Immunoglobulin G Index as A Biomarker of Relapse Response to Corticosteroids during Early Stages of Multiple Sclerosis
Publication date: Available online 6 November 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Farouk Talaat, Eman HamdyAbstractBackgroundDespite the considerable advances in disease modifying therapy in multiple sclerosis (MS), management of acute MS relapses remains understudied. The response to relapse therapy is heterogenous among patients, and the exact reason behind such response remains elusive. Identification of a reliable biomarker for relapse responsiveness would contribute considerably to optimizing the relapse outcome.Objectivesto explore whether the immunoglobulin G (IgG) index during acute relap...
Source: Multiple Sclerosis and Related Disorders - November 7, 2019 Category: Neurology Source Type: research

Cognitive Performance and Cognitive Workload in Multiple Sclerosis: Two Different Constructs of Cognitive Functioning?
ConclusionCognitive performance and cognitive workload seem to measure different cognitive constructs of cognitive functioning in MS. Our results suggest that iwMS+ do not show effective allocation of cognitive resources to compensate for deteriorated performance in cognitive tests. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 7, 2019 Category: Neurology Source Type: research

Olfactory identification associates with cognitive function and the third ventricle width in patients with relapsing-remitting multiple sclerosis
ConclusionsOur results suggest that olfactory identification impairment occurs in association with cognitive dysfunction and central brain atrophy. Thus, olfactory identification is a possible disease marker of RRMS as with cognitive impairment, especially PS, reflecting the diffuse neurodegeneration in RRMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 7, 2019 Category: Neurology Source Type: research

Alemtuzumab treatment of multiple sclerosis in real-world clinical practice: a report from a single Italian center.
ConclusionsIn a real-world MS population like the one investigated in our study, alemtuzumab was found to be an effective treatment when employed as an escalation or rescue therapy. The compound exhibits a variable safety profile and frequent adverse events that are likely depending on previous treatments and their impact on the immune system. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 7, 2019 Category: Neurology Source Type: research

A Possible Link between Intracranial Lipomas and Localization-related Relapses in Multiple Sclerosis
Publication date: Available online 6 November 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Thomas Mengesha, Natalie Squires, John Oas, Jaime ImitolaAbstractIntracranial lipomas are congenital malformations representing less than 0.5% of intracranial tumors. They are found incidentally and are asymptomatic in the majority of patients. Here we present three patients with Multiple sclerosis (MS) and intracranial lipomas (IL). The patients showed increased flares and burden of disabling and worsening MS symptoms with cognitive, neurovestibular dysfunction, and gait alterations associated with the localization...
Source: Multiple Sclerosis and Related Disorders - November 7, 2019 Category: Neurology Source Type: research

Tumefactive inflammatory leukoencephalopathy in cocaine users: report of three cases
ConclusionsBased on the history and images of our patients and other two similar case reports, we suggest a probable pathophysiological relationship between levamisole-adulterated cocaine use and the occurrence of MIL with atypical demyelinating lesions, even when they present following a BCS imaging pattern. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 5, 2019 Category: Neurology Source Type: research

Risk factors for reactivation of clinical disease activity in multiple sclerosis after natalizumab cessation
Publication date: Available online 5 November 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mustonen Tiina, Rauma Ilkka, Hartikainen Päivi, Krüger Johanna, Niiranen Marja, Selander Tuomas, Simula Sakari, Anne M. Remes, Kuusisto HannaAbstractBackgroundNatalizumab (NTZ) is widely used for highly active relapsing-remitting multiple sclerosis (MS). Inflammatory disease activity often returns after NTZ treatment discontinuation. We aimed to identify predictive factors for such reactivation in a real-life setting.MethodsWe conducted a retrospective survey in four Finnish hospitals. A computer-based sea...
Source: Multiple Sclerosis and Related Disorders - November 5, 2019 Category: Neurology Source Type: research

Anti-myelin oligodendrocyte glycoprotein antibody-positive acute disseminated encephalomyelitis mimicking limbic encephalitis: A case report
We report an atypical case of MOG-ab-associated encephalomyelitis with part of the clinical manifestations resembling limbic encephalitis. Multifocal, hyperintense, bilateral lesions predominantly affecting the white matter on brain magnetic resonance imaging and marked response to steroid therapy were compatible with a MOG-ab-associated disease. This case illustrates that MOG-ab-associated disease should be considered in encephalomyelitis involving the bilateral limbic system. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 5, 2019 Category: Neurology Source Type: research

