Emerging role of mitophagy in cardiovascular physiology and pathology
Publication date: Available online 3 October 2019Source: Molecular Aspects of MedicineAuthor(s): Pablo E. Morales, Carla Arias-Durán, Yáreni Ávalos-Guajardo, Geraldine Aedo, Hugo E. Verdejo, Valentina Parra, Sergio LavanderoAbstractHealthy mitochondrial function is imperative for most tissues, but especially those with a high energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular disease has demonstrated that mitochondrial activity is highly relevant to cardiac muscle performance. Mitochondrial homeostasis is maintained through coordination among the processes that comprise the so-called mi...
Source: Molecular Aspects of Medicine - October 4, 2019 Category: Molecular Biology Source Type: research
Current concepts of non-coding RNA regulation of immune checkpoints in cancer
Publication date: Available online 30 September 2019Source: Molecular Aspects of MedicineAuthor(s): Maria Anna Smolle, Felix Prinz, George Adrian Calin, Martin PichlerAbstractThe discovery of immune checkpoint molecules as important regulators of immune responses in healthy individuals as well as immune escape of malignant tumours has led to profound changes in understanding, research and treatment of human cancer. Especially the introduction of immune checkpoint inhibitors in cancer therapy has set anti-cancer therapy on a novel level. With increasing experience of approved CTLA-4 and PD1/PD-L1 inhibitors and the evolutio...
Source: Molecular Aspects of Medicine - October 1, 2019 Category: Molecular Biology Source Type: research
Circulating cell-free tumor DNA analysis in pediatric cancers
Publication date: Available online 25 September 2019Source: Molecular Aspects of MedicineAuthor(s): Daniel Andersson, Henrik Fagman, Martin G. Dalin, Anders StåhlbergAbstractAnalysis of circulating cell-free tumor DNA (ctDNA) has shown promising results within several clinical applications, including cancer detection, mutation profiling, treatment monitoring and early detection of relapse. Here, we discuss the potential and limitations of ctDNA analysis in pediatric cancer detection, therapy decision making and research. Biological properties associated to ctDNA are highlighted and related to technical constraints in down...
Source: Molecular Aspects of Medicine - September 27, 2019 Category: Molecular Biology Source Type: research
Epithelial keratins: Biology and implications as diagnostic markers for liquid biopsies
Publication date: Available online 25 September 2019Source: Molecular Aspects of MedicineAuthor(s): Stefan Werner, Laura Keller, Klaus PantelAbstractKeratins are essential elements of the cytoskeleton of normal and malignant epithelial cells. Because carcinomas commonly maintain their specific keratin expression pattern during malignant transformation, keratins are extensively used as tumor markers in cancer diagnosis including the detection of circulating tumor cells in blood of carcinoma patients. Interestingly, recent biological insights demonstrate that epithelial keratins should not only be considered as mere tumor ma...
Source: Molecular Aspects of Medicine - September 27, 2019 Category: Molecular Biology Source Type: research
MiR-200 family and cancer: From a meta-analysis view
Publication date: Available online 23 September 2019Source: Molecular Aspects of MedicineAuthor(s): Guo-Liang Huang, Jiancong Sun, Yan Lu, Yuke Liu, Huiyuan Cao, Huanyu Zhang, George A. CalinAbstractThe role of microRNAs (miRNAs) in cancer development was implicated as oncogene or tumor suppressor. One of the miRNA family, the miR-200 family, was mainly characterized as tumor suppressor. However, controversial results were reported. The associations between miR-200 family (consisting of five miRNAs: miR-141/200a/200b/200c/429) and cancer prognosis were inconsistent. Therefore, we conducted a meta-analysis by searching PubM...
Source: Molecular Aspects of Medicine - September 24, 2019 Category: Molecular Biology Source Type: research
The extensive role of miR-155 in malignant and non-malignant diseases
Publication date: Available online 23 September 2019Source: Molecular Aspects of MedicineAuthor(s): Diana Gulei, Lajos Raduly, Elisabetta Broseghini, Manuela Ferracin, Ioana Berindan-NeagoeAbstractMicroRNAs (miRNAs) have rapidly emerged as key molecules in cancer initiation and development, showing the capability to regulate pivotal oncogenic pathways. MiR-155 has gathered an increased attention especially in oncology, but also in non-malignanat pathologies. Nowadays, this noncoding RNA is one of the most important miRNAs in cancer, due to the extensive signaling network associated with it, implication in immune system reg...
