Vascular malformations masquerading as demyelinating disease
Publication date: Available online 1 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Gabriel Lupu (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Incident cardiovascular disease in patients diagnosed with multiple sclerosis: a multi-database study
ConclusionMS patients in the UK and the US have increased risk of venous thromboembolism and peripheral vascular disease. The risk of myocardial infarction is increased among female MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Correlation between EDSS scores and cervical spinal cord atrophy at 3T MRI in multiple sclerosis: A systematic review and meta-analysis
Publication date: Available online 1 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Xiaodong Song, Dawei Li, Zhandong Qiu, Shengyao Su, Yan Wu, Jingsi Wang, Zheng Liu, Huiqing DongAbstractBackgroundCervical spinal cord atrophy (CSCA), which partly reflects the axonal loss in the spinal cord, is increasingly recognized as a valuable predictor of disease outcome. However, inconsistent results have been reported regarding the correlation of CSCA and clinical disability in multiple sclerosis (MS). The aim of this meta-analysis was to synthesize the available data obtained from 3.0-Tesla (3T) MRI scanner...
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Fatigue scores correlate with other self-assessment data, but not with clinical and biomarker parameters, in CIS and RRMS
ConclusionsIn this cohort of patients with newly diagnosed CIS and RRMS, fatigue scores were associated with mood, disease impact on daily life and quality of life as well as with alterations of attentive functions. Study results indicate that subjective fatigue scores are not well reflected by some commonly used and objectively measurable disease parameters like EDSS, T2 lesions and NFL levels. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Grassroot efforts towards diversity in MS care and research: win-win for patients and science
Publication date: Available online 2 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Emmanuelle Waubant, Michael Levy, Jeannette Lechner-Scott, Gavin Giovannoni, Christopher Hawkes (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

TNFRSF13C/BAFFR P21R and H159Y polymorphisms in multiple sclerosis
Publication date: Available online 30 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Panagiotis Ntellas, Efthimios Dardiotis, Eirini Sevdali, Vasileios Siokas, Athina-Maria Aloizou, Gerasimina Tsinti, Anastasios E. Germenis, Georgios M Hadjigeorgiou, Hermann Eibel, Matthaios SpeletasABSTRACTRecent studies implicate B cells in multiple sclerosis (MS) pathogenesis, and consequently, several molecules participating in B cell survival and proliferation, including B-cell activating factor (BAFF), have recently been analyzed in MS patients. BAFF mediates its function through binding to three receptors; ...
Source: Multiple Sclerosis and Related Disorders - October 1, 2019 Category: Neurology Source Type: research

Psoriasis in family members of patients with multiple sclerosis
ConclusionFamily members of those with MS may be at greater risk of developing psoriasis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 1, 2019 Category: Neurology Source Type: research

Commentary re: Multiple sclerosis and psychosis: A case report. Cheema J, Huyh AC, Prat SS. 2019 Jun 3;34:158–161
Publication date: November 2019Source: Multiple Sclerosis and Related Disorders, Volume 36Author(s): Rosalie Greenberg (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 1, 2019 Category: Neurology Source Type: research

Clinical observation during alemtuzumab administration
Publication date: Available online 25 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Christopher M Allen, Jenny J Feng, Mark D Willis, Marisa McGinley, Daniel Ontaneda, Emma C Tallantyre, Nikos Evangelou (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 29, 2019 Category: Neurology Source Type: research

