Association between suicide and multiple sclerosis: an updated meta-analysis
ConclusionOur meta-analysis shows a significant association between suicide and multiple sclerosis, although ethnic and geographical differences were not considered. These findings should be confirmed and extended in future large studies. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 20, 2019 Category: Neurology Source Type: research

Disease Course, Progression and Activity of Neuromyelitis Optica (NMOSD) in Patients who were Treated with Rituximab, 6 and 12 months after receiving the first dose of drug, in Isfahan City
The objective of this study is to evaluate the clinical efficacy of Rituximab as a newly introduced treatment to NMOSD in Iran.Methods and MaterialsThis is an observational cohort study carried out,on 56 patients who have been diagnosed with NMOSD. The patients’ information registered in Kashani Hospital MS clinic. They received the first dose of Rituximab for approximately 6 months before the beginning of study. In the first session, every patient was interviewed and examined based on necessary information for the study. Follow up visits were done as needed in a period of 12 months after the first dose. Patient's ag...
Source: Multiple Sclerosis and Related Disorders - June 20, 2019 Category: Neurology Source Type: research

Trigeminal neuralgia: Comparison of characteristics and impact in patients with or without multiple sclerosis
ConclusionspwTNMS have a more intractable TN, one which may necessitate a more complex approach to treatment, earlier referral to secondary care and an extensive assessment of mental health. Quality of life in pwTNMS is severely affected by both their MS and their TN, suggesting management should occur in specialist centres with access to a multidisciplinary team. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 20, 2019 Category: Neurology Source Type: research

A differential sex-specific pattern of IgG2 and IgG4 subclasses of anti-drug antibodies (ADAs) induced by Glatiramer acetate in relapsing-remitting multiple sclerosis patients
ConclusionThis study showed differences in the levels of IgG2 and IgG4 subclasses of ADA between male and female RR-MS patients. Further studies are necessary to take advantage of the clinical potential of this finding. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Acute Myocardial Infarction Associated with Initial Alemtuzumab Infusion Cycle in Relapsing-Remitting Multiple Sclerosis
We report a 30-year-old woman with relapsing-remitting multiple sclerosis who developed a type 2 non-ST elevated myocardial infarction (NSTEMI) during her first alemtuzumab infusion cycle. While acute coronary syndrome has been described with alemtuzumab in the treatment of lymphoma, alemtuzumab-associated cardiac ischemia in multiple sclerosis is uncommon and can occur in patients without cardiovascular risk factors. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Development of a Brief Clinician-Reported Outcome Measure of Multiple Sclerosis Signs and Symptoms: The Clinician Rating of Multiple Sclerosis (CRoMS)
ConclusionThe CRoMS may be a useful tool for efficiently assessing the severity of MS symptoms. This brief clinician-reported measure could help standardize and quantify assessments in clinical studies and clinical settings. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Letter to the Editor
Publication date: Available online 19 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Stuart D Cook, Peter C Dowling (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Trigeminal neuralgia : comparison of characteristics and impact in patients with or without multiple sclerosis
ConclusionspwTNMS have a more intractable TN, one which may necessitate a more complex approach to treatment, earlier referral to secondary care and an extensive assessment of mental health. Quality of life in pwTNMS is severely affected by both their MS and their TN, suggesting management should occur in specialist centres with access to a multidisciplinary team. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patient
ConclusionThis case is unique since this fulminant multifocal relapse occurred in a patient with grade 3 lymphopenia and irreproachable adherence. This observation should be known as a possible side effect of fingolimod treatment. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Intensity-dependent clinical effects of an individualized technology-supported task-oriented upper limb training program in Multiple sclerosis: a pilot randomized controlled trial
The objective of the study was to investigate the feasibility and the clinical effects of a task-oriented upper limb training program at different individualized training intensities with conventional occupational therapy.MethodsPeople with MS (n=20, EDSS range 4-8) were divided into three groups, receiving task-oriented training at 100% (n=7) or 50% (n=8) of their individual maximal number of repetitions, or conventional occupational therapy (n=5). Effects were evaluated using different upper limb capacity and perceived performance measures on activity level, and measures on body functions and structures level.ResultsMixe...
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

