Molecular and Cellular Neuroscience This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Strain differences in hippocampal synaptic dysfunction in the TgCRND8 mouse model of Alzheimer's disease: Implications for improving translational capacity
Publication date: Available online 4 November 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Wanda M. Snow, Kensuke Oikawa, Jelena Djordjevic, Benedict C. AlbensiAbstractIn Alzheimer's disease (AD), characterized by cognitive deterioration, synaptic alterations are frequently reported. The TgCRND8 model, in which mice develop AD-like amyloid β plaque formation, has been used to investigate the effects of amyloidosis on synaptic function. Background strain impacts the behavioral and neuropathological phenotype of mice in this model, but whether this extends to synaptic function is unknown. We investigated the in...
Source: Molecular and Cellular Neuroscience - November 4, 2018 Category: Neuroscience Source Type: research

A new function for prokineticin 2: Recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury
Publication date: Available online 1 November 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Mayara Vieira Mundim, Laura Nicoleti Zamproni, Agnes Araújo Sardinha Pinto, Layla Testa Galindo, André Machado Xavier, Isaias Glezer, Marimélia PorcionattoAbstractTraumatic brain injury is an important cause of global morbidity and mortality. After an initial injury, there is a cascade of cellular and molecular events that ultimately lead to cell death. Therapies aim to both counteract these mechanisms and replenish the lost cell population in order to improve recovery. The adult mammal brain has at least two neurogen...
Source: Molecular and Cellular Neuroscience - November 2, 2018 Category: Neuroscience Source Type: research

d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production
Publication date: Available online 19 October 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Takahiro Seki, Masahiro Sato, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Akinori Hisatsune, Hiroshi KatsukiAbstractHydrogen sulfide and reactive sulfur species are regulators of physiological functions, have antioxidant effects against oxidative stresses, and are endogenously generated from l-cysteine. Recently, a novel pathway that generates hydrogen sulfide and reactive sulfur species from d-cysteine has been identified. d-Amino acid oxidase (DAO) is involved in this pathway and, among the various brain regions, is es...
Source: Molecular and Cellular Neuroscience - October 20, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: October 2018Source: Molecular and Cellular Neuroscience, Volume 92Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - October 13, 2018 Category: Neuroscience Source Type: research

Validation of reference genes for normalization of real-time quantitative PCR studies of gene expression in brain capillary endothelial cells cultured in vitro
ConclusionOverall we found that the validation of reference genes was important in order to normalize target gene expression correctly, and suggest sets of reference genes to be used under different experimental conditions, in order to quantify mRNA transcript levels in blood-brain barrier cell models correctly. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - October 10, 2018 Category: Neuroscience Source Type: research

Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice
This study investigates the effects of CAW on learning, memory and executive function as well as mitochondrial function and antioxidant response in the 5xFAD model of Aβ accumulation.Seven month old 5xFAD female mice were treated with CAW (2 mg/mL) in their drinking water for two weeks prior to behavioral testing. Learning, memory and executive function were assessed using the object location memory task (OLM), conditioned fear response (CFR) and odor discrimination reversal learning (ODRL) test. Mitochondrial function was profiled using the Seahorse XF platform in hippocampal mitochondria isolated from these animals an...
Source: Molecular and Cellular Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Reduced retromer function results in the accumulation of amyloid-beta oligomers
Publication date: December 2018Source: Molecular and Cellular Neuroscience, Volume 93Author(s): Anna Ansell-Schultz, Juan F. Reyes, My Samuelsson, Martin HallbeckAbstractAlzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive loss of multiple cognitive functions. Accumulation of amyloid beta oligomers (oAβ) play a major role in the neurotoxicity associated with the disease process. One of the early affected brain regions is the hippocampus, wherein a reduction of the vacuolar protein sorting-associated protein 35 (VPS35), the core protein comprising the retromer complex involved in cellular...
Source: Molecular and Cellular Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: September 2018Source: Molecular and Cellular Neuroscience, Volume 91Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - September 5, 2018 Category: Neuroscience Source Type: research

Membrane trafficking and cytoskeletal dynamics in neuronal function
Publication date: September 2018Source: Molecular and Cellular Neuroscience, Volume 91Author(s): Harold D. MacGillavry, Casper C. Hoogenraad (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - September 5, 2018 Category: Neuroscience Source Type: research