Evaluating the Efficacy and Safety of ZytuxTM (Rituximab, AryoGen Pharmed) in Iranian Multiple Sclerosis Patients: An observational Study
Conclusion: The observed results revealed that the ZytuxTM could have a positive and significant effect on all types of MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Long-term outcome and prognosis in patients with neuromyelitis optica spectrum disorder from serbia
ConclusionOur results support the benefits of early diagnosis and treatment of NMOSD, especially in persons with severe optic and spinal disability at onset. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Transient MOG antibody seroconversion associated with immunomodulating therapy
We present the case of a 35-year-old patient who was seronegative for MOG-IgG (as confirmed by means of three independent immunoassays) during two corticosteroid-responsive attacks of brainstem encephalitis and optic neuritis, respectively, but turned positive for MOG-IgG under treatment with interferon-beta (IFN-beta), which was commenced 6 months after onset of the first attack. MOG-IgG serum levels declined after therapy was switched to glatiramer acetate. The fact that seroconversion was first observed under treatment with IFN-beta is in accordance with previous evidence suggesting a role of IFN-beta in disease exacerb...
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Role of B cells and Antibodies in Multiple Sclerosis
Publication date: Available online 26 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Pitchaya Wanleenuwat, Piotr IwanowskiAbstractMultiple sclerosis (MS) is a chronically progressive auto-immune mediated inflammatory demyelinating disease of the central nervous system (CNS) which manifests as disturbances in sensorimotor function and cognitive impairment. Although believed to be a T-cell mediated disease, the role of B cells has recently become a central issue in MS pathogenesis. Both antibody dependent and independent theories have been suggested to play a role in the initiation of inflammatory d...
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

The correlation between dyslipidemia and cognitive impairment in multiple sclerosis patients
DiscussionOur findings proposed a possible correlation between the increased serum LDL cholesterol, serum total cholesterol and cognitive dysfunction among MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Magnetic Resonance Imaging Markers of Disability in Egyptian Multiple Sclerosis Patients
ConclusionThis is the first Egyptian study to show that infratentorial lesions, confluent brain lesions and T1 hypointense lesions are conventional MRI parameters that correlate with the degree of disability in Egyptian MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Retinal nerve fiber layer thickness associates with cognitive impairment and physical disability in multiple sclerosis
Publication date: Available online 26 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ulrika Birkeldh, Ali Manouchehrinia, Max Albert Hietala, Jan Hillert, Tomas Olsson, Fredrik Piehl, Ingrid Kockum, Lou Brundin, Ori Zahavi, Marika Wahlberg-Ramsay, Rune Brautaset, Maria NilssonABSTRACTBackgroundReductions of the peripapillary retinal nerve fiber layer (pRNFL) thickness has been indicated even in early-stages of multiple sclerosis (MS). The aim was to investigate the association between pRNFL thickness, measured with optical coherence tomography (OCT), and physical disability and cognitive impairmen...
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

False memories in relapsing remitting multiple sclerosis patients: a preliminary investigation with the DRM paradigm
ConclusionWe found a reduced susceptibility to false memories in RRMS patients compared to HCs. The potential mechanisms underlying this effect are discussed in light of the alterations in the structure of semantic memory. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Title: Clinical observation during alemtuzumab administration
Publication date: Available online 25 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Christopher M Allen, Jenny J Feng, Mark D Willis, Marisa McGinley, Daniel Ontaneda, Emma C Tallantyre, Nikos Evangelou (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 26, 2019 Category: Neurology Source Type: research

Predictors of Vocational Status Among Persons with Multiple Sclerosis
ConclusionsPhysical disability, depressive symptoms, and reduced information processing affect work-related disability and vocational status among PwMS. Interventions targeting these factors should be prioritized by clinicians. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 26, 2019 Category: Neurology Source Type: research

Randomized-controlled trial of a modified Mediterranean dietary program for multiple sclerosis: a pilot study
Publication date: Available online 24 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ilana Katz Sand, Emma KT Benn, Michelle Fabian, Kathryn C. Fitzgerald, Elise Digga, Richa Deshpande, Aaron Miller, Samantha Gallo, Lenore ArabAbstractBackgroundThere is a high level of interest in the potential role of diet among the MS community. There is a limited level of evidence for a Mediterranean-style dietary pattern in MS; the feasibility of conducting studies using educational tools to deliver this type of intervention and study its effects is unknown.ObjectivesTo establish clinical trial feasibility for...
Source: Multiple Sclerosis and Related Disorders - September 25, 2019 Category: Neurology Source Type: research

