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Trimethyl chitosan-hyaluronic acid nano-polyplexes for intravitreal VEGFR-2 siRNA delivery: Formulation and in-vivo efficacy evaluation
Publication date: Available online 10 March 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Farkhondeh Chaharband, Narsis Daftarian, Mozhgan Rezaei Kanavi, Reyhaneh Varshochian, Maliheh Hajiramezanali, Parisa Norouzi, Ehsan Arefian, Fatemeh Atyabi, Rassoul Dinarvand (Source: Nanomedicine: Nanotechnology, Biology and Medicine)
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 11, 2020 Category: Nanotechnology Source Type: research

Liquid metal based Theranostic Nanoplatforms: Application in Cancer therapy, imaging and biosensing
Publication date: Available online 6 March 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Abhijeet Pandey, Sanjay Kulkarni, Srinivas Mutalik (Source: Nanomedicine: Nanotechnology, Biology and Medicine)
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 7, 2020 Category: Nanotechnology Source Type: research

Photoactivation of Sulfonated Polyplexes enables localized gene silencing by DsiRNA in breast Cancer cells
Publication date: Available online 6 March 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Anu Puri, Mathias Viard, Paul Zakrevsky, Serena Zampino, Arabella Chen, Camryn Isemann, Sohaib Alvi, Jeff Clogston, Upendra Chitgupi, Jonathan F. Lovell, Bruce A. Shapiro (Source: Nanomedicine: Nanotechnology, Biology and Medicine)
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 7, 2020 Category: Nanotechnology Source Type: research

Thin graphene oxide nanoflakes modulate glutamatergic synapses in the amygdala cultured circuits: Exploiting synaptic approaches to anxiety disorders
Publication date: Available online 5 March 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Nicola Secomandi, Audrey Franceschi Biagoni, Kostas Kostarelos, Giada Cellot, Laura Ballerini (Source: Nanomedicine: Nanotechnology, Biology and Medicine)
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 7, 2020 Category: Nanotechnology Source Type: research

Factors Influencing Safety and Efficacy of Intravenous Iron-Carbohydrate Nanomedicines: From Production to Clinical Practice
Publication date: Available online 5 March 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Niusha Nikravesh, Gerrit Borchard, Heinrich Hofmann, Erik Philipp, Beat Flühmann, Peter Wick (Source: Nanomedicine: Nanotechnology, Biology and Medicine)
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 6, 2020 Category: Nanotechnology Source Type: research

MMP activatable nanoprobe for MRI of aortic aneurysms
Publication date: Available online 4 March 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Yuyu Yao, Kai Cheng, Zhen Cheng (Source: Nanomedicine: Nanotechnology, Biology and Medicine)
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 4, 2020 Category: Nanotechnology Source Type: research

Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination
Publication date: Available online 18 February 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Anastasiia S. Garanina, Victor A. Naumenko, Aleksey A. Nikitin, Eirini Myrovali, Anna Y. Petukhova, Svetlana V. Klimyuk, Yulia A. Nalench, Artem R. Ilyasov, Stepan S. Vodopyanov, Alexander S. Erofeev, Peter V. Gorelkin, Makis Angelakeris, Alexander G. Savchenko, Ulf Wiedwald, Alexander G. Majouga Dr, Maxim A. AbakumovAbstractMagnetic hyperthermia (MHT) is a promising approach for cancer therapy. However, a systematic MHT characterization as function of temperature on the therapeutic efficiency is barely a...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 19, 2020 Category: Nanotechnology Source Type: research

Folate receptor-targeted RNAi nanoparticles for silencing STAT3 in tumor-associated macrophages and tumor cells
Publication date: Available online 18 February 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Jing Chen, Yushun Dou, Yue Tang, Xinru ZhangAbstractWe developed a STAT3 silencing siRNA to both tumor cells and M2 macrophages. The dual-targeting system prepared by electronic self-assembly was composed of folic acid-conjugated carboxymethyl chitosan for targeting and cationic chitosan derivatives for siRNA package. The effects of siRNA delivery was investigated in M2 macropahges and Lewis lung cancer cells(LLC). Due to the enhanced delivery efficiency, the dual-targeting delivery system exhibited a hig...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 19, 2020 Category: Nanotechnology Source Type: research

Pegylated carbon nitride nanosheets for enhanced reactive oxygen species generation and photodynamic therapy under hypoxic conditions
Publication date: Available online 14 February 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Qian Huang, Yang Chen, Liying Hao, Ronghui Zhou, Yanjing Li, Qirong Li, Bofeng Zhu, Xiaoxiao CaiAbstractThe application of photodynamic therapy (PDT) is of ever-increasing importance in the treatment of malignant tumors; however, there are several major constraints that make it impossible to achieve optimal therapeutic effects. Our objective is to develop a novel photosensitizing drug for skin cancer. In the experiment, we fabricated four-arm-poly ethylene glycol modified amino-rich graphite phase carbon ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 15, 2020 Category: Nanotechnology Source Type: research

