Physical Activity and Walking Performance across the Lifespan among Adults with Multiple Sclerosis
Conclusion: Interventions targeting MVPA may be an appropriate approach for managing walking impairment, particularly in older adults with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2019 Category: Neurology Source Type: research

Higher health care use before a clinically isolated syndrome with or without subsequent MS
ConclusionHealth care use was higher in individuals with a CIS than without a CIS in the five years before an incident demyelinating event, regardless of whether they were subsequently diagnosed with MS. This suggests that there is a prodromal period before CIS which is not unique to MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 4, 2019 Category: Neurology Source Type: research

The prevalence and utility of screening for urinary tract infection at the time of presumed multiple sclerosis relapse
ConclusionUTIs at the time of a suspected MS relapse are relatively uncommon. Female sex is a strong risk factor for UTI in people with MS; foul-smelling urine is a potential predictor of UTI in people with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 2, 2019 Category: Neurology Source Type: research

Editorial on: Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder
Publication date: Available online 2 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Santiago Pardo, Gavin Giovannoni, Christopher Hawkes, Jeannette Lechner-Scott, Emmanuelle Waubant, Michael Levy (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 2, 2019 Category: Neurology Source Type: research

Pulmonary embolism during the third cycle of alemtuzumab in a patient with relapsing multiple sclerosis
Publication date: Available online 29 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mario Habek, Berislav Ruška, Tin Pavičić, Ana Marija Alduk, Tereza Gabelić, Ivan AdamecAbstractAlemtuzumab is one of immunomodulatory drugs used for treatment of multiple sclerosis (MS). Although it is very effective it carries significant risk for various side effects. This paper reports a case of young patient who developed pulmonary embolism during the third cycle of alemtuzumab. It is suggested that awareness about possible vascular toxicity of this drug should be raised. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 1, 2019 Category: Neurology Source Type: research

Laboratory testing for Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorders (MOGAD)
Publication date: Available online 29 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Sebastian Lopez-Chiriboga, Sean J. Pittock, Brian G. Weinshenker, John J. Chen, Eoin Flanagan (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 1, 2019 Category: Neurology Source Type: research

Three-week inpatient energy management education (IEME) for persons with multiple sclerosis-related fatigue: feasibility of a randomized clinical trial.
Publication date: Available online 29 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ruth Hersche, Andrea Weise, Gisela Michel, Jürg Kesselring, Sara Della Bella, Marco Barbero, Jan KoolAbstractBackground: Multiple sclerosis (MS)-related fatigue limits participation in everyday activities and has a considerable impact on quality of life (QoL), thereby affecting productivity and employment. Outpatient education interventions involving energy conservation strategies and cognitive behavioral therapy techniques are helpful. However, no inpatient program is currently available. The inpatient energy man...
Source: Multiple Sclerosis and Related Disorders - July 1, 2019 Category: Neurology Source Type: research

Safety outcomes of disease-modifying therapies for relapsing–remitting multiple sclerosis: a network meta-analysis
ConclusionSafety outcomes are poorly reported in primary studies of DMTs in RRMS, precluding the conduction of robust meta-analyses. Therefore, the current available data on safety of these drugs is not contributing to regulatory and clinical decision making, with adverse event reports underbalanced compared to efficacy outcomes. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 29, 2019 Category: Neurology Source Type: research

The clinical value of complement proteins in differentiating AQP4-IgG-positive from MOG-IgG-positive neuromyelitis optica spectrum disorders
ConclusionThe combination of C3 and C4 could assist in the differential diagnosis of AQP4-IgG-positive NMOSD from MOG-IgG-positive NMOSD. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 29, 2019 Category: Neurology Source Type: research