“Differences in age of diagnosis in familial multiple sclerosis”
Publication date: Available online 17 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Vanesa Pytel (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Fingolimod reduces CXCR4-mediated B cell migration and induces regulatory B cells-mediated anti-inflammatory immune repertoire
ConclusionsFingolimod promotes anti-inflammatory cytokine profiles of B and T cells, through induction of regulatory B cells. Reduced B cell migration capacity in Fingolimod-treated patients leading to decreased cerebral inflammatory infiltration, may be part of the mechanism by which Fingolimod reduces disease activity in MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

TLR-2 and TLR-4 agonists favor expansion of CD4+ T cell subsets implicated in the severity of neuromyelitis optica spectrum disorders
ConclusionsIn summary, our data suggest that microbial antigens may affect NMOSD outcomes by favoring an imbalance between Th17 and TFH-like cells and regulatory T cell subsets. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

The effect of cycling using active-passive trainers on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe Multiple Sclerosis (MS); a feasibility study.
Publication date: Available online 18 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): A. Barclay, L. Paul, N. MacFarlane, A.K. McFadyenAbstractBackground: Exercise options for those with moderate to high levels of disability are limited. The aim of the study was to evaluate the feasibility of a progressive, four week lower limb cycling programme using active-passive trainers (APT's) on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe MS.Methods: Participants were in-patients in the Physical Disability Rehabilitation Unit, Queen Elizabeth University Hospi...
Source: Multiple Sclerosis and Related Disorders - June 19, 2019 Category: Neurology Source Type: research

Multiple sclerosis and Fabry disease - diagnostic “mixup”
Publication date: Available online 15 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Miljenka-Jelena Jurašić, Vanja Bašić Kes, Iris ZavoreoAbstractA common disease like multiple sclerosis (MS) usually dominates the arena of demyelinating disorders; however, when a red flag such as a first relative family history of neurologic disease other than MS is present, the diagnostics may be more challenging.Recently, we have come across an intriguing clinical and diagnostic dilemma requiring extensive literature search and finally, decision making. Namely, initial presentation in our patient was...
Source: Multiple Sclerosis and Related Disorders - June 16, 2019 Category: Neurology Source Type: research

Optic neuritis, encephalitis and leptomeningeal enhancement in a patient with anti-MOG antibodies: a case study
Publication date: Available online 14 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Nichola Haddad, Breton Roussel, Ari Pelcovits, Syed Rizvi (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 16, 2019 Category: Neurology Source Type: research

Risk of relapses during pregnancy among multiple sclerosis patients
Publication date: Available online 10 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Raed Alroughani, Saeed Akhtar, Maya Zeineddine, Y. EL Kouzi, N.K. El Ayoubi, Samar F. Ahmed, Raed Behbehani, Samia J. Khoury, Jasem Y. Al-Hashel, Bassem I. YamoutAbstractBackgroundRelapse rate in women with MS is reduced during pregnancy especially in the third trimester according to the previous studies.ObjectivesTo measure the annual relapse rate (ARR) in women with MS during pregnancy.MethodsA retrospective study was conducted using prospectively collected data from two MS registries in Kuwait and Lebanon. Demograph...
Source: Multiple Sclerosis and Related Disorders - June 11, 2019 Category: Neurology Source Type: research

Sirtuins in Multiple Sclerosis: the crossroad of neurodegeneration, autoimmunity and metabolism
Publication date: Available online 9 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Forough Foolad, Fariba Khodagholi, Mohammad JavanAbstractMultiple Sclerosis (MS) is a challenging and disabling condition particularly in the secondary progressive (SP) phase of this disease. The available treatments cannot ameliorate or stop disease progression in this phase, and there is an urgent need to focus on effective therapies and the molecular pathways involved SPMS. Given the significant impact of neurodegeneration, autoimmunity and metabolic alterations in MS, focusing on the molecules that target these diff...
Source: Multiple Sclerosis and Related Disorders - June 10, 2019 Category: Neurology Source Type: research