Prognostic impact of epilepsy in multiple sclerosis
ConclusionEpilepsy in MS is associated with increased mortality although death from epilepsy is rare. Most MS patients with epilepsy died of MS, and epilepsy was most lethal when developed in SPMS. We thus suggest that development of epilepsy is a marker of severe MS. Despite this, we found no association between epilepsy and conversion to SPMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 5, 2019 Category: Neurology Source Type: research

A rare case of aquaporin-4-antibody-positive neuromyelitis optica associated with bladder cancer
ConclusionCase reports on paraneoplastic syndrome associated with cancer increases the knowledge on this topic, especially on rare presentations. Our findings further support that early diagnosis of various paraneoplastic symptoms is critical for patient´s treatment and prognosis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 5, 2019 Category: Neurology Source Type: research

Responder Rates to Fampridine Differ between Clinical Subgroups of Ms Patients and Patient Reported Outcome Influences Treatment Decision Making
Publication date: Available online 5 November 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): C.E.P. van Munster, L. Kaya, K.H. Lam, N.F. Kalkers, J. Killestein, B.M.J. UitdehaagABSTRACTBackgroundFampridine is an effective treatment to improve ambulation for some multiple sclerosis (MS) patients. Remarkable discrepancies exist between responder rates in clinical trials and the proportion of patients continuing treatment in clinical practice. This may be related to clinical phenotypes of MS patients, and the influence of patient reported outcome (PRO) on treatment decision making.Objective: To analyse respond...
Source: Multiple Sclerosis and Related Disorders - November 5, 2019 Category: Neurology Source Type: research

Effects of Inspiratory Muscle Training in Advanced Multiple Sclerosis
This study was a repeated measures within-subject design (before-after trial).. Participants were recruited from a long-term care facility specialized in progressive neurologic conditions. Thirty-six non-ambulatory persons with advanced MS volunteered. Inspiratory muscle exercise using the threshold IMT were performed daily for 10 weeks at 3 sets of 15 repetitions per day. Resistance was progressed weekly based on perceived rate of exertion and symptoms. Primary outcome measures were maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) that were measured at baseline, after 5 and 10 weeks of IMT exercise...
Source: Multiple Sclerosis and Related Disorders - November 2, 2019 Category: Neurology Source Type: research

The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: a systematic review
Conclusion: The existing literature provides preliminary support for the use of a number of nutraceutical interventions in MS. However, sufficiently powered long-term trials are required to expand the currently limited literature and to investigate unexplored nutraceuticals that may target relevant pathways involved in MS such as the gut microbiome and mitochondrial dysfunction. Prospero ID: CRD42018111736. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 2, 2019 Category: Neurology Source Type: research

Interrupting rituximab treatment in relapsing-remitting multiple sclerosis; no evidence of rebound disease activity
ConclusionFindings are consistent with a low rate of RTX interruptions, with pregnancy and adverse events as most frequent reasons. A small proportion of patients switched due to breakthrough disease in context of incomplete B-lymphocyte depletion. Signs of ongoing disease activity in the remaining group was low regardless of whether a new DMT was started. These findings are consistent with a long acting effect of RTX in RRMS and absence of rebound disease activity phenomena upon stopping therapy. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 2, 2019 Category: Neurology Source Type: research

The Priorities of Neurologists for Exercise Promotion in Comprehensive Multiple Sclerosis Care
ConclusionsThis research sets an agenda regarding approaches for exercise promotion among patients with MS through interactions with neurologists in comprehensive care settings. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

The Frequency of Longitudinally Extensive Transverse Myelitis in MS; A Population-Based Study
ConclusionLETM is rare in adult MS myelitis and its presence should prompt evaluation for AQP4-IgG, MOG-IgG or other etiologies. Careful scrutiny of axial images is important as coalescence of multiple short lesions may lead to the artefactual appearance of an LETM. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

Validation of Claims-based Diagnoses of Adult and Pediatric Neuromyelitis Optica Spectrum Disorder and Variations in Diagnostic Evaluation and Treatment Initiation
Conclusion: The ICD-9 code for neuromyelitis optica (NMO) is inaccurate for identification of NMO/NMOSD. Using case-finding algorithms increases the PPV. The initial diagnostic evaluation and treatment of NMOSD differs significantly between children and adults. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

