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PRRT1 regulates basal and plasticity-induced AMPA receptor trafficking
Publication date: Available online 16 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Eva Troyano-Rodriguez, Shivani Mann, Raja Ullah, Mohiuddin AhmadAbstractAMPA-type glutamate receptors (AMPAR) are one of the principal mediators of fast excitatory synaptic transmission in the brain. These receptors associate with multiple integral membrane proteins which influence their trafficking and channel properties. Proline-rich transmembrane protein 1 (PRRT1) is a membrane protein and an understudied component of native AMPAR complexes. In order to understand the regulation of AMPARs by PRRT1, we have performed elec...
Source: Molecular and Cellular Neuroscience - June 17, 2019 Category: Neuroscience Source Type: research

Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA)
Publication date: Available online 14 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Wen-Ning Zhao, Norma K. Hylton, Jennifer Wang, Peter S. Chindavong, Begum Alural, Iren Kurtser, Aravind Subramanian, Ralph Mazitschek, Roy H. Perlis, Stephen J. HaggartyAbstractA subset of individuals with major depressive disorder (MDD) elects treatment with complementary and alternative medicines (CAMs), including the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Previous studies in rodents suggests that DHA modulates neurodevelopmental processes, including adult neurogenesis and neuropla...
Source: Molecular and Cellular Neuroscience - June 14, 2019 Category: Neuroscience Source Type: research

BDNF elevates the axonal levels of hnRNPs Q and R in cultured rat cortical neurons
Publication date: Available online 14 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Hui-Wen Chung, Ju-Chen Weng, Chih-En King, Chih-Fan Chuang, Wei-Yuan Chow, Yen-Chung ChangAbstractLocal translation plays important roles in the maintenance and various functions of axons, and dysfunctions of local translation in axons are implicated in various neurological diseases. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA binding proteins with multiple functions in RNA metabolism. Here, we identified 20 hnRNPs in the axons of cultured rat cortical neurons by interrogating published axon mass spectrometric...
Source: Molecular and Cellular Neuroscience - June 14, 2019 Category: Neuroscience Source Type: research

Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration
Publication date: Available online 12 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Glen Acosta, Nicholas Race, Seth Herr, Joseph Fernandez, Jonathan Tang, Edmond Rogers, Riyi ShiAbstractSurvivors of blast-induced traumatic brain injury (bTBI) have increased susceptibility to Parkinson's disease (PD), characterized by α-synuclein aggregation and the progressive degeneration of nigrostriatal dopaminergic neurons. Using an established bTBI rat model, we evaluated the changes of α-synuclein and tyrosine hydroxylase (TH), known hallmarks of PD, and acrolein, a reactive aldehyde and marker of oxidative stress...
Source: Molecular and Cellular Neuroscience - June 14, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: June 2019Source: Molecular and Cellular Neuroscience, Volume 97Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - June 12, 2019 Category: Neuroscience Source Type: research

mir-234 controls neuropeptide release at the Caenorhabditis elegans neuromuscular junction
Publication date: Available online 12 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Goda Snieckute, Oguzhan Baltaci, Haowen Liu, Lei Li, Zhitao Hu, Roger PocockAbstractmiR-137 is a highly conserved microRNA (miRNA) that is associated with the control of brain function and the etiology of psychiatric disorders including schizophrenia and bipolar disorder. The Caenorhabditis elegans genome encodes a single miR-137 ortholog called mir-234, the function of which is unknown. Here we show that mir-234 is expressed in a subset of sensory, motor and interneurons in C. elegans. Using a mir-234 deletion strain, we s...
Source: Molecular and Cellular Neuroscience - June 12, 2019 Category: Neuroscience Source Type: research

1H NMR profiling of the 6-OHDA parkinsonian rat brain reveals metabolic alterations and signs of recovery after N-acetylcysteine treatment
Publication date: Available online 12 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Ana Virel, Ilona Dudka, Rutger Laterveer, Sara af BjerkénAbstractParkinson's disease is the second most common neurodegenerative disease caused by degeneration of dopamine neurons in the substantia nigra. The origin and causes of dopamine neurodegeneration in Parkinson's disease are not well understood but oxidative stress may play an important role in its onset. Much effort has been dedicated to find biomarkers indicative of oxidative stress and neurodegenerative processes in parkinsonian brains. By using 1H NMR (nuclear ...
Source: Molecular and Cellular Neuroscience - June 12, 2019 Category: Neuroscience Source Type: research

