Messages from the third International Conference on Clinical Metagenomics (ICCMg3)
Publication date: Available online 2 March 2019Source: Microbes and InfectionAuthor(s): Etienne Ruppé, Jacques SchrenzelAbstractClinical metagenomics (CMg), referring to as the application of metagenomic sequencing of clinical samples in order to recover clinically-relevant information, has been rapidly evolving these last years. Following this trend, we held the third International Conference on Clinical Metagenomics (ICCMg3) in Geneva in October 2018. During the two days of the conference, several aspects of CMg were addressed, which we propose to summarize in the present manuscript. During this ICCMg3, we kept on follo...
Source: Microbes and Infection - March 4, 2019 Category: Infectious Diseases Source Type: research
Advances in diagnostics, vaccines and therapeutics for Nipah virus
Publication date: Available online 26 February 2019Source: Microbes and InfectionAuthor(s): Nazia Thakur, Dalan BaileyAbstractNipah virus is an emerging zoonotic paramyxovirus that causes severe and often fatal respiratory and neurological disease in humans. The virus was first discovered after an outbreak of encephalitis in pig farmers in Malaysia and Singapore with subsequent outbreaks in Bangladesh or India occurring almost annually. Due to the highly pathogenic nature of NiV, its pandemic potential, and the lack of licensed vaccines or therapeutics, there is a requirement for research and development into highly sensit...
Source: Microbes and Infection - February 26, 2019 Category: Infectious Diseases Source Type: research
Pam3CSK4 adjuvant given intranasally boosts anti-Leishmania immunogenicity but not protective immune responses conferred by LaAg vaccine against visceral leishmaniasis
Publication date: Available online 25 February 2019Source: Microbes and InfectionAuthor(s): Caio Loureiro Salgado, Emmanoel Loss Dias, Lorenzzo Lyrio Stringari, Luciana Polaco Covre, Reynaldo Dietze, Fausto Edimundo Lima Pereira, Herbet Leonel De Mattos Guedes, Bartira Rossi-Bergmann, Daniel Claudio Oliveira GomesAbstractThe use of adjuvants in vaccine formulations is a well-established practice to improve immunogenicity and protective immunity against diseases. Previously, we have demonstrated the feasibility of intranasal vaccination with the antigen of killed Leishmania amazonensis promastigotes (LaAg) against experimen...
Source: Microbes and Infection - February 25, 2019 Category: Infectious Diseases Source Type: research
Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections
Publication date: Available online 22 February 2019Source: Microbes and InfectionAuthor(s): Olga Kotelnikova, Alexander Alliluev, Alexei Zinchenko, Larisa Zhigis, Yuri Prokopenko, Elena Nokel, Olga Razgulyaeva, Vera Zueva, Marina Tokarskaya, Natalia Yastrebova, Elena Gordeeva, Tatyana Melikhova, Elena Kaliberda, Lev RumshAbstractImmunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including N. meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits i...
Source: Microbes and Infection - February 22, 2019 Category: Infectious Diseases Source Type: research
Editorial board
Publication date: January–February 2019Source: Microbes and Infection, Volume 21, Issue 1Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - February 15, 2019 Category: Infectious Diseases Source Type: research
Colonic adenoma-associated Escherichia coli express specific phenotypes
This study was aimed at characterizing isolates collected from polyps and adjacent tissue in comparison with those from normal mucosa.From colonoscopy biopsies, 1500 E. coli isolates were retrieved and genotyped; 272 were characterized for phylogroup and major phenotypic traits (i.e., biofilm formation, motility, hemolysins, and proteases). Selected isolates were analyzed for extraintestinal pathogenic E. coli (ExPEC)-associated virulence genes and in vivo pathogenicity using Galleria mellonella.The majority of isolates collected from polyps were strong biofilm and poor protease producers, whereas those isolates from norma...
Source: Microbes and Infection - February 12, 2019 Category: Infectious Diseases Source Type: research
Porphyromonas gingivalis promotes the motility of esophageal squamous cell carcinoma by activating NF-κB signaling pathway
Publication date: Available online 11 February 2019Source: Microbes and InfectionAuthor(s): Fan Meng, Ruifeng Li, Liyu Ma, Lifang Liu, Xiaorong Lai, Dongyang Yang, Junmin Wei, Dong Ma, Zijun LiAbstractEsophageal carcinoma, with a increasing incidence, is one of the most aggressive carcinomas in gastrointestinal tract. Epidemiologic studies demonstrate an association of oral pathogens with multiple diseases, including rheumatoid arthritis, cardiovascular diseases, diabetes, and gastrointestinal malignancies. Nevertheless, a causal relationship between oral pathogens and esophageal squamous cell carcinoma (ESCC) has not been...
