Influences of pregnancy on neuromyelitis optica spectrum disorders and multiple sclerosis
ConclusionsBoth NMOSD and MS presented increased onset and relapses after delivery/abortion. Significant differences were observed in ARRs at different stages between them. Both delivery and abortion exerted detrimental effects on disease courses in NMOSD and MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Epidemiology of Multiple Sclerosis in Northeast of Iran during 1985-2016; Conversion of a Rare Disease to a Middle-high Prevalence Disease
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Vahid Kazemi Moghaddam, Mohammad Sarmadi, Maryam Tatari, Fereshteh Najafi, Amir Esmaeili, Mostafa HadeiAbstractMany researchers believed that the risk of multiple sclerosis (MS) is associated with latitude gradient. Due to the increasing prevalence of MS in some areas around the equator such as Iran, this theory has been criticized in recent years. Since the distribution of multiple sclerosis in Iran is not uniform, this study was designed to describe the prevalence and incidence of MS in Northeastern area of Iran.The p...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Increased CCL18 plasma levels are associated with neurodegenerative MRI outcomes in multiple sclerosis patients
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Nicole Ziliotto, Francesco Bernardi, Dejan Jakimovski, Marcello Baroni, Niels Bergsland, Deepa P. Ramasamy, Bianca Weinstock-Guttman, Paolo Zamboni, Giovanna Marchetti, Robert Zivadinov, Murali RamanathanABSTRACTBackground: Chemokine ligands and co-stimulatory factors are involved in macrophage activation and differentiation processes that could contribute to multiple sclerosis (MS) pathogenesis.Objective: To investigate associations of C-C motif Ligand 18 (CCL18), C-C motif ligand 5 (CCL5) and soluble Cluster of Differ...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Measures of Adiposity Differentially Correlate with C-Reactive Protein Among Persons with Multiple Sclerosis
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Tracy Baynard, Thessa I.M. Hilgenkamp, Elizabeth C. Schroeder, Robert W. Motl, Bo FernhallAbstractBackgroundWhile MS is considered, in part, an inflammatory disease, the relationship between measures of adiposity and MS have not been well studied. This is important considering the strength of the association between adiposity and inflammation reported in the general population, and the resultant increased risk for cardiovascular and metabolic disease. Evidence demonstrates MS is associated with higher prevalence rates o...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Use of the new oral disease-modifying therapies for multiple sclerosis in British Columbia, Canada: the first five-years
Conclusion: The uptake and use of the oral DMTs increased substantially over the first 2 to 5 years after their introduction. These recent changes highlight the importance of monitoring the risks and benefits in the real world. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Cardiovascular conditions in persons with multiple sclerosis, neuromyelitis optica and transverse myelitis
ConclusionCardiovascular conditions are as common in those with demyelinating diseases compared to unaffected individuals, with hypertension being more common among those with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Limbic encephalitis associated with systemic sclerosis
We report the case of a patient affected by systemic sclerosis (SSc) who developed autoimmune limbic encephalitis, which improved under immunosuppressant agents and high-dose intravenous immunoglobulins. In our patient the autoimmune encephalitis occurred during apparently quiescent SSc, though concomitantly with novel arthritis. Moreover, our patient showed auto-antibodies directed against SSA antigen but the panel of auto-antibodies associated with autoimmune encephalitis was negative.We discuss the potential for immunopathogenic inflammatory events affecting the central nervous system in SSc then favoring the occurrence...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

2017 McDonald diagnostic criteria: A review of the evidence
Publication date: August 2018Source: Multiple Sclerosis and Related Disorders, Volume 24Author(s): N McNicholas, M Hutchinson, C McGuigan, J ChatawayAbstractThe diagnosis of Multiple Sclerosis (MS) has continuously evolved, allowing for an earlier and more accurate diagnosis of MS over time. The McDonald Criteria for diagnosis of MS were originally proposed in 2001, with previous revisions in both 2005 and 2010. The International Panel on Diagnosis in MS have recently reviewed the 2010 McDonald Criteria, and made recommendations for the revised 2017 McDonald Criteria. Any revisions made relied entirely on the available evi...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

