Alterations of complex IV in the tissues of a septic mouse model
ConclusionsChanges in complex IV activity and mitochondrial ultrastructure, a manifestation of the mitochondrial dysfunction varied depending on cell type. These changes are partly reversed by fluid therapy. Therapies aimed at mitochondrial resuscitation should be explored. (Source: Mitochondrion)
Source: Mitochondrion - July 28, 2019 Category: Biochemistry Source Type: research
Apomorphine rescues reactive oxygen species-induced apoptosis of fibroblasts with mitochondrial disease
In conclusion, apomorphine rescued fibroblasts from cell death under oxidative stress and improved the mitochondrial respiratory activity and appears to be potentially useful for treating mitochondrial disease. (Source: Mitochondrion)
Source: Mitochondrion - July 28, 2019 Category: Biochemistry Source Type: research
Mitochondrial Dynamics in signaling and disease
Publication date: Available online 27 July 2019Source: MitochondrionAuthor(s): (Source: Mitochondrion)
Source: Mitochondrion - July 28, 2019 Category: Biochemistry Source Type: research
Exploring the links between lipid geometry and mitochondrial fission: Emerging concepts
We present evidence from recent experimental measurements ably supported and validated by computational modeling studies to support our notion that conical lipids play a catalytic as well as a structural role in mitochondrial fission. (Source: Mitochondrion)
Source: Mitochondrion - July 26, 2019 Category: Biochemistry Source Type: research
Increased PDK4 mRNA expression is a sensitive marker of upregulated fatty acid oxidation
Publication date: Available online 25 July 2019Source: MitochondrionAuthor(s): Ina Katrine Nitschke Pettersen, Deusdedit Tusubira, Hanan Ashrafi, Sissel Elisabeth Dyrstad, Lena Hansen, Xiao-Zheng Liu, Linn Iren Hodneland Nilsson, Nils Gunnar Løvsletten, Kjetil Berge, Hege Wergedahl, Bodil Bjørndal, Øystein Fluge, Ove Bruland, Arild Christian Rustan, Nils Halberg, Gro Vatne Røsland, Rolf Kristian Berge, Karl Johan TronstadAbstractFatty acid oxidation is a central fueling pathway for mitochondrial ATP production. Regulation occurs through multiple nutrient- and energy-sensitive molecular mechanisms. We explored if upregu...
Source: Mitochondrion - July 26, 2019 Category: Biochemistry Source Type: research
Mitochondrial-associated protein biomarkers in patients with attention-deficit/hyperactivity disorder
This study aimed to determine the role of mitochondria-associated proteins (HtrA2, α-synuclein, and Park7) in attention deficit/hyperactivity disorder (ADHD). A total of 125 patients with ADHD (77.6% were males) and 66 healthy controls (66.7% were males) were recruited. We found that girls with ADHD demonstrated higher plasma HtrA2 level than control girls, and their HtrA2 levels were positively correlated with verbal comprehensive ability, and negatively correlated to behavior symptoms. Among boys, we observed no correlations between these mitochondrial proteins, neuropsychological findings, and clinical symptoms. Our fi...
Source: Mitochondrion - July 24, 2019 Category: Biochemistry Source Type: research
A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells
In this study, we report on attempts to develop liposome-based carriers for mitochondrial delivery using mouse myoblasts (C2C12) by varying the lipid composition of the carriers. We found that a liposome that contains an optimal lipid modified with the KALA peptide (a cellular uptake and mitochondrial targeting device) was the most effective nanocarrier for achieving mitochondrial delivery in C2C12 cells. We also report on successful mitochondrial transgene expression using the carriers encapsulating a mitochondrial DNA vector as we previously reported. (Source: Mitochondrion)
Source: Mitochondrion - July 19, 2019 Category: Biochemistry Source Type: research
Complex I and II are required for normal mitochondrial Ca2+ homeostasis
Publication date: Available online 13 July 2019Source: MitochondrionAuthor(s): Fabian Jaña, Galdo Bustos, José Rivas, Pablo Cruz, Felix Urra, Carla Basualto-Alarcón, Eduardo Sagredo, Melany Ríos, Alenka Lovy, Zhiwei Dong, Oscar Cerda, Muniswamy Madesh, César CárdenasAbstractCytosolic calcium (cCa2+) entry into mitochondria is facilitated by the mitochondrial membrane potential (ΔΨm), an electrochemical gradient generated by the electron transport chain (ETC). Is has been assumed that as long as mutations that affect the ETC do not affect the ΔΨm, the mitochondrial Ca2+ (mCa2+) homeostasis remains normal. We show ...
