Corrigendum to “Endocan is useful biomarker of survival and severity in sepsis” [Microvasc. Res. 93 (2014) 92–97]
Publication date: Available online 29 February 2020Source: Microvascular ResearchAuthor(s): Dunja M. Mihajlovic, Dajana F. Lendak, Biljana G. Draskovic, Snezana V. Brkic, Gorana P. Mitic, Aleksandra S. Novakov Mikic, Tatjana N. Cebovic (Source: Microvascular Research)
Source: Microvascular Research - February 29, 2020 Category: Biochemistry Source Type: research
Diclofenac sodium loaded PLGA nanoparticles for inflammatory diseases with high anti-inflammatory properties at low dose: Formulation, characterization and in vivo HET-CAM analysis
Publication date: Available online 24 February 2020Source: Microvascular ResearchAuthor(s): A. Alper Öztürk, İrem Namlı, Kadri Güleç, H. Tuba Kıyan (Source: Microvascular Research)
Source: Microvascular Research - February 25, 2020 Category: Biochemistry Source Type: research
Three-dimensional visualization of coronary microvasculature in rats with myocardial infarction
ConclusionThree-dimensional visualization of opened coronary microvascular vessels is feasible in DiI-labelled myocardium in this rat MI model. This novel technique might be useful for defining the underlying mechanisms of coronary microvascular diseases and observe the efficacy of various therapy strategies on coronary microvessels. (Source: Microvascular Research)
Source: Microvascular Research - February 21, 2020 Category: Biochemistry Source Type: research
Resveratrol prevented experimental pulmonary vascular remodeling via miR-638 regulating NR4A3/cyclin D1 pathway
ConclusionOur data indicated that resveratrol prevented MCT-induced pulmonary vascular remodeling via miR-638 regulating NR4A3/cyclin D1 pathway. (Source: Microvascular Research)
Source: Microvascular Research - February 10, 2020 Category: Biochemistry Source Type: research
The role of circulating soluble fms-like tyrosine kinase-1 in patients with diabetic foot ulcer: A possible mechanism of pathogenesis via a novel link between oxidative stress, inflammation and angiogenesis
ConclusionThis study revealed that sFlt-1 is a major player in DFU pathogenesis and may be considered as a novel diagnostic biomarker for early detection of DFU. (Source: Microvascular Research)
Source: Microvascular Research - February 8, 2020 Category: Biochemistry Source Type: research
Fibulin-7 C-terminal fragment and its active synthetic peptide suppress choroidal and retinal neovascularization
Publication date: Available online 1 February 2020Source: Microvascular ResearchAuthor(s): Tomoko Ikeuchi, Yogita Kanan, Da Long, Susana de Vega, Kentaro Hozumi, Motoyoshi Nomizu, Peter A. Campochiaro, Yoshihiko YamadaAbstractWet age-related macular degeneration (AMD) and diabetic retinopathy are the leading causes of blindness through increased angiogenesis. Although VEGF-neutralizing proteins provide benefit, inconsistent responses indicate a need for new therapies. We previously identified the Fibulin-7 C-terminal fragment (Fbln7-C) as an angiogenesis inhibitor in vitro. Here we show that Fbln7-C inhibits neovasculariza...
Source: Microvascular Research - February 2, 2020 Category: Biochemistry Source Type: research
Utility of discovery approach using proteomics to create a biomarker profile for coronary microvascular dysfunction
ConclusionMass spectrometry using discovery approach may not be an adequate method for quantitative assessment of serum proteins in CMD patients. Future MS studies should evaluate other approaches including tissue samples or serial measurements. (Source: Microvascular Research)
Source: Microvascular Research - January 30, 2020 Category: Biochemistry Source Type: research
Association between impaired cutaneous microvascular endothelial function and lectin-like oxidized low-density lipoprotein receptor-1 in patients with coronary slow flow
ConclusionThese data suggest that cutaneous microvascular endothelial function is impaired in patients with CSF, which is closely associated with increased LOX-1 expression. (Source: Microvascular Research)
Source: Microvascular Research - January 17, 2020 Category: Biochemistry Source Type: research
Angiogenic circular RNAs: A new landscape in cardiovascular diseases
Publication date: Available online 14 January 2020Source: Microvascular ResearchAuthor(s): Tian-Rong Zhang, Wei-Qiang HuangAbstractAngiogenesis refers to the formation of new blood vessels from existing blood vessels, including endothelial progenitor cells differentiation and cytokine regulation. Circular RNAs, a type of non-coding RNA, are a stable and conservative endogenous transcriptional product with a circular structure that is produced by the reverse and scrambled splicing of mRNA precursors. They can be used as microRNA sponges, are involved in transcription and protein translation, and regulate the pathophysiologi...
Source: Microvascular Research - January 15, 2020 Category: Biochemistry Source Type: research
Editorial Board
Publication date: March 2020Source: Microvascular Research, Volume 128Author(s): (Source: Microvascular Research)
Source: Microvascular Research - January 15, 2020 Category: Biochemistry Source Type: research
Activating α7nAChRs enhances endothelial progenitor cell function partially through the JAK2/STAT3 signaling pathway
This study reveals that α7nAChRs are potential therapeutic targets for angiogenesis and that the JAK2/STAT3 pathway plays a vital role in the associated therapeutic mechanism. (Source: Microvascular Research)
Source: Microvascular Research - January 9, 2020 Category: Biochemistry Source Type: research
Aortic stiffness is not only associated with structural but also functional parameters of retinal microcirculation
ConclusionIn conclusion, the study provides a strong evidence that microcirculation is coupled with macrocirculation not only in terms of structural but also functional parameters. (Source: Microvascular Research)
Source: Microvascular Research - January 7, 2020 Category: Biochemistry Source Type: research
Sublingual microvasculature in diabetic patients
In conclusion, diabetes is associated with loss of glycocalyx density. (Source: Microvascular Research)
Source: Microvascular Research - December 30, 2019 Category: Biochemistry Source Type: research
Up-regulation of brain cytokines and metalloproteinases 1 and 2 contributes to neurological deficit and brain damage in transient ischemic stroke
Publication date: Available online 28 December 2019Source: Microvascular ResearchAuthor(s): Edna Constanza Gómez Victoria, Eliana Cristina de Brito Toscano, Fabrício Marcus Silva Oliveira, Bárbara Andrade de Carvalho, Marcelo Vidigal Caliari, Antônio Lúcio Teixeira, Aline Silva de Miranda, Milene Alvarenga RachidAbstractIschemic stroke represents a major cause of adult death and severe neurological disability worldwide. Reperfusion following brain ischemia produces an inflammatory cascade that increases brain damage. In this context, matrix metalloproteinases (MMPs) play an important role as pro-inflammatory mediators...
Source: Microvascular Research - December 30, 2019 Category: Biochemistry Source Type: research
Nailfold capillaroscopic changes in patients with chronic viral hepatitis
ConclusionNailfold capillary abnormalities are one of the extrahepatic dermatologic finding which could be a sign of the endothelial tissue damage in chronic viral hepatitis, we do not have any data about the effects of these two usual infections on the nailfold capillary morphology. This is the first study evaluating the microvasculature abnormalities of the nailfold capillaries in hepatitis B and hepatitis C infected individuals by capillaroscopic examination. (Source: Microvascular Research)
Source: Microvascular Research - December 30, 2019 Category: Biochemistry Source Type: research