High intensity interval training for people with multiple sclerosis: A systematic review
ConclusionHIIT appears to be safe and effective in increasing fitness in people with MS and low levels of disability. Further research is required to explore the effectiveness of HIIT in people with progressive MS and in those with higher levels of disability. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

An introduction to Mendelian randomization with applications in neurology
Publication date: August 2018Source: Multiple Sclerosis and Related Disorders, Volume 24Author(s): Phillip H. Allman, Inmaculada B. Aban, Hemant K. Tiwari, Gary R. CutterAbstractMendelian randomization studies have become increasingly common due to the maturation of genome-wide association studies and its potential to ascertain causal relationships. With the increasing use of this method comes the need for medical practitioners and clinicians to develop an understanding of its rationale, limitations, and interpretation. Mendelian randomization attempts to ascertain a causal relationship between some risk factor of interest...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Radiologically isolated syndrome in children: Current knowledge and future directions
Publication date: August 2018Source: Multiple Sclerosis and Related Disorders, Volume 24Author(s): Colin Wilbur, E. Ann YehAbstractAs the use of magnetic resonance imaging (MRI) grows in clinical practice, clinicians are increasingly faced with the difficult task of interpreting the significance of incidental findings on brain MRI. Among individuals found to have incidental brain MRI findings, a small number have white matter abnormalities on MRI that resemble the demyelinating lesions of multiple sclerosis (MS) in the absence of a history of relevant clinical symptoms. This has been termed radiologically isolated syndrome...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Effects of exercise training on cytokines and adipokines in multiple Sclerosis: A systematic review
ConclusionResearch regarding the effects of exercise training on cytokines and adipokines in MS is in its infancy, but exercise represents an adjuvant therapy in MS, and future studies are essential for clarifying the role of exercise on cytokines and adipokines in MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Validating the portal population of the United Kingdom Multiple Sclerosis Register
Publication date: August 2018Source: Multiple Sclerosis and Related Disorders, Volume 24Author(s): R.M. Middleton, W.J. Rodgers, J. Chataway, K. Schmierer, D. Rog, I. Galea, A. Akbari, K. Tuite-Dalton, H. Lockhart-Jones, D. Griffiths, D.G. Noble, K.H. Jones, A. Al-Din, M. Craner, N. Evangelou, P. Harman, T. Harrower, J. Hobart, H. Husseyin, M. KastiAbstractThe UK Multiple Sclerosis Register (UKMSR) is a large cohort study designed to capture ‘real world’ information about living with multiple sclerosis (MS) in the UK from diverse sources. The primary source of data is directly from people with Multiple Sclerosi...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Teeth loss after teriflunomide treatment: Casual or causal? A short case series
ConclusionsWe underline the importance to assess concomitant teeth morbidity and to recommend accurate oral hygiene before and during teriflunomide treatment. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Disease activity in progressive multiple sclerosis can be effectively reduced by cladribine
ConclusionspwPMS with detectable disease activity (MRI, elevated NfL) should be considered for DMT. NfL appears to be a sensitive index of treatment effect in pwPMS, and may be a useful outcome in clinical trials targeting this patient group. Over and above its licensed indication (relapsing MS), cladribine may be an effective treatment option for pwPMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Depression is a predictor for balance in people with multiple sclerosis
ConclusionDepression and balance were found frequent and associated in people with MS. Importantly depression was a significant predictor for balance impairments in individuals with MS. Balance rehabilitation may be hindered by depression. Therefore, depression should be evaluated and treated properly in individuals with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Analysing the relationship between polysomnographic measures of sleep with measures of physical and cognitive fatigue in people with multiple sclerosis
ConclusionsSleep impairment is a very common problem in people with MS justifying routine polysomnographic evaluation. We have found evidence that though sleep impairment is not related to physical fatigue, it is strongly related to cognitive fatigue. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Real-life persistence and tolerability with dimethyl fumarate
We examined real-world tolerability to DMF, and also compared adherence data between two MS clinics.MethodsAdverse events (AE), discontinuation rates, and causes of discontinuation were investigated.Results253 patients participated in this retrospective study. In the total cohort, 27.7% of the patients discontinued DMF. Higher rate of discontinuation was associated with higher number of previous disease modifying treatments (p 
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Heart rate variability analysis in patients with multiple sclerosis
ConclusionThese findings reveals that our study population with multiple sclerosis had decreased heart rate variability compared to healthy controls. This was reflected by dysfunction of both parasympathetic and sympathetic parameters of hearth rate variability analysis. However, there is no significant relationship between hearth rate variability analysis and the findings on cranial, cervical, thoracic spinal magnetic resonance imaging findings, number of attack, Expanded Disability Status Scale score or Multiple Sclerosis Functional Composite scores in patients with multiple sclerosis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Cardiac autonomic function during postural changes and exercise in people with multiple sclerosis: A cross-sectional study
Publication date: August 2018Source: Multiple Sclerosis and Related Disorders, Volume 24Author(s): Elisa Gervasoni, Marco Bove, Mattia Sinatra, Cristina Grosso, Marco Rovaris, Davide Cattaneo, Giampiero MeratiAbstractBackgroundPeople with multiple sclerosis (PwMS) often develop an autonomic dysfunction (AD), which onset should be assessed early at a subclinical level, as it may interfere with pharmacological treatments and exercise.ObjectiveTo evaluate basal cardiac autonomic tone, its modulations during sit-to-stand, sub-maximal exercise and recovery in PwMS without clinical overt AD and its relationships with fatigue per...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Trunk control: The essence for upper limb functionality in patients with multiple sclerosis
The objective of this study was to point out the impairments of and relationship between trunk control and comprehensive upper-limb functions in individuals with MS.MethodsTasks that were sought are optimal screening for deterioration in trunk control (Trunk Control Test [TCT] and Trunk Impairment Scale [TIS]) and upper-limb functionality by comparing them with the Expanded Disability Status Scale (EDSS), Nine Hole Peg Test (NHPT), Duruoz's Hand Index (DHI), and Functional Independence Measurement (FIM) results of 49 well-defined relapsing-remitting MS (RRMS) participants with those of 49 age-gender matched healthy subject...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Access to social security benefits among multiple sclerosis patients in Italy: A cross-sectional study.
ConclusionExcept for full exemption from co-payments, the proportions of MS patients who enjoyed social security benefits seem to be limited in our study sample. The EDSS score is the strongest predictor of the probability of receiving all the benefits. Only a small proportion of patients received care allowance and working permits, probably because such benefits are only granted to people with a high level of disability. On the other hand, the low proportion of patients who enjoyed fiscal benefits for home and car adaptations could have been influenced by the way such benefits are granted in our country. (Source: Multiple...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Efficacy and safety of natalizumab extended interval dosing
ConclusionIn patients treated with natalizumab, shifting from SID to EID has no negative effect on efficacy as evidenced by relapse rate, disability progression and MRI activity. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

