Alemtuzumab as rescue therapy in case of multiple sclerosis rebound following Natalizumab break: clinical case and literature review.
ConclusionsOur case further adds to the available literature evidence on Alemtuzumab as first-choice rescue therapy following Natalizumab discontinuation. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - March 6, 2019 Category: Neurology Source Type: research

Assessing the effects of post-acute rehabilitation services on health care outcomes for people with multiple sclerosis
ConclusionPwMS used post-acute rehabilitation services at SNFs for a median of ∼10 hours/week. Those who used more rehabilitative services in the post-acute care setting were more likely to be successfully discharged to the community and experience functional improvement after adjustment for major confounders. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - March 6, 2019 Category: Neurology Source Type: research

Efficacy and safety of alemtuzumab in Korean multiple sclerosis patients
Publication date: Available online 2 March 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Hyunjin Kim, Eun-Jae Lee, Sung Keun Kim, Kwang-Kuk Kim, Young-Min LimAbstractBackgroundEfficacy and safety profiles of alemtuzumab for relapsing-remitting multiple sclerosis (RRMS) mainly come from Western countries and have not been reported in Asian populations. The aim of this study was to report the efficacy and safety of alemtuzumab for RRMS patients in a Korean population.MethodsWe retrospectively reviewed RRMS patients treated with alemtuzumab. Study outcomes included annualized relapse rate (ARR), expanded disa...
Source: Multiple Sclerosis and Related Disorders - March 4, 2019 Category: Neurology Source Type: research

Changes in Patient-Reported Outcomes Between Continuers and Discontinuers of Disease Modifying Therapy in Patients with Multiple Sclerosis over age 60
ConclusionMost patients over age 60 who discontinued DMT remained off treatment. Among the outcomes, only EQ-5D demonstrated significant differences over time, with continuers having lower quality of life scores compared to DBD. There were no significant group differences in PS, T25FW and PHQ-9. Overall, stopping DMT appears to have minimal effect on outcomes over the study period in patients over age 60. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - March 1, 2019 Category: Neurology Source Type: research

SFX-01 reduces residual disability after experimental autoimmune encephalomyelitis
Conclusions: SFX-01 is efficacious in EAE. In first-in-man and phase II clinical trials for other indications, SFX-01 was found to be well-tolerated. A trial comparing BG-12 and SFX-01 would address whether SFX-01 can offer RRMS patients a better option with respect to efficacy and tolerability.Graphical abstract (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 27, 2019 Category: Neurology Source Type: research

Polyneuropathies and Chronic Inflammatory Demyelinating Polyradiculoneuropathy in Multiple Sclerosis
Publication date: Available online 27 February 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Narupat Suanprasert, Bruce V Taylor, Christopher J. Klein, Matthew M. Roforth, Chafic Karam, B. Mark Keegan, P. James B. DyckAbstractBackgroundPolyneuropathies co-occurring with multiple sclerosis (MS) may be underdiagnosed while causing additional disability burden.ObjectiveTo determine polyneuropathy presence and type in MS and compare MS with chronic inflammatory demyelinating polyradiculoneuropathy (MS-CIDP) versus MS with other non-inflammatory polyneuropathies.MethodsRetrospective chart review of Mayo Clinic ...
Source: Multiple Sclerosis and Related Disorders - February 27, 2019 Category: Neurology Source Type: research

Repetitive intrathecal injection of human NMO-IgG with complement exacerbates disease severity with NMO pathology in experimental allergic encephalomyelitis mice
Publication date: Available online 25 February 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Chao-Lin Lee, Kai-Chen Wang, Shyi-Jou Chen, Chieh-Min Chen, Ching-Piao Tsai, Shao-Yuan ChenAbstractNeuromyelitis optica (NMO) is recognized as a different CNS autoimmune disease from multiple sclerosis (MS). Whether NMO-IgG contributes directly to the pathogenesis of NMO or is just a serologic marker of autoimmune responses of the disease needs to be clarified. We created MOG-induced experimental autoimmune encephalomyelitis (EAE) mice by passively transferring NMO-IgG to model the pathogenic findings in NMO patien...
Source: Multiple Sclerosis and Related Disorders - February 26, 2019 Category: Neurology Source Type: research

