Mutation Research Genetic Toxicology and Environmental Mutagenesis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Editorial Board
Publication date: February 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 838Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 23, 2019 Category: Genetics & Stem Cells Source Type: research

The application of the Comet assay in fish cell lines
Publication date: Available online 21 January 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Bojana Žegura, Metka FilipičAbstractThe use of fish models has been proven to be an effective and sensitive tool for the evaluation of genotoxicity of pure compounds and complex mixtures of chemicals in the context of environmental screening of pollutants and hazard assessment in aquatic toxicology. In particular, fish cell lines have been successfully introduced for detection of genotoxic effects and can serve as an alternative to animal testing in preliminary eco-/genotoxicological stud...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 22, 2019 Category: Genetics & Stem Cells Source Type: research

Genotoxicity Of (+)- And (-)-Usnic Acid In Mice
Publication date: Available online 21 January 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Ilya Prokopiev, Galina Filippova, Eduard Filippov, Ivan Voronov, Igor Sleptsov, Aliy ZhanataevAbstractUsnic acid, which is the most widespread and well-studied secondary lichen compound, has antibacterial and cytotoxic effects. Usnic acid is present in lichens as the (+)- and (-)-enantiomers, which have different biological activities. We used a DNA-comet assay to determine the genotoxic effect of (+)- and (-)-usnic acid in the liver and kidney cells of mice. The genotoxic effect of usnic a...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 22, 2019 Category: Genetics & Stem Cells Source Type: research

Assessing relative sensitivity of marine and freshwater bivalves following exposure to copper: Application of classical and novel genotoxicological biomarkers
Publication date: Available online 18 January 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Emily L. Vernon, Awadhesh N. JhaAbstractDetermination of relative sensitivity of biota following exposures to contaminants including metals is important for environmental protection. Copper (Cu), although biologically essential can be highly toxic to biota if present at higher concentrations in the natural environment. Given its ubiquitous presence within coastal and inland water bodies, we compared Cu-induced genotoxicity in two ecologically important mussel species, the freshwater Dreisse...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 20, 2019 Category: Genetics & Stem Cells Source Type: research

A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals
The objective was to compare the sensitivity of the two assays for detecting genotoxicity. Critical aspects of study design and results were tabulated for each dataset. There were fewer datasets from rats than mice, particularly for the TGR assay, and therefore, results from both species were combined for further analysis. TGR and comet responses were compared in liver and bone marrow (the most commonly studied tissues), and in stomach and colon evaluated either separately or in combination with other GI tract segments. Overall positive, negative, or equivocal test results were assessed for each chemical across the tissues...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 20, 2019 Category: Genetics & Stem Cells Source Type: research

Investigation of Spatial and Temporal Variation of Particulate Matter in vitro Genotoxicity and Cytotoxicity in Relation to the Elemental Composition
Publication date: Available online 18 January 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Gonca Çakmak, Pelin Ertürk Arı, Esra Emerce, Akif Arı, Mustafa Odabası, Roel Schıns, Sema Burgaz, Eftade O. GagaAbstractEven though the outdoor air pollution and its major component Particulate Matter (PM) are recently classified as human carcinogen, attempts to elucidate the underlying mechanisms of PM toxicity are still crucial and continuing with in vitro approaches in various environmental circumstances. Present study investigated the genotoxicity (Comet assay) and the cytotoxicit...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 20, 2019 Category: Genetics & Stem Cells Source Type: research

Periodontitis: Genomic instability implications and associated risk factors
Publication date: Available online 17 January 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Tatiana T. Borba, Patrícia Molz, Diene S. Schlickmann, Caroline Santos, Caio F. Oliveira, Daniel Prá, Léo Kreather Neto, Silvia I.R. FrankeAbstractPeriodontitis is a bacterial infection characterized by the presence of a dense inflammatory infiltrate, which may result in increased DNA damage and other nuclear/cellular abnormalities. Therefore, it is important to evaluate the periodontal diseases influence on DNA damage and other nuclear/cellular abnomalies formation as cancer risk marker...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 18, 2019 Category: Genetics & Stem Cells Source Type: research

Association of BER and NER pathway polymorphism haplotypes and micronucleus frequencies with global DNA methylation in benzene-exposed workers of China: Effects of DNA repair genes polymorphisms on genetic damage
ConclusionIn benzene-exposed workers, BER and NER pathway polymorphism haplotypes are associated with different levels of chromosome damage and had little effect on global DNA methylation. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 17, 2019 Category: Genetics & Stem Cells Source Type: research