A phase II baseline versus treatment study to determine the efficacy of raltegravir (Isentress) in preventing progression of relapsing remitting multiple sclerosis as determined by gadolinium-enhanced MRI: The INSPIRE study
ConclusionsRaltegravir did not have any impact on MS disease activity. This could be due to the choice of antiretroviral agent used in this study, the need for a combination of agents, as used in treating HIV infection, the short treatment period or dosing regimen, or the lack of a role of HERV expression in MS once the disease is established. Borderline significance for the association between EBV shedding and the total number of lesions, probably driven by new lesion development, may indicate EBV shedding as a marker of inflammatory disease activity. In conclusion, interesting correlations between HERV-W markers, EBV she...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Patient awareness about family planning represents a major knowledge gap in multiple sclerosis
ConclusionThis survey uncovered a low level of knowledge about DMTs’ teratogenic risks among MS patients irrespective of sex. Knowledge about potential teratogenic risks for male MS patients receiving DMTs while planning to start a family was largely absent. 10% of female patients had experienced unplanned pregnancies on MS treatment. In general, patients use the internet and their neurologist to the same extent for information on parenthood planning. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis
ConclusionsWhile this finding requires confirmation, it is interesting given the association between pesticide exposure and other neurological diseases. The study also demonstrates the application of LASSO to identify environmental exposures with reduced multiple statistical testing penalty. Machine learning approaches may be useful for future investigations of concomitant MS risk or prognostic factors. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

