Stanniocalcin-1 ameliorates cerebral ischemia by decrease oxidative stress and blood brain barrier permeability
Publication date: Available online 13 November 2019Source: Microvascular ResearchAuthor(s): Sandra Bonfante, Amanda Della Giustina, Lucineia Gainski Danielski, Tais Denicol, Larissa Joaquim, Erica Biehl, Gabriel Scopel, Raquel Jaconi de Carli, Marcos Hubner, Taise Cardoso, Talita Tuon, Jaqueline Generoso, Tatiana Barichello, Silvia Terra, Fabricia PetronilhoAbstractBlood brain barrier (BBB) permeability and oxidative stress have been reported to be important mechanisms for brain damage following ischemic stroke and stanniocalcin-1 (STC-1), a neuroprotective protein, has anti-inflammatory and anti-oxidative stress propertie...
Source: Microvascular Research - November 15, 2019 Category: Biochemistry Source Type: research
Unique changes in the retinal microvasculature reveal subclinical retinal impairment in patients with systemic lupus erythematosus
ConclusionSignificantly lower density in SRCP and regional thinning in inner retina were observed in the SLE patients without clinical fundus changes. OCT equipped with Angiovue might be useful in evaluating the microvascular and microstructural disorders of the inner retinal layers in SLE patients, which may contribute a quantitative approach to the early diagnosis and progression of LR. (Source: Microvascular Research)
Source: Microvascular Research - November 15, 2019 Category: Biochemistry Source Type: research
Degradation of group V secretory phospholipase A2 in lung endothelium is mediated by autophagy
Publication date: Available online 13 November 2019Source: Microvascular ResearchAuthor(s): Lucille N. Meliton, Xiangdong Zhu, Mary Brown, Yulia Epshtein, Takeshi Kawasaki, Eleftheria Letsiou, Steven M. DudekAbstractGroup V secretory phospholipase A2 (gVPLA2) is a potent inflammatory mediator in mammalian tissues that hydrolyzes phospholipids and initiates eicosanoid biosynthesis. Previous work has demonstrated that multiple inflammatory stimuli induce its expression and secretion in several cell types, including the lung endothelium. However, little is known about the mechanism(s) by which gVPLA2 inflammatory signaling is...
Source: Microvascular Research - November 13, 2019 Category: Biochemistry Source Type: research
The novel axis of YAP1, transcription enhancer factor 3 and Down Syndrome Candidate Region 1 isoform 1L is a common signaling pathway downstream of several angiogenic factors
In this study, we found that the expressions of DSCR1-1L mRNA and proteins were upregulated by other angiogenic factors, including VEGF-A121, VEGF-E, histamine, PAF, the endothelial cell (EC) growth medium, and the conditional medium obtained from cancer cells, but not by PlGF, bFGF, PDGF, and serotonin. The EC proliferation, migration and elongation induced by histamine and EC growth medium were inhibited by knocking down the mRNA and protein expressions of DSCR1-1L and TEF3. The TEF3 activation was regulated by its interaction with YAP1, and translocation from cytosol to nuclei, but not by increase of protein expression,...
Source: Microvascular Research - November 13, 2019 Category: Biochemistry Source Type: research
Fc-saxatilin inhibits VEGF-induced permeability by regulating claudin-5 expression in human brain microvascular endothelial cells
In this study, we show that Fc–saxatilin prevents VEGF-induced permeability in human brain microvascular endothelial cells (HBMECs). The activation of Src and Fak, downstream signaling proteins of VEGF in the induction of endothelial permeability, was inhibited by Fc–saxatilin in HBMECs. The downregulation of a tight junction protein, claudin-5, at the protein and mRNA levels by VEGF was recovered by Fc–saxatilin. Our findings suggest that Fc–saxatilin attenuates VEGF-induced endothelial permeability via the regulation of downstream signaling, and this may contribute to its protective effect against vascular leakag...
Source: Microvascular Research - November 9, 2019 Category: Biochemistry Source Type: research
Comment on the paper “Electrokinetically modulated peristaltic transport of power-law fluids, Prakash Goswami, Jeevanjyoti Chakraborty, Aditya Bandopadhyay, Suman Chakraborty, Microvascular Research 103 (2016) 41–54”
Publication date: Available online 6 November 2019Source: Microvascular ResearchAuthor(s): Asterios PantokratorasAbstractIn the above paper, some basic equations are wrong. (Source: Microvascular Research)
Source: Microvascular Research - November 7, 2019 Category: Biochemistry Source Type: research
TSGA10 overexpression inhibits angiogenesis of HUVECs: A HIF-2α biased perspective
This study elucidated that increased expression of TSGA10 in manipulated human umbilical vein endothelial cells (HUVECs) decreased the proliferation and migration of these cells as affirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and wound healing tests, respectively. It also inhibited in vitro angiogenesis of these cells in 3D collagen-cytodex model. Expression levels of genes controlled by HIF-2α including autocrine vascular endothelial growth factor (VEGF) were also assessed using real-time PCR. Our bioinformatic analysis also showed that TSGA10 could bind HIF-2α. Moreover, flow cytometry...
