Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Therapeutic opportunities for PLK1 inhibitors: Spotlight on BRCA1-deficiency and triple negative breast cancers
Publication date: Available online 25 February 2020Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Iris Alejandra García, Cintia Garro, Elmer Fernandez, Gastón Soria (Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis)
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 26, 2020 Category: Cytology Source Type: research

Genome sequencing of ion-beam-induced mutants facilitates detection of candidate genes responsible for phenotypes of mutants in rice
Publication date: Available online 21 February 2020Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Yutaka Oono, Hiroyuki Ichida, Ryouhei Morita, Shigeki Nozawa, Katsuya Satoh, Akemi Shimizu, Tomoko Abe, Hiroshi Kato, Yoshihiro HaseAbstractIon beams are physical mutagens used for plant and microbe breeding that cause mutations via a mechanism distinct from those of chemical mutagens or gamma rays. We utilized whole-exome sequencing of rice DNA in order to understand the properties of ion beam-induced mutations in a genome-wide manner. DNA libraries were constructed from selected carbo...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 22, 2020 Category: Cytology Source Type: research

Targeting AKT/PKB to improve treatment outcomes for solid tumors
Publication date: Available online 20 February 2020Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): M. Iida, P.M. Harari, D.L. Wheeler, M. ToulanyAbstractThe serine/threonine kinase AKT, also known as protein kinase B (PKB), is the major substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα), AKT2 (PKBβ) and AKT3 (PKBγ). The PI3K/AKT pathway is normally activated by binding of ligands to membrane-bound receptor tyrosine kinases (RTKs) as well as downstream to G-protein coupled receptors and integrin-linked kinase. Through multiple downstream subst...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 20, 2020 Category: Cytology Source Type: research

Gene (HPRT) and Chromosomal (MN) Mutations of Nickel Metal Powder in V79 Chinese Hamster cells
Publication date: Available online 27 January 2020Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Samuel Buxton, Yvonne Voges, Claudia Donath, Adriana OllerAbstractNickel metal is a naturally occurring element used in many industrial and consumer applications. Human epidemiological data and animal cancer bioassays indicate that nickel metal is not likely to be a human carcinogen. Yet, nickel metal is classified as a suspected human carcinogen (CLP) and possibly carcinogenic to humans (IARC). There are no reliable studies on the potential for nickel metal to induce gene and micronucle...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - January 29, 2020 Category: Cytology Source Type: research

An insight into the mechanism of DNA damage response in plants- role of SUPPRESSOR OF GAMMA RESPONSE 1: an overview
Publication date: Available online 23 January 2020Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Kalyan Mahapatra, Sujit RoyAbstractBecause of their sessile lifestyle, plants are inescapably exposed to various kinds of environmental stresses throughout their lifetime. Therefore, to regulate their growth and development, plants constantly monitor the environmental signals and respond appropriately. However, these environmental stress factors, along with some endogenous metabolites, generated in response to environmental stress factors often induce various forms of DNA damage in plant...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - January 25, 2020 Category: Cytology Source Type: research

Mutational Landscape screening of Methylene tetrahydrofolate reductase to predict Homocystinuria associated variants: an integrative computational approach
Publication date: Available online 16 January 2020Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Hemavathy Nagarajan, Saratha Narayanaswamy, Umashankar VetrivelAbstractMethylene tetrahydrofolate reductase (MTHFR) is a flavoprotein, involved in one-carbon pathway and is responsible for folate and homocysteine metabolism. Regulation of MTHFR is pivotal for maintaining the cellular concentrations of methionine and SAM (S-adenosyl methionine) which are essential for the synthesis of nucleotides and amino acids, respectively. Therefore, mutations in MTHFR leads to its dysfunction resulti...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - January 17, 2020 Category: Cytology Source Type: research

Editorial Board
Publication date: November 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volumes 816–818Author(s): (Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis)
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - November 17, 2019 Category: Cytology Source Type: research

microRNAs: Potential Glioblastoma Radiosensitizer by Targeting Radiation-Related Molecular Pathways
Publication date: Available online 21 October 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Mohammad-Taghi Bahreyni-Toossi, Elham Dolat, Hashem Khanbabaei, Navid Zafari, Hosein AzimianAbstractGlioblastoma (GBM) is the most lethal type of primary brain tumor. Currently, even with optimal and multimodal cancer therapies, the survival rate of GBM patients remains poor. One reason for inadequate response of GBM tumors to radiotherapy is radioresistance (RR). Thus, there is a critical need for new insights about GBM treatment to increase the chance of treatment. microRNAs (miRNAs) a...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - October 22, 2019 Category: Cytology Source Type: research