Characteristics and treatment of Multiple Sclerosis-related trigeminal neuralgia: An Italian multi-centre study
ConclusionMS patients with a higher disability at TN onset and with a longer interval between MS and TN onset had differing clinical features and outcomes: pain was more frequently bilateral, surgery was more frequent and anticipated, and preventive medication discontinuation due to pain remission was less common. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

Rebound of multiple sclerosis activity after fingolimod withdrawal due to planning pregnancy: analysis of predisposing factors
We describe a series of cases of rebound syndrome after the cessation of fingolimod due to pregnancy planning.Methods: The clinical and radiological data of 7 MS patients who discontinued fingolimod therapy between May 2012 and March 2018 to plan a pregnancy was analysed.Results: Three (42.8%) of the 7 patients experienced a rebound effect, all of whom became pregnant. During pregnancy, the 3 patients had a mean (SD) of 5.3 (1.3) relapses, and 13 of the 15 relapses were treated with intravenous steroids and/or immunoglobulin. These patients experienced a median increase of 3 points in the Expanded Disability Status Scale (...
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

Introducing Multiple Screener: an unsupervised digital screening tool for cognitive deficits in MS
Conclusions: Performance on an adjusted, digital version of the BICAMS correlates highly with the standard paper-and-pencil based test scores in HCs. Multiple Screener is an unsupervised, digital tool, with available norm scores, ultimately allowing for easy monitoring of cognitive decline in patients with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

HA280 immunoadsorption, an alternative treatment for neuromyelitis optica spectrum disorders?
We report a case of neuromyelitis optica spectrum disorders (NMOSD) with complete loss of vision in the left eye in a patient who was not satisfied with the effect of methylprednisolone therapy, which was improved by HA280 immunoadsorption (IA) therapy. HA280 is a relatively cheaper IA column (made in China) often used in the treatment of rheumatoid immune-related diseases. HA280 can effectively remove inflammatory markers in serum. However, whether the HA280 IA column is suitable for NMOSD is unknown. This case suggests that the HA280 IA column has a potential therapeutic effect on NMOSD and may be an alternative treatmen...
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

The prevalence and types of oral- and pharyngeal-stage dysphagia in patients with demyelinating diseases based on subjective assessment by the study subjects
ConclusionThere is a need for further research, which should include a detailed dysphagia-oriented diagnosis, with a view to gaining a detailed insight into the pathophysiology of deglutition in this group of patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

Evaluating Functional Electrical Stimulation (FES) Cycling on Cardiovascular, Musculoskeletal and Functional Outcomes in Adults with Multiple Sclerosis and Mobility Impairment: A systematic review
ConclusionFindings suggest FES cycle training may reduce CVD risk alongside trends for a reduction in spasticity post training, however the low quality of the literature precludes any definitive conclusions. FES cycle training appears to be well tolerated in PwMS with mobility impairment, with no serious adverse events. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

Mastery is associated with greater physical and mental health-related quality of life in two international cohorts of people with multiple sclerosis
Conclusions: Greater mastery is associated with better physical and mental quality of life. Efforts to improve the sense of self control and agency of people with MS may have benefits for their quality of life, even despite clinical features of the illness. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 1, 2019 Category: Neurology Source Type: research

Conducting Dietary Intervention Trials in People with Multiple Sclerosis: Lessons Learned and a Path Forward
Publication date: Available online 29 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Kathryn C. Fitzgerald, Ilana Katz Sand, Angela Senders, Rebecca Spain, Barbara Giesser, Patrick Sullivan, David J. Baer, Nicholas LaRocca, Kathleen Zackowski, Ellen M. MowryAbstractDisease course in people with multiple sclerosis (MS) is heterogeneous. The impact of dietary and nutritional factors on MS prognosis is of interest to both patients and clinicians; differences in diet are hypothesized to contribute to disease evolution over time. However, studying diet, especially in people with MS, introduces methodolog...
Source: Multiple Sclerosis and Related Disorders - October 30, 2019 Category: Neurology Source Type: research

Clinical and radiological findings of facial paralysis in multiple sclerosis
ConclusionsFP clinically classified as peripheral may be caused by central lesions in the cortex or pons and not only by peripheral facial nerve damage. In MS patients, FP may appear at the onset of the disease and be misdiagnosed as Bell ’s palsy. Clinicians should carefully approach FP diagnosis and perform a brain as well as temporal bone MRI before pursuing pharmacological treatment.Graphical abstract (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 26, 2019 Category: Neurology Source Type: research

