chan Han Ji-Yun Seo Inkuk Park Wookjin Park Hyun-Woo Jeong Su Hyeon Lee Sung-hwan Bae Jinwoo Seong Min-Kyu Yum Sang-Hyeon Hann Young-Guen Kwon Daekwan Seo Man Ho Choi Young-Yun Kong Tags: Article Source Type: research
G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/ β-catenin pathway
Nature Cell Biology 18, 993 (2016).
doi:10.1038/ncb3395
Authors: Shih-Ting Cha, Ching-Ting Tan, Cheng-Chi Chang, Chia-Yu Chu, Wei-Jiunn Lee, Been-Zen Lin, Ming-Tsan Lin & Min-Liang Kuo (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 14, 2016 Category: Cytology Authors: Shih-Ting Cha Ching-Ting Tan Cheng-Chi Chang Chia-Yu Chu Wei-Jiunn Lee Been-Zen Lin Ming-Tsan Lin Min-Liang Kuo Tags: Article Source Type: research
NOTCH1 mediates a switch between two distinct secretomes during senescence
Nature Cell Biology 18, 979 (2016).
doi:10.1038/ncb3397
Authors: Matthew Hoare, Yoko Ito, Tae-Won Kang, Michael P. Weekes, Nicholas J. Matheson, Daniel A. Patten, Shishir Shetty, Aled J. Parry, Suraj Menon, Rafik Salama, Robin Antrobus, Kosuke Tomimatsu, William Howat, Paul J. Lehner, Lars Zender & Masashi Narita (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 14, 2016 Category: Cytology Authors: Matthew Hoare Yoko Ito Tae-Won Kang Michael P. Weekes Nicholas J. Matheson Daniel A. Patten Shishir Shetty Aled J. Parry Suraj Menon Rafik Salama Robin Antrobus Kosuke Tomimatsu William Howat Paul J. Lehner Lars Zender Masashi Narita Tags: Article Source Type: research
Nuclear GSK3 β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22
Nature Cell Biology 18, 954 (2016).
doi:10.1038/ncb3396
Authors: Aidong Zhou, Kangyu Lin, Sicong Zhang, Yaohui Chen, Nu Zhang, Jianfei Xue, Zhongyong Wang, Kenneth D. Aldape, Keping Xie, James R. Woodgett & Suyun Huang (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 7, 2016 Category: Cytology Authors: Aidong Zhou Kangyu Lin Sicong Zhang Yaohui Chen Nu Zhang Jianfei Xue Zhongyong Wang Kenneth D. Aldape Keping Xie James R. Woodgett Suyun Huang Tags: Article Source Type: research
Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation
Nature Cell Biology 18, 917 (2016).
doi:10.1038/ncb3394
Authors: Yi Tang, Tamar Feinberg, Evan T. Keller, Xiao-Yan Li & Stephen J. Weiss (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 31, 2016 Category: Cytology Authors: Yi Tang Tamar Feinberg Evan T. Keller Xiao-Yan Li Stephen J. Weiss Tags: Article Source Type: research
Hippo's Q for a big liver
Nature Cell Biology 18, 835 (2016).
doi:10.1038/ncb3391
Author: Dimitrios Anastasiou
The Hippo pathway is a key regulator of organ size that has also been implicated in tumorigenesis. Yap, one of the effectors of Hippo signalling, is now reported to support these functions by promoting glutamine synthesis. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 26, 2016 Category: Cytology Authors: Dimitrios Anastasiou Tags: News and Views Source Type: research
p53 mutations promote proteasomal activity
Nature Cell Biology 18, 833 (2016).
doi:10.1038/ncb3392
Authors: Moshe Oren & Eran Kotler
p53 mutations occur very frequently in human cancer. Besides abrogating the tumour suppressive functions of wild-type p53, many of those mutations also acquire oncogenic gain-of-function activities. Augmentation of proteasome activity is now reported as a common gain-of-function mechanism shared by different p53 mutants, which promotes cancer resistance to proteasome inhibitors. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 26, 2016 Category: Cytology Authors: Moshe Oren Eran Kotler Tags: News and Views Source Type: research
The mammalian dynein –dynactin complex is a strong opponent to kinesin in a tug-of-war competition
Nature Cell Biology 18, 1018 (2016).
doi:10.1038/ncb3393
Authors: Vladislav Belyy, Max A. Schlager, Helen Foster, Armando E. Reimer, Andrew P. Carter & Ahmet Yildiz
Kinesin and dynein motors transport intracellular cargos bidirectionally by pulling them in opposite directions along microtubules, through a process frequently described as a ‘tug of war’. While kinesin produces 6 pN of force, mammalian dynein was found to be a surprisingly weak motor (0.5–1.5 pN) in vitro, suggesting that many dyneins are required to counteract the pull of a single kinesin. Mammalian dynein’s ass...
Source: Nature Cell Biology - July 24, 2016 Category: Cytology Authors: Vladislav Belyy Max A. Schlager Helen Foster Armando E. Reimer Andrew P. Carter Ahmet Yildiz Tags: Letter Source Type: research
F-actin dismantling through a redox-driven synergy between Mical and cofilin
Nature Cell Biology 18, 876 (2016).
doi:10.1038/ncb3390
Authors: Elena E. Grintsevich, Hunkar Gizem Yesilyurt, Shannon K. Rich, Ruei-Jiun Hung, Jonathan R. Terman & Emil Reisler (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 24, 2016 Category: Cytology Authors: Elena E. Grintsevich Hunkar Gizem Yesilyurt Shannon K. Rich Ruei-Jiun Hung Jonathan R. Terman Emil Reisler Tags: Article Source Type: research
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
Nature Cell Biology 18, 886 (2016).
doi:10.1038/ncb3389
Authors: Andrew G. Cox, Katie L. Hwang, Kristin K. Brown, Kimberley J. Evason, Sebastian Beltz, Allison Tsomides, Keelin O’Connor, Giorgio G. Galli, Dean Yimlamai, Sagar Chhangawala, Min Yuan, Evan C. Lien, Julia Wucherpfennig, Sahar Nissim, Akihiro Minami, David E. Cohen, Fernando D. Camargo, John M. Asara, Yariv Houvras, Didier Y. R. Stainier & Wolfram Goessling (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 17, 2016 Category: Cytology Authors: Andrew G. Cox Katie L. Hwang Kristin K. Brown Kimberley J. Evason Sebastian Beltz Allison Tsomides Keelin O ’Connor Giorgio G. Galli Dean Yimlamai Sagar Chhangawala Min Yuan Evan C. Lien Julia Wucherpfennig Sahar Nissim Akihiro Minami David E. Cohen Fer Tags: Article Source Type: research