Multiple sclerosis national registry system in Iran: Validity and reliability of a minimum data set
ConclusionThe use of standardized validated minimum data set has the potential to enable the researchers and policy-makers to systematically compare and analyze patient information. The Persian version of the minimum data set found to be valid and reliable in Iran. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 10, 2019 Category: Neurology Source Type: research

The effects of a combination of ion channel inhibitors on pathology in a model of demyelinating disease
ConclusionOur findings suggest that excess Ca2+ influx contributes to protein nitration, and associated changes to OPC densities and Node of Ranvier structure in demyelinating disease. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 10, 2019 Category: Neurology Source Type: research

Severe cutaneous adverse event in a daclizumab-treated multiple sclerosis patient
Publication date: Available online 8 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Johannis A van Rossum, Marieke A.D. Peters, Paul van der Valk, Brigit A. de Jong (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 8, 2019 Category: Neurology Source Type: research

B Cell Depletion and Pregnancy: Review and applications for MS treatment
Publication date: Available online 6 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Suma Shah, Christopher EcksteinAbstractMultiple sclerosis (MS) is a chronic autoimmune condition primarily affecting young adults. As there are numerous uncertainties faced by young women of childbearing age who are living with this chronic condition and the gender ratio is increasingly skewed towards women, it has become critical to define a clear approach to questions of disease management prior to and during pregnancy. With the approval of B cell depletion therapy for treatment of relapsing remitting and primary prog...
Source: Multiple Sclerosis and Related Disorders - June 7, 2019 Category: Neurology Source Type: research

Emotional Expressions associated with Therapeutic Inertia in Multiple Sclerosis Care
Publication date: Available online 4 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Gustavo Saposnik, Jiwon Oh, Maria A. Terzaghi, Pawel Kostyrko, Fabien Bakdache, Alonso Montoya, Blessing N.R. Jaja, Rosane Nisenbaum, Christian C. Ruff, Philippe N. ToblerAbstractBackgroundEmotions play a critical role in our daily decisions. However, it remains unclear how and what sort of emotional expressions are associated with therapeutic decisions in multiple sclerosis (MS) care. Our goal was to evaluate the relationship between emotions and affective states (as captured by muscle facial activity and emotional exp...
Source: Multiple Sclerosis and Related Disorders - June 6, 2019 Category: Neurology Source Type: research

Incidence of pediatric NMOSD and MOG-associated disease in Denmark 2008‒2018: a nationwide, population-based cohort study
Publication date: Available online 5 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Magnus S. Boesen, Poul E.H. Jensen, Alfred P. Born, Melinda Magyari, Anna C. Nilsson, Christina Hoei-Hansen, Morten Blinkenberg, Finn SellebjergAbstractBackgroundThe incidence of pediatric neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease have not been reported previously. Our aim was to estimate the incidence of pediatric NMOSD and the occurrence of anti-MOG antibody-associated disease in Denmark during 2008–18, and to evaluate the diagnostic ...
Source: Multiple Sclerosis and Related Disorders - June 6, 2019 Category: Neurology Source Type: research

Neuromyelitis optica and pregnancy-puerperal cycle
Discussion19 women with 30 pregnancies. In only 8 pregnancies, there were no relapses up to 1 year postpartum, some associated with the use of immunosuppressants and/or human immunoglobulin in immediate delivery. Annualized relapses rates stood out in the puerperal period, especially in the first 3 months postpartum, in relation to before- pregnancy ARR. It was observed that pregnancy also increased functional disability in these women. Gestational complications such as miscarriage have not been shown to be more frequent in pregnant women with NMO than in the general population. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 6, 2019 Category: Neurology Source Type: research

Multiple Sclerosis and Psychosis: A case report
We describe the process which led us to make the diagnosis of Psychotic Disorder due to Medical Condition (Multiple Sclerosis). Because her criminal charges brought significant attention to her case, we also address the difficulty in treating a neurological condition with psychiatric features within the forensic context. Moreover, one of the main concerns of the patient was that Lyme Disease was the correct diagnosis as opposed to MS. We also report the difficulty of treating and initiating successful follow-up for a patient whose paranoia is enabled by the opinions of certain health advocacy groups. (Source: Multiple Scle...
Source: Multiple Sclerosis and Related Disorders - June 4, 2019 Category: Neurology Source Type: research