Clinical Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody Neuromyelitis Optica Spectrum Disorder.
We describe their epidemiological and clinical features.ResultsTwenty-three patients were included in the study with a female to male ratio of 2.3:1. The mean age of the cohort was 42.6 years, while the mean age at onset was 37 years. The most frequent initial presentation was optic neuritis, followed by ADEM-like encephalopathic clinical picture and transverse myelitis. Five patients showed a monophasic disease course while the rest experienced a relapsing phenotype. Nine patients (39%) experienced immediate relapses on withdrawal of steroids.conclusions. Our cohort showed clinical characteristics comparable with previous...
Source: Multiple Sclerosis and Related Disorders - February 23, 2019 Category: Neurology Source Type: research

Validation of the Brazilian version of the Patient-Determined Disease Steps scale in persons with multiple sclerosis
We examined overall correct classification of disability categories (i.e., mild, moderate, or severe disability) by the PDDS/BR in relation to the EDSS. Test-retest reproducibility of PDDS/BR scores was examined in a subsample of 31 participants after 15 days. Results: There was a strong relationship between the PDDS/BR and EDSS scores (ρ= 0.723, p
Source: Multiple Sclerosis and Related Disorders - February 22, 2019 Category: Neurology Source Type: research

Cognitive speed and white matter integrity in secondary progressive multiple sclerosis
ConclusionsIn patients with SPMS, PS abilities are mainly dependent on the degree of both macrostructural and microstructural WM integrity. Preservation of associative WM tracts that support information integration seems crucial to sustain performance in tasks requiring fast cognitive processes. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 18, 2019 Category: Neurology Source Type: research

Hypocomplementemic Urticarial Vasculitis and Multiple Sclerosis: a rare association or an atypical presentation?
ConclusionsIn the presence of concurrent immune-mediated diseases, the diagnosis of MS can be challenging. This clinical presentation posed significant difficulties in disease management, influencing therapeutic options and their effectiveness/adverse effects profile. The best approach in MS patients with concurrent autoimmune diseases remains to be established and more reports are needed to help clarify this subject. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 16, 2019 Category: Neurology Source Type: research

Does Cognitive Reserve play any role in Multiple Sclerosis? A meta-analytic study
Publication date: Available online 14 February 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Gabriella Santangelo, Manuela Altieri, Antonio Gallo, Luigi TrojanoAbstractBackground. Inconsistent evidence is available about the possibility that cognitive reserve (CR) moderates the impact of disease progression, evaluated by MRI biomarkers (lesion load, white matter or gray matter volumes) or clinical proxies of physical disability (i.e. the Expanded Disability Status Scale, EDSS) on cognition in Multiple Sclerosis (MS). A meta-analytic study with a meta-regression approach was performed to investigate the pos...
Source: Multiple Sclerosis and Related Disorders - February 15, 2019 Category: Neurology Source Type: research

Potential mechanisms of action related to the efficacy and safety of cladribine
Publication date: Available online 14 February 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): David Baker, Gareth Pryce, Samuel S. Herrod, Klaus SchmiererAbstractOral cladribine is a novel treatment for relapsing multiple sclerosis (MS). This is a semi-selective immune-reconstitution therapy that induces long-term therapy from short treatment cycles. It has a relatively good safety profile that currently does not require extensive monitoring associated with some continuous immunosuppressive and relatively non-selective immune reconstitution therapies. The efficacy and safety of cladribine relates to its par...
Source: Multiple Sclerosis and Related Disorders - February 14, 2019 Category: Neurology Source Type: research