Source: Molecular Aspects of Medicine - September 24, 2019 Category: Molecular Biology Source Type: research
Editorial Board
Publication date: October 2019Source: Molecular Aspects of Medicine, Volume 69Author(s): (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - September 18, 2019 Category: Molecular Biology Source Type: research
Introduction to special issue – “New insights on the molecular aspects of colorectal cancer”
Publication date: October 2019Source: Molecular Aspects of Medicine, Volume 69Author(s): Sergi Castellví-Bel (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - September 18, 2019 Category: Molecular Biology Source Type: research
Circulating tumor cell as the functional aspect of liquid biopsy to understand the metastatic cascade in solid cancer
Publication date: Available online 21 August 2019Source: Molecular Aspects of MedicineAuthor(s): Luis Enrique Cortés-Hernández, Zahra Eslami-S, Catherine Alix-PanabièresAbstractMetastasis is the main cause of death in patients with cancer. The molecular mechanisms underlying the different metastasis steps are not yet fully known, partly because most studies have been focusing only on cancer cells within the tumor. Currently, with the development of technologies for the enrichment and capture of circulating tumor cells (CTCs), it is possible to characterize cancer cells at the exact moment of metastasis initiation. There...
Source: Molecular Aspects of Medicine - August 22, 2019 Category: Molecular Biology Source Type: research
Editorial Board
Publication date: August 2019Source: Molecular Aspects of Medicine, Volume 68Author(s): (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - August 20, 2019 Category: Molecular Biology Source Type: research
Switching on the furnace: Regulation of heat production in brown adipose tissue
Publication date: Available online 5 August 2019Source: Molecular Aspects of MedicineAuthor(s): Li Li, Baoguo Li, Min Li, John R. SpeakmanAbstractEndothermy requires a source of endogenous heat production. In birds, this is derived primarily from shivering, but in mammals it is mostly non-shivering thermogenesis (NST). Brown adipose tissue (BAT) is a specialized tissue found in Eutherian mammals that is the source of most NST. Heat production in BAT depends primarily on the activity of uncoupling protein 1 (UCP1), which decouples transport of protons across the inner mitochondrial membrane from synthesis of ATP. UCP1 and h...
Source: Molecular Aspects of Medicine - August 6, 2019 Category: Molecular Biology Source Type: research
The landscape of genomic copy number alterations in colorectal cancer and their consequences on gene expression levels and disease outcome
Publication date: Available online 6 August 2019Source: Molecular Aspects of MedicineAuthor(s): Thomas Ried, Gerrit A. Meijer, David J. Harrison, Godfrey Grech, Sebastià Franch-Expósito, Romina Briffa, Beatriz Carvalho, Jordi CampsAbstractAneuploidy, the unbalanced state of the chromosome content, represents a hallmark of most solid tumors, including colorectal cancer. Such aneuploidies result in tumor specific genomic imbalances, which emerge in premalignant precursor lesions. Moreover, increasing levels of chromosomal instability have been observed in adenocarcinomas and are maintained in distant metastases. A number o...
Source: Molecular Aspects of Medicine - August 6, 2019 Category: Molecular Biology Source Type: research
Glucocorticoids and Brown Adipose Tissue: Do glucocorticoids really inhibit thermogenesis?
Publication date: Available online 27 July 2019Source: Molecular Aspects of MedicineAuthor(s): Ineke H.N. Luijten, Barbara Cannon, Jan NedergaardAbstractA reduction in the thermogenic activity of brown adipose tissue (BAT) is presently discussed as a possible determinant for the development of obesity in humans. One group of endogenous factors that could potentially affect BAT activity is the glucocorticoids (e.g. cortisol). We analyse here studies examining the effects of alterations in glucocorticoid signaling on BAT recruitment and thermogenic capacity. We find that irrespective of which manipulation of glucocorticoid s...
Source: Molecular Aspects of Medicine - July 28, 2019 Category: Molecular Biology Source Type: research
Fifty shades of brown: The functions, diverse regulation and evolution of brown adipose tissue
Publication date: Available online 22 July 2019Source: Molecular Aspects of MedicineAuthor(s): John R. Speakman (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - July 23, 2019 Category: Molecular Biology Source Type: research
The importance of long non-coding RNAs in neuropsychiatric disorders
Publication date: Available online 19 July 2019Source: Molecular Aspects of MedicineAuthor(s): Ebrahim Hosseini, Zahra Bagheri-Hosseinabadi, Ilario De Toma, Moslem Jafarisani, Iman SadeghiAbstractIn the last decade, transcriptome analyses have discovered thousands of long non-coding RNAs (lncRNAs) which are assumed as a fundamental part of the gene regulatory networks in the cell. Intriguingly, lncRNAs are abundantly enriched in the brain, displaying elaborate spatiotemporal expression profiles and modulation. They diversely participate in the delicate regulation of the central nervous system (CNS) development including se...
Source: Molecular Aspects of Medicine - July 21, 2019 Category: Molecular Biology Source Type: research