Complete sequence analysis of human toll-like receptor 3 gene in natural killer cells of multiple sclerosis patients
ConclusionThere appears to be a possible association between the TLR3 missense mutation rs3775291 and multiple sclerosis, which might be attributed to changes in the TLR3 functional properties. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis
ConclusionThe study shows that the perceptual DM capacity is reduced in MS. Moreover, the link between neural mechanisms of perceptual DM and neuropsychiatric symptoms suggests that an impairment in this domain is clinically relevant. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

Access and unmet needs to multiple sclerosis care in a cohort of Argentinean patients
ConclusionThis study showed that MS patients had access barriers to receive MS medication properly, especially those with SRHI (public sector). (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

Five Year Iron Changes in Relapsing-Remitting Multiple Sclerosis Deep Gray Matter Compared to Healthy Controls
ConclusionsThalamic atrophy was the only bulk effect that demonstrated different rates of changes over 5 years compared to age-matched controls. DARE Iron decrease in regions of the caudate, putamen, and thalamus were prominent features in stable RRMS over 5 years. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

The Real-World Effectiveness Of Natalizumab And Fingolimod In Relapsing-Remitting Multiple Sclerosis. An Italian Multicentre Study.
ConclusionsBoth drugs were highly effective in our cohort. Natalizumab proved superior in inducing regression of disability and 2-year-NEDA-3. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

Multiple sclerosis prevalence and incidence in San Vicente del Raspeig, Spain
ConclusionsThe results are consistent with the increased risk of MS in Spain observed over the last three decades, with growing prevalence rates that place the country in the high-risk prevalence zone. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

A narrative to explain worsening secondary progressive multiple sclerosis
Publication date: Available online 30 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Gavin Giovannoni, Chris Hawkes, Jeannette Lechner-Scott, Michael Levy, Emmanuelle Waubant (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

Neurodevelopmental retardation in a baby born to a multiple sclerosis patient being treated with fingolimod
This report is about a female child born to a multiple sclerosis mother who continued fingolimod during her first trimester of pregnancy. The child was born with normal full-term delivery but showed neurodevelopmental retardation in the following years. it is recommended that multiple sclerosis patients undergoing treatment with fingolimod use contraceptive methods for at least two months after discontinuation of the medication. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 31, 2019 Category: Neurology Source Type: research

MOG antibody-associated demyelinating disease mimicking typical multiple sclerosis: a case for expanding anti-MOG testing?
Publication date: Available online 28 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Marianthi Breza, Georgios Koutsis, John S. Tzartos, Georgios Velonakis, Maria Eleftheria Evangelopoulos, Dimitrios Tzanetakos, Katerina Karagiorgou, Georgia Angelopoulou, Dimitrios Kasselimis, Constantin Potagas, Maria Anagnostouli, Leonidas Stefanis, Constantinos KilidireasAbstractMOG-antibody associated demyelinating disease is a new emerging diagnostic entity. Recently, international recommendations for testing of anti-MOG antibodies were published. Herein, we describe a case of anti-MOG antibody-associated demyelina...
Source: Multiple Sclerosis and Related Disorders - May 29, 2019 Category: Neurology Source Type: research

Long-term disease activity and disability progression in relapsing-remitting multiple sclerosis patients on natalizumab
ConclusionThe results suggest that starting natalizumab early, during active inflammatory disease results in a more favorable outcome. When taking into account early inflammation and the impact of natalizumab on disease activity during the initial treatment phase, a higher than expected proportion of patients showed disability progression. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 29, 2019 Category: Neurology Source Type: research