A case of Takotsubo syndrome during a multiple sclerosis brainstem relapse
ConclusionOur case adds to previous reports in this field and calls for awareness of this exceptional extra-neurological manifestation of MS. It seems also to confirm the possible association between MS relapses and ovarian stimulation. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Mortality from Listeria monocytogenes meningoencephalitis following escalation to alemtuzumab therapy for relapsing-remitting Multiple Sclerosis
We report the case of a patient who died from the rare complication of Listeriosis in the immediate phase following alemtuzumab administration one month after discontinuing dimethyl fumarate (DMF). There is considerable overlap with typical post-infusion symptoms therefore high surveillance and low threshold for empirical or possible prophylactic antibiotic therapy is advocated. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Progressive visual function impairment as the predominant symptom of the transition phase to secondary progressive multiple sclerosis: A case report
Conclusions. Impairment of vision, together with walking and cognition, should be considered to better define the transition from relapsing/remitting to secondary-progressive MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

White matter hyperintensities in myotonic dystrophy type 2: Not always another expression of the disease
We report herein the case of a 38-year old woman, with the rare co-existence of DM2 and MS and argue about the challenging differential diagnosis if CNS involvement is present in DM2 patients. Thus, is it another expression of a multisystem disorder or an unfortunate pure coincidence? (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Time to consider alternative environmental risk factor rather than ultra violet-B for multiple sclerosis
Publication date: August 2018Source: Multiple Sclerosis and Related Disorders, Volume 24Author(s): Seyed Aidin Sajedi (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting
ConclusionsIn TOP patients with a median (range) baseline EDSS score of 3.5 (0.0–9.5) who completed 24 months of natalizumab treatment, the rate of 48-week confirmed disability worsening events was below 15%; after approximately 5.5 years of natalizumab treatment, 86.5% and 94.7% of patients did not have EDSS score increases of ≥1.0 or ≥2.0 points, respectively. The presence of relapses was associated with higher rates of overall disability worsening. These results were confirmed by assessing transition to EDSS milestones. Lower rates of overall 48-week confirmed EDSS worsening and of transitioning from EDSS sc...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Epidemiology of Multiple Sclerosis in Northeast of Iran during 1985-2016; Conversion of a Rare Disease to a Middle-high Prevalence Disease
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Vahid Kazemi Moghaddam, Mohammad Sarmadi, Maryam Tatari, Fereshteh Najafi, Amir Esmaeili, Mostafa HadeiAbstractMany researchers believed that the risk of multiple sclerosis (MS) is associated with latitude gradient. Due to the increasing prevalence of MS in some areas around the equator such as Iran, this theory has been criticized in recent years. Since the distribution of multiple sclerosis in Iran is not uniform, this study was designed to describe the prevalence and incidence of MS in Northeastern area of Iran.The p...
Source: Multiple Sclerosis and Related Disorders - July 8, 2018 Category: Neurology Source Type: research