Patients’ expectations of autologous hematopoietic stem cell transplantation as a treatment for MS
ConclusionMany MS patients are considering aHSCT as a treatment option, although they think that they are not well-informed regarding aHSCT. They prefer their neurologist as a source of information. Therefore, neurologists should pro-actively inform their patients about the potential benefits and risks of aHSCT to enable them to choose the best treatment option. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 26, 2019 Category: Neurology Source Type: research

Response to Commentary of Shirani and Okuda regarding "Unilateral arm rehabilitation for persons with multiple sclerosis using serious games in a virtual reality approach: Bilateral treatment effect?": Shirani A and Okuda DT. Handedness and potential implications for neurorehabilitation in multiple sclerosis
Publication date: Available online 23 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): J. Jonsdottir, G. Perini, A. Ascolese, T. Bowman, A. Montesano, M. Lawo, R. Bertoni (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 24, 2019 Category: Neurology Source Type: research

Usefulness of Lyso-Globotriaosylsphingosine in Dried Blood Spots in the differential diagnosis between multiple sclerosis and Anderson- Fabry´s disease
Publication date: Available online 23 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Olivera Susana, Iñiguez Cristina, García-Fernández Lorena, Sierra José-Luis, Camón Ana-María, Menao Sebastián, Torralba Miguel-ÁngelAbstractBackgroundThe presence of white mater lesions in the central nervous system forces the differential diagnosis between multiple sclerosis (MS) and Anderson-Fabry disease (FD). Due to the type of inheritance, linked to the X chromosome, the diagnosis of FD is especially difficult in women. Tissue´s deposits of globotria...
Source: Multiple Sclerosis and Related Disorders - October 24, 2019 Category: Neurology Source Type: research

Title: Interrupting rituximab treatment in relapsing-remitting multiple sclerosis; No evidence of rebound disease activity
ConclusionFindings are consistent with a low rate of RTX interruptions, with pregnancy and adverse events as most frequent reasons. A small proportion of patients switched due to breakthrough disease in context of incomplete B-lymphocyte depletion. Signs of ongoing disease activity in the remaining group was low regardless of whether a new DMT was started. These findings are consistent with a long acting effect of RTX in RRMS and absence of rebound disease activity phenomena upon stopping therapy. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 24, 2019 Category: Neurology Source Type: research

Do people with multiple sclerosis want to discuss their long-term prognosis? A nationwide study in Argentina
Publication date: January 2020Source: Multiple Sclerosis and Related Disorders, Volume 37Author(s): Edgar Carnero Contentti, Pablo A. López, Juan Pablo Pettinicchi, Ricardo Alonso, Santiago Tizio, Verónica Tkachuk, Alejandro Caride, Ian GaleaAbstractBackgroundDemographics, clinical and imaging prognostic factors have been reported in large series of people with multiple sclerosis (PwMS). However, personalized long-term prognosis (LTP) is varied and uncertain in each particular case. Currently, there is limited evidence on how PwMS feel about prognosis communication and their coping strategies. Therefore, we a...
Source: Multiple Sclerosis and Related Disorders - October 24, 2019 Category: Neurology Source Type: research

Physical Disability and Personality Traits in Multiple Sclerosis
Publication date: Available online 22 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mar Estrada-López, María Mercedes Reguera-García, Francisco Javier Pérez Rivera, Antonio José Molina (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

Physician Referral Improves Adherence to the Physical Activity Guidelines for Adults with MS: A Randomized Controlled Trial
Publication date: Available online 22 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Karissa L. Canning, Audrey L. HicksAbstractBackgroundCommitment and adherence to community-based physical activity can be a challenge for clinical populations. The aim of this study was to explore the effectiveness of physician referral on adherence to the Physical Activity Guidelines (PAGs) for adults with MS.MethodsNinety-one participants with MS (age: 47.9 ± 10.4 years, EDSS score: 3.5 ± 1.8) were randomized into a direct referral to PAGs from a physician (REF) or control (CON) group (given a print ...
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

Identification of Multiple Sclerosis key genetic factors through multi-staged data mining
Publication date: Available online 22 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mohammad Navaderi, Saeideh Rajaei, Samira Rahimirad, Aysan Jafari Harandi, Zahra Ghaleh, Kowsar Falahati, Zahra Behgar, Alireza Mirzaee Sedigh, Mohammad Hossein Sanati (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