Intractable axonal neuropathy with multifocal peripheral nerve swelling in neuromyelitis optica spectrum disorders: a case report
We report a patient with neuromyelitis optica spectrum disorders (NMOSD) with anti-aquaporin 4 (AQP4) antibodies, who developed intractable axonal neuropathy presenting with multifocal peripheral nerve swelling by magnetic resonance (MR) neurography. A 52-year-old woman with a 12-year history of polymyositis and rheumatoid arthritis had been treated with prednisolone, tacrolimus, and abatacept (CTLA-4-Ig). She developed progressive numbness and tingling sensations in the distal parts of all limbs at the age of 50 years, followed by weakness of both upper limbs 6 months later. Neurological examination revealed severe muscle...
Source: Multiple Sclerosis and Related Disorders - June 29, 2019 Category: Neurology Source Type: research

Co-occurrence of Multiple Sclerosis and Myasthenia Gravis: A case report and review of immunological theories
Publication date: Available online 26 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Sara Dehbashi, Diaa Hamouda, Elena ShaninaAbstractAutoimmune mechanisms are implicated in both Myasthenia Gravis (MG) and Multiple Sclerosis (MS), and hypothesis of a common immunological mechanism of pathogenesis is supported by the fact that this rare combination of the two diseases occurs more frequently than expected by random association. Although MS is primarily mediated by T lymphocytes and MG primarily involves the destruction of the neuromuscular junction by antibodies, there are evidences that support both ce...
Source: Multiple Sclerosis and Related Disorders - June 28, 2019 Category: Neurology Source Type: research

Pediatric Acquired Demyelinating Syndrome (ADS) in Inpatient Hospital Settings: the hospitalization rate, costs, and outcomes in the US.
ConclusionHospital utilization by pediatric patients with ADS increased during the period 2003 through 2012. The cross-sectional analysis for the year 2016 indicated that the trend could be ongoing, although the direct comparison was not feasible due to the changes in the coding system of the dataset from ICD9-CM to ICD10-CM. Although relatively rare, pediatric ADS warrant long-term follow-ups and hospitalizations, impacting the developmental trajectory of the affected children and the lives of their family members. Th potentially increasing trend of pediatric ADS hospital utilization should be acknowledged when allocating...
Source: Multiple Sclerosis and Related Disorders - June 28, 2019 Category: Neurology Source Type: research

Plasma Cell And B Cell-Targeted Treatments For Use In Advanced Multiple Sclerosis
Publication date: Available online 26 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): David Baker, Benjamin M. Jacobs, Sharmilee Gnanapavan, Klaus Schmierer, Gavin GiovannoniABSTRACTThere is increasing evidence that agents that target peripheral B cells and in some instances plasma cells can exhibit marked effects on relapsing multiple sclerosis. In addition, B cells, including plasma cells, within the central nervous system compartment are likely to play an important role in disease progression in both relapsing and progressive MS. However, current B cell-targeting antibodies may not inhibit these, bec...
Source: Multiple Sclerosis and Related Disorders - June 26, 2019 Category: Neurology Source Type: research

Fulminant and fatal onset of pan-aquaporinopathy
We report the case of a first devastating NMOSD attack leading to death despite optimal treatment. While receiving steroids during a bilateral blinding optic neuritis, this female patient suffered a severe attack involving the spinal cord and circumventricular organs (CVOs), including the pineal gland. Early adjunctive daily PE failed to prevent sudden death. AQP4-antibodies were strongly positive.To our knowledge, this is the first case of exceptionally severe monophasic NMOSD leading to full-blown lesions in all AQP4-expressing sites. Lesions of the periventricular ependyma and CVOs are highly exceptional and the involve...
Source: Multiple Sclerosis and Related Disorders - June 25, 2019 Category: Neurology Source Type: research

Differences in age of diagnosis in familial multiple sclerosis
Publication date: September 2019Source: Multiple Sclerosis and Related Disorders, Volume 34Author(s): Vanesa Pytel, Jordi A. Matias-Guiu, Laura Torre-Fuentes, Paloma Montero-Escribano, Jorge Matias-Guiu (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 25, 2019 Category: Neurology Source Type: research