ATR kinase inhibition sensitizes quiescent human cells to the lethal effects of cisplatin but increases mutagenesis
Publication date: Available online 17 September 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Rebekah J. Hutcherson, Michael G. KempAbstractThe ATR protein kinase is known to protect cells from DNA damage induced during the replicative phase of the cell cycle. Small molecule ATR kinase inhibitors have therefore been developed to improve the effectiveness of DNA damage-based chemotherapy regimens aimed at killing rapidly proliferating tumor cells. However, whether ATR functions in a similar manner in non-replicating cells has not been examined and is important considering the fa...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - September 18, 2019 Category: Cytology Source Type: research

Mutation, methylation and expression analysis of LIFR gene in Indian breast cancer patients
Publication date: Available online 12 August 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Sumayya Abdul Sattar RealAbstractLIFR functions as a tumor suppressor and metastatic suppressor of breast cancer. The present study investigates the status of LIFR gene in Indian breast cancer patients. A total of 137 breast cancer tissue and 137 adjacent normal tissue which served as controls were analyzed for the mutation by automated DNA sequencing, methylation through methylation-specific polymerase chain reaction and its corresponding expression at mRNA and protein level using real-t...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - August 13, 2019 Category: Cytology Source Type: research

Corrigendum to “Phosphorylation of PTEN at STT motif is associated with DNA damage response” [Mutat. Res./Fundam. Mol. Mech. Mutagen. 770 (December) (2014), 112–119]
Publication date: Available online 26 July 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Sandip Misra, Ananda Mukherjee, Parimal Karmakar (Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis)
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - July 27, 2019 Category: Cytology Source Type: research

Molecular Pathogenesis of Gallbladder Cancer: An Update
Publication date: Available online 6 July 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Shravan Kumar Mishra, Niraj Kumari, Narendra KrishnaniAbstractGallbladder carcinoma (GBC) is the most aggressive gastrointestinal malignancy throughout the world, with wide geographical variance. It is the subtype of biliary tract malignancy that has the poorest prognosis and lower survival among all biliary tract malignancies. Various factors are associated with GBC pathogenesis such as environmental, microbial, metabolic and molecular. Chronic inflammation of gallbladder due to presence of...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - July 8, 2019 Category: Cytology Source Type: research

Nanoscopic analysis of 53BP1, BRCA1 and Rad51 reveals new insights in temporal progression of DNA-repair and pathway choice
Publication date: Available online 28 June 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Benjamin SchwarzAbstractThe accumulation and spatial distribution of 53BP1, BRCA1 and Rad51, key proteins in DNA double-strand break (DSB) repair, was investigated with high temporal resolution over a time span of 24 h, using STED nanoscopy. DNA lesions were induced by irradiation with high-LET (linear energy transfer) α-particles. We show that 53BP1 IRIF formation occurs quickly in almost all cells and after about 6 h the fraction of 53BP1 IRIF positive cells slowly declines. Against ...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - June 29, 2019 Category: Cytology Source Type: research

Editorial Board
Publication date: May 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 815Author(s): (Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis)
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - June 16, 2019 Category: Cytology Source Type: research

The multi-faceted high order polymorphic synergistic interactions among nucleotide excision repair genes increase the risk of lung cancer in North Indians
Publication date: Available online 8 June 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Shweta Lawania, Amrita Singh, Siddharth Sharma, Navneet Singh, Digamber BeheraAbstractIt is evident that gene-gene interactions are pervasive in the determination of the susceptibility of human diseases. Polymorphisms in nucleotide excision repair pathway (NER) genes can cause variations in the repair capacity and therefore, might lead to increase in susceptibility towards lung cancer through complex gene-gene and gene-smoking interactions.Logistic regression analysis, along with high order ...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - June 9, 2019 Category: Cytology Source Type: research