The value of anti-JCV antibody index assessment in multiple sclerosis patients treated with natalizumab with respect to demographic, clinical and radiological findings
Publication date: Available online 14 February 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Jan Kolcava, Monika Hulova, Yvonne Benesova, Josef Bednarik, Pavel StouracAbstractBackgroundNatalizumab-related progressive multifocal leukoencephalopathy (PML) is associated with the presence of anti-John Cunningham virus (JCV) antibodies. The aim of this investigation was to evaluate the long-term stability of anti-JCV antibody serum levels and their relation to various demographic, clinical and radiological characteristics in patients suffering from multiple sclerosis (MS).MethodsSeventy-eight relapsing-remittin...
Source: Multiple Sclerosis and Related Disorders - February 14, 2019 Category: Neurology Source Type: research

Isolated recurrent myelitis in a persistent MOG positive patient
We report a 30-year-old woman with positive serum MOG-Ab suffering two discrete episodes of transverse myelitis without ophthalmic involvement. Repeated serum MOG-Ab test after the second relapse was positive, correlating with high likelihood of relapsing disease. Of note, our patient relapsed under Rituximab therapy, which does not seem to be uncommon for MOG-Ab patients. Patients with isolated or recurrent myelitis without optic involvement should be screened for anti MOG IgG as a part of their workup. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 13, 2019 Category: Neurology Source Type: research

Trial of intrathecal rituximab in progressive multiple sclerosis patients with evidence of leptomeningeal contrast enhancement
ConclusionsIT rituximab was well tolerated in PMS patients and had transient effects on CSF biomarkers but did not change LME. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 12, 2019 Category: Neurology Source Type: research

Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS
Conclusion: In a large prospective cohort study of depression in people with MS, we substantiated several potential determinants of a positive depression-screen and depression trajectory, particularly fatigue. Given that fatigue is the most common and most significant clinical symptom for people with MS, efforts to reduce fatigue may have follow-on benefits for reducing depression. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 12, 2019 Category: Neurology Source Type: research

Clinical Course of NeuroMyelitis Optica Spectrum Disorder in a Moroccan Cohort
ConclusionData from our study suggest more similarities between North African NMOSD patients and non-Caucasian populations. More studies are needed to assess other pathological patterns and compare disease course to other populations. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 11, 2019 Category: Neurology Source Type: research

Erdheim–Chester disease mimicking multiple sclerosis or a new association?
We report the case of a patient initially diagnosed with relapsing-remitting MS with an atypical course who developed ECD during the disease progression. Given the patient's clinical-radiological characteristics, two diagnostic possibilities were proposed: the coexistence of both diseases or a new presentation of ECD mimicking MS. We conducted a literature review, analyzing the various diagnostic and therapeutic possibilities. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 10, 2019 Category: Neurology Source Type: research

Increased Cerebrospinal Fluid Neurofilament Light Chain in Central Nervous System Inflammatory Demyelinating Disease
ConclusionThe NFL level of CSF is conducive to assessing the severity and probable progress of IDD but is not helpful in distinguishing IDD among Chinese. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 8, 2019 Category: Neurology Source Type: research

Aquaporin-4 antibody positive short transverse myelitis associated with breast cancer
We report a case of a 35-year-old woman with STM and left eye optic neuritis. The patient was positive for serum aquaporin-4 antibodies (AQP4-IgG), and a biopsy of the left breast showed invasive ductal carcinoma. The patient was diagnosed with NMOSD and breast malignancy. This is the first report of a patient with NMOSD whose spinal MRI showed STM and serum test showed that the patient's AQP4-IgG was positive and complicated by breast cancer. This case improves our understanding of the association between NMOSD and cancer and raises the question of whether it was a coincidental occurrence. It is important to search for ex...
Source: Multiple Sclerosis and Related Disorders - February 8, 2019 Category: Neurology Source Type: research

