Molecular and Cellular Neuroscience This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mechanism of mitochondrial complex I damage in brain ischemia/reperfusion injury. A hypothesis
Publication date: Available online 5 September 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Vadim Ten, Alexander GalkinAbstractThe purpose of this review is to integrate available data on the effect of brain ischemia/reperfusion (I/R) on mitochondrial complex I. Complex I is a key component of the mitochondrial respiratory chain and it is the only enzyme responsible for regenerating NAD+ for the maintenance of energy metabolism. The vulnerability of brain complex I to I/R injury has been observed in multiple animal models, but the mechanisms of enzyme damage have not been studied. This review summarizes old an...
Source: Molecular and Cellular Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum
Publication date: Available online 3 September 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Yuko Yamakage, Michinao Kato, Aya Hongo, Himari Ogino, Keisuke Ishii, Takumi Ishizuka, Takana Kamei, Hitomi Tsuiji, Tomomi Miyamoto, Hisashi Oishi, Takao Kohno, Mitsuharu HattoriAbstractReelin plays important roles in regulating neuronal development, modulating synaptic function, and counteracting amyloid β toxicity. A specific proteolytic cleavage (N-t cleavage) of Reelin abolishes its biological activity. We recently identified ADAMTS-3 (a disintegrin and metalloproteinase with thrombospondin motifs 3) as the major N...
Source: Molecular and Cellular Neuroscience - September 3, 2019 Category: Neuroscience Source Type: research

Role of fast inhibitory synaptic transmission in neonatal respiratory rhythmogenesis and pattern formation
Publication date: Available online 28 August 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Michael George Zaki Ghali, Sarah BeshayAbstractSeveral studies have investigated the general role of chloride-based neurotransmission (GABAA and glycinergic signaling) in respiratory rhythmogenesis and pattern formation. In several brain regions, developmental alterations in these signaling pathways have been shown to be mediated by changes in cation-chloride cotransporter (CC) expression. For instance, CC expression changes over the neonatal period in medullary respiratory nuclei and other brain/spinal cord regions in a ...
Source: Molecular and Cellular Neuroscience - August 29, 2019 Category: Neuroscience Source Type: research

Adequate expression of Globin1 is required for development and maintenance of nervous system in Drosophila
Publication date: Available online 28 August 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Nisha, Prerna Aggarwal, Surajit SarkarAbstractNeurogenesis is driven by spatially and temporally regulated proliferation of neuronal progenitor cells that generates enormous number of assorted neurons to drive the complex behavior of an organism. Drosophila nervous system provides an advantageous model for identification and elucidation of the functional significance of the novel gene(s) involved in neurogenesis. The present study attempts to investigate the role(s) of globin1 (glob1) in the development and maintenance of...
Source: Molecular and Cellular Neuroscience - August 29, 2019 Category: Neuroscience Source Type: research

PlexinD1 and Sema3E determine laminar positioning of heterotopically projecting callosal neurons
In this study, we showed that the axon guidance receptor PlexinD1 is expressed by a large proportion of heterotopically projecting CPNs in layer 5A of the primary somatosensory (S1) and motor (M1) areas. Retrograde tracing of M1 CPNs projecting to the contralateral striatum revealed the presence of ectopic neurons aberrantly located in layers 2/3 of Plxnd1 and Sema3e mutant cortices. These results showed that Sema3E/PlexinD1 signalling controls the laminar distribution of heterotopically projecting CPNs. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - August 25, 2019 Category: Neuroscience Source Type: research

TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration
Publication date: Available online 21 August 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Ju Gao, Luwen Wang, Tingxiang Yan, George Perry, Xinglong WangAbstractGenetic mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Importantly, TDP-43 proteinopathy, characterized by aberrant phosphorylation, ubiquitination, cleavage or nuclear depletion of TDP-43 in neurons and glial cells, is a common prominent pathological feature of various major neurodegenerative diseases including ALS, FTD, and Alzheimer's disease (AD). Although the pathomechan...
Source: Molecular and Cellular Neuroscience - August 22, 2019 Category: Neuroscience Source Type: research

Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor
This study explores how two injury-induced molecules are intimately connected and suggests a potential link between p75 signaling and the expression of BACE1 after brain injury. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - August 15, 2019 Category: Neuroscience Source Type: research

Gamma secretase modulators and BACE inhibitors reduce Aβ production without altering gene expression in Alzheimer's disease iPSC-derived neurons and mice
Publication date: Available online 2 August 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Carlo Cusulin, Isabelle Wells, Solveig Badillo, Gonzalo Christian Duran Pacheco, Karlheinz Baumann, Christoph PatschAbstractIn drug discovery, as well as in the study of disease biology, it is fundamental to develop models that recapitulate aspects of a disorder, in order to understand the pathology and test therapeutic approaches. Patient-derived induced pluripotent stem cells (iPSCs) offer the potential of obtaining tissue-specific cells with a given human genotype. Here we derived neural cultures from Alzheimer's diseas...
Source: Molecular and Cellular Neuroscience - August 3, 2019 Category: Neuroscience Source Type: research

