Differential diagnosis of multiple sclerosis and other inflammatory CNS diseases
Publication date: Available online 15 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Paula Wildner, Mariusz Stasiołek, Mariola MatysiakAbstractMultiple sclerosis (MS) is the most common acquired demyelinating disorder of the central nervous system (CNS). Diagnosing MS can be very challenging owing to its variable clinical features and lack of specific tests. Magnetic resonance imaging (MRI) is a key measure in this process. Although white matter lesions on brain MRI are regarded as a hallmark of MS, they are a common radiological finding and their pattern may overlap in particular CNS inflammatory ...
Source: Multiple Sclerosis and Related Disorders - October 17, 2019 Category: Neurology Source Type: research

Effects of aging on finger movements in multiple sclerosis
ConclusionFinger motor performance assessment provides important hints about upper limb disability, which should be evaluated in relation to age, disease duration and EDSS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

Neuromyelitis Optica Spectrum Disorder after treatment with pembrolizumab
Publication date: Available online 14 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Tomoyo Shimada, Yasunobu Hoshino, Taiji Tsunemi, Anri Hattori, Emi Nakagawa, Kazumasa Yokoyama, Nobutaka HattoriAbstractWhile immune checkpoint inhibitors (ICIs) have contributed to the development of therapeutic treatments for previously incurable advanced malignancies, they may induce immune-related adverse events (irAEs) in many organs including the CNS [1]. Because immune checkpoint molecules are predominantly expressed on T cells, irAEs are largely not B cell-mediated. Here, we report a patient who was treated ...
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

Optic perineuritis with anti-myelin oligodendrocyte glycoprotein antibody
Publication date: Available online 14 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): M. Yanagidaira, T. Hattori, H. Emoto, M. Kiyosawa, T. YokotaAbstractA 25-year-old male presented with blurred peripheral vision and movement pain in his right eye. Fundus examination revealed unilateral disc swelling in his right eye with normal intracranial pressure. MRI showed remarkably high intensity in the optic nerve sheath and slightly high intensity in the optic nerve, indicating optic perineuritis (OPN). Anti-myelin oligodendrocyte glycoprotein (MOG) antibody was positive in both serum and cerebrospinal flu...
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

Impairments of humour comprehension in multiple sclerosis
ConclusionThese preliminary results suggest that a high proportion of relapsing-remitting multiple sclerosis patients may be impaired in humour comprehension, some as a primary deficit and others as a secondary deficit to more general comprehension difficulties. On a theoretical level, the dissociations obtained between verbal and visual material do not support an amodal humour comprehension model. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

Initiation of rituximab therapy for new onset neuromyelitis optica spectrum disorder during pregnancy
ConclusionThis case demonstrated a favorable outcome in administering rituximab for NMOSD with disease onset during pregnancy. This description of therapy for disease onset during pregnancy is novel, and adds to the few existing case reports of administering rituximab during pregnancy. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

Gender Identity and Sexual Orientation Affect Healthcare Satisfaction, but not Utilization, in Persons with Multiple Sclerosis
Publication date: Available online 12 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Shahin Khayambashi, Amber Salter, Tuula Tyry, Gary R Cutter, Robert J Fox, Ruth Ann MarrieAbstractObjectiveWe aimed to determine the association between gender identity and sexual orientation on healthcare-related utilization in persons with multiple sclerosis (MS), as well as satisfaction with their doctor and comfort discussing sexual health with their doctor.MethodsWe surveyed participants from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry regarding their gender identity and sexua...
Source: Multiple Sclerosis and Related Disorders - October 14, 2019 Category: Neurology Source Type: research

The effect of galanin gene polymorphism rs948854 on the severity of multiple sclerosis: a significant association with the age of onset.
Conclusion: Collectively, our data support the contribution of galanin gene polymorphism rs948854 to the mechanisms of adverse course of the disease in the late onset MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 11, 2019 Category: Neurology Source Type: research