Source: Microbes and Infection - February 12, 2019 Category: Infectious Diseases Source Type: research
Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus
This study suggests that elevated DMP1 concentrations may be associated with disease stage, severity, and the degree of acute kidney injury. DMP1 is involved in the regulation of capillary permeability in HFRS caused by hantavirus infection. (Source: Microbes and Infection)
Source: Microbes and Infection - February 6, 2019 Category: Infectious Diseases Source Type: research
Endocrine modulation of Brucella abortus-infected osteocytes function and osteoclastogenesis via modulation of RANKL/OPG
Publication date: Available online 5 February 2019Source: Microbes and InfectionAuthor(s): Ayelén Ivana Pesce Viglietti, Guillermo Hernán Giambartolomei, María Victoria DelpinoAbstractOsteoarticular brucellosis is the most frequent complication of active disease. A large amount of cells in bone are osteocytes. Since bone remodeling process is regulated by hormones we sought to study the effect of cortisol and DHEA in B. abortus-infected osteocytes. Cortisol treatment inhibited the expression of IL-6, TNF-α, MMP-2 and RANKL in B. abortus-infected osteocytes. DHEA could reverse the inhibitory effect of cortisol on MMP-2 ...
Source: Microbes and Infection - February 6, 2019 Category: Infectious Diseases Source Type: research
Asymptomatic dengue virus cases in misiones, Argentina: a seroprevalence study in the university population
In this study, 288 samples were analyzed, and the IgG anti dengue antibodies detected accounted for 6.6% of cases, while 89% corresponded to individuals who lived with people diagnosed or suspected of having contracted dengue, p= <0.001. (Source: Microbes and Infection)
Source: Microbes and Infection - February 5, 2019 Category: Infectious Diseases Source Type: research
Guns N′ viruses
Publication date: Available online 23 January 2019Source: Microbes and InfectionAuthor(s): Sophia Häfner (Source: Microbes and Infection)
Source: Microbes and Infection - February 5, 2019 Category: Infectious Diseases Source Type: research
Guns N' Viruses
Publication date: Available online 23 January 2019Source: Microbes and InfectionAuthor(s): Sophia Häfner (Source: Microbes and Infection)
Source: Microbes and Infection - January 24, 2019 Category: Infectious Diseases Source Type: research
Transcriptional profiles of cytokines and chemokines reveal important pro-inflammatory response from endothelial cells during Orientia tsutsugamushi infection
Publication date: Available online 23 January 2019Source: Microbes and InfectionAuthor(s): Hong Ge, Christina M. Farris, Min Tong, Alice Maina, Allen L. RichardsAbstractEndothelial cells (EC) are key targets during Orientia tsutsugamushi infection. Knowledge of the pro-inflammatory response against O. tsutsugamushi by ECs is limited. The aim of the present study was to characterize the pro-inflammatory transcriptional response during the first 24 hours of infection of the human dermal microvascular endothelial cell line with O. tsutsugamushi Karp by examining five-time points. The transcriptional profiles of 84 genes inclu...
Source: Microbes and Infection - January 24, 2019 Category: Infectious Diseases Source Type: research
Inhibition of antigen presentation by Brucella: many more than many ways
Publication date: Available online 21 January 2019Source: Microbes and InfectionAuthor(s): Paula Barrionuevo, Guillermo H. GiambartolomeiAbstractBrucella infection activates the immune system and favors the differentiation of CD4+ and CD8+ T cells. To persist during a long time inside macrophages evading immune surveillance of these T cells the pathogen must exploit different evasion strategies. We review the mechanisms whereby Brucella, through TLR signaling, inhibits MHC class I and II antigen presentation, allowing infected macrophages to become effective niches for Brucella survival. (Source: Microbes and Infection)
Source: Microbes and Infection - January 21, 2019 Category: Infectious Diseases Source Type: research
TableAsymptomatic dengue virus cases in misiones, Argentina: a seroprevalence study in the university population
In this study, 288 samples were analyzed, and the IgG anti dengue antibodies detected accounted for 6.6% of cases, while 89% corresponded to individuals who lived with people diagnosed or suspected of having contracted dengue, p= <0.001. (Source: Microbes and Infection)
Source: Microbes and Infection - January 20, 2019 Category: Infectious Diseases Source Type: research