Barriers against a successful MS treatment: The importance of effectiveness beyond efficacy
Publication date: Available online 7 February 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ricardo Alonso, Edgar Carnero Contentti, Gaston Imhoff, Pablo A. Lopez, Adrian Rubstein, Santiago TizioAbstractCurrent multiple sclerosis (MS) therapeutic options have significantly increased treatment algorithm complexity. This urges physicians to take into account multiple factors in the decision-making process and make an even more thorough analysis of the risk-benefit balance. We carried out a descriptive review aiming to assess some factors that endanger the proper MS treatment fulfilment, focusing mainly on La...
Source: Multiple Sclerosis and Related Disorders - February 7, 2019 Category: Neurology Source Type: research

Kappa free light chains could predict early disease course in multiple sclerosis
ConclusionOur study suggests KFLC as a CSF quantitative marker to predict early disability in MS (despite not being a substitute for OB). (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 7, 2019 Category: Neurology Source Type: research

Clinical and MRI correlates of CSF neurofilament light chain levels in relapsing and progressive MS
Publication date: Available online 5 February 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Alfredo Damasceno, Rafael Paterno C. Dias-Carneiro, Adriel Santos Moraes, Vinícius O. Boldrini, Raphael Patrício S. Quintiliano, Verônica Almeida de Paula Galdino da Silva, Alessandro S. Farias, Carlos Otavio Brandão, Benito Pereira Damasceno, Leonilda Maria Barbosa dos Santos, Fernando CendesAbstractBackgoundA major aim in MS field has been the search for biomarkers that enable accurate detection of neuronal damage. Besides MRI, recent studies have shown that neuroaxonal damage can also b...
Source: Multiple Sclerosis and Related Disorders - February 7, 2019 Category: Neurology Source Type: research

Increased level of Plasma Salusin-α and Salusin-β in patients with Multiple Sclerosis
Publication date: Available online 5 February 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Murat Çakır, Seda Sabah-Özcan, Hikmet SaçmacıAbstractBACKGROUND: Multiple Sclerosis (MS) is a potentially progressive autoimmune disorder of the central nervous system. The pathology of MS is characterized by inflammation, demyelination, reactive gliosis and neuronal damage. Salusin-α and salusin-β have been shown to be widely expressed in many tissues, including the central nervous system. In our study, we investigated whether salusin-α and salusin-β peptides had a relatio...
Source: Multiple Sclerosis and Related Disorders - February 7, 2019 Category: Neurology Source Type: research

Tolerability, treatment satisfaction and quality of life outcomes in stable multiple sclerosis patients switched from injectable therapies to auto injected intramuscular interferon beta 1a: the SFERA Study
Publication date: Available online 6 February 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Chiara Zecca, Zbyšek Pavelek, Katerina Prikrylova, Mascia Ghielmetti, Andreas Beeler, Claudio GobbiAbstractBackgroundInterferon beta (IFNB) and Glatiramer acetate, long-term first line disease modifying treatments (DMTs) for multiple sclerosis (MS), have different injection frequencies crucial for injection site related side effects. We aimed at investigating whether switching to intramuscular IFNB-1a injected once/week with the Avonex®PenTM device improves treatment tolerability and quality of life in st...
Source: Multiple Sclerosis and Related Disorders - February 7, 2019 Category: Neurology Source Type: research

Erdheim-Chester disease mimicking multiple sclerosis or a new association?
We report the case of a patient initially diagnosed with relapsing-remitting MS with an atypical course who developed ECD during the disease progression. Given the patient's clinical-radiological characteristics, two diagnostic possibilities were proposed: the coexistence of both diseases or a new presentation of ECD mimicking MS. We conducted a literature review, analyzing the various diagnostic and therapeutic possibilities. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 7, 2019 Category: Neurology Source Type: research

