Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis
Mucosal Immunology, Published online: 25 March 2022; doi:10.1038/s41385-022-00502-1Intestinal epithelial VDR is important for maintaining cellular and physiological levels of TJ protein Claudin-5 to prevent inflammation and tumorigenesis in the colon. At the molecular level, the CLDN-5 gene is a newly discovered downstream target of the transcriptional factor VDR. Lack of VDR led to a reduction of Claudin-5 and more tumors, whereas enhancing VDR increased Claudin-5 to protect the intestinal epithelial cells from tumorigenesis. Overall, we noted a link between VDR signaling and barrier functions in CRC. (Source: Mucosal Immunology)
Source: Mucosal Immunology - March 25, 2022 Category: Allergy & Immunology Authors: Yongguo Zhang Shari Garrett Robert E. Carroll Yinglin Xia Jun Sun Source Type: research
FoxO1 suppresses IL-10 producing B cell differentiation via negatively regulating Blimp-1 expression and contributes to allergic asthma progression
Mucosal Immunology, Published online: 23 March 2022; doi:10.1038/s41385-022-00504-zFoxO1 suppresses IL-10 producing B cell differentiation via negatively regulating Blimp-1 expression and contributes to allergic asthma progression (Source: Mucosal Immunology)
Source: Mucosal Immunology - March 23, 2022 Category: Allergy & Immunology Authors: Song-Rong Wang Ren-Dong Hu Min Ma Xing You Haiyan Cui Yi He Damo Xu Zhi-Bin Zhao Carlo Selmi M. Eric Gershwin Liang Li Zhe-Xiong Lian Source Type: research
A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation
Mucosal Immunology, Published online: 21 March 2022; doi:10.1038/s41385-022-00495-xA potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation (Source: Mucosal Immunology)
Source: Mucosal Immunology - March 21, 2022 Category: Allergy & Immunology Authors: Courtney M. Jackson Martin Demmert Shibabrata Mukherjee Travis Isaacs Ravyn Thompson Chase Chastain Jerilyn Gray Paranth Senthamaraikannan Pietro Presicce Kashish Chetal Nathan Salomonis Lisa A. Miller Alan H. Jobe Suhas G. Kallapur William J. Zacharias I Source Type: research
Correction to: Plectin ensures intestinal epithelial integrity and protects colon against colitis
Mucosal Immunology, Published online: 17 March 2022; doi:10.1038/s41385-022-00501-2Correction to: Plectin ensures intestinal epithelial integrity and protects colon against colitis (Source: Mucosal Immunology)
Source: Mucosal Immunology - March 17, 2022 Category: Allergy & Immunology Authors: Alzbeta Krausova Petra Buresova Lenka Sarnova Gizem Oyman-Eyrilmez Jozef Skarda Pavel Wohl Lukas Bajer Eva Sticova Lenka Bartonova Jiri Pacha Gizela Koubkova Jan Prochazka Marina Sp örrer Christopher D ürrbeck Zuzana Stehlikova Martin Vit Natalia Ziolko Source Type: research
Correction: Cellular and functional heterogeneity of the airway epithelium
Mucosal Immunology, Published online: 16 March 2022; doi:10.1038/s41385-022-00500-3Correction: Cellular and functional heterogeneity of the airway epithelium (Source: Mucosal Immunology)
Source: Mucosal Immunology - March 16, 2022 Category: Allergy & Immunology Authors: Jordan D. Davis Tomasz P. Wypych Source Type: research
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages
Mucosal Immunology, Published online: 15 March 2022; doi:10.1038/s41385-021-00482-8Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of eicosanoids in airway inflammation. Here we report that MDM from SARS-CoV-2-infected individuals with mild disease show an inflammatory transcriptional and metabolic imprint that lasts for at least 5 months after SARS-CoV-2 infection. MDM from convalescent SARS-CoV-2-infected individuals showed a downregulation of pro-resolving factors and an increased production of pro-inflammatory...