Descriptive Analysis of Free-Text Comments on Healthcare Priorities and Experiences in a National Sample of People with Multiple Sclerosis
Conclusion: PwMS prioritize accessibility, affordability, insurance coverage, and comprehensiveness in MS healthcare services. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 25, 2019 Category: Neurology Source Type: research

Response Heterogeneity to Home-Based Restorative Cognitive Rehabilitation in Multiple Sclerosis: An Exploratory Study
Publication date: Available online 22 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Tom A. Fuchs, Stefano Ziccardi, Michael G. Dwyer, Leigh E. Charvet, Alexander Bartnik, Rebecca Campbell, Jose Escobar, David Hojnacki, Chana Kolb, Devon Oship, Jeta Pol, Michael T. Shaw, Curtis Wojcik, Faizan Yasin, Bianca Weinstock-Guttman, Robert Zivadinov, Ralph H.B. BenedictAbstractBackgroundGrowing evidence supports the efficacy of restorative cognitive training in people with multiple sclerosis (PwMS), but the effects vary across individuals. Differences in treatment efficacy may be related to baseline individual...
Source: Multiple Sclerosis and Related Disorders - June 25, 2019 Category: Neurology Source Type: research

Concurrent aquaporin-4-positive NMOSD and neurosyphilis: a case report
In this report we describe a rare case of concurrent AQP4-positive NMOSD and neurosyphilis. A 60-year-old man was admitted to our hospital with a complaint of progressive weakness in his legs for one month. T2-weighted magnetic resonance images of the spinal cord showed longitudinal extensive lesions at C7–T7. The rapid plasma reagin test and T. pallidum particle agglutination assay performed using patient serum and cerebrospinal fluid (CSF) were positive. Additionally, the AQP4-immunoglobulin (Ig) G was detected in the serum and CSF. The patient's symptom gradually improved after penicillin and methylprednisolo...
Source: Multiple Sclerosis and Related Disorders - June 25, 2019 Category: Neurology Source Type: research

Reply to Letter to the Editor
Publication date: Available online 20 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Kassandra L. Munger, Hilda Dejong, Feng Zhu, Helen Tremlett, Alberto Ascherio (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 22, 2019 Category: Neurology Source Type: research

Association between suicide and multiple sclerosis: an updated meta-analysis
ConclusionOur meta-analysis shows a significant association between suicide and multiple sclerosis, although ethnic and geographical differences were not considered. These findings should be confirmed and extended in future large studies. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 20, 2019 Category: Neurology Source Type: research

Disease Course, Progression and Activity of Neuromyelitis Optica (NMOSD) in Patients who were Treated with Rituximab, 6 and 12 months after receiving the first dose of drug, in Isfahan City
The objective of this study is to evaluate the clinical efficacy of Rituximab as a newly introduced treatment to NMOSD in Iran.Methods and MaterialsThis is an observational cohort study carried out,on 56 patients who have been diagnosed with NMOSD. The patients’ information registered in Kashani Hospital MS clinic. They received the first dose of Rituximab for approximately 6 months before the beginning of study. In the first session, every patient was interviewed and examined based on necessary information for the study. Follow up visits were done as needed in a period of 12 months after the first dose. Patient's ag...
Source: Multiple Sclerosis and Related Disorders - June 20, 2019 Category: Neurology Source Type: research

Trigeminal neuralgia: Comparison of characteristics and impact in patients with or without multiple sclerosis
ConclusionspwTNMS have a more intractable TN, one which may necessitate a more complex approach to treatment, earlier referral to secondary care and an extensive assessment of mental health. Quality of life in pwTNMS is severely affected by both their MS and their TN, suggesting management should occur in specialist centres with access to a multidisciplinary team. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 20, 2019 Category: Neurology Source Type: research