Induction of antitumor immunity in mice by the combination of nanoparticle-based Photothermolysis and anti-PD-1 checkpoint inhibition
In this study, we investigated the impact of nanoparticle-mediated photothermolysis in combination with checkpoint inhibition on the induction of systemic antitumor immunity. Photothermolysis based on near-infrared light-absorbing copper sulfide nanoparticles and 15-ns laser pulses combined with the immune checkpoint inhibitor anti-PD-1 antibody (αPD-1) increased tumor infiltration by antigen-presenting cells and CD8-positive T lymphocytes in the B16-OVA mouse model. Moreover, combined photothermolysis, polymeric conjugate of the Toll-like receptor 9 agonist CpG, and αPD-1 significantly prolonged mouse survival after re-...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 13, 2020 Category: Nanotechnology Source Type: research

Laser ablation for pharmaceutical Nanoformulations: Multi-drug Nanoencapsulation and Theranostics for HIV
Publication date: Available online 13 February 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Ajay Singh, Hilliard L. Kutscher, Julia C. Bulmahn, Supriya D. Mahajan, Guang S. He, Paras N. PrasadAbstractWe introduce the use of laser ablation to develop a multi-drug encapsulating theranostic nanoformulation for HIV-1 antiretroviral therapy. Laser ablated nanoformulations of ritonavir, atazanavir, and curcumin, a natural product that has both optical imaging and pharmacologic properties, were produced in an aqueous media containing Pluronic® F127. Cellular uptake was confirmed with the curcumin fluo...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 13, 2020 Category: Nanotechnology Source Type: research

Insertion of channel of phi29 DNA packaging motor into polymer membrane for high-throughput sensing
Publication date: Available online 6 February 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Zhouxiang Ji, Michael Jordan, Lakmal Jayasinghe, Peixuan GuoAbstractThe connector channel of bacteriophage phi29 DNA packaging motor has been inserted into the lipid bilayer membrane and has shown potential for the sensing of DNA, RNA, chemicals, peptides, and antibodies. Properties such as high solubility and large channel size have made phi29 channel an advantageous system for those applications; however, previously studied lipid membranes have short lifetimes, and they are frangible and unstable under v...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 6, 2020 Category: Nanotechnology Source Type: research

Nanostructured lipid carriers accumulate in atherosclerotic plaques of ApoE−/− mice
In this study, we evaluated the biodistribution, targeting ability and safety of 64Cu-fonctionalized NLC in atherosclerotic mice. 64Cu-chelating-NLC (51.8±3.1 nm diameter) with low dispersity index (0.066±0.016) were produced by high pressure homogenization at tens-of-grams scale. 24 h after injection of 64Cu-chelated particles in ApoE−/− mice, focal regions of the aorta showed accumulation of particles on autoradiography that colocalized with Oil Red O lipid mapping. Signal intensity was significantly greater in aortas isolated from ApoE−/− mice compared to wild type (WT) control (8.95 [7.58, 10.16] × ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 31, 2020 Category: Nanotechnology Source Type: research

Cationic HDL mimetics enhance in vivo delivery of self-replicating mRNA
Publication date: Available online 24 January 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Wei He, Angela C. Evans, Amy Rasley, Feliza Bourguet, Sandra Peters, Kurt I. Kamrud, Nathaniel Wang, Bolyn Hubby, Martina Felderman, Heather Gouvis, Matthew A. Coleman, Nicholas O. FischerAbstractIn vivo delivery of large RNA molecules has significant implications for novel gene therapy, biologics delivery, and vaccine applications. We have developed cationic nanolipoprotein particles (NLPs) to enhance the complexation and delivery of large self-replicating mRNA (replicon) in vivo. NLPs are high-density li...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 25, 2020 Category: Nanotechnology Source Type: research

Bone targeted delivery of Salmon calcitonin hydroxyapatite nanoparticles for sublingual osteoporosis therapy (SLOT)
We present salmon calcitonin (SCT) loaded Hydroxyapatite nanoparticles (HAP-NPs) for sublingual osteoporosis therapy. Surface stabilized HAP-NPs were prepared by aqueous precipitation. SCT was loaded by ionic complexation, as confirmed by FTIR. SCT-HAP-NPs exhibited high loading efficiency (~85%), average size (~100 nm), and zeta potential (~ − 25 mv). Stability of SCT was established by circular dichroism spectroscopy and HPLC analysis. Confocal laser scanning microscopy confirmed deep penetration of SCT-HAP-NPs into the mucosa with>4-fold enhancement in permeability relative to SCT solution. Sublingual S...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 25, 2020 Category: Nanotechnology Source Type: research