Saccadic eye movements are able to reduce body sway in mildly-affected people with Multiple Sclerosis
Publication date: Available online 4 February 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Felipe Balistieri Santinelli, Richard E A van Emmerik, Fabiana Araújo Silva, Luis Felipe Itikawa Imaizumi, Tiago Penedo, Ana Maria Canzonieri, Sérgio Tosi Rodrigues, Paula Favaro Polastri Zago, Fabio Augusto BarbieriAbstractBackground: Multiple Sclerosis (MS) is a neurodegenerative and inflammatory disease that impacts both visual and postural control. It is currently unknown how the integration between visual and postural control is affected in people with MS (PwMS). It has been shown in healthy indiv...
Source: Multiple Sclerosis and Related Disorders - February 5, 2019 Category: Neurology Source Type: research

Clinical, Neuroimaging and Therapeutic response in AQP4-positive NMO patients from India
ConclusionsClinical manifestations in AQP4+ve NMO patients may vary depending on the age at onset of illness. MRI features affecting cervicomedullary junction, obex, differential T2 hyperintensities of the spinal cord may form a useful diagnostic clue. Plasmapheresis is helpful in achieving remission along with immunomodulation. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 5, 2019 Category: Neurology Source Type: research

Intra-family phenotype variations in familial neuromyelitis optica spectrum disorders
ConclusionThe present study offers a preliminary view of the clinical and neuroimaging features of patients with familial NMO spectrum disorder. Clinical heterogeneities were found among the family members, especially the mother and daughter pairs. The presence of risk allele HLA-DR*03:01 may be an important genetic finding for familial NMO spectrum disorder patients. To the best of our knowledge, this clinical heterogeneity has not been previously examined or reported in the literature. For better delineation of the intra-familial phenotype variations in familial NMO spectrum disorder, further large-scale studies are need...
Source: Multiple Sclerosis and Related Disorders - February 5, 2019 Category: Neurology Source Type: research

A case of neuromyelitis optica spectrum disorder following seasonal influenza vaccination
We report a case of neuromyelitis optica spectrum disorder following seasonal influenza vaccination. Neuromyelitis optica spectrum disorder may have been triggered by the recent influenza vaccination, although a pathogenic link has not been established. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 5, 2019 Category: Neurology Source Type: research

Time between Expanded Disability Status Scale (EDSS) scores
ConclusionsTime between specific EDSS levels varies considerably. Certain functional system scores have greater predictive power for future EDSS-related disability despite same present EDSS level. These findings will assist in adaptation of the EDSS as an outcome measure to assess MS-related disability in clinical trials. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 5, 2019 Category: Neurology Source Type: research

Disease Modifying Therapies Continue To Drive Up Health Care Cost Among Individuals With Multiple Sclerosis
This study is to estimate recent drug costs for DMTs and examine its impact on overall health care costs among individuals with MS enrolled in commercial insurance.MethodsThis study is a population-based, retrospective study using 2011-2015 IBM MarketScan® Commercial Database. Individuals aged
Source: Multiple Sclerosis and Related Disorders - February 5, 2019 Category: Neurology Source Type: research

Differential multiple sclerosis treatment allocation between Australia and New Zealand associated with clinical outcomes but not mood or quality of life
ConclusionThe differential treatment allocation associations in NZ are evident in the DMD-disability association, but there is no evidence that this treatment regimen has negative associations with fatigue, mood, or QoL. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 5, 2019 Category: Neurology Source Type: research

Suspected bacterial meningoencephalomyelitis as the trigger or presentation of neuromyelitis optica spectrum disorder flare
Conclusion: Suspected bacterial meningoencephalomyelitis as the presentation or trigger of NMOSD flare was considered in our case. Literature review revealed that bacterial meningitis-like presentation was a rare presentation in the attack phase of NMOSD. Corticosteroid therapy should be initiated in such cases. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 2, 2019 Category: Neurology Source Type: research