Leptin rs7799039 polymorphism is associated with Multiple Sclerosis risk in Kuwait
ConclusionLEP rs7799039AA is a risk factor for MS in our Kuwaiti population, and leptin levels are lower in MS patients compared to healthy controls. Our findings suggest future studies must consider all factors influencing leptin levels to resolve its controversial involvement in MS pathogenesis or progression. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 25, 2019 Category: Neurology Source Type: research

Early initiation of fingolimod reduces the rate of severe relapses over the long term: Post hoc analysis from the FREEDOMS, FREEDOMS II, and TRANSFORMS studies
The objective of this study was to report the effect of early initiation of fingolimod on relapse severity in patients with RRMS.MethodsThis is a post hoc descriptive analysis of data from the pooled placebo-controlled FREEDOMS/FREEDOMS II studies and from the active-comparator TRANSFORMS study. Patients were analyzed under 2 groups: patients initially randomized to receive fingolimod 0.5 mg during the core phase and continued fingolimod 0.5 mg in the extension phase (immediate fingolimod group), and patients initially randomized to placebo or IFN β-1a during the core phase and switched to fingolimod during the exte...
Source: Multiple Sclerosis and Related Disorders - September 25, 2019 Category: Neurology Source Type: research

The Norwegian translation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS)
Publication date: Available online 21 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ellen Skorve, Astri J. Lundervold, Øivind Torkildsen, Kjell-Morten MyhrAbstractBackgroundCognitive impairment is a common symptom in all stages of multiple sclerosis (MS), yet it is underreported and not routinely evaluated. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) is a short and easily administered test battery for screening of cognitive impairment in MS that can be completed within 15 minutes and incorporated into routine clinical practice. The test battery consists of ...
Source: Multiple Sclerosis and Related Disorders - September 22, 2019 Category: Neurology Source Type: research

Commentary re: Multiple Sclerosis and psychosis: A case report. Cheema J, Huyh AC,, Prat SS. 2019 Jun 3;34:158-161.
Publication date: Available online 21 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Dr Rosalie Greenberg (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 22, 2019 Category: Neurology Source Type: research

Handedness and potential implications for neurorehabilitation in multiple sclerosis
Publication date: Available online 19 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Afsaneh Shirani, Darin T. Okuda (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 20, 2019 Category: Neurology Source Type: research

Long noncoding RNAs associated with phenotypic severity in multiple sclerosis
ConclusionsThis study is the first to investigate possible lncRNA biomarkers to differentiate phenotypic severity in MS. Although the findings are preliminary based on our small sample size, they are sufficient to identify hypotheses for future investigation, and give guidance regarding the design of future studies. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 20, 2019 Category: Neurology Source Type: research

Expert opinion: criteria for second-line treatment failure in patients with multiple sclerosis
ConclusionsExperts compared therapeutic attitudes and practices regarding second-line treatment failure between French regions. They identified convergences that were used to propose a national agreement on second-line treatment failure criteria, which should be evaluated in real-life prospective cohorts. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 20, 2019 Category: Neurology Source Type: research

Examining the validity of the Multiple-Sclerosis Walking Scale-12 with Rasch analysis: Results from an Italian study
Publication date: Available online 19 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): D Marengo, R Rosato, G Gamberini, P Cavalla, M Gironi, F Patti, L Prosperini, C SolaroAbstractBackgroundThe Multiple Sclerosis Walking Scale (MSWS-12) has showed good psychometric properties in reports exploring its validity using Classical Test Theory methods. Findings from recent studies using Item Response Theory methods advance the idea that some aspects of the MSWS-12 does not fully comply with some requirements of sound measurement.Research questionThe present study investigated whether the measurement prope...
Source: Multiple Sclerosis and Related Disorders - September 20, 2019 Category: Neurology Source Type: research

