Tctgcttat attact tggattactcat gataatgct
Publication date: Available online 24 December 2018Source: Microbes and InfectionAuthor(s): Sophia HäfnerAbstractArticle highlight based on “AIM2 senses Brucella abortus DNA in dendritic cells to induce IL-1β secretion, pyroptosis and resistance to bacterial infection in mice" by Miriam Maria Silva Costa Franco et al. (Source: Microbes and Infection)
Source: Microbes and Infection - January 10, 2019 Category: Infectious Diseases Source Type: research

Tctgcttat Attact Tggattactcat Gataatgct∗
Publication date: Available online 24 December 2018Source: Microbes and InfectionAuthor(s): Sophia HäfnerAbstractArticle highlight based on “AIM2 senses Brucella abortus DNA in dendritic cells to induce IL-1β secretion, pyroptosis and resistance to bacterial infection in mice" by Miriam Maria Silva Costa Franco et al. (Source: Microbes and Infection)
Source: Microbes and Infection - December 25, 2018 Category: Infectious Diseases Source Type: research

Pertactin-deficient Bordetella pertussis isolates in Poland—a country with whole-cell pertussis primary vaccination
Publication date: Available online 21 December 2018Source: Microbes and InfectionAuthor(s): Maciej Polak, Aleksandra Anna Zasada, Ewa Mosiej, Katarzyna Krysztopa-Grzybowska, Lucjan Witkowski, Magdalena Rzeczkowska, Katarzyna Piekarska, Anna LutyńskaAbstractThe introduction of pertussis vaccination in the 1950s resulted in a significant decrease in the incidence of disease. However, since the 1990s many highly vaccinated countries have observed the re-emergence of the disease. One of the causes of this phenomenon might be related to the adaptation of Bordetella pertussis to vaccination. The purpose of the presented study w...
Source: Microbes and Infection - December 21, 2018 Category: Infectious Diseases Source Type: research

Cognate T and B cell interaction and association of follicular helper T cells with B cell responses in Vibrio cholerae O1 infected Bangladeshi adults
Publication date: Available online 21 December 2018Source: Microbes and InfectionAuthor(s): Rasheduzzaman Rashu, Taufiqur Rahman Bhuiyan, Mohammad Rubel Hoq, Lazina Hossain, Anik Paul, Ashraful Islam Khan, Fahima Chowdhury, Jason B. Harris, Edward T. Ryan, Stephen B. Calderwood, Ana A. Weil, Firdausi QadriAbstractVibrio cholerae O1 can cause life threatening diarrheal disease if left untreated. T cells can play critical roles in inducing B cell mediated immunity. As the mechanism of T cell dependent B cell maturation is not well established, we hypothesized that a specific population of T (follicular helper T, Tfh)) cells,...
Source: Microbes and Infection - December 21, 2018 Category: Infectious Diseases Source Type: research

Immunobiology of monocytes and macrophages during Chlamydia trachomatis infection
Publication date: Available online 8 December 2018Source: Microbes and InfectionAuthor(s): Mads Lausen, Gunna Christiansen, Thomas Bouet Guldbæk Poulsen, Svend BirkelundAbstractInfections caused by the intracellular bacterium Chlamydia trachomatis are a global health burden affecting more than 100 million people annually causing damaging long-lasting infections. In this review, we will present and discuss important aspects of the interaction between C. trachomatis and monocytes/macrophages. (Source: Microbes and Infection)
Source: Microbes and Infection - December 8, 2018 Category: Infectious Diseases Source Type: research

Hepatitis E virus is not detected in association with neurological disorders among Brazilian children
Publication date: Available online 7 December 2018Source: Microbes and InfectionAuthor(s): Lucas Nobrega Morgado, Jaqueline Mendes de Oliveira, Marcelo Alves Pinto, Fernanda Marcicano Burlandy, Edson Elias da Silva, Jaquelline Pereira da Silva, Claudia Lamarca VitralAbstractHepatitis E virus is increasingly being associated with idiopathic neurological disease. We tested 325 stool samples from Brazilian children presenting acute flaccid paralysis or Guillain-Barré syndrome using a broadly reactive and sensitive Reverse-transcription Polymerase chain reaction. Hepatitis E genome was not detected in any of the samples teste...
Source: Microbes and Infection - December 7, 2018 Category: Infectious Diseases Source Type: research

Editorial board
Publication date: December 2018Source: Microbes and Infection, Volume 20, Issues 11–12Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - December 4, 2018 Category: Infectious Diseases Source Type: research

Editorial board
Publication date: October–November 2018Source: Microbes and Infection, Volume 20, Issues 9–10Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - November 17, 2018 Category: Infectious Diseases Source Type: research