A differential sex-specific pattern of IgG2 and IgG4 subclasses of anti-drug antibodies (ADAs) induced by Glatiramer acetate in relapsing-remitting multiple sclerosis patients
ConclusionThis study showed differences in the levels of IgG2 and IgG4 subclasses of ADA between male and female RR-MS patients. Further studies are necessary to take advantage of the clinical potential of this finding. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Acute Myocardial Infarction Associated with Initial Alemtuzumab Infusion Cycle in Relapsing-Remitting Multiple Sclerosis
We report a 30-year-old woman with relapsing-remitting multiple sclerosis who developed a type 2 non-ST elevated myocardial infarction (NSTEMI) during her first alemtuzumab infusion cycle. While acute coronary syndrome has been described with alemtuzumab in the treatment of lymphoma, alemtuzumab-associated cardiac ischemia in multiple sclerosis is uncommon and can occur in patients without cardiovascular risk factors. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Development of a Brief Clinician-Reported Outcome Measure of Multiple Sclerosis Signs and Symptoms: The Clinician Rating of Multiple Sclerosis (CRoMS)
ConclusionThe CRoMS may be a useful tool for efficiently assessing the severity of MS symptoms. This brief clinician-reported measure could help standardize and quantify assessments in clinical studies and clinical settings. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Letter to the Editor
Publication date: Available online 19 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Stuart D Cook, Peter C Dowling (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Trigeminal neuralgia : comparison of characteristics and impact in patients with or without multiple sclerosis
ConclusionspwTNMS have a more intractable TN, one which may necessitate a more complex approach to treatment, earlier referral to secondary care and an extensive assessment of mental health. Quality of life in pwTNMS is severely affected by both their MS and their TN, suggesting management should occur in specialist centres with access to a multidisciplinary team. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patient
ConclusionThis case is unique since this fulminant multifocal relapse occurred in a patient with grade 3 lymphopenia and irreproachable adherence. This observation should be known as a possible side effect of fingolimod treatment. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Intensity-dependent clinical effects of an individualized technology-supported task-oriented upper limb training program in Multiple sclerosis: a pilot randomized controlled trial
The objective of the study was to investigate the feasibility and the clinical effects of a task-oriented upper limb training program at different individualized training intensities with conventional occupational therapy.MethodsPeople with MS (n=20, EDSS range 4-8) were divided into three groups, receiving task-oriented training at 100% (n=7) or 50% (n=8) of their individual maximal number of repetitions, or conventional occupational therapy (n=5). Effects were evaluated using different upper limb capacity and perceived performance measures on activity level, and measures on body functions and structures level.ResultsMixe...
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

“Differences in age of diagnosis in familial multiple sclerosis”
Publication date: Available online 17 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Vanesa Pytel (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Fingolimod reduces CXCR4-mediated B cell migration and induces regulatory B cells-mediated anti-inflammatory immune repertoire
ConclusionsFingolimod promotes anti-inflammatory cytokine profiles of B and T cells, through induction of regulatory B cells. Reduced B cell migration capacity in Fingolimod-treated patients leading to decreased cerebral inflammatory infiltration, may be part of the mechanism by which Fingolimod reduces disease activity in MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

TLR-2 and TLR-4 agonists favor expansion of CD4+ T cell subsets implicated in the severity of neuromyelitis optica spectrum disorders
ConclusionsIn summary, our data suggest that microbial antigens may affect NMOSD outcomes by favoring an imbalance between Th17 and TFH-like cells and regulatory T cell subsets. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

The effect of cycling using active-passive trainers on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe Multiple Sclerosis (MS); a feasibility study.
Publication date: Available online 18 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): A. Barclay, L. Paul, N. MacFarlane, A.K. McFadyenAbstractBackground: Exercise options for those with moderate to high levels of disability are limited. The aim of the study was to evaluate the feasibility of a progressive, four week lower limb cycling programme using active-passive trainers (APT's) on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe MS.Methods: Participants were in-patients in the Physical Disability Rehabilitation Unit, Queen Elizabeth University Hospi...
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Multiple sclerosis and Fabry disease - diagnostic “mixup”
Publication date: Available online 15 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Miljenka-Jelena Jurašić, Vanja Bašić Kes, Iris ZavoreoAbstractA common disease like multiple sclerosis (MS) usually dominates the arena of demyelinating disorders; however, when a red flag such as a first relative family history of neurologic disease other than MS is present, the diagnostics may be more challenging.Recently, we have come across an intriguing clinical and diagnostic dilemma requiring extensive literature search and finally, decision making. Namely, initial presentation in our patient was...
Source: Multiple Sclerosis and Related Disorders - June 16, 2019 Category: Neurology Source Type: research

