Morphometric analysis of the branching of the vascular tree in the chick embryo area vasculosa
In this study, we have analyzed by a modern morphometric approach the total length of the vascular network, the number of vascular branches, of the branching points density, the modality of vessel ramification, and spatial arrangement of the vascular network in four consecutive stages of development of the area vasculosa. The results have shown that there is a significant 15% increase in the total length of the vascular network associated with a progressive increase of the number of vascular branches and of the branching points density. Moreover, the results indicated that vascular spatial disorder significantly decreased ...
Source: Microvascular Research - October 25, 2019 Category: Biochemistry Source Type: research
Acute consumption of flavanol-rich cocoa beverage improves attenuated cutaneous microvascular function in healthy young African Americans
Publication date: Available online 22 October 2019Source: Microvascular ResearchAuthor(s): Kiyoung Kim, R. Matthew BrothersAbstractFlavanols have beneficial effects on vascular health and we have recently demonstrated that cerebral vasodilatory capacity in healthy young African Americans (AA) is improved with acute flavanol intake relative to aged-matched Caucasian Americans (CA). However, whether the positive benefits of acute flavanol consumption would also be present in the cutaneous microvascular circulation of AA remains unknown. Thus, we hypothesized that acute consumption of flavanol-rich cocoa (FC) would improve th...
Source: Microvascular Research - October 23, 2019 Category: Biochemistry Source Type: research
Orphan nuclear receptor TR3/Nur77 biologics inhibit tumor growth by targeting angiogenesis and tumor cells
Publication date: Available online 23 October 2019Source: Microvascular ResearchAuthor(s): Chen Chen, Yan Li, Shiqiang Hou, Pierre M. Bourbon, Liuliang Qin, Kevin Zhao, Taiyang Ye, Dezheng Zhao, Huiyan ZengAbstractPathological angiogenesis is a hallmark of many diseases. Previously, we reported that orphan nuclear receptor TR3/Nur77 was a critical mediator of angiogenesis to regulate tumor growth, sepsis and skin wound healing. However, none of the TR3/Nur77 targeting molecule has been in clinical trial so far. Here, we designed and generated novel TR3 shRNAs and two minigenes that had therapeutic potential for cancer trea...
Source: Microvascular Research - October 23, 2019 Category: Biochemistry Source Type: research
Passive smoking acutely affects the microcirculation in healthy non-smokers
ConclusionsOur results suggest that acute exposure to passive smoking delays peripheral tissue oxygen consumption and adversely affects microcirculatory responsiveness after stagnant ischemia in healthy non-smokers. (Source: Microvascular Research)
Source: Microvascular Research - October 22, 2019 Category: Biochemistry Source Type: research
Retinal vessel caliber and caliber responses in true normotensive black and white adults: The African-PREDICT study
ConclusionsAlready at a young age, healthy black adults showed narrower retinal arteries relative to the white population. Follow-up studies are underway to show if this will be related to increased risk for hypertension development. The reason for the larger vessel dilation responses to FLIP in the black population is unclear and warrants further investigation. (Source: Microvascular Research)
Source: Microvascular Research - October 22, 2019 Category: Biochemistry Source Type: research
Advances on fluid shear stress regulating blood-brain barrier
Publication date: Available online 19 October 2019Source: Microvascular ResearchAuthor(s): Xiaoli Wang, Bowen Xu, Mengya Xiang, Xinyue Yang, Yi Liu, Xiaoheng Liu, Yang ShenAbstractThe integrity of the structure and function of the blood-brain barrier (BBB) plays a central role in maintaining the homeostasis of the central nervous system. Patients with severe cerebrovascular stenosis often undergo cerebrovascular bypass surgery. However, the sharply increased fluid shear stress (FSS) after cerebrovascular bypass disrupts the physiological function of brain microvascular endothelial cells (BMECs) at the lesion site, damaging...