Subclinical cochlear dysfunction in newly diagnosed relapsing-remitting multiple sclerosis
ConclusionsThis study shows decreased otoacoustic emission amplitudes in untreated multiple sclerosis patients with clinically normal hearing and no brainstem demyelinating plaques, suggesting a subclinical cochlear impairment. This alteration may represent an early sign of peripheral hearing damage, suggesting a role for otoacoustic emissions in the early diagnosis of cochlear dysfunction in multiple sclerosis patients. However, given that otoacoustic emissions primarily reflects cochlear function, and that the wave I of the auditory brainstem responses was spared, the evidence supporting a peripheral involvement of acous...
Source: Multiple Sclerosis and Related Disorders - May 28, 2019 Category: Neurology Source Type: research

Review: Patient-reported outcomes in multiple sclerosis care
Publication date: Available online 27 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Emanuele D'Amico, Rocco Haase, Tjalf ZiemssenAbstractPatient-reported outcomes (PROs) are increasingly used in multiple sclerosis (MS) research and clinical practice for understanding the effects that the disease and its treatments have on patients’ lives. PROs are captured directly from patients and include symptoms, function, health status, and health-related quality of life. No universal guidance on appropriateness of each applied tool exists. However, collecting clear and comprehensive outcome measures represe...
Source: Multiple Sclerosis and Related Disorders - May 28, 2019 Category: Neurology Source Type: research

Susac syndrome: clinical characteristics, diagnostic findings and treatment in 19 Cases
Publication date: Available online 27 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): S. Zengin Karahan, C. Boz, S. Saip, N. Kale, S. Demirkaya, Y. Celik, S. Demir, A. Tuncer, S. Erer Ozbek, M. TerziAbstractSusac's Syndrome (SS), which was first described in 1979, is a rare and presumably autoimmune disorder characterized by encephalopathy, hearing loss, and visual disturbance resulting from branch retinal artery occlusion (BRAO). This sudy reports 19 SS patients’ clinical characteristics, MRI features, CSF analysis, treatment strategies and outcomes. At initial presentation, only three of 19 patie...
Source: Multiple Sclerosis and Related Disorders - May 28, 2019 Category: Neurology Source Type: research

Gene and environment interplay in cognition: Evidence from twin and molecular studies, future directions and suggestions for effective candidate gene x environment (cGxE) research
Publication date: Available online 25 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Anam Hasan, Mohammad AfzalAbstractLast decade of molecular research in the field of cognitive science has shown that no single approach can give satisfactory results as far as gene hunt is concerned. Cohesive theory of gene-environment interaction seems to be a rational idea for bridging the gap in our knowledge of disorders involving cognitive deficit. It may even be helpful to some extent in resolving issues of missing heritability. We review the current state of play in the area of cognition at genetic and environmen...
Source: Multiple Sclerosis and Related Disorders - May 27, 2019 Category: Neurology Source Type: research

Switching for convenience from first-line injectable treatments to oral treatments in multiple sclerosis: data from a retrospective cohort study
Publication date: Available online 25 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Géraldine Buard, Jonathan Giovannelli, Olivier Outteryck, Nawal Hadhoum, Julien Lannoy, Patrick Vermersch, Hélène Zéphir (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 25, 2019 Category: Neurology Source Type: research

Long-term outcomes with teriflunomide in patients with clinically isolated syndrome: Results of the TOPIC extension study
Conclusions: Reduced risk of relapse determining conversion to CDMS in patients with early MS receiving teriflunomide 14 mg in the core study remained throughout the extension supporting the benefits of early treatment. No new safety signals were observed for teriflunomide 7 or 14 mg. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 25, 2019 Category: Neurology Source Type: research

Higher satisfaction and adherence with glatiramer acetate 40 mg/mL TIW vs 20 mg/mL QD in RRMS
Publication date: August 2019Source: Multiple Sclerosis and Related Disorders, Volume 33Author(s): Gary Cutter, Antonella Veneziano, Augusto Grinspan, Mahir Al-Banna, Alexey Boyko, Maria Zakharova, Eva Maida, Marija Bosnjak Pasic, Sanjay K. Gandhi, Robin Everts, Cinzia Cordioli, Silvia RossiAbstractBackgroundPatients who perceive their medication to be ineffective or inconvenient are less likely to be adherent to treatment, with potentially significant consequences on long-term clinical outcomes. Many patients with multiple sclerosis (MS) are nonadherent to treatment despite demonstrated efficacy of disease-modifying thera...
Source: Multiple Sclerosis and Related Disorders - May 25, 2019 Category: Neurology Source Type: research

