A paradigm shift in preventing diabetic heart failure? A review of SGLT2 inhibitors.
Authors: Khadke S, Jawaid H, Yasmin F, Binte Ali M, Rehman A
Abstract
Recent trials have reported sodium-glucose co-transporter 2 (SGLT2) inhibitors to decrease cardiac morbidity and hospitalization in diabetic patients. They have a remarkable ability to modify the cardio-renal axis and have a safer metabolic profile among the existing pharmacotherapy in diabetes. There are multiple proposed mechanisms postulated behind the cardioprotection offered by these drugs as seen in CANVAS and EMPA-REG OUTCOME trial. The pathophysiological evidence which directly contributes to improved cardiac mechanics remains el...
Source: Minerva Endocrinologica - December 19, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Rubrometabolic syndrome.
Authors: Kalra S, Coetzee A, Kalra PA, Saldaña JR, Kilov G
Abstract
Metabolic syndrome (MS), a conglomeration of several conditions including obesity, type 2 diabetes mellitus (T2DM), insulin resistance, elevated blood pressure, and dyslipidemia is reaching epidemic proportions. Anemia is caused by iron deficiency or dysregulation of iron homeostasis, leading to tissue hypoxia. Coexistence of anemia and MS or its components has been reported in the literature. The term "rubrometabolic syndrome" acts as a unifying entity linking the importance of blood in health and anemia in MS; it justifies two principle...
Source: Minerva Endocrinologica - December 19, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
GPR56 gene down-regulation in patients with Klinefelter syndrome: a candidate for infertility?
CONCLUSIONS: The possible contribution of the GPR56 gene down-regulation in the pathogenesis of spermatogenic failure in patients with KS is worthy to be further explored.
PMID: 33331742 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 19, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
The triglyceride glucose index (TyG) and CDKAL1 gene rs10946398 SNP are associated with NAFLD in Chinese adults.
CONCLUSIONS: We identified an association between the rs10946398 genotypes of CDKAL1 and NAFLD and the TyG index, and the TyG index was related to the risk of NAFLD.
PMID: 33269568 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Analysis of defects in GNAS and STX16 genes in a Chinese family with pseudohypoparathyroidism.
Authors: Zhao P, Liu J, Cheng J, Li Q, Fu S, Wang Y, Yang X, Ma X
PMID: 33269569 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Continuous glucose monitoring in diabetes patients with chronic kidney disease on dialysis: a meta-analysis.
CONCLUSIONS: CGM is an efficient method of glycemic monitoring in diabetes patients on dialysis. CGM had similar correlations with HbA1c and glycated albumin.
PMID: 33269570 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Evaluation of management of patients with postoperative permanent hypoparathyroidism. How close are we to the targets?
CONCLUSIONS: Our study shows that the management of the patients with PO-HypoPT is suboptimal with active vitamin D and cholecalciferol treatment.
PMID: 33269571 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Hormonal therapy potentiates the effect of surgery on gene expression profile of peripheral blood mononuclear cells in patients affected by endometriosis.
CONCLUSIONS: Results support the concept that a systemic chronic inflammatory status is among the mechanisms underlying endometriosis. Moreover, they shed light into the mechanisms of action of COCs and strength the rationale for their use to improve quality of life of women affected by the disease.
PMID: 33269572 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Downregulation of plasma microRNA-29c-3p expression may be a new risk factor for diabetic retinopathy.
CONCLUSIONS: Plasma miR-29c-3p expression is downregulated in diabetic patients with and without retinopathy, and changes in this miRNA are an independent risk factor for the development of DR.
PMID: 33213115 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Vitamin D in obesity and obesity-related diseases: an overview.
Authors: Barrea L, Frias-Toral E, Pugliese G, Garcia-Velasquez E, De Los Angeles Carignano M, Savastano S, Colao A, Muscogiuri G
Abstract
Hypovitaminosis D and obesity represent two pandemic conditions sometimes associated with each other. Although it is known that there is a close relationship between these two health problems, the underlying pathophysiological mechanism has not yet been fully clarified. In fact, on the one hand, obesity per se seems to involve low circulating levels of vitamin D due to low sun exposure, physical activity, and intake of foods rich in vitamin D, volumetric dilution and seq...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
TSH modulation in advanced differentiated thyroid cancer: a continuous walk on the tightrope between prognostic stratification, adverse events, and levothyroxine bioavailability.
Authors: Marotta V, Botti G, Ionna F, Pezzullo L
PMID: 33213117 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Liquid biopsy in thyroid cancer: from circulating biomarkers to a new prospective of tumor monitoring and therapy.
The objective of this monography is to describe the main components studied in liquid biopsy (circulating tumor nucleic acids, circulating tumor cells and extracellular vesicles) and how they have been explored in thyroid cancer, through an in-depth scientific literature review. While circulating tumor cells are the most represented component in the literature of liquid biopsy in thyroid cancer, circulating tumor nucleic acids and extracellular vesicles have also been recently explored. One important challenge in this field of research, especially for differentiated thyroid cancer, has been the low quantity of circulating ...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Personalized treatment for thyroid cancer: current data and new perspectives.
Authors: Colombo C, Giancola N, Fugazzola L
Abstract
More conservative and personalized treatment options have been developed in recent years to face the rising diagnosis of low-risk differentiated thyroid carcinoma (DTC). The present review describes the changes in the direction toward a more risk-adapted management either in the treatment or in the follow-up of DTC. Particular attention is given to the innovations introduced by the latest guidelines for low-risk tumors, starting from the most appropriate extension of surgery up to the post-operative management. The emerging role of active surveillance fo...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Very-low-calorie ketogenic diet for the management of obesity, overweight and related disorders.
Authors: Castellana M, Biacchi E, Procino F, Casanueva FF, Trimboli P
Abstract
Very-low-calorie ketogenic diet (VLCKD) is a promising lifestyle intervention for the management of overweight and obesity. It is characterized by a restriction of both calories and carbohydrates, while assuring the adequate proteins, fats and micronutrients intake. Significant results in terms of excess body weight loss have been reported and this strategy considered also in the preoperative settings, accordingly. Improvements in hypertension, type 2 diabetes and dyslipidemia follows. The present narrative review discusses avai...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Obesity and physical exercise.
Authors: Celik O, Yildiz BO
Abstract
Obesity represents a major health problem worldwide and is associated with increased prevalance of numerous health-related conditions, including diabetes, hypertension, cardiovascular disease, some forms of cancer and musculoskeletal disorders among others. Studies that have examined the impact of physical exercise combined with energy restriction diets on weight have shown greater weight loss compared to interventions of exercise-only. Accodingly, the most effective approach to achieve significant weigt loss includes a combination of diet, exercise and behavioral strat...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
