Zika Virus Infection: An Update
Publication date: Available online 31 May 2019Source: Microbes and InfectionAuthor(s): Pauline Ferraris, Hans Yssel, Dorothée MisséAbstractSince the ZIKV outbreak in Brazil in 2015, the scientific community has joined efforts to gather more information on the epidemiology, clinical features and pathogenicity of the virus. Here, we summarize the most important advances made recently and discuss promising, innovative aproaches to understand and control ZIKV infection. (Source: Microbes and Infection)
Source: Microbes and Infection - June 1, 2019 Category: Infectious Diseases Source Type: research
Helicobacter pylori pediatric infection changes FcεRI expression in dendritic cells and Treg profile in vivo and in vitro
Publication date: Available online 22 May 2019Source: Microbes and InfectionAuthor(s): Miguel A. Leon, Camila Palma, Caroll Hernandez, Mauricio Sandoval, Colomba Cofre, Guillermo Perez-Mateluna, Arturo Borzutzky, Paul R. Harris, Carolina A. SerranoAbstractH. pylori infection shows an inverse relationship with allergies. Dendritic cells regulate mucosal immune responses including the induction of T regulatory cells which are fundamental in H. pylori-induced dampening of allergies. In this respect expression of high-affinity IgE receptor (FcεRI) has been associated with a regulatory dendritic cell profile. Therefore we aime...
Source: Microbes and Infection - May 23, 2019 Category: Infectious Diseases Source Type: research
ESCMID/ESGMD postgraduate technical workshop on diagnostic microbiology
Publication date: Available online 16 May 2019Source: Microbes and InfectionAuthor(s): Aurélie Scherler, Silvia Ardissone, Jacob Moran-Gilad, Gilbert GreubAbstractThe European Society of Clinical Microbiology and Infectious Diseases (ESCMID) workshop on diagnostic microbiology was held in Lausanne from 25th to 28th September 2018. A total of 87 participants from 31 countries participated to this postgraduate technical workshop. Over 4 days, the mornings were dedicated to talks, which covered many subjects including MALDI-TOF, molecular diagnosis, genomics and metagenomics as well as new innovative approaches. The afternoo...
Source: Microbes and Infection - May 16, 2019 Category: Infectious Diseases Source Type: research
Role of Escherichia coli endopeptidases and DD-carboxypeptidases in infection and regulation of innate immune response
Publication date: Available online 11 May 2019Source: Microbes and InfectionAuthor(s): Sathi Mallick, Joyjyoti Das, Jyoti Verma, Samatha Mathew, Tapas K. Maiti, Anindya S. GhoshAbstractThe low-molecular-mass penicillin-binding proteins, involved in peptidoglycan recycling can also produce peptidoglycan fragments capable of activating an innate immune response in host. To investigate how these proteins in Enterobacteriaceae play a role to elicit/evade innate immune responses during infections, we deleted certain endopeptidases and DD-carboxypeptidases from E. coli CS109 and studied the viability of these mutants in macropha...
Source: Microbes and Infection - May 12, 2019 Category: Infectious Diseases Source Type: research
The influence of pH on S. saprophyticus iron metabolism and the production of siderophores
Publication date: Available online 7 May 2019Source: Microbes and InfectionAuthor(s): Bianca Silva Vieira de Souza, Karla Christina Sousa Silva, Ana Flávia Alves Parente, Clayton Luiz Borges, Juliano Domiraci Paccez, Maristela Pereira, Célia Maria de Almeida Soares, Marcia Giambiagi-deMarval, Mirelle Garcia Silva Bailão, Juliana Alves Parente-RochaAbstractStaphylococcus saprophyticus is a gram-positive coagulase negative bacteria which shows clinical importance due to its capability of causing urinary tract infections (UTI), as well as its ability to persist in this environment. Little is known about how S. saprophyticu...
Source: Microbes and Infection - May 8, 2019 Category: Infectious Diseases Source Type: research
An Imbalance of T Cell Subgroups Exists in Children with Sepsis
Publication date: Available online 19 April 2019Source: Microbes and InfectionAuthor(s): Qing Ye, Wen-xia Shao, Qing-qing Wang, Jian-hua MaoAbstractThe purpose of this study is to explore the role of different T cell subgroups in the pathogenesis of sepsis in children. Flow cytometry was used to detect the changes in the activation status and the number of T cell subgroups in the peripheral blood of children with sepsis; healthy children were selected as the control group. Compared with healthy children, the number of CD4+ T cells in the peripheral blood of children with sepsis did not change significantly (Z = 1.945, P = ...
Source: Microbes and Infection - April 20, 2019 Category: Infectious Diseases Source Type: research
Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection
This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease. (Source: Microbes and Infection)
Source: Microbes and Infection - April 20, 2019 Category: Infectious Diseases Source Type: research
VraSR has an important role in immune evasion of Staphylococcus aureus with low level vancomycin resistance
Publication date: Available online 19 April 2019Source: Microbes and InfectionAuthor(s): Caihong Gao, Yuanyuan Dai, Wenjiao Chang, Chao Fang, Ziran Wang, Xiaoling MaAbstractVancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) are increasingly being reported as associated with treatment failure. Previous studies indicated that VISA/hVISA resists clearance by the host immune system, thereby allowing persistence within the host. VraSR is a vancomycin-resistance-associated sensor/regulator that is highly expressed in VISA/hVISA strains. Whether VraSR plays an important role in immune escape by VI...
Source: Microbes and Infection - April 20, 2019 Category: Infectious Diseases Source Type: research
Cholera in the time of Likes Inspirational Pathogens and an Important Pump
Publication date: Available online 17 April 2019Source: Microbes and InfectionAuthor(s): Sophia Häfner (Source: Microbes and Infection)
Source: Microbes and Infection - April 18, 2019 Category: Infectious Diseases Source Type: research
Identification and characterization of Paracoccidioides lutzii proteins interacting with macrophages
Publication date: Available online 2 April 2019Source: Microbes and InfectionAuthor(s): Mariana Vieira Tomazett, Lílian Cristiane Baeza, Juliano Domiraci Paccez, Juliana Alves Parente