Effects of gem-dihydroperoxides against mutant copper‑zinc superoxide dismutase-mediated neurotoxicity
Publication date: Available online 5 September 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Tomoyuki Ueda, Masatoshi Inden, Yuta Asaka, Yuji Masaki, Hisaka Kurita, Wakako Tanaka, Eiji Yamaguchi, Akichika Itoh, Isao HozumiAbstractAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive muscle weakness, paralysis, and death. Although its neuropathology is well investigated, currently, effective treatments are unavailable. The mechanism of ALS involves the aggregation and accumulation of several mutant proteins, including mutant copper‑zinc superoxide dismutase (SOD1), TA...
Source: Molecular and Cellular Neuroscience - September 5, 2018 Category: Neuroscience Source Type: research

Deletion of Kir6.2/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD
Publication date: Available online 29 August 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Qian Zhang, Chengwu Li, Ting Zhang, Yaping Ge, Xiaojuan Han, Sifan Sun, Jianhua Ding, Ming Lu, Gang HuAbstractATP-sensitive potassium (K-ATP) channels express in the central nervous system extensively which coupling cell metabolism and cellular electrical activity. K-ATP channels in mature substantia nigra (SN) dopaminergic (DA) neurons are composed of inwardly rectifying potassium channel (Kir) subunit 6.2 and sulfonylurea receptor 1 (SUR1). Our previous study revealed that regulating K-ATP channel exerts the protective ...
Source: Molecular and Cellular Neuroscience - August 29, 2018 Category: Neuroscience Source Type: research

Polyglutamine repeat proteins disrupt actin structure in Drosophila photoreceptors
Publication date: Available online 24 August 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Annie Vu, Tyler Humphries, Sean Vogel, Adam HabermanAbstractExpansions of polygutamine-encoding stretches in several genes cause neurodegenerative disorders including Huntington's Disease and Spinocerebellar Ataxia type 3. Expression of the human disease alleles in Drosophila melanogaster neurons recapitulates cellular features of these disorders, and has therefore been used to model the cell biology of these diseases. Here, we show that polyglutamine disease alleles expressed in Drosophila photoreceptors disrupt actin st...
Source: Molecular and Cellular Neuroscience - August 25, 2018 Category: Neuroscience Source Type: research

Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation
Publication date: Available online 23 August 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Avery J. Zucco, Valentina Dal Pozzo, Alina Afinogenova, Ronald P. Hart, Orrin Devinsky, Gabriella D'ArcangeloAbstractTuberous Sclerosis Complex (TSC) is a disease caused by autosomal dominant mutations in the TSC1 or TSC2 genes, and is characterized by tumor susceptibility, brain lesions, seizures and behavioral impairments. The TSC1 and TSC2 genes encode proteins forming a complex (TSC), which is a major regulator and suppressor of mammalian target of rapamycin complex 1 (mTORC1), a signaling complex that promotes cell g...
Source: Molecular and Cellular Neuroscience - August 23, 2018 Category: Neuroscience Source Type: research

Defective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signaling
Publication date: Available online 3 August 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Hannes Glaß, Arun Pal, Peter Reinhardt, Jared Sterneckert, Florian Wegner, Alexander Storch, Andreas HermannAbstractMutations in the VPS13A gene leading to depletion of chorein protein are causative for Chorea Acanthocytosis (ChAc), a rare devastating disease, which is characterized by neurodegeneration mainly affecting the basal ganglia as well as deformation of erythrocytes. Studies on patient blood samples highlighted a dysregulation of Actin cytoskeleton caused by downregulation of the PI3K pathway and hyper-activatio...
Source: Molecular and Cellular Neuroscience - August 3, 2018 Category: Neuroscience Source Type: research

The effect of Jun dimerization on neurite outgrowth and motif binding
Publication date: Available online 3 August 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Matt C. Danzi, Saloni T. Mehta, Kireeti Dulla, Giulia Zunino, Daniel J. Cooper, John L. Bixby, Vance P. LemmonAbstractAxon regeneration is a necessary step toward functional recovery after spinal cord injury. The AP-1 transcription factor c-Jun has long been known to play an important role in directing the transcriptional response of Dorsal Root Ganglion (DRG) neurons to peripheral axotomy that results in successful axon regeneration. Here we performed ChIPseq for Jun in mouse DRG neurons after a sciatic nerve crush or sha...
Source: Molecular and Cellular Neuroscience - August 3, 2018 Category: Neuroscience Source Type: research