Efficacy and tolerability of azathioprine for neuromyelitis optica spectrum disorder: a systematic review and meta-analysis
ConclusionAZA improves relapses and disability in patients with NMOSD but this regimen is associated with relatively frequent adverse events based on limited published evidences. More well-conducted clinical trials are necessary to establish with certainty the beneficial and harmful effects of AZA in patients with NMOSD. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 23, 2019 Category: Neurology Source Type: research

Susceptibility-weighted imaging in the differential diagnosis of autoimmune central nervous system vasculitis and multiple sclerosis
Publication date: Available online 23 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Xuehong Huang, Tingting Lu, Zhuoxin Guo, Lei Wei, Shaoqiong Chen, Wei Qiu, Zhengqi LuAbstractObjectivesTo determine the differentiating features of autoimmune central nervous system (CNS) vasculitis and multiple sclerosis (MS) on susceptibility-weighted imaging (SWI).MethodsSeventy-three patients (27 with autoimmune CNS vasculitis and 46 with MS) who underwent magnetic resonance imaging with SWI sequence were included. The features of lesions and distinct SWI findings were investigated in both diseases.ResultsOn SWI, au...
Source: Multiple Sclerosis and Related Disorders - May 23, 2019 Category: Neurology Source Type: research

Caesarean section and infant formula feeding are associated with an earlier age of onset of multiple sclerosis
Publication date: Available online 21 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Gloria Dalla Costa, Marzia Romeo, Federica Esposito, Francesca Sangalli, Bruno Colombo, Marta Radaelli, Lucia Moiola, Giancarlo Comi, Vittorio MartinelliAbstractMode of delivery and lactation are among the earliest factors influencing gut microbiota composition and potentially MS risk, but their contribution to MS susceptibility has been controversial. We investigated whether these factors could influence age at MS onset (AAO) on 2055 RRMS patients (mean age 28.4 years). Patients born by means of a caesarean section (10...
Source: Multiple Sclerosis and Related Disorders - May 22, 2019 Category: Neurology Source Type: research

Profile of Polish patients with primary progressive multiple sclerosis
ConclusionsPPMS occurs in about 10% of Polish patients with multiple sclerosis, and the first symptoms appear at around 40 years of age with the same frequency in both sexes. PPMS diagnosis takes more than twice the time for RRMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 22, 2019 Category: Neurology Source Type: research

Neuromyelitis Optica Testing and Treatment: Availability and Affordability in 60 Countries
Publication date: Available online 22 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Kathryn Holroyd, Andre Vogel, Kat Lynch, Brittany Gazdag, Matthew Voghel, Nicholas Alakel, Bryan N. Patenaude, Horacio Chiong-Rivero, Farrah J. MateenAbstractBackgroundWe characterize the variations in availability and affordability of NMO diagnostic testing and treatment by geographic region and country-level income group.MethodsA structured survey was distributed in English, French, and Spanish, in late 2018 to neurologists and other physicians who encounter NMO patients.ResultsRespondents (response rate 45%, 64/...
Source: Multiple Sclerosis and Related Disorders - May 22, 2019 Category: Neurology Source Type: research

Illegal cannabis use is common among Danes with multiple sclerosis
ConclusionThis study shows that illegal cannabis use is common among Danes with MS as only 21% of the current cannabis users received prescribed cannabis-based medicine. Current cannabis users reported high efficacy in relieving pain, spasticity and sleep disturbances. In addition, only mild to moderate severity of adverse effects were reported. To the best of our knowledge, this is the most comprehensive survey of cannabis use among MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 17, 2019 Category: Neurology Source Type: research

THE ARGENTINEAN MULTIPLE SCLEROSIS REGISTRY (RelevarEM): METHODOLOGICAL ASPECTS AND DIRECTIONS
ConclusionRelevarEM is the first MS nationwide registry in Argentina, as well as in LATAM, with the objective of providing reliable real-world data of MS in the country. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 16, 2019 Category: Neurology Source Type: research