IRAK1 polymorphisms are associated with susceptibility to neuromyelitis optica spectrum disorder
ConclusionsThis study is first to demonstrate that X-chromosome-linked IRAK1 polymorphisms are associated with the risk of NMOSD and provide novel insights into the underlying mechanisms of this disease. Further studies are needed to elucidate the function of IRAK1 variants in the pathogenesis of NMOSD and the underlying molecular mechanisms. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 11, 2019 Category: Neurology Source Type: research

Progressive sensorineural hearing loss many years preceding completion of Susac's syndrome triad: A case report
We report a 7-year-old girl who presented with chronic, progressive sensorineural hearing loss, who, years later, presented with encephalopathy and vision loss. Such prolonged period between symptoms is unusual and to our knowledge, this is the longest interval between onset of hearing loss and completion of the full triad in SuS. In addition, she had a protracted disease course, requiring multiple immune therapies for disease control. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 9, 2019 Category: Neurology Source Type: research

Skin Warts during Fingolimod Treatment in Patients with Multiple Sclerosis
Conclusions: In conclusion, we report five patients who developed skin warts during fingolimod therapy, especially HPV-related, for an overall incidence of 2.2%. Larger cohorts are needed to confirm this proposed higher susceptibility of fingolimod-treated patients to HPV infections. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 9, 2019 Category: Neurology Source Type: research

Clinical characteristics and use of disease modifying therapy in the nationwide Danish cohort of paediatric onset multiple sclerosis
Publication date: Available online 8 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Julie Laub Erdal, Tine Iskov Kopp, Morten Blinkenberg, Thor Petersen, Per Soelberg Sørensen, Melinda MagyariAbstractBackgroundSeveral disease-modifying therapies (DMT) are used in paediatric patients with multiple sclerosis (MS) despite the limited number of randomised controlled clinical trials leading to approved indication in children.ObjectivesThe aim of this study was to describe clinical characteristics of the Danish population of paediatric onset MS, and the patterns of DMT utilisation in patients who s...
Source: Multiple Sclerosis and Related Disorders - October 9, 2019 Category: Neurology Source Type: research

Spinal cord infarction in a patient with multiple sclerosis
We describe a 49 year old woman with relapsing-remitting multiple sclerosis (MS) with a suspected severe recurrent attack of myelitis that was ultimately diagnosed as a spinal cord infarction (SCI). This case of SCI in a patient with an established diagnosis of MS highlights the clinical, laboratory, and radiographic characteristics that help distinguish SCI from inflammatory myelitis due to MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 8, 2019 Category: Neurology Source Type: research

Subcortical Structural Abnormalities in Female Neuromyelitis Optica Patients with Neuropathic Pain
Publication date: Available online 5 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ting Wang, Zhiyun Lian, Xi Wu, Yazhuo Kong, Dr Hongyu Zhou, Min WeiAbstractNeuromyelitis optica (NMO) is a disease characterised by severe relapses of optic neuritis and longitudinally extensive transverse myelitis and it has a strong female predilection. Pain is one of the most typical symptom in NMO. However, few studies have been conducted to examine the neuropathic pain mechanism of NMO patients or gender-specific effects using magnetic resonance imaging technique. A total of 38 female patients with NMO, 28 with ...
Source: Multiple Sclerosis and Related Disorders - October 6, 2019 Category: Neurology Source Type: research

The Relation between Memory and Decision-Making in Multiple Sclerosis Patients
Conclusions. Taken together, our study suggests that the memory problems, frequently reported in MS patients, may reach out to higher-order cognitive functions, such as decision making skills. Supporting shared decision-making and patient autonomy within MS thus requires to take memory impairments into account and to match the information provided to the patient’s memory abilities. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 6, 2019 Category: Neurology Source Type: research