Rituximab-induced serum sickness in multiple sclerosis patients
Publication date: Available online 17 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Andrew B. Wolf, Lana Zhovtis Ryerson, Krupa Pandey, Brett M. McGettigan, Timothy Vollmer, John R. Corboy, Enrique AlvarezAbstractRituximab is a chimeric anti-CD20 monoclonal antibody that is an effective therapy for multiple sclerosis. Rituximab has been associated with the development of serum sickness (type III hypersensitivity) characterized by arthralgia, fever, and rash during the treatment of other conditions, such as rheumatoid arthritis. Here we describe serum sickness associated with rituximab in multiple...
Source: Multiple Sclerosis and Related Disorders - September 19, 2019 Category: Neurology Source Type: research

Epilepsy in multiple sclerosis as a network disease
Publication date: Available online 17 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mihaela Bustuchina VlaicuAbstractThis is a review paper, essentially a commentary with summary of literature that actualizes the problem of epilepsy in patients with multiple sclerosis. There is a bidirectional relation between multiple sclerosis and epilepsy. A possible associate pathophysiological pathway is considered. In multiple sclerosis, a combination of grey matter involvement and inflammation could influence epileptogenesis. Patients with multiple sclerosis have individual profiles and an inter-individual...
Source: Multiple Sclerosis and Related Disorders - September 19, 2019 Category: Neurology Source Type: research

Fatigue in Multiple Sclerosis is related to relapses, autonomic dysfunctions and introversion: a quasi-experimental study
ConclusionsThis study shows that a relapse is accompanied by an increase in MS-related fatigue. Moreover, autonomic dysfunctions and introversion, more than depression and apathy, play a major role in the explanation of MS-related fatigue. This finding represents additional evidence for the relationship between inflammation, vagal afferent signalling, autonomic dysfunctions, introversion and the feeling of MS-related fatigue.KeywordsMultiple Sclerosis, fatigue, relapse, autonomic dysfunctions, vagal afferents (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 19, 2019 Category: Neurology Source Type: research

Letter to the Editor - Late-onset neuromyelitis optica associated with cryptogenic organizing pneumonia
Publication date: Available online 16 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Sofia Oliveira, Renato Oliveira (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 17, 2019 Category: Neurology Source Type: research

The imbalance between regulatory and memory B cells accompanied by an increased number of circulating T-follicular helper cells in MOG–antibody-associated demyelination
ConclusionsThe immuno-regulatory functions of B cells were significantly impaired whereas TFH cells were markedly increased in the acute phase of MOG-antibody-associated demyelination. Despite having distinct clinical features, MOG-antibody-associated demyelination shared a similar lymphocytic profile with AQP4-antibody-positive NMOSD in the acute relapse phase. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 17, 2019 Category: Neurology Source Type: research

Emotion Dysregulation in Multiple Sclerosis: Impact on Symptoms of Depression and Anxiety
ConclusionsEmotion dysregulation is associated with symptoms of depression and anxiety in PwMS. Given the malleability of this construct, this study underscores the importance of further investigating emotion dysregulation, and possibly adopting it as a surrogate endpoint in interventions targeting affective disorders in PwMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 17, 2019 Category: Neurology Source Type: research

Atypical presentation of MOG-related disease: Slowly progressive behavioral and personality changes following seizure
Conclusion: Slowly progressive behavioral and personality changes following a seizure may be a manifestation of MOG-related disease in children. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 11, 2019 Category: Neurology Source Type: research

Economic burden of multiple sclerosis in france estimated from a regional medical registry and national sick fund claims
Publication date: Available online 10 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Detournay Bruno, Debouverie Marc, Pereira Ouarda, Seyer Dominique, Soudant Marc, Courouve Laurène, Jomaa Khalil, Epstein Jonathan, Guillemin FrancisAbstractBackgroundEstimating direct healthcare costs of patients with multiple sclerosis (MS) and identifying risk factors of high costs including relapse are important drivers of public health decision making in France.MethodsThis is a longitudinal retrospective study based on patient charts (qualified registry of MS in Lorraine (ReLSEP)) and claims data (from ...
Source: Multiple Sclerosis and Related Disorders - September 11, 2019 Category: Neurology Source Type: research