Measures of Adiposity Differentially Correlate with C-Reactive Protein Among Persons with Multiple Sclerosis
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Tracy Baynard, Thessa I.M. Hilgenkamp, Elizabeth C. Schroeder, Robert W. Motl, Bo FernhallAbstractBackgroundWhile MS is considered, in part, an inflammatory disease, the relationship between measures of adiposity and MS have not been well studied. This is important considering the strength of the association between adiposity and inflammation reported in the general population, and the resultant increased risk for cardiovascular and metabolic disease. Evidence demonstrates MS is associated with higher prevalence rates o...
Source: Multiple Sclerosis and Related Disorders - July 8, 2018 Category: Neurology Source Type: research

Increased CCL18 plasma levels are associated with neurodegenerative MRI outcomes in multiple sclerosis patients
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Nicole Ziliotto, Francesco Bernardi, Dejan Jakimovski, Marcello Baroni, Niels Bergsland, Deepa P. Ramasamy, Bianca Weinstock-Guttman, Paolo Zamboni, Giovanna Marchetti, Robert Zivadinov, Murali RamanathanABSTRACTBackground: Chemokine ligands and co-stimulatory factors are involved in macrophage activation and differentiation processes that could contribute to multiple sclerosis (MS) pathogenesis.Objective: To investigate associations of C-C motif Ligand 18 (CCL18), C-C motif ligand 5 (CCL5) and soluble Cluster of Differ...
Source: Multiple Sclerosis and Related Disorders - July 7, 2018 Category: Neurology Source Type: research

Shortening the Washout to 4 Weeks when Switching from Natalizumab to Fingolimod and Risk of Disease Reactivation in Multiple Sclerosis
CONCLUSIONSOur study suggests that switching from natalizumab to fingolimod with a shorter washout of 4 weeks might reduce the risk of disease reactivation after switching. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 7, 2018 Category: Neurology Source Type: research

Influences of pregnancy on neuromyelitis optica spectrum disorders and multiple sclerosis
ConclusionsBoth NMOSD and MS presented increased onset and relapses after delivery/abortion. Significant differences were observed in ARRs at different stages between them. Both delivery and abortion exerted detrimental effects on disease courses in NMOSD and MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 7, 2018 Category: Neurology Source Type: research

Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes
Publication date: Available online 11 June 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Magnus Spangsberg Boesen, Poul Erik Hyldgaard Jensen, Melinda Magyari, Alfred Peter Born, Peter Vilhelm Uldall, Morten Blinkenberg, Finn SellebjergAbstractBackgroundChitinase 3-like 1 (CHI3L1), neurofilament light chain (NFL) and oligoclonal bands (OCB) in cerebrospinal fluid are associated with central nervous system demyelination in adults. CHI3L1 and OCB are markers of central nervous system inflammation, whereas NFL is a marker of white-matter axonal injury. The aim was to examine whether CHI3L1 and NFL in cerebros...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Patient awareness about family planning represents a major knowledge gap in multiple sclerosis
ConclusionThis survey uncovered a low level of knowledge about DMTs’ teratogenic risks among MS patients irrespective of sex. Knowledge about potential teratogenic risks for male MS patients receiving DMTs while planning to start a family was largely absent. 10% of female patients had experienced unplanned pregnancies on MS treatment. In general, patients use the internet and their neurologist to the same extent for information on parenthood planning. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis
ConclusionsWhile this finding requires confirmation, it is interesting given the association between pesticide exposure and other neurological diseases. The study also demonstrates the application of LASSO to identify environmental exposures with reduced multiple statistical testing penalty. Machine learning approaches may be useful for future investigations of concomitant MS risk or prognostic factors. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Coping strategies and quality of life in Mexican Multiple Sclerosis patients: physical, psychological and social factors relationship
CONCLUSIONThe use of positive coping strategies in conjunction with a suitable psycho-social environment and good physical health result in a better perception of QoL in Mexican patients living with MS. Still, the negative factors are ineffectively diagnosed and hence generally under treated in medical MS monitoring. An interdisciplinary evaluation will provide the adequate tools to confront the diagnosis and the uncertainty of multiple sclerosis evolution, benefiting the QoL of Mexican patients with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