Optic neuritis, encephalitis and leptomeningeal enhancement in a patient with anti-MOG antibodies: a case study
Publication date: Available online 14 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Nichola Haddad, Breton Roussel, Ari Pelcovits, Syed Rizvi (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 16, 2019 Category: Neurology Source Type: research

Risk of relapses during pregnancy among multiple sclerosis patients
Publication date: Available online 10 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Raed Alroughani, Saeed Akhtar, Maya Zeineddine, Y. EL Kouzi, N.K. El Ayoubi, Samar F. Ahmed, Raed Behbehani, Samia J. Khoury, Jasem Y. Al-Hashel, Bassem I. YamoutAbstractBackgroundRelapse rate in women with MS is reduced during pregnancy especially in the third trimester according to the previous studies.ObjectivesTo measure the annual relapse rate (ARR) in women with MS during pregnancy.MethodsA retrospective study was conducted using prospectively collected data from two MS registries in Kuwait and Lebanon. Demograph...
Source: Multiple Sclerosis and Related Disorders - June 11, 2019 Category: Neurology Source Type: research

Sirtuins in Multiple Sclerosis: the crossroad of neurodegeneration, autoimmunity and metabolism
Publication date: Available online 9 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Forough Foolad, Fariba Khodagholi, Mohammad JavanAbstractMultiple Sclerosis (MS) is a challenging and disabling condition particularly in the secondary progressive (SP) phase of this disease. The available treatments cannot ameliorate or stop disease progression in this phase, and there is an urgent need to focus on effective therapies and the molecular pathways involved SPMS. Given the significant impact of neurodegeneration, autoimmunity and metabolic alterations in MS, focusing on the molecules that target these diff...
Source: Multiple Sclerosis and Related Disorders - June 10, 2019 Category: Neurology Source Type: research

Multiple sclerosis national registry system in Iran: Validity and reliability of a minimum data set
ConclusionThe use of standardized validated minimum data set has the potential to enable the researchers and policy-makers to systematically compare and analyze patient information. The Persian version of the minimum data set found to be valid and reliable in Iran. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 10, 2019 Category: Neurology Source Type: research

The effects of a combination of ion channel inhibitors on pathology in a model of demyelinating disease
ConclusionOur findings suggest that excess Ca2+ influx contributes to protein nitration, and associated changes to OPC densities and Node of Ranvier structure in demyelinating disease. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 10, 2019 Category: Neurology Source Type: research

Severe cutaneous adverse event in a daclizumab-treated multiple sclerosis patient
Publication date: Available online 8 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Johannis A van Rossum, Marieke A.D. Peters, Paul van der Valk, Brigit A. de Jong (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 8, 2019 Category: Neurology Source Type: research

B Cell Depletion and Pregnancy: Review and applications for MS treatment
Publication date: Available online 6 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Suma Shah, Christopher EcksteinAbstractMultiple sclerosis (MS) is a chronic autoimmune condition primarily affecting young adults. As there are numerous uncertainties faced by young women of childbearing age who are living with this chronic condition and the gender ratio is increasingly skewed towards women, it has become critical to define a clear approach to questions of disease management prior to and during pregnancy. With the approval of B cell depletion therapy for treatment of relapsing remitting and primary prog...
Source: Multiple Sclerosis and Related Disorders - June 7, 2019 Category: Neurology Source Type: research