Estimating the prevalence of cognition and mental health among multiple sclerosis patients: a population-based cross-sectional study
ConclusionMS in Kuwait seems to have an earlier age at onset. There is significant gender difference in mental health impairment among patients. Future interventions should be directed toward women, low-income, and non-Kuwaiti-Arabs. The estimated prevalence is based on self-reported data, tertiles as cut-off points, and hence should be interpreted with caution. PDQ and MHI are MSQOLI scales used as screening tools that don't correlate well with an objective test and shouldn't replace objective measures of physical and cognitive function tests including expanded disability status scale or magnetic resonance imaging. (Sourc...
Source: Multiple Sclerosis and Related Disorders - September 11, 2019 Category: Neurology Source Type: research

An overview of the current state of evidence for the role of specific diets in multiple sclerosis
ConclusionThere is insufficient evidence to recommend the routine use of any specific diet by people with MS. Some diets touted for MS may have potential negative health consequences. It is important that clinicians inquire regarding dietary manipulations, so they can educate patients on any known efficacy data and potential adverse effects of individual diets. Consultation with a registered dietician is recommended for patients undertaking restrictive diets. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 11, 2019 Category: Neurology Source Type: research

Teriflunomide's effect on humoral response to Epstein-Barr Virus and development of cortical gray matter pathology in multiple sclerosis
Publication date: Available online 9 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Robert Zivadinov, Murali Ramanathan, Jesper Hagemeier, Niels Bergsland, Deepa Ramasamy, Jacqueline Durfee, Channa Kolb, Bianca Weinstock-GuttmanAbstractBackgroundTeriflunomide has been shown to slow cortical gray matter (GM) atrophy in patients with multiple sclerosis (MS). Previous work showed that higher levels of Epstein-Barr virus (EBV) are associated with greater development of cortical pathology in MS.ObjectivesTo investigate whether the effect of teriflunomide on cortical volume loss in relapsing MS patients...
Source: Multiple Sclerosis and Related Disorders - September 11, 2019 Category: Neurology Source Type: research

Nocebo in multiple sclerosis trials: a meta-analysis on oral and newer injectable disease-modifying treatments
ConclusionsOral DMTs may be associated with a higher incidence and greater nocebo severity than newer injectables. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 11, 2019 Category: Neurology Source Type: research

Homocysteine, vitamin B12, and folate levels in patients with multiple sclerosis in Chinese population: a case-control study and meta-analysis
Publication date: Available online 10 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Lishou Pan, Yanying Yin, Jinying Chen, Zhenyu Ma, Yong Chen, Xinbo Deng, Han-Ting Zhang, Huilin Leng, Kuaiying WuAbstractBackgroundCurrent studies suggested discrepancies on the correlations between multiple sclerosis (MS) and blood levels of homocysteine (Hcy), vitamin B12 (VB12), and folate. We performed a case-control study and meta-analysis to help resolve the controversy of these lab values in Chinese patients with MS.MethodsWe recruited 80 Chinese MS patients, 86 age/sex matched neurological controls (patien...
Source: Multiple Sclerosis and Related Disorders - September 11, 2019 Category: Neurology Source Type: research

Quality of life in patients with multiple sclerosis and its association with depressive symptoms and physical disability
ConclusionsQuality of life, in patients with multiple sclerosis is an issue that worries health personnel, it is essential to implement strategies for reducing the impact of the disease on patients' lives, mainly through the application of programs aimed to decrees depression and improve social support. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 9, 2019 Category: Neurology Source Type: research

The association between executive functioning, coping styles and depressive symptoms in patients with Multiple Sclerosis
ConclusionOur findings suggest that task-oriented and emotion-oriented coping do not influence the relationship between executive functioning and depression in MS patients, but their mental health might benefit from more reliance on avoidance coping. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 9, 2019 Category: Neurology Source Type: research