A phase II baseline versus treatment study to determine the efficacy of Raltegravir (Isentress) in preventing progression of relapsing remitting multiple sclerosis as determined by gadolinium-enhanced MRI: The INSPIRE Study
ConclusionsRaltegravir did not have any impact on MS disease activity. This could be due to the choice of antiretroviral agent used in this study, the need for a combination of agents, as used in treating HIV infection, the short treatment period or dosing regimen, or the lack of a role of HERV expression in MS once the disease is established. Borderline significance for the association between EBV shedding and the total number of lesions, probably driven by new lesion development, may indicate EBV shedding as a marker of inflammatory disease activity. In conclusion, interesting correlations between HERV-W markers, EBV she...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Teeth loss after teriflunomide treatment: casual or causal? A short case series
ConclusionsWe underline the importance to assess concomitant teeth morbidity and to recommend accurate oral hygiene before and during teriflunomide treatment. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Neutropenia with fatal outcome in a multiple sclerosis patient 23 days after alemtuzumab infusion
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Konstantina G Yiannopoulou, Dimitra Papadimitriou, Aikaterini I Anastasiou, Marina SiakantarisABSTRACTA 47-year-old Caucasian female with relapsing- remitting Multiple Sclerosis, received alemtuzumab after a serious relapse. She had ceased receiving any treatment during the previous year. 23 days after alemtuzumab infusion she developed severe early neutropenia, which resulted in septic shock by Staphylococcus aureus and death. This is the first report of alemtuzumab infusion-related death due to early neutropenia in non-immuno...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

HPV-related papillary squamous cell carcinoma of the tonsil during treatment with fingolimod
We describe the case of a 50-year old man on fingolimod since 2011 who presented, in April 2017, with a voluminous swelling of the left tonsil. A left tonsillectomy was performed, and histological exam disclosed a papillary squamous cell carcinoma of the palatine tonsil, with an in situ hybridization positive for human papillomavirus (HPV)-16 DNA. Neither lymph nodes involvement nor other metastases were detected. Fingolimod was stopped as a precautionary measure in May 2017, and the patient currently continues his follow up at our Department. Immunocompromised patients are at risk for developing HPV-related malignancies p...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Cauda equina involvement following dengue fever
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Beuy Joob, Viroj Wiwanitkit (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Dimethyl fumarate downregulates the immune response through the HCA2/GPR109A pathway: Implications for the treatment of multiple sclerosis
ConclusionAlthough the DMF/MMF mechanism of action remains unclear, evidence suggests that the activation of HCA2/GPR109A pathway downregulates the immune response and may activate anti-inflammatory response in the intestinal mucosa, possibly leading to reduction in CNS tissue damage in MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

The efficacy of vitamin D in multiple sclerosis: A meta-analysis
ConclusionOur findings suggest that vitamin D appeared to have no therapeutic effect on EDSS score or ARR in the patients with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Peripheral blood memory B cell frequency predicts conversion from clinically isolated syndrome to multiple sclerosis
ConclusionOur results suggest that conversion from CIS to MS occurs due to the inability of the immune system to suppress effector B cell production. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Phase sensitive reconstruction of T1-weighted inversion recovery in the evaluation of the cervical cord lesions in multiple Sclerosis; is it similarly eligible in 1.5 T magnet fields?
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): A. Shayganfar, A.H. Sarrami, S. Fathi, V. Shaygannejad, S. ShamsianAbstractBackgroundIn primary studies with 3 T Magnets, phase sensitive reconstruction of T1-weighted inversion recovery (PSIR) have showed ability to depict the cervical multiple sclerosis (MS) lesions some of which may not be detected by short tau inversion recovery (STIR). Regarding to more availability of 1.5 T MRI, this study was designed to evaluate the eligibility of PSIR in 1.5 T for detection of spinal cord MS lesions.MethodIn a study betw...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research