PLD1 promotes dendritic spine morphogenesis via activating PKD1
Publication date: Available online 26 July 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Wen-Qi Li, Li-Da Luo, Zhi-Wen Hu, Tian-Jie Lyu, Cheng Cen, Yun WangAbstractDendritic spines on the dendrites of pyramidal neurons are one of the most important components for excitatory synapses, where excitatory information exchanges and integrates. The defects of dendritic spine development have been closely connected with many nervous system diseases including autism, intellectual disability and so forth. Based on our previous studies, we here report a new functional signaling link between phospholipase D1 (PLD1) and pro...
Source: Molecular and Cellular Neuroscience - July 28, 2019 Category: Neuroscience Source Type: research

Evoked potentials as a translatable biomarker to track functional remyelination
Publication date: Available online 26 July 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Brandon J. Farley, Elena Morozova, Jessica Dion, Bin Wang, Brian D. Harvey, Davide Gianni, Brian Wipke, Diego Cadavid, Marion Wittmann, Mihaly HajosAbstractEnhancing remyelination is a key therapeutic strategy for demyelinating diseases such as multiple sclerosis. To achieve this goal, a central challenge is being able to quantitatively and longitudinally track functional remyelination, especially with translatable biomarkers that can be performed in both preclinical models and in the clinic. We developed the methodology to...
Source: Molecular and Cellular Neuroscience - July 28, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: July 2019Source: Molecular and Cellular Neuroscience, Volume 98Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - July 5, 2019 Category: Neuroscience Source Type: research

Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice
Publication date: Available online 2 July 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Chaitanya Chakravarthi Gali, Elham Fanaee-Danesh, Martina Zandl-Lang, Nicole Maria Albrecher, Carmen Tam-Amersdorfer, Anika Stracke, Vinay Sachdev, Florian Reichmann, Yidan Sun, Afrim Avdili, Marielies Reiter, Dagmar Kratky, Peter Holzer, Achim Lass, Karunya K. Kandimalla, Ute PanzenboeckAbstractAberrant insulin signaling constitutes an early change in Alzheimer's disease (AD). Insulin receptors (IR) and low-density lipoprotein receptor-related protein-1 (LRP-1) are expressed in brain capillary endothelial cells (BCEC) formi...
Source: Molecular and Cellular Neuroscience - July 3, 2019 Category: Neuroscience Source Type: research

Modulating proteoglycan receptor PTPσ using intracellular sigma peptide improves remyelination and functional recovery in mice with demyelinated optic chiasm
Publication date: Available online 2 July 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Parvin Niknam, Mohammad Reza Raoufy, Yaghoub Fatholahi, Mohammad JavanAbstractMultiple sclerosis (MS) is an autoimmune disease characterized by myelin and axonal damage in the central nervous system (CNS). Glial scar which is a hallmark of MS contains repair inhibitory molecules including chondroitin sulfate proteoglycans (CSPGs). CSPGs inhibit repair of damaged area through various receptors including protein tyrosine phosphatase sigma (PTPσ). In the current study we use intracellular sigma peptide (ISP), an inhibitor of P...
Source: Molecular and Cellular Neuroscience - July 3, 2019 Category: Neuroscience Source Type: research

Mitochondrial dynamics and transport in Alzheimer's disease
Publication date: Available online 16 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Padraig J. Flannery, Eugenia TrushinaAbstractMitochondrial dysfunction is now recognized as a contributing factor to the early pathology of multiple human conditions including neurodegenerative diseases. Mitochondria are signaling organelles with a multitude of functions ranging from energy production to a regulation of cellular metabolism, energy homeostasis, stress response, and cell fate. The success of these complex processes critically depends on the fidelity of mitochondrial dynamics that include the ability of mitoch...
Source: Molecular and Cellular Neuroscience - June 18, 2019 Category: Neuroscience Source Type: research

A novel bungarotoxin binding site-tagged construct reveals MAPK-dependent Kv4.2 trafficking
Publication date: Available online 15 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): G. Travis Tabor, Jung M. Park, Jonathan G. Murphy, Jia-Hua Hu, Dax A. HoffmanAbstractKv4.2 voltage-gated K+ channel subunits, the primary source of the somatodendritic A-type K+ current in CA1 pyramidal neurons of the hippocampus, play important roles in regulating dendritic excitability and plasticity. To better study the trafficking and subcellular distribution of Kv4.2, we created and characterized a novel Kv4.2 construct encoding a bungarotoxin binding site in the extracellular S3–S4 linker region of the α-subunit. W...
Source: Molecular and Cellular Neuroscience - June 17, 2019 Category: Neuroscience Source Type: research