Progressive dopaminergic defect in a patient with primary progressive multiple sclerosis
Publication date: Available online 7 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Valtteri Kaasinen, Juho Joutsa, Eero Rissanen, Laura Airas, Merja Soilu-Hänninen, Tommi NoponenAbstractDopamine has a modulatory role in a number of autoimmune diseases, but there are no published cases of longitudinal dopaminergic imaging in multiple sclerosis (MS). Here we report a patient with primary progressive multiple sclerosis (PPMS) who was scanned twice with brain dopamine transporter single photon emission computed tomography (SPECT) with an interval of four years. The results showed a loss of trace...
Source: Multiple Sclerosis and Related Disorders - September 8, 2019 Category: Neurology Source Type: research

Early Neuroaxonal Injury is Seen in the Acute Phase of Pediatric Optic Neuritis
The objective of this study was to describe changes in RNFL and GCIPL thickness in the acute phase following pediatric ON.MethodsData were collected prospectively from consecutive children presenting with ON as part of an incident acquired demyelinating event. Children with a final diagnosis of multiple sclerosis (n=9, 10 ON-affected eyes) or monophasic demyelination (n=16, 25 ON-affected eyes) who underwent spectral-domain optical coherence tomography (OCT) testing within 30 days of symptom onset were included. Standardized visual assessment was performed at presentation and 6-18 months follow-up. OCT measures were compar...
Source: Multiple Sclerosis and Related Disorders - September 8, 2019 Category: Neurology Source Type: research

Adipokines are associated with pediatric multiple sclerosis risk and course
ConclusionsFABP4 and leptin levels are higher, while adiponectin levels are lower in pediatric MS compared to controls in sex-specific patterns. These adipokines could serve as biomarkers and therapeutic targets of disease risk and course in early forms of MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 6, 2019 Category: Neurology Source Type: research

MRI Features Associated with High Likelihood of Conversion of Radiologically Isolated Syndrome to Multiple Sclerosis
Publication date: Available online 2 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Joseph Bisulca, Amy De Lury, PK Coyle, Olga Syritsyna, Robert Peyster, Lev Bangiyev, Tim Q DuongAbstractRadiologically isolated syndrome (RIS) is the asymptomatic precursor to clinically isolated syndrome, relapsing-remitting multiple sclerosis (MS) or primary progressive MS. RIS is frequently diagnosed when an individual gets an MRI for an unrelated medical issue, such as headache or trauma. Treating RIS patients is controversial, but physicians may be inclined to offer prophylactic treatment for high-risk RIS pat...
Source: Multiple Sclerosis and Related Disorders - September 4, 2019 Category: Neurology Source Type: research

Predictors of people's perceptions of second hand smoke exposure as a risk factor for multiple sclerosis
ConclusionThe study results could guide in the development of stop second hand smoking campaigns on social media, TV and bus stop shelters and enforcement of stricter policies on smoking areas. This could help raise awareness about the risk of second hand smoking and its detrimental effect on people living with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 4, 2019 Category: Neurology Source Type: research

Abnormalities and erythroblasts in peripheral blood of multiple sclerosis patients treated with natalizumab
Conclusion: Hematopoietic abnormalities are common during natalizumab treatment. Given the lack of consequences of this finding during long-term follow-up, it is generally justifiable to refrain from further diagnostic procedures when observing hematopoietic abnormalities in patients using natalizumab. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 4, 2019 Category: Neurology Source Type: research

Physical activity interventions can improve emotion regulation and dimensions of empathy in persons with multiple sclerosis: An exploratory study
ConclusionsBoth endurance and coordinative exercise training had favorable effects on some aspects of emotion regulation and social cognition such as empathy in PwMS. Such initial results support for examination of exercise training for the treatment of issues of emotion regulation and social interactions in PwMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 1, 2019 Category: Neurology Source Type: research