Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic β-cells
Publication date: Available online 25 June 2019Source: MitochondrionAuthor(s): Petr Ježek, Andrea DlaskováAbstractType 2 diabetes progression stems from dysfunction of β-cells, besides the peripheral insulin resistance. Mitochondria as glucose sensor and regulation center are impaired at various stages of this progression. Their biogenesis and functional impairment is reflected by altered morphology of the mitochondrial network and ultramorphology of cristae and mitochondrial DNA loci, termed nucleoids. Aspects of all above changes are reviewed here together with a brief introduction to proteins involved in mitochondria...
Source: Mitochondrion - June 27, 2019 Category: Biochemistry Source Type: research
Myasthenia graves-like symptoms associated with rare mitochondrial mutation (m.5728T>C)
We report here on a patient who presented with myasthenia gravis type symptoms (fatigable ptosis, increased jitter on single fiber EMG, and a thymic mass) who was subsequently diagnosed with a mitochondrial myopathy. Sequencing of the mitochondrial genome (mtDNA) identified a transition variant in the tRNA asparagine gene (MT-TN) (m.5728T>C) at in 41% of mtDNA molecules in muscle tissue. The variant was not detectable in blood. The m.5728T>C variant has been reported previously in a ten year old male with global developmental delays, failure to thrive, ataxia, weakness, cognitive regression, seizures, and glomerulosclerosi...
Source: Mitochondrion - June 27, 2019 Category: Biochemistry Source Type: research
Corrigendum to “Mitochondria in health and disease” [Mitochondrion 43(2018) 25–29]
Publication date: Available online 22 June 2019Source: MitochondrionAuthor(s): Sanjiban Chakrabarty, Shama Prasada Kabekkodu, Rana P. Singh, K. Thangaraj, Keshav K. Singh, Kapaettu Satyamoorthy (Source: Mitochondrion)
Source: Mitochondrion - June 22, 2019 Category: Biochemistry Source Type: research
Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function?
This study suggests that Silene species with peculiar mt genomes still show relatively normal mt respiration. This may be due to strong purifying selection on mt variants, coevolutionary responses in the nucleus, or a combination of both. Future experiments should explore such questions using a comparative framework and investigating other lineages with unusual mitogenomes. (Source: Mitochondrion)
Source: Mitochondrion - June 21, 2019 Category: Biochemistry Source Type: research
Is mitochondrial DNA profiling predictive for athletic performance?
Publication date: Available online 19 June 2019Source: MitochondrionAuthor(s): Erika Stefano, Santo Marsigliante, Carla Vetrugno, Antonella MuscellaAbstractMitochondrial DNA encodes some proteins of the oxidative phosphorylation enzymatic complex, playing an important role in aerobic ATP production; therefore, it can contribute to the ability to respond to endurance exercise training. The accumulation of mitochondrial mutations and the migratory processes of populations have given a great contribution to the development of haplogroups with a different distribution in the world. Several studies have shown the important role...
Source: Mitochondrion - June 20, 2019 Category: Biochemistry Source Type: research