An Uncommon Neurological Manifestation of Chronic Lymphocytic Leukemia: Longitudinally Extensive Transverse Myelitis
We describe a 50-year-old male patient who was admitted to the emergency department with complaints of fever and fatigue that had suddenly started two weeks ago. In the laboratory evaluation, a white blood cell count of 131.000/mm3 was detected. The patient was hospitalized and developed fecal incontinence on the first day of hospitalization. Detailed neurological examination revealed the patient had tetraparesis. Long segment high signal intensity was observed on spinal MRI. Flow cytometry examination of the CSF and biopsy findings of the bone marrow were compatible with Chronic Lymphocytic Leukemia (CLL). The patient's M...
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

CSF β-amyloid predicts early cerebellar atrophy and is associated with a poor prognosis in multiple sclerosis
Publication date: Available online 21 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Anna M. Pietroboni, Francesca Schiano di Cola, Annalisa Colombi, Tiziana Carandini, Chiara Fenoglio, Laura Ghezzi, Milena A. De Riz, Fabio Triulzi, Elio Scarpini, Alessandro Padovani, Daniela GalimbertiAbstractBackgroundNeurodegeneration is present from the earliest stages of multiple sclerosis (MS) and is critically involved in MS related clinical disability. Aim of the present study was to assess the connection between amyloid burden and early cerebellar grey matter (GM) atrophy compared to early brain GM atrophy ...
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

Independent Outdoor Mobility of Persons with Multiple Sclerosis – A systematic review
Conclusions: The reduced mobility may prevent pwMS participating in society. However, few studies investigating interventions or rehabilitation options to improve mobility were found in the existing literature, highlighting an until now under recognised unmet need. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

Neuromyelitis optica spectrum disorders in Arabian Gulf (NMOAG); establishment and initial characterization of a patient registry
Publication date: Available online 19 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Eslam Shosha, Abdulla Al Asmi, Eman Nasim, Jihad Inshasi, Fatima Abdulla, Yaser Al Malik, Ahmed Althobaiti, Mohamed Alzawahmah, Hind A Alnajashi, Mohamed Binfalah, Awad AlHarbi, Ibtisam A. Thubaiti, Samar F Ahmed, Jasem Al-Hashel, Mortada Elyas, Ramachandiran Nandhagopal, Arunodaya Gujjar, Talal Al Harbi, Ghadah Al Towaijri, Isa A AlsharooqiAbstractObjectiveTo describe the clinical and radiological characteristics of neuromyelitis optica spectrum disorders (NMOSD) patients from the Arabian Gulf relative to anti-aqua...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Efficacy of tocilizumab for fulminant multiple sclerosis with a tumefactive cervical lesion: A 12-year-old boy
Publication date: Available online 19 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Hiroki Hoshino, Yoko Shirai, Hiroe Konishi, Takashi Yamamura, Norikazu ShimizuAbstractFulminant demyelinating disease including acute disseminating encephalitis, multiple sclerosis (MS) variants, and neuromyelitis optica spectrum disorder (NMOSD) are often managed with similar acute treatment such as intravenous methylprednisolone and plasma exchange. On the other hand, long-term management varies. The choice of the drug is based on several factors including the activity and severity of the disease course. Tocilizum...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Consensus Recommendations for the Diagnosis and Treatment of Multiple Sclerosis: 2019 revisions to The MENACTRIMS Guidelines
Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): B. Yamout, M. Sahraian, S. Bohlega, M. Al-Jumah, R. Goueider, M. Dahdaleh, J. Inshasi, S. Hashem, I. Alsharoqi, S. Khoury, M Alkhawajah, Riyadh S. Koussa, J. Al Khaburi, A. Almahdawi, T. Alsaadi, E. Slassi, S Daodi, M. Zakaria, R. AlroughaniAbstractWith evolving diagnostic criteria and the advent of new oral and parenteral therapies for MS, most current diagnostic and treatment algorithms need revision and updating. The diagnosis of MS relies on incorporating clinical and paraclinical findings to prove dissemination...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS): A Danish validation study of sensitivity in early stages of MS
Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Lisbet Marstrand, Ole Østerberg, Trine Walsted, Amalie C. Skov, Karen I. Schreiber, Finn SellebjergAbstractBackgroundCognitive impairment is highly prevalent in multiple sclerosis (MS). Due to the lack of specialized neuropsychological resources in many MS clinics, a brief cognitive monitoring tool that can be administered by other MS clinic staff is needed. BICAMS (Brief International Cognitive As-sessment for Multiple Sclerosis) has been developed and recommended by MS experts to monitor MS-related cognitiv...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Clinical and radiological findings of facial paralysis in multiple sclerosis: a case series.
ConclusionsFP clinically classified as peripheral may be caused by central lesions in the cortex or pons and not only by peripheral facial nerve damage. In MS patients, FP may appear at the onset of the disease and be misdiagnosed as Bell ’s palsy. Clinicians should carefully approach FP diagnosis and perform a brain as well as temporal bone MRI before pursuing pharmacological treatment.Graphical Abstract (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Acute effects of whole-body vibration training on neuromuscular performance and mobility in hypoxia and normoxia in persons with Multiple Sclerosis: A crossover study
Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Luis Andreu, Domingo J. Ramos-Campo, Vicente Ávila-Gandía, Tomas Freitas, Linda H. Chung, Jacobo Á. Rubio-AriasAbstractBackgroundWhole-body vibration training (WBVT) has been used in people with relapsing-remitting multiple sclerosis (pwMS), showing improvements in different neuromuscular and mobility variables. However, the acute effects of this training are still unknown. The acute effects of WBVT on neuromuscular performance, mobility and rating of perceived exertion (RPE) were evaluated in 1...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Extensive linear scleroderma en coup de sabre with exertion-induced hemiplegic migraine
We report the case of a 9-year-old girl with linear scleroderma en coup de sabre (LSCS) who developed progressive white matter involvement, presenting as intractable hemiplegic migraine-like attacks induced by exercise. After a period of severely aggressive course, clinical and radiological stabilization was achieved under immunosuppressant treatment. Intrathecal synthesis of IgG and lymphocytic pleocytosis provided indirect evidence of a chronic inflammatory process of the central nervous system. We discuss the possible immunopathogenic mechanisms responsible for the neurocutaneous involvement in LSCS, favouring the hypot...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Characteristics and treatment of Multiple Sclerosis – related trigeminal neuralgia: an Italian multi-centre study
ConclusionMS patients with a higher disability at TN onset and with a longer interval between MS and TN onset had differing clinical features and outcomes: pain was more frequently bilateral, surgery was more frequent and anticipated, and preventive medication discontinuation due to pain remission was less common. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Gender identity and sexual orientation affect health care satisfaction, but not utilization, in persons with Multiple Sclerosis
Publication date: Available online 12 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Shahin Khayambashi, Amber Salter, Tuula Tyry, Gary R. Cutter, Robert J. Fox, Ruth Ann MarrieAbstractObjectiveWe aimed to determine the association between gender identity and sexual orientation on health care utilization in persons with multiple sclerosis (MS), as well as satisfaction with their doctor and comfort discussing sexual health with their doctor.MethodsWe surveyed participants from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry regarding their gender identity and sexual ori...
Source: Multiple Sclerosis and Related Disorders - October 18, 2019 Category: Neurology Source Type: research