A-scan ultrasonography as a supportive diagnostic tool in case of acute optic neuritis
Publication date: Available online 5 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Maddalena De Bernardo, Livio Vitiello, Nicola Rosa (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 6, 2019 Category: Neurology Source Type: research

Efficacy of different rituximab therapeutic strategies in patients with neuromyelitis optica spectrum disorders
Publication date: Available online 4 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Giovanni Novi, Francesca Bovis, Marco Capobianco, Jessica Frau, Giorgia Mataluni, Erica Curti, Luigi Zuliani, Paola Cavalla, Laura Brambilla, Pietro Annovazzi, Anna Maria Repice, Roberta Lanzillo, Sabrina Esposito, Luana Benedetti, Ilaria Maietta, Francesco Sica, Fabio Buttari, Simona Malucchi, Giuseppe Fenu, Doriana LandiAbstractObjectiveTo evaluate disease activity according to rituximab (RTX) induction and maintenance regimens in a multicenter real-life dataset of NMOSD patients.Methodsthis is an observational-ret...
Source: Multiple Sclerosis and Related Disorders - October 5, 2019 Category: Neurology Source Type: research

School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis: A nationwide population-based cohort study
Publication date: Available online 3 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Magnus Spangsberg Boesen, Annika Langkilde, Alfred Peter Born, Melinda Magyari, Morten Blinkenberg, Tanuja Chitnis, Lau Caspar Thygesen, Frank ErikssonAbstractBackgroundAcute disseminated encephalomyelitis (ADEM) can cause cognitive impairment in children. However, long-term consequences for school performance and psychiatric morbidity have never been characterized. Our aim was to investigate long-term school performance and psychiatric morbidity after pediatric ADEM (
Source: Multiple Sclerosis and Related Disorders - October 4, 2019 Category: Neurology Source Type: research

Rituximab Associated Necrosis: A Case Report
ConclusionThe present case raises the possibility of anti-CD20 antibody contributing to the development of palatal mucosal necrosis in some patients. Given the increasing administration of rituximab as a result of its efficacy against several diseases, a report on the potential iatrogenic effects of this drug is essential. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 4, 2019 Category: Neurology Source Type: research

The Multiple Sclerosis Gut Microbiota: A Systematic Review
Conclusion: Gut microbiota diversity did not differ between MS cases and controls in the majority of studies. However, taxonomic differences were found, with consistent patterns emerging across studies. Longitudinal studies are warranted to elucidate the relationship between IMD exposure and differences in the gut microbiota composition. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 4, 2019 Category: Neurology Source Type: research

Vascular malformations masquerading as demyelinating disease
Publication date: Available online 1 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Gabriel Lupu (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Incident cardiovascular disease in patients diagnosed with multiple sclerosis: a multi-database study
ConclusionMS patients in the UK and the US have increased risk of venous thromboembolism and peripheral vascular disease. The risk of myocardial infarction is increased among female MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Correlation between EDSS scores and cervical spinal cord atrophy at 3T MRI in multiple sclerosis: A systematic review and meta-analysis
Publication date: Available online 1 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Xiaodong Song, Dawei Li, Zhandong Qiu, Shengyao Su, Yan Wu, Jingsi Wang, Zheng Liu, Huiqing DongAbstractBackgroundCervical spinal cord atrophy (CSCA), which partly reflects the axonal loss in the spinal cord, is increasingly recognized as a valuable predictor of disease outcome. However, inconsistent results have been reported regarding the correlation of CSCA and clinical disability in multiple sclerosis (MS). The aim of this meta-analysis was to synthesize the available data obtained from 3.0-Tesla (3T) MRI scanner...
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Fatigue scores correlate with other self-assessment data, but not with clinical and biomarker parameters, in CIS and RRMS
ConclusionsIn this cohort of patients with newly diagnosed CIS and RRMS, fatigue scores were associated with mood, disease impact on daily life and quality of life as well as with alterations of attentive functions. Study results indicate that subjective fatigue scores are not well reflected by some commonly used and objectively measurable disease parameters like EDSS, T2 lesions and NFL levels. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Grassroot efforts towards diversity in MS care and research: win-win for patients and science
Publication date: Available online 2 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Emmanuelle Waubant, Michael Levy, Jeannette Lechner-Scott, Gavin Giovannoni, Christopher Hawkes (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

