Life style factors, tumor cell plasticity and cancer stem cells
Publication date: Available online 22 April 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Ilaria Chiodi, Chiara Mondello (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - April 23, 2020 Category: Genetics & Stem Cells Source Type: research

Rogue versus chromothriptic cell as biomarker of cancer
Publication date: April–June 2020Source: Mutation Research/Reviews in Mutation Research, Volume 784Author(s): Aleksandra Fucic, Vladimir Druzhinin, Anna Aghajanyan, Predrag Slijepcevic, Marina Bakanova, Elizaveta Baranova, Varvara Minina, Tatiana Golovina, Kirill Kourdakov, Anna Timofeeva, Victor Titov (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - March 18, 2020 Category: Genetics & Stem Cells Source Type: research

The dark side of RNA:DNA hybrids
Publication date: Available online 29 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Alessandra Brambati, Luca Zardoni, Eleonora Nardini, Achille Pellicioli, Giordano Liberi (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - February 29, 2020 Category: Genetics & Stem Cells Source Type: research

Nuclear localization and actions of the insulin-like growth factor 1 (IGF-1) system components: transcriptional regulation and DNA damage response
Publication date: Available online 27 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Elzbieta Poręba, Julia Durzyńska (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - February 28, 2020 Category: Genetics & Stem Cells Source Type: research

Rogue versus chromothriptic cells as biomarkers cancer
Publication date: Available online 25 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Aleksandra Fucic, Vladimir Druzhinin, Anna Aghajanyan, Predrag Slijepcevic, Marina Bakanova, Elizaveta Baranova, Varvara Minina, Tatiana Golovina, Kirill Kourdakov, Anna Timofeeva, Victor Titov (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - February 26, 2020 Category: Genetics & Stem Cells Source Type: research

Deciphering and Simulating Models of Radiation Genotoxicity with CRISPR/Cas9 Systems
Publication date: Available online 3 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Dusan Vukmirovic, Colin Seymour, Carmel MothersillAbstractThis short review explores the utility and applications of CRISPR/Cas9 systems in experimentally simulating genotoxic effects of Ionizing Radiation (IR) to determine the contribution of DNA targets and ‘Complex Double-Stranded Breaks (complex DSBs)’ to the response. To elucidate this objective, this review considers applications of CRISPR/Cas9 to target nuclear DNA to recognize the respective ‘nucleocentric’ response as well as mitochondrial DNA...
Source: Mutation Research Reviews in Mutation Research - February 4, 2020 Category: Genetics & Stem Cells Source Type: research

Passing of the pen: Editorship of Mutation Research – Reviews in Mutation Research
Publication date: Available online 13 January 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Barbara L. Parsons, Catherine B. Klein (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - January 14, 2020 Category: Genetics & Stem Cells Source Type: research

Genotoxicity assessment of carbon-based nanomaterials; Have their unique physicochemical properties made them double-edged swords?
Publication date: Available online 11 January 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Hadi Samadian, Mohammad Saeid Salami, Mehdi Jaymand, Asaas Azarnezhad, Masoud Najafi, Hamed Barabadi, Amirhossein AhmadiAbstractCarbon-based nanomaterials (CNMs) have attracted a great deal of attention because of their outstanding combinations of physicochemical properties. The unique physicochemical properties of CNMs have made them promising nanomaterials (NMs) for a large number of applications. However, these size-dependent properties serve as a double-edged sword, which makes them fascinating materials w...
Source: Mutation Research Reviews in Mutation Research - January 11, 2020 Category: Genetics & Stem Cells Source Type: research

Role of oxidative stress, genome damage and DNA methylation as determinants of pathological conditions in the newborn: an overview from conception to early neonatal stage
Publication date: Available online 26 December 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Roberto Scarpato, Serena Testi, Valentina Colosimo, Carlos Garcia Crespo, Consuelo Micheli, Alessia Azzarà, Maria Giulia Tozzi, Paolo GhirriAbstractIncreasing evidence suggests that early-life events can predispose the newborn to a variety of health issues in later life. In adverse pre- and perinatal conditions, oxidative stress appears to play an important role in the development of future pathological outcomes. From a molecular point of view, oxidative stress can result in genome damage and changes in DNA ...
Source: Mutation Research Reviews in Mutation Research - December 28, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: October–December 2019Source: Mutation Research/Reviews in Mutation Research, Volume 782Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - December 17, 2019 Category: Genetics & Stem Cells Source Type: research

Application of the comet assay in human biomonitoring: an hCOMET perspective
Publication date: Available online 9 November 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Amaya Azqueta, Carina Ladeira, Lisa Giovannelli, Elisa Boutet-Robinet, Stefano Bonassi, Monica Neri, Goran Gajski, Susan Duthie, Cristian Del Bo’, Patrizia Riso, Gudrun Koppen, Nursen Basaran, Andrew Collins, Peter MøllerAbstractThe comet assay is a well-accepted biomonitoring tool to examine the effect of dietary, lifestyle, environmental and occupational exposure on levels of DNA damage in human cells. With such a wide range of determinants for DNA damage levels, it becomes challenging to deal with confou...
Source: Mutation Research Reviews in Mutation Research - November 10, 2019 Category: Genetics & Stem Cells Source Type: research

Retrospective biodosimetry techniques: Focus on cytogenetics assays for individuals exposed to ionizing radiation
Publication date: Available online 8 November 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): C. Herate, L. SabatierAbstractIn the absence of physical data, biodosimetry tools are required for fast dose and risk assessment in the event of radiological or nuclear mass accidents or attacks to triage exposed humans and take immediate medical countermeasures. Biodosimetry tools have mostly been developed for retrospective dose assessment and the follow-up of victims of irradiation. Among them, cytogenetics analyses, to reveal chromosome damage, are the most developed and allow the determination of doses fr...
Source: Mutation Research Reviews in Mutation Research - November 9, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: July–September 2019Source: Mutation Research/Reviews in Mutation Research, Volume 781Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - August 14, 2019 Category: Genetics & Stem Cells Source Type: research

The characteristics and biological significance of NPC2: Mutation and disease
Publication date: Available online 8 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Xu Yanan, Qian Zhang, Liang Tan, Xubiao Xie, Yong ZhaoAbstractNiemann–Pick C disease (NPC) is a rare autosomal recessive disorder characterized by severe neurodegeneration of central nervous system. Linkage studies in multiplex NPC families and genetic complementation research revealed two disease genes, NPC1 and NPC2, both of which are important transporters for cholesterol trafficking. NPC2 executes cholesterol-transport function through protein-protein interaction with NPC1 as well as through protein-membrane...
Source: Mutation Research Reviews in Mutation Research - July 10, 2019 Category: Genetics & Stem Cells Source Type: research

Roles of microRNAs and prospective view of competing endogenous RNAs in mycotoxicosis
Publication date: Available online 8 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Yuxiao Liao, Zhao Peng, Liangkai Chen, Liegang Liu, Qinghua Wu, Wei YangAbstractMycotoxins, produced by fungi, are secondary metabolites causing adverse, toxic and pathological effects on human and animals. Studies about the association between mycotoxins and microRNAs (miRNAs) were developed since miRNAs have been demonstrated to play a critical role in many developmental processes for regulating messenger RNA (mRNA). As published studies showed, dozens of miRNAs were influenced by mycotoxins, indicating that miR...
Source: Mutation Research Reviews in Mutation Research - July 10, 2019 Category: Genetics & Stem Cells Source Type: research