Source: Mitochondrion - July 15, 2019 Category: Biochemistry Source Type: research
Physics-based oligomeric models of the yeast mitofusin Fzo1 at the molecular scale in the context of membrane docking
Publication date: Available online 12 July 2019Source: MitochondrionAuthor(s): Astrid Brandner, Dario De Vecchis, Marc Baaden, Mickael M. Cohen, Antoine TalyAbstractTethering and homotypic fusion of mitochondrial outer membranes is mediated by large GTPases of the dynamin-related proteins family called the mitofusins. The yeast mitofusin Fzo1 forms high molecular weight complexes and its assembly during membrane fusion likely involves the formation of high order complexes. Consistent with this possibility, mitofusins form oligomers in both cis (on the same lipid bilayer) and trans to mediate membrane attachment and fusion....
Source: Mitochondrion - July 13, 2019 Category: Biochemistry Source Type: research
Role of ectopically expressed mtDNA encoded cytochrome c oxidase subunit I (MT-COI) in tumorigenesis
Publication date: Available online 9 July 2019Source: MitochondrionAuthor(s): Rajnish Kumar Singh, Sunil Kumar Saini, Gopinath Prakasam, Ponnuusamy Kalairasan, Rameshwar N.K. BamezaiAbstractSomatic mutations within mitochondrial DNA (mtDNA) encoded cytochrome c oxidase subunit I (MT-COI) are frequent in various cancer types. In addition, perturbation from orchestrated expression of mitochondrial DNA encoded genes is also associated with complex disorders, including cancer. Since codon bias and the mitochondrial translation system restricts functional characterization of over-expressed wild type or mutant mitochondrial DNA ...
Source: Mitochondrion - July 10, 2019 Category: Biochemistry Source Type: research
Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling
Publication date: Available online 6 July 2019Source: MitochondrionAuthor(s): Yuanbo Wu, Meiqiao Chen, Jielong JiangAbstractMitochondrial dysfunction is becoming one of the most emerging pathological process in the etiology of neurological disorders. Other common etiologies of the neurological disorders are aging and oxidative stress. Neurodegenerative disorders for instance Huntington's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Epilepsy, Schizophrenia, Multiple sclerosis, Neuropathic pain and Alzheimer's disease involves mitochondrial dysfunction and is regarded as the core of their pathological process...
Source: Mitochondrion - July 7, 2019 Category: Biochemistry Source Type: research
Identifying pig mitochondrial TSS: Structure and functional features
Publication date: Available online 4 July 2019Source: MitochondrionAuthor(s): Hao Liu, Tao Yin, Xing Zhang, Xingbo ZhaoAbstractThe transcription start sites (TSSs) of porcine mitochondrial genome were firstly identified in this study, including heavy-strand promoter 1 and 2 (HSP1 and HSP2) harbored at nt 903 and nt 1369 in H strand, respectively, and light-strand promoter (LSP) located at nt 166 in L strand. HSP1 structure and expression features were investigated by analyzing mtDNA copy number, expression of 11 nucleoplasmic genes, mtDNA methylation levels, and gene expression levels of methyl-modifying enzymes, DNMT1 and...
Source: Mitochondrion - July 5, 2019 Category: Biochemistry Source Type: research
Leigh syndrome caused by mitochondrial DNA-maintenance defects revealed by whole exome sequencing
Publication date: Available online 2 July 2019Source: MitochondrionAuthor(s): Paulo Victor Sgobbi de Souza, Thiago Bortholin, Carlos Alberto Castro Teixeira, Daniel Delgado Seneor, Vitor Dias Gomes Barrios Marin, Renan Braido Dias, Igor Braga Farias, Bruno de Mattos Lombardi Badia, Luiz Henrique Libardi Silva, Wladimir Bocca Vieira de Rezende Pinto, Acary Souza Bulle Oliveira, Salvatore DiMauroAbstractLeigh syndrome represents a complex inherited neurometabolic and neurodegenerative disorder associated with different clinical, genetic and neuroimaging findings in the context of bilateral symmetrical lesions involving the b...
Source: Mitochondrion - July 3, 2019 Category: Biochemistry Source Type: research
Mitonuclear gene X environment effects on lifespan and health: How common, how big?
Publication date: Available online 26 June 2019Source: MitochondrionAuthor(s): Emma Drummond, Emma Short, David ClancyAbstractMitochondrial genetic variation can have profound effects on fitness, and the mitotype must interact with both the nuclear genes and the environment. We used Drosophila to investigate the extent to which mitotype effects on lifespan and activity are modulated by nucleotype and environmental variation. When nucleotype is varied, mitochondrial effects on lifespan persisted but were relatively small, and still male biased. Varying food as well, mitotype had substantial effects on male climbing speed, m...
Source: Mitochondrion - June 27, 2019 Category: Biochemistry Source Type: research
Editorial Board
Publication date: July 2019Source: Mitochondrion, Volume 47Author(s): (Source: Mitochondrion)
Source: Mitochondrion - June 27, 2019 Category: Biochemistry Source Type: research