TNFRSF13C/BAFFR P21R and H159Y polymorphisms in multiple sclerosis
Publication date: Available online 30 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Panagiotis Ntellas, Efthimios Dardiotis, Eirini Sevdali, Vasileios Siokas, Athina-Maria Aloizou, Gerasimina Tsinti, Anastasios E. Germenis, Georgios M Hadjigeorgiou, Hermann Eibel, Matthaios SpeletasABSTRACTRecent studies implicate B cells in multiple sclerosis (MS) pathogenesis, and consequently, several molecules participating in B cell survival and proliferation, including B-cell activating factor (BAFF), have recently been analyzed in MS patients. BAFF mediates its function through binding to three receptors; ...
Source: Multiple Sclerosis and Related Disorders - October 1, 2019 Category: Neurology Source Type: research

Psoriasis in family members of patients with multiple sclerosis
ConclusionFamily members of those with MS may be at greater risk of developing psoriasis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 1, 2019 Category: Neurology Source Type: research

Commentary re: Multiple sclerosis and psychosis: A case report. Cheema J, Huyh AC, Prat SS. 2019 Jun 3;34:158–161
Publication date: November 2019Source: Multiple Sclerosis and Related Disorders, Volume 36Author(s): Rosalie Greenberg (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 1, 2019 Category: Neurology Source Type: research

Clinical observation during alemtuzumab administration
Publication date: Available online 25 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Christopher M Allen, Jenny J Feng, Mark D Willis, Marisa McGinley, Daniel Ontaneda, Emma C Tallantyre, Nikos Evangelou (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 29, 2019 Category: Neurology Source Type: research

Evaluating the Efficacy and Safety of ZytuxTM (Rituximab, AryoGen Pharmed) in Iranian Multiple Sclerosis Patients: An observational Study
Conclusion: The observed results revealed that the ZytuxTM could have a positive and significant effect on all types of MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Long-term outcome and prognosis in patients with neuromyelitis optica spectrum disorder from serbia
ConclusionOur results support the benefits of early diagnosis and treatment of NMOSD, especially in persons with severe optic and spinal disability at onset. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Transient MOG antibody seroconversion associated with immunomodulating therapy
We present the case of a 35-year-old patient who was seronegative for MOG-IgG (as confirmed by means of three independent immunoassays) during two corticosteroid-responsive attacks of brainstem encephalitis and optic neuritis, respectively, but turned positive for MOG-IgG under treatment with interferon-beta (IFN-beta), which was commenced 6 months after onset of the first attack. MOG-IgG serum levels declined after therapy was switched to glatiramer acetate. The fact that seroconversion was first observed under treatment with IFN-beta is in accordance with previous evidence suggesting a role of IFN-beta in disease exacerb...
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Role of B cells and Antibodies in Multiple Sclerosis
Publication date: Available online 26 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Pitchaya Wanleenuwat, Piotr IwanowskiAbstractMultiple sclerosis (MS) is a chronically progressive auto-immune mediated inflammatory demyelinating disease of the central nervous system (CNS) which manifests as disturbances in sensorimotor function and cognitive impairment. Although believed to be a T-cell mediated disease, the role of B cells has recently become a central issue in MS pathogenesis. Both antibody dependent and independent theories have been suggested to play a role in the initiation of inflammatory d...
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