Embryonic and postnatal development of mouse olfactory tubercle
Publication date: Available online 11 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Eduardo Martin-Lopez, Christine Xu, Teresa Liberia, Sarah J. Meller, Charles A. GreerAbstractThe olfactory tubercle (OT) is located in the ventral-medial region of the brain where it receives primary input from olfactory bulb (OB) projection neurons and processes olfactory behaviors related to motivation, hedonics of smell and sexual encounters. The OT is part of the dopamine reward system that shares characteristics with the striatum. Together with the nucleus accumbens, the OT has been referred to as the “ventral striat...
Source: Molecular and Cellular Neuroscience - June 11, 2019 Category: Neuroscience Source Type: research

Spinocerebellar ataxia type 14 caused by a nonsense mutation in the PRKCG gene
Publication date: Available online 31 May 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Toshihiko Shirafuji, Haruo Shimazaki, Tatsuhiro Miyagi, Takehiko Ueyama, Naoko Adachi, Shigeru Tanaka, Izumi Hide, Naoaki Saito, Norio SakaiAbstractSpinocerebellar ataxia type 14 (SCA14) is an autosomal dominant neurodegenerative disorder characterized by cerebellar ataxia with myoclonus, dystonia, spasticity, and rigidity. Although missense mutations and a deletion mutation have been found in the protein kinase C gamma (PRKCG) gene encoding protein kinase C γ (PKCγ) in SCA14 families, a nonsense mutation has not been repo...
Source: Molecular and Cellular Neuroscience - June 1, 2019 Category: Neuroscience Source Type: research

Disease signatures: Biomarkers/indicators of neurodegeneration
Publication date: Available online 25 May 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Henrik Zetterberg, Mathias Bähr (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - May 25, 2019 Category: Neuroscience Source Type: research

Hippocampal sub-regional differences in the microRNA response to forebrain ischemia
The objective of the present study was to assess and compare post-injury miRNA profiles between CA1 and DG using a rat model of forebrain ischemia. CA1 and DG sub-regions were dissected from rat hippocampi following 10 min of forebrain ischemia at three time points (3 h, 24 h, and 72 h) and at baseline. Pronounced differences between CA1 and DG were observed for several select miRNAs, including miR-181a-5p, a known regulator of cerebral ischemic injury. We complexed fluorescent in situ hybridization with immunohistochemistry to observe cell-type specific and temporal differences in mir-181a-5p expression between CA...
Source: Molecular and Cellular Neuroscience - May 23, 2019 Category: Neuroscience Source Type: research

Exposing immature hippocampal neurons to excitotoxins reveals distinct transcriptome and protein regulation with induction of common survival signaling pathways
Publication date: Available online 11 May 2019Source: Molecular and Cellular NeuroscienceAuthor(s): L.K. Friedman, N. Osei-tutu, B. ZhangAbstractEarly life traumas lead to neuroprotection by preconditioning mechanisms. To determine which genes and pathways are most likely involved in specific adaptive effects, immature hippocampal cultures were exposed to a single high dose of glutamate (250 μM), NMDA (100 μM), or KA (300 μM) for 48 h (5–7 DIV) based on our prior “two hit” in vitro model of preconditioning. Transcriptome profiling and immunocytochemistry of gene candidates were performed 7 days later whe...
Source: Molecular and Cellular Neuroscience - May 12, 2019 Category: Neuroscience Source Type: research

Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density
In this study we sought to further understand the cellular consequences of knocking out Epac2 on the development of neuronal and synaptic structure and organization of cortical neurons. Using primary cortical neurons generated from Epac2+/+ or Epac2−/− mice, we confirm that EPAC2 is required for cAMP-dependent spine shrinkage. Neurons from Epac2−/− mice also displayed increased synaptic expression of GluA2/3-containing AMPA receptors, as well as of the adhesion protein N-cadherin. Intriguingly, analysis of excitatory and inhibitory synaptic proteins revealed that loss of EPAC2 resulted in altered expression of vesi...
Source: Molecular and Cellular Neuroscience - May 4, 2019 Category: Neuroscience Source Type: research

Cross talk between SOD1 and the mitochondrial UPR in cancer and neurodegeneration
Publication date: Available online 24 April 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Maria Gomez, Doris GermainAbstractThe mitochondrial unfolded protein response (UPRmt) is rapidly gaining attention. While the CHOP (ATF4/5) axis of the UPRmt was the first to be described, other axes have subsequently been reported. Validation of this complex pathway in C. elegans has been extensively studied. However, validation of the UPRmt in mouse models of disease known to implicate mitochondrial reprogramming or dysfunction, such as cancer and neurodegeneration, respectively, is only beginning to emerge. This review ...
Source: Molecular and Cellular Neuroscience - April 24, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: April 2019Source: Molecular and Cellular Neuroscience, Volume 96Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - April 18, 2019 Category: Neuroscience Source Type: research