Dimethyl fumarate therapy reduces memory T cells and the CNS migration potential in patients with multiple sclerosis
ConclusionDMF influences the balance between proinflammatory and regulatory T cells, presumably favoring a less proinflammatory environment. DMF also reduces the CNS migratory potential of CD4+ T cells whereas CD8+ T cells are less affected. Altogether, our study suggests an anti-inflammatory effect of DMF mainly on the CD4+ T cell compartment. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 18, 2019 Category: Neurology Source Type: research

MSDo people with multiple sclerosis want to discuss their long-term prognosis? A nationwide study in Argentina
Publication date: Available online 16 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Edgar Carnero C, Pablo A. López, Juan Pablo Pettinicchi, Ricardo Alonso, Santiago Tizio, Verónica Tkachuk, Alejandro Caride, Ian GaleaAbstractBackgroundDemographics, clinical and imaging prognostic factors have been reported in large series of people with multiple sclerosis (PwMS). However, personalized long-term prognosis (LTP) is varied and uncertain in each particular case. Currently, there is limited evidence on how PwMS feel about prognosis communication and their coping strategies. Therefore, we ...
Source: Multiple Sclerosis and Related Disorders - October 18, 2019 Category: Neurology Source Type: research

Silent symptoms of multiple sclerosis
Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Jeannette Lechner-Scott, Emmanuelle Waubant, Michael Levy, Christopher Hawkes (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 18, 2019 Category: Neurology Source Type: research

Alemtuzumab-induced lung injury in multiple sclerosis: learning from adversity in three patients
ConclusionsClinicians should be aware to early recognize acute and subacute respiratory adverse events for a promptly management. In these patients re-treatment is challenging. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 17, 2019 Category: Neurology Source Type: research