The correlation between dyslipidemia and cognitive impairment in multiple sclerosis patients
DiscussionOur findings proposed a possible correlation between the increased serum LDL cholesterol, serum total cholesterol and cognitive dysfunction among MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Magnetic Resonance Imaging Markers of Disability in Egyptian Multiple Sclerosis Patients
ConclusionThis is the first Egyptian study to show that infratentorial lesions, confluent brain lesions and T1 hypointense lesions are conventional MRI parameters that correlate with the degree of disability in Egyptian MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Retinal nerve fiber layer thickness associates with cognitive impairment and physical disability in multiple sclerosis
Publication date: Available online 26 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ulrika Birkeldh, Ali Manouchehrinia, Max Albert Hietala, Jan Hillert, Tomas Olsson, Fredrik Piehl, Ingrid Kockum, Lou Brundin, Ori Zahavi, Marika Wahlberg-Ramsay, Rune Brautaset, Maria NilssonABSTRACTBackgroundReductions of the peripapillary retinal nerve fiber layer (pRNFL) thickness has been indicated even in early-stages of multiple sclerosis (MS). The aim was to investigate the association between pRNFL thickness, measured with optical coherence tomography (OCT), and physical disability and cognitive impairmen...
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

False memories in relapsing remitting multiple sclerosis patients: a preliminary investigation with the DRM paradigm
ConclusionWe found a reduced susceptibility to false memories in RRMS patients compared to HCs. The potential mechanisms underlying this effect are discussed in light of the alterations in the structure of semantic memory. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Title: Clinical observation during alemtuzumab administration
Publication date: Available online 25 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Christopher M Allen, Jenny J Feng, Mark D Willis, Marisa McGinley, Daniel Ontaneda, Emma C Tallantyre, Nikos Evangelou (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 26, 2019 Category: Neurology Source Type: research

Predictors of Vocational Status Among Persons with Multiple Sclerosis
ConclusionsPhysical disability, depressive symptoms, and reduced information processing affect work-related disability and vocational status among PwMS. Interventions targeting these factors should be prioritized by clinicians. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 26, 2019 Category: Neurology Source Type: research

Randomized-controlled trial of a modified Mediterranean dietary program for multiple sclerosis: a pilot study
Publication date: Available online 24 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ilana Katz Sand, Emma KT Benn, Michelle Fabian, Kathryn C. Fitzgerald, Elise Digga, Richa Deshpande, Aaron Miller, Samantha Gallo, Lenore ArabAbstractBackgroundThere is a high level of interest in the potential role of diet among the MS community. There is a limited level of evidence for a Mediterranean-style dietary pattern in MS; the feasibility of conducting studies using educational tools to deliver this type of intervention and study its effects is unknown.ObjectivesTo establish clinical trial feasibility for...
Source: Multiple Sclerosis and Related Disorders - September 25, 2019 Category: Neurology Source Type: research

Leptin rs7799039 polymorphism is associated with Multiple Sclerosis risk in Kuwait
ConclusionLEP rs7799039AA is a risk factor for MS in our Kuwaiti population, and leptin levels are lower in MS patients compared to healthy controls. Our findings suggest future studies must consider all factors influencing leptin levels to resolve its controversial involvement in MS pathogenesis or progression. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 25, 2019 Category: Neurology Source Type: research

Early initiation of fingolimod reduces the rate of severe relapses over the long term: Post hoc analysis from the FREEDOMS, FREEDOMS II, and TRANSFORMS studies
The objective of this study was to report the effect of early initiation of fingolimod on relapse severity in patients with RRMS.MethodsThis is a post hoc descriptive analysis of data from the pooled placebo-controlled FREEDOMS/FREEDOMS II studies and from the active-comparator TRANSFORMS study. Patients were analyzed under 2 groups: patients initially randomized to receive fingolimod 0.5 mg during the core phase and continued fingolimod 0.5 mg in the extension phase (immediate fingolimod group), and patients initially randomized to placebo or IFN β-1a during the core phase and switched to fingolimod during the exte...
Source: Multiple Sclerosis and Related Disorders - September 25, 2019 Category: Neurology Source Type: research