Source: Mucosal Immunology - March 15, 2022 Category: Allergy & Immunology Authors: Sina Bohnacker Franziska Hartung Fiona Henkel Alessandro Quaranta Johan Kolmert Alina Priller Minhaz Ud-Dean Johanna Giglberger Luisa M. Kugler Lisa Pechtold Sarah Yazici Antonie Lechner Johanna Erber Ulrike Protzer Paul Lingor Percy Knolle Adam M. Chaker Source Type: research
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)
Mucosal Immunology, Published online: 14 March 2022; doi:10.1038/s41385-022-00496-wThe IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF) (Source: Mucosal Immunology)
Source: Mucosal Immunology - March 14, 2022 Category: Allergy & Immunology Authors: Fumi Varyani Stephan L öser Kara J. Filbey Yvonne Harcus Claire Drurey Marta Campillo Poveda Orhan Rasid Madeleine P. J. White Danielle J. Smyth Fran çois Gerbe Philippe Jay Rick M. Maizels Source Type: research
Microbial regulation of intestinal motility provides resistance against helminth infection
Mucosal Immunology, Published online: 14 March 2022; doi:10.1038/s41385-022-00498-8Microbial regulation of intestinal motility provides resistance against helminth infection (Source: Mucosal Immunology)
Source: Mucosal Immunology - March 14, 2022 Category: Allergy & Immunology Authors: Mati Moyat Luc Lebon Olaf Perdijk Lakshanie C. Wickramasinghe Mario M. Zaiss Ilaria Mosconi Beatrice Volpe Nadine Guenat Kathleen Shah Gillian Coakley Tiffany Bouchery Nicola L. Harris Source Type: research
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity
Mucosal Immunology, Published online: 09 March 2022; doi:10.1038/s41385-022-00494-yGoblet cells through their production and secretion of mucins play an essential role in protecting the host against luminal insults, and contribute to the mutualism between host and gut microbiota. Loss of epithelial Gpr35 disrupts the goblet cell compartment by reducing their numbers and increasing pyroptosis levels. Dysregulation of goblet cells is correlated with changes in the mucosa-associated bacterial communities. As a result, Gpr35f/fVil+ mice displayed increased susceptibility to C. rodentium-induced colitis. (Adapted from SERVIER M...
Source: Mucosal Immunology - March 9, 2022 Category: Allergy & Immunology Authors: Hassan Melhem Berna Kaya Tanay Kaymak Philipp Wuggenig Emilio Flint Julien Roux Koen C. Oost Claudia Cavelti-Weder Maria L. Balmer Jean-Claude Walser Rodrigo A. Morales Christian U. Riedel Prisca Liberali Eduardo J. Villablanca Jan Hendrik Niess Source Type: research
Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity
Mucosal Immunology, Published online: 08 March 2022; doi:10.1038/s41385-022-00497-9Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity (Source: Mucosal Immunology)
Source: Mucosal Immunology - March 8, 2022 Category: Allergy & Immunology Authors: Ajibola Omokanye Li Ching Ong Cristina Lebrero-Fernandez Valentina Bernasconi Karin Sch ön Anneli Str ömberg Mats Bemark Xavier Saelens Paulo Czarnewski Nils Lycke Source Type: research
The LIGHT switch: mechanisms of fibroblast pathology in eosinophilic esophagitis
Mucosal Immunology, Published online: 23 February 2022; doi:10.1038/s41385-022-00486-yThe LIGHT switch: mechanisms of fibroblast pathology in eosinophilic esophagitis (Source: Mucosal Immunology)
Source: Mucosal Immunology - February 23, 2022 Category: Allergy & Immunology Authors: Zoe M. X. Chua Anne L. Fletcher Source Type: research
A spotlight on heightened T cell complexity and relevance in mucosal tissues
Mucosal Immunology, Published online: 23 February 2022; doi:10.1038/s41385-022-00485-zA spotlight on heightened T cell complexity and relevance in mucosal tissues (Source: Mucosal Immunology)
Source: Mucosal Immunology - February 23, 2022 Category: Allergy & Immunology Authors: Jennifer M. Lund Source Type: research
Regulation of tissue-resident memory T cells by the Microbiota
Mucosal Immunology, Published online: 22 February 2022; doi:10.1038/s41385-022-00491-1Regulation of tissue-resident memory T cells by the Microbiota (Source: Mucosal Immunology)
Source: Mucosal Immunology - February 22, 2022 Category: Allergy & Immunology Authors: Abigail E. Overacre-Delgoffe Timothy W. Hand Source Type: research
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node
Mucosal Immunology, Published online: 18 February 2022; doi:10.1038/s41385-022-00493-zNeonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node (Source: Mucosal Immunology)
Source: Mucosal Immunology - February 18, 2022 Category: Allergy & Immunology Authors: Conglei Li Lesley A. Ward Albert Nguyen Evelyn Lam Dragos Dasoveanu Musaddeque Ahmed Kei Haniuda Matthew B. Buechler Housheng Hansen He Burkhard Ludewig Kelly Marshall McNagny Jennifer L. Gommerman Source Type: research
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells
Mucosal Immunology, Published online: 17 February 2022; doi:10.1038/s41385-022-00488-wIL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells (Source: Mucosal Immunology)
Source: Mucosal Immunology - February 17, 2022 Category: Allergy & Immunology Authors: Gemma Leon Yasmina E. Hernandez Santana Naoise Irwin Eirini Giannoudaki Sadhbh O ’Neill Ilona Csizmadia Martina Gogarty Tae J. Lee Darren Ruane Aideen Long Padraic G. Fallon Seamus Hussey Patrick T. Walsh Source Type: research