Targeting the R domain of coagulase by active vaccination protects mice against lethal Staphylococcus aureus infection
In this study, we constructed a new R domain, CoaR6, consisting of 6 repeats that occur most frequently in clinical isolates. By fusing CoaR6 with Hc, the C-terminal fragment of the heavy chain of tetanus neurotoxin, we successfully increased anti-CoaR6 IgG levels in immunized mice which were hardly detected in mice immunized with CoaR6 plus alum. To further improve anti-CoaR6 responses, the combination adjuvants alum plus CpG were formulated with the antigen and exhibited a significantly higher specific antibody response. Moreover, active Th1/Th17 immune responses were observed in Hc-CoaR6 immunized group rather than CoaR...
Source: Microbes and Infection - November 15, 2018 Category: Infectious Diseases Source Type: research

A proteomics approach for the identification of species-specific immunogenic proteins in the Mycobacterium abscessus complex
In this study seven clinical M. abscessus complex strains and the M. abscessus reference strain ATCC19977 were used to find species-specific proteins for their use in immune assays. Six strains showed rough and smooth colony morphotypes simultaneously, two strains only showed rough mophotypes, resulting in 14 separate isolates. Clinical isolates were submitted to whole genome sequencing. Proteomic analysis was performed on bacterial lysates and culture supernatant of all 14 isolates. Species-specificity for M. abscessus complex was determined by a BLAST search for proteins present in all supernatants. Species-specific prot...
Source: Microbes and Infection - November 14, 2018 Category: Infectious Diseases Source Type: research

Acinetobacter baumannii outer membrane protein 34 elicits NLRP3 inflammasome activation via mitochondria-derived reactive oxygen species in RAW264.7 macrophages
Publication date: Available online 13 November 2018Source: Microbes and InfectionAuthor(s): Zhiyuan An, Jianrong SUAbstractAcinetobacter baumannii (A. baumannii) is a Gram-negative bacterium, which acts as an opportunistic pathogen and causes hospital-acquired pneumonia and bacteremia by infecting the alveoli of epithelial cells and macrophages. Evidence reveals that A. baumannii outer membrane protein 34 (Omp34) elicits cellular immune responses and inflammation. The innate immunity NOD-like receptor 3 (NLRP3) inflammasome exerts critical function against pneumonia caused by A. baumannii infection, however, the role of Om...
Source: Microbes and Infection - November 14, 2018 Category: Infectious Diseases Source Type: research

Editorial board
Publication date: August–September 2018Source: Microbes and Infection, Volume 20, Issues 7–8Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - November 11, 2018 Category: Infectious Diseases Source Type: research

Insights into Streptococcus agalactiae PI-2b pilus biosynthesis and role in adherence to host cells
Publication date: Available online 10 November 2018Source: Microbes and InfectionAuthor(s): Bruno Périchon, Julie Guignot, Noémi Szili, Cherry Gao, Claire Poyart, Patrick Trieu-Cuot, Shaynoor DramsiAbstractThe core PI-2b pilus present in “hypervirulent” ST-17 S. agalactiae strains consists of three pilin subunits (Spb1, Ap1 and Ap2) assembled by sortase SrtC1 and cell-wall anchored by Srt2. Spb1 was shown to be the major pilin and Ap2 the anchor pilin. Ap1 is a putative adhesin. Two additional genes, orf and lep, are part of this operon. The contribution of Lep and Ap1 to the biogenesis of the PI-2b pilus was investi...
Source: Microbes and Infection - November 11, 2018 Category: Infectious Diseases Source Type: research

Evaluation of monocyte subsets and markers of activation in leprosy reactions
Publication date: Available online 31 October 2018Source: Microbes and InfectionAuthor(s): Mayume Shibuya, Giovana Bergheme, Sara Passos, Ivonete Queiroz, Jamile Rêgo, Lucas P. Carvalho, Paulo R.L. MachadoAbstractUnderstanding host immune pathways associated with tissue damage during reactions are of upmost importance to the development of immune intervention strategies. The participation of monocytes in leprosy reactions was evaluated by determining the frequency of monocyte subsets and the degree of cellular activation through the expression of MHCII and the co-stimulatory molecules CD40, CD80, CD86. Leprosy subjects wi...
Source: Microbes and Infection - October 31, 2018 Category: Infectious Diseases Source Type: research

Human leukocyte antigen-associated gag and nef polymorphisms in HIV-1 subtype A/E-infected individuals in Vietnam
Publication date: Available online 30 October 2018Source: Microbes and InfectionAuthor(s): Naofumi Takahashi, Saori Matsuoka, Tam Tran Thi Minh, Hien Pham Ba, Taeko K. Naruse, Akinori Kimura, Teiichiro Shiino, Ai Kawana-Tachikawa, Koichi Ishikawa, Tetsuro Matano, Lan Anh Nguyen ThiAbstractNumbers of HLA-associated polymorphisms have been reported on HIV-1 subtypes B and C, but few on other subtypes. Here, we analyzed HLA-associated gag and nef polymorphisms in HIV-1 subtype A/E prevalent in Vietnam. We determined HLA-A, B and C genotypes in 179 HIV-1-infected Vietnamese by next generation sequencing and analyzed proviral g...
Source: Microbes and Infection - October 30, 2018 Category: Infectious Diseases Source Type: research