Chimeric mice with human hepatocytes: a new system for genotoxicity studies
Publication date: Available online 14 January 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Chise Tateno, Masahito Fukumuro, Shoji Masumori, Masakazu Kakuni, Yuji Ishida, Takashi Shimada, Makoto HayashiAbstractGenotoxicity assays are characterized by a method, an in vitro or in vivo target, and an endpoint. Many cell types have been used as targets, including bacterial cells, cultured mammalian cells, and rodent cells in vivo. Human cells are the most important target for evaluating the risk to humans associated with exposure to chemicals. Almost exclusively, the human cells used ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 15, 2019 Category: Genetics & Stem Cells Source Type: research

XRCC1 deficiency correlates with increased DNA damage and male infertility
Publication date: Available online 15 January 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Vertika Singh, Sujit Kumar Mohanty, Priyanka Verma, Arijit Chakraborty, Sameer Trivedi, Singh Rajender, Kiran SinghAbstractHigh fidelity DNA repair is critical to sustain the genomic integrity and quality of developing germ cells. Deficiencies in DNA repair machinery may result in increased DNA damage in germ cell leading to abnormal spermatogenesis and infertility. X-ray repair cross-complementing group 1 (XRCC1) is a testis enriched protein that plays a crucial role in the DNA base excisi...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 15, 2019 Category: Genetics & Stem Cells Source Type: research

Genotoxicity of engineered nanoparticles in higher plants
Publication date: Available online 11 January 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Manosij Ghosh, Ilika Ghosh, Lode Godderis, Peter Hoet, Anita MukherjeeAbstractNanoparticles (NPs) are an emerging environmental threat. However, studies of NPs in different environmental components are limited. In this review, we discuss studies that have evaluated the genotoxicity of NPs in higher plants. Among the 29 studies reviewed, silver NPs were most studied (n = 7 articles), with fewer studies reporting the genotoxicity of carbon nanotubes (n = 3), titanium dioxide NPs (n ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 12, 2019 Category: Genetics & Stem Cells Source Type: research

Cyto/genotoxicological evaluation of hot spots of soil pollution using Allium bioassays in relation to geochemistry
Publication date: Available online 4 January 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Asta Stapulionytė, Violeta Kleizaitė, Raimondas Šiukšta, Donatas Žvingila, Ričardas Taraškevičius, Tatjana ČėsnienėAbstractSoil from industrial and landfill sites affected by anthropogenic activity was screened for implicit negative effects in an Allium test-system in relation to geochemistry. The concentrations of 15 elements were compared to the ecotoxicologically-based soil guideline values. Admitted geoindices were used to classify test-soils according to risk/hazard categorie...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 5, 2019 Category: Genetics & Stem Cells Source Type: research

18F-FDG PET/CT scanning: Biological effects on patients: Entrance surface dose, DNA damage, and chromosome aberrations in lymphocytes
Publication date: February 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 838Author(s): Akshaya Prasad, Shangamithra Visweswaran, Karthik Kanagaraj, Venkateswarlu Raavi, M. Arunan, E. Venkatachalapathy, S. Paneerselvam, M.T. Jose, Annalakshmi Ozhimuthu, Venkatachalam PerumalAbstractPositron Emission Tomography/Computed Tomography (PET/CT), a combination of PET and CT, is used in tumor staging, therapy planning, and treatment response monitoring. During PET imaging, patients receive low doses of radiation, which can induce an adaptive response and necessitate higher doses for therapeu...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 29, 2018 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: January 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 837Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 28, 2018 Category: Genetics & Stem Cells Source Type: research

Scots pine as a promising indicator organism for biomonitoring of the polluted environment: A case study on chronically irradiated populations
Publication date: Available online 26 December 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Stanislav Geras’kin, Polina Volkova, Denis Vasiliyev, Nina Dikareva, Alla Oudalova, Elizaveta Kazakova, Ekaterina Makarenko, Gustavo Duarte, Alexey KuzmenkovAbstractIn this paper the main results of long-term (2003-2016) observations on Scots pine populations inhabiting sites affected by the Chernobyl accident are presented. Populations growing for many years under chronic radiation exposure are characterized by the enhanced mutation rates, increased genetic diversity, changes in the gen...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 27, 2018 Category: Genetics & Stem Cells Source Type: research