The Norwegian translation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS)
Publication date: Available online 21 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ellen Skorve, Astri J. Lundervold, Øivind Torkildsen, Kjell-Morten MyhrAbstractBackgroundCognitive impairment is a common symptom in all stages of multiple sclerosis (MS), yet it is underreported and not routinely evaluated. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) is a short and easily administered test battery for screening of cognitive impairment in MS that can be completed within 15 minutes and incorporated into routine clinical practice. The test battery consists of ...
Source: Multiple Sclerosis and Related Disorders - September 22, 2019 Category: Neurology Source Type: research

Commentary re: Multiple Sclerosis and psychosis: A case report. Cheema J, Huyh AC,, Prat SS. 2019 Jun 3;34:158-161.
Publication date: Available online 21 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Dr Rosalie Greenberg (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 22, 2019 Category: Neurology Source Type: research

Handedness and potential implications for neurorehabilitation in multiple sclerosis
Publication date: Available online 19 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Afsaneh Shirani, Darin T. Okuda (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 20, 2019 Category: Neurology Source Type: research

Long noncoding RNAs associated with phenotypic severity in multiple sclerosis
ConclusionsThis study is the first to investigate possible lncRNA biomarkers to differentiate phenotypic severity in MS. Although the findings are preliminary based on our small sample size, they are sufficient to identify hypotheses for future investigation, and give guidance regarding the design of future studies. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 20, 2019 Category: Neurology Source Type: research

Expert opinion: criteria for second-line treatment failure in patients with multiple sclerosis
ConclusionsExperts compared therapeutic attitudes and practices regarding second-line treatment failure between French regions. They identified convergences that were used to propose a national agreement on second-line treatment failure criteria, which should be evaluated in real-life prospective cohorts. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 20, 2019 Category: Neurology Source Type: research

Examining the validity of the Multiple-Sclerosis Walking Scale-12 with Rasch analysis: Results from an Italian study
Publication date: Available online 19 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): D Marengo, R Rosato, G Gamberini, P Cavalla, M Gironi, F Patti, L Prosperini, C SolaroAbstractBackgroundThe Multiple Sclerosis Walking Scale (MSWS-12) has showed good psychometric properties in reports exploring its validity using Classical Test Theory methods. Findings from recent studies using Item Response Theory methods advance the idea that some aspects of the MSWS-12 does not fully comply with some requirements of sound measurement.Research questionThe present study investigated whether the measurement prope...
Source: Multiple Sclerosis and Related Disorders - September 20, 2019 Category: Neurology Source Type: research

Rituximab-induced serum sickness in multiple sclerosis patients
Publication date: Available online 17 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Andrew B. Wolf, Lana Zhovtis Ryerson, Krupa Pandey, Brett M. McGettigan, Timothy Vollmer, John R. Corboy, Enrique AlvarezAbstractRituximab is a chimeric anti-CD20 monoclonal antibody that is an effective therapy for multiple sclerosis. Rituximab has been associated with the development of serum sickness (type III hypersensitivity) characterized by arthralgia, fever, and rash during the treatment of other conditions, such as rheumatoid arthritis. Here we describe serum sickness associated with rituximab in multiple...
Source: Multiple Sclerosis and Related Disorders - September 19, 2019 Category: Neurology Source Type: research

Epilepsy in multiple sclerosis as a network disease
Publication date: Available online 17 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mihaela Bustuchina VlaicuAbstractThis is a review paper, essentially a commentary with summary of literature that actualizes the problem of epilepsy in patients with multiple sclerosis. There is a bidirectional relation between multiple sclerosis and epilepsy. A possible associate pathophysiological pathway is considered. In multiple sclerosis, a combination of grey matter involvement and inflammation could influence epileptogenesis. Patients with multiple sclerosis have individual profiles and an inter-individual...
Source: Multiple Sclerosis and Related Disorders - September 19, 2019 Category: Neurology Source Type: research