Source: Microvascular Research - November 6, 2019 Category: Biochemistry Source Type: research
Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats via suppressing PI3K/Akt signaling
ConclusionsTMP exerts its protective effects and prevents basilar artery remodeling in RHRSP rats at least partly through the inhibition of PI3K/Akt pathway. (Source: Microvascular Research)
Source: Microvascular Research - November 3, 2019 Category: Biochemistry Source Type: research
Editorial Board
Publication date: January 2020Source: Microvascular Research, Volume 127Author(s): (Source: Microvascular Research)
Source: Microvascular Research - November 3, 2019 Category: Biochemistry Source Type: research
New insights to the potential mechanisms driving coronary flow reserve impairment in Cushing's syndrome: A pilot noninvasive study by transthoracic Doppler echocardiography
ConclusionsFunctional microvascular regulatory impairment seems to be the potential mechanism of CMD in CS. CMD seems to be related to decreased myocardial contractility and diastolic dysfunction associated with cortisol excess.Graphical abstract (Source: Microvascular Research)
Source: Microvascular Research - November 1, 2019 Category: Biochemistry Source Type: research
Ex vivo model for studying endothelial tip cells: Revisiting the classical aortic-ring assay
Publication date: Available online 30 October 2019Source: Microvascular ResearchAuthor(s): Yash T. Katakia, Sushmitha Duddu, S. Nithya, Pavitra Kumar, Farhana Rahman, Govindasamy Kumaramanickavel, Suvro ChatterjeeAbstractA drug undergoes several in silico, in vitro, ex vivo and in vivo assays before entering into the clinical trials. In 2014, it was reported that only 32% of drugs are likely to make it to Phase-3 trials, and overall, only one in 10 drugs makes it to the market. Therefore, enhancing the precision of pre-clinical trial models could reduce the number of failed clinical trials and eventually time and financial...
Source: Microvascular Research - October 31, 2019 Category: Biochemistry Source Type: research
An automated method for segmentation and quantification of blood vessels in histology images
Publication date: Available online 30 October 2019Source: Microvascular ResearchAuthor(s): Faiza Bukenya, Culi Nerissa, Sébastien Serres, Marie-Christine Pardon, Li BaiAbstractAlzheimer’s disease (AD) is a chronic neuro-degenerative disease that adversely affect many people on a global scale. Despite different diagnostic and therapeutic treatment, there is no cure for AD. The brain is one of the most complex organ and researchers are still trying to understand so as to find a cure. Objective: To complement the efforts of clinical researchers engaged in research in alzheimer’s disease, accurate segmentation and quantif...
Source: Microvascular Research - October 31, 2019 Category: Biochemistry Source Type: research
PEAR1 suppresses the proliferation of pulmonary microvascular endothelial cells via PI3K/AKT pathway in ALI model
ConclusionsPEAR1 acts as a negative regulator in the proliferation of HPMECs in ALI model via the PI3K/AKT pathway. (Source: Microvascular Research)
Source: Microvascular Research - October 31, 2019 Category: Biochemistry Source Type: research
Noninvasive assessment of increases in microvascular endothelial function following repeated bouts of hyperaemia
ConclusionsSpectral analysis appears sufficiently sensitive to measure changes over time in cutaneous endothelial activity that are consistent with standard physiological (local heating) and pharmacological (acetylcholine) interventions of assessing cutaneous endothelial function, and may be useful not only in research but also clinical diagnosis and treatment. (Source: Microvascular Research)
Source: Microvascular Research - October 29, 2019 Category: Biochemistry Source Type: research
Effects of walking speeds and durations on plantar skin blood flow responses
ConclusionsOur results provide the first evidence that walking speeds affect plantar skin blood flow and a fast walking speed (9 km/h) significantly increases plantar skin blood flow compared to moderate (6 km/h) and slow (3 km/h) walking speeds. (Source: Microvascular Research)
Source: Microvascular Research - October 26, 2019 Category: Biochemistry Source Type: research