Source: Microvascular Research - October 20, 2019 Category: Biochemistry Source Type: research
Comparison of laser speckle contrast imaging and laser-Doppler fluxmetry in boys and men
ConclusionsLSCI presented with higher values than LDF during rest, PORH, and exercise; the disparity between the two measures was larger as blood flow increased. The assessments were generally consistent, both methods appear to provide usable data for the assessment of microvascular reactivity in both boys and men. There are biases to each method and the data are not interchangeable between LDF and LSCI. (Source: Microvascular Research)
Source: Microvascular Research - October 6, 2019 Category: Biochemistry Source Type: research
Blood flow velocity comparison in the eye capillaries and postcapillary venules between normal pregnant and non-pregnant women
ConclusionsNormal pregnancy increases significantly axial blood velocity (Vax) in capillaries (CAP) with diameter <9 μm. (Source: Microvascular Research)
Source: Microvascular Research - September 13, 2019 Category: Biochemistry Source Type: research
Angiogenic effects of mesenchymal stem cells in combination with different scaffold materials
In conclusion, seeding β-TCP scaffolds with MSCs can accelerate vitalization and a combination of both significantly improves angiogenesis. (Source: Microvascular Research)
Source: Microvascular Research - September 13, 2019 Category: Biochemistry Source Type: research
miR-23c regulates wound healing by targeting stromal cell-derived factor-1α (SDF-1α/CXCL12) among patients with diabetic foot ulcer
In conclusion, miR-23c may function as a new regulator to inhibit angiogenesis by targeting SDF-1α.Graphical abstract (Source: Microvascular Research)
Source: Microvascular Research - September 13, 2019 Category: Biochemistry Source Type: research
Toll-like receptor protein 4 monoclonal antibody inhibits mmLDL-induced endothelium-dependent vasodilation dysfunction of mouse mesenteric arteries
In conclusion, pretreatment with TLR4 mAb lessens mmLDL-induced EDV dysfunction and inhibits overexpression of inflammatory factors. Regulation of the TLR4 pathway, as well as its downstream NF-κB p65 and p38 MAPK pathways, may be an effective strategy for the prevention and treatment of cardiovascular diseases. (Source: Microvascular Research)
Source: Microvascular Research - September 7, 2019 Category: Biochemistry Source Type: research
The effects of the analysis strategy on the correlation between the NIRS reperfusion measures and the FMD response
This study aimed to investigate the correlation between near-infrared spectroscopy (NIRS)-derived measures of microvascular responses using a range of different analysis and flow-mediated dilation (FMD). Additionally, we aimed to investigate whether assessing NIRS and FMD simultaneously or non-simultaneously would affect this association. Thirty-five healthy young individuals (26 ± 13 years old) participated in the study. Twenty were submitted to a simultaneous NIRS/FMD test (NIRS probe placed below the cuff during FMD test) and fifteen to a non-simultaneous FMD and NIRS intervention (NIRS test performed 20 min af...
Source: Microvascular Research - August 31, 2019 Category: Biochemistry Source Type: research
Editorial Board
Publication date: November 2019Source: Microvascular Research, Volume 126Author(s): (Source: Microvascular Research)
Source: Microvascular Research - August 30, 2019 Category: Biochemistry Source Type: research
Assessment of microvascular function in vivo using flow mediated skin fluorescence (FMSF) in patients with obstructive lung diseases: A preliminary study
ConclusionsThe FMSF technique makes it possible to identify impairments of the microvascular function in patients with COPD, but not in asthma patients. These exploratory findings require further validation in a larger patients cohort. (Source: Microvascular Research)
Source: Microvascular Research - August 29, 2019 Category: Biochemistry Source Type: research
miR-320/VEGFA axis affects high glucose-induced metabolic memory during human umbilical vein endothelial cell dysfunction in diabetes pathology
In conclusion, we demonstrate that miR-320/VEGFA axis is crucial to high glucose-induced metabolic memory during HUVEC dysfunction and may be involved in the pathology of diabetes. (Source: Microvascular Research)
Source: Microvascular Research - August 23, 2019 Category: Biochemistry Source Type: research