Emotional Expressions associated with Therapeutic Inertia in Multiple Sclerosis Care
Publication date: Available online 4 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Gustavo Saposnik, Jiwon Oh, Maria A. Terzaghi, Pawel Kostyrko, Fabien Bakdache, Alonso Montoya, Blessing N.R. Jaja, Rosane Nisenbaum, Christian C. Ruff, Philippe N. ToblerAbstractBackgroundEmotions play a critical role in our daily decisions. However, it remains unclear how and what sort of emotional expressions are associated with therapeutic decisions in multiple sclerosis (MS) care. Our goal was to evaluate the relationship between emotions and affective states (as captured by muscle facial activity and emotional exp...
Source: Multiple Sclerosis and Related Disorders - June 5, 2019 Category: Neurology Source Type: research

Incidence of pediatric NMOSD and MOG-associated disease in Denmark 2008‒2018: a nationwide, population-based cohort study
Publication date: Available online 5 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Magnus S. Boesen, Poul E.H. Jensen, Alfred P. Born, Melinda Magyari, Anna C. Nilsson, Christina Hoei-Hansen, Morten Blinkenberg, Finn SellebjergAbstractBackgroundThe incidence of pediatric neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease have not been reported previously. Our aim was to estimate the incidence of pediatric NMOSD and the occurrence of anti-MOG antibody-associated disease in Denmark during 2008–18, and to evaluate the diagnostic ...
Source: Multiple Sclerosis and Related Disorders - June 5, 2019 Category: Neurology Source Type: research

Neuromyelitis optica and pregnancy-puerperal cycle
Discussion19 women with 30 pregnancies. In only 8 pregnancies, there were no relapses up to 1 year postpartum, some associated with the use of immunosuppressants and/or human immunoglobulin in immediate delivery. Annualized relapses rates stood out in the puerperal period, especially in the first 3 months postpartum, in relation to before- pregnancy ARR. It was observed that pregnancy also increased functional disability in these women. Gestational complications such as miscarriage have not been shown to be more frequent in pregnant women with NMO than in the general population. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 5, 2019 Category: Neurology Source Type: research

Multiple Sclerosis and Psychosis: A case report
We describe the process which led us to make the diagnosis of Psychotic Disorder due to Medical Condition (Multiple Sclerosis). Because her criminal charges brought significant attention to her case, we also address the difficulty in treating a neurological condition with psychiatric features within the forensic context. Moreover, one of the main concerns of the patient was that Lyme Disease was the correct diagnosis as opposed to MS. We also report the difficulty of treating and initiating successful follow-up for a patient whose paranoia is enabled by the opinions of certain health advocacy groups. (Source: Multiple Scle...
Source: Multiple Sclerosis and Related Disorders - June 4, 2019 Category: Neurology Source Type: research

Complete sequence analysis of human toll-like receptor 3 gene in natural killer cells of multiple sclerosis patients
ConclusionThere appears to be a possible association between the TLR3 missense mutation rs3775291 and multiple sclerosis, which might be attributed to changes in the TLR3 functional properties. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis
ConclusionThe study shows that the perceptual DM capacity is reduced in MS. Moreover, the link between neural mechanisms of perceptual DM and neuropsychiatric symptoms suggests that an impairment in this domain is clinically relevant. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

Access and unmet needs to multiple sclerosis care in a cohort of Argentinean patients
ConclusionThis study showed that MS patients had access barriers to receive MS medication properly, especially those with SRHI (public sector). (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

Five Year Iron Changes in Relapsing-Remitting Multiple Sclerosis Deep Gray Matter Compared to Healthy Controls
ConclusionsThalamic atrophy was the only bulk effect that demonstrated different rates of changes over 5 years compared to age-matched controls. DARE Iron decrease in regions of the caudate, putamen, and thalamus were prominent features in stable RRMS over 5 years. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

The Real-World Effectiveness Of Natalizumab And Fingolimod In Relapsing-Remitting Multiple Sclerosis. An Italian Multicentre Study.
ConclusionsBoth drugs were highly effective in our cohort. Natalizumab proved superior in inducing regression of disability and 2-year-NEDA-3. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research