MOG antibody disease manifesting as progressive cognitive deterioration and behavioral changes with primary central nervous system vasculitis
We report a 60-year-old male with anti-myelin oligodendrocyte glycoprotein (MOG) antibody who developed progressive cognitive deterioration and behavioral changes, with no other focal signs, over 9 months. MRI showed numerous T2-hyperintense lesions with partial contrast enhancement in white and grey matter of cerebrum, cerebellum and spinal cord. A brain biopsy revealed perivascular inflammatory cell infiltration, disturbed vascular continuity and no demyelination, indicative of a lymphocytic pattern of primary CNS vasculitis (PCNSV). Contrast enhancement disappeared after immunotherapy; however, cognitive impairment was ...
Source: Multiple Sclerosis and Related Disorders - February 2, 2019 Category: Neurology Source Type: research

Incidence of Multiple Sclerosis Misdiagnosis in Referrals to Two Academic Centers
Conclusion: MS misdiagnosis is common; in our combined cohort, almost 1 in 5 patients who carried an established diagnosis of MS did not fulfill contemporary McDonald Criteria and had a more likely alternate diagnosis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - February 2, 2019 Category: Neurology Source Type: research

Depressive Symptoms and Fatigue as Predictors of Objective-Subjective Discrepancies in Cognitive Function in Multiple Sclerosis
Publication date: Available online 31 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Abbey Jean HughesAbstractObjectiveTo examine the degree to which depressive symptoms and fatigue in individuals with multiple sclerosis (MS) are associated with discrepancies between subjective and objective cognitive impairment.MethodsNinety-nine adults with MS who were receiving care in a university-affiliated MS center completed the Patient Health Questionnaire – 8 (PHQ-8), Fatigue Severity Scale (FSS), MS Neuropsychological Screening Questionnaire (MSNQ), and Brief International Cognitive Assessment for MS...
Source: Multiple Sclerosis and Related Disorders - February 1, 2019 Category: Neurology Source Type: research

New Onset Transverse Myelitis Diagnostic Accuracy and Patient Experiences
Publication date: Available online 31 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Benjamin M. Greenberg, Chitra Krishnan, Lana HarderAbstractImportancePatients afflicted with rare diseases often have a delay in diagnosis and treatment. Understanding the prevalence and impact of delayed diagnosis in transverse myelitis could trigger directed educational initiatives to increase clinician awareness and improve care.ObjectiveTo determine if symptoms at onset or care provider initially approached was associated with time to diagnosis, treatment or outcome in patients with transverse myelitis.DesignThi...
Source: Multiple Sclerosis and Related Disorders - February 1, 2019 Category: Neurology Source Type: research

Determinants of quality of life in relapsing-remitting and progressive multiple sclerosis
Conclusions: Depression and psychological distress symptoms are among the factors with the most essential impact on subjective well-being in MS patients. Since they can be targeted by both psychopharmacological and psychotherapeutic treatment, focusing on mental comorbidity could substantially increase QoL in MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 31, 2019 Category: Neurology Source Type: research

Protective Stepping in Multiple Sclerosis: Impacts of a Single Session of In-Place Perturbation Practice
DiscussionProtective step characteristics have been shown to be important predictors of fall risk in populations affected by neurological disorders. The present study indicates that these characteristics may be amenable to intervention through exposure to repeated, perturbations requiring protective stepping. Further research is needed to establish the predictive utility of these biomechanical markers for falls in MS specifically; however, the present findings suggest that perturbation training may be a valuable means of decreasing fall risk among those affected by MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 31, 2019 Category: Neurology Source Type: research

Validity of a Multi-Domain Computerized Cognitive Assessment battery for Patients with Multiple Sclerosis
ConclusionThe specific computerized assessment battery evaluated is valid for cognitive screening of people with MS and may be more likely to detect prolonged response times and impaired executive function. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 31, 2019 Category: Neurology Source Type: research

Misdiagnosis of Multiple Sclerosis in a Female Heterozygote with Fabry's Disease
Publication date: Available online 30 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Joseph R. BergerAbstractFabry's disease is an X-linked disorder of enzyme alpha-galactosidase A which leads to an accumulation of the glycolipids in lysosomes in vessels and organs. The disorder is rare with an estimated incidence of 1 in 40,000 and disease occurs more rarely in women than men. Paresthesias, hearing loss, and stroke are the typical neurological manifestations. Brain magnetic resonance imaging abnormalities may mimic those seen in multiple sclerosis (MS). Reported here is one of the rarely reported c...
Source: Multiple Sclerosis and Related Disorders - January 31, 2019 Category: Neurology Source Type: research

Foxp3+ regulatory T cells expression in Neuromyelitis optica spectrum disorders
ConclusionsThe present study shows downregulation at the mRNA expression level of a Treg key transcription factor FoxP3, in NMOSD. Exploration of Tregs function and interconnections in the peripheral immune system should advance our understanding of NMOSD pathogenesis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 30, 2019 Category: Neurology Source Type: research

Evidence for a white matter lesion size threshold to support the diagnosis of relapsing remitting multiple sclerosis
Conclusion: The stipulated WML size threshold of 3 millimeter in diameter for the diagnostic criteria of MS seems a reasonable choice for three-dimensional MRI sequences at 3 Tesla. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 29, 2019 Category: Neurology Source Type: research

Erythroblast appearance associated with natalizumab
We report two cases of multiple sclerosis wherein NTZ treatment led to erythroblast appearance in peripheral blood. Erythroblasts appeared after NTZ administration; however, their counts did not increase and the administration of medication was continued. NTZ can inhibit erythroblastic island formation associated with maturing of erythroblast via VLA-4. Clinicians do not need to be afraid; however, careful observation is recommended because some patients may develop anemia. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 29, 2019 Category: Neurology Source Type: research

Ocrelizumab infusion experience in patients with relapsing and primary progressive multiple sclerosis: results from the phase 3 randomized OPERA I, OPERA II, and ORATORIO studies
ConclusionFindings from the OPERA I, OPERA II, and ORATORIO trials show that IRRs were the most frequently reported adverse events with ocrelizumab, were mostly mild to moderate in severity, were reduced with appropriate pretreatment, and decreased with subsequent dosing. IRRs that did occur were effectively managed through infusion rate adjustment and symptomatic treatment. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 29, 2019 Category: Neurology Source Type: research

Clinical correlates of 9-hole peg test in a large population of people with multiple sclerosis
Publication date: Available online 28 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Claudio Solaro, Davide Cattaneo, Giampaolo Brichetto, Letizia Castelli, Andrea Tacchino, Elisa Gervasoni, Luca ProsperiniAbstractObjective: To assess the distribution of Nine Hole Peg Test (9-HPT) and its clinical correlates in a large sample of patients with multiple sclerosis (MS).Methods: Data was collected in a multi-centre, cross-sectional study involving 4 Italians MS centres. We collected demographic and clinical data of 363 patients (244 women, 199 men), including year of symptom onset, disease course, Expan...
Source: Multiple Sclerosis and Related Disorders - January 29, 2019 Category: Neurology Source Type: research

Prognostic factors of disability in relapsing remitting multiple sclerosis
Conclusion: We identified multiple longitudinal predictors of disability in relapsing remitting patients. Modifiable factors (including smoking and BMI) and adverse socioeconomic conditions were independently, and negatively associated with walking speed, global disability, and depression. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 29, 2019 Category: Neurology Source Type: research

How much does balance and muscle strength impact walking in persons with multiple sclerosis? - A cross-sectional study
Publication date: Available online 24 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Jacob Callesen, Ulrik Dalgas, John Brincks, Davide CattaneoAbstractIntroductionDespite the multitude of rehabilitation interventions targeting gait impairments in persons with multiple sclerosis (PwMS), only little is known about the relative association of muscle strength and balance on different gait outcomes.AimTo determine the relative association of balance and muscle strength to three gait performance outcomes in PwMS.Method90 PwMS were enrolled in this cross-sectional study (72% women; mean age=49.8± 1...
Source: Multiple Sclerosis and Related Disorders - January 25, 2019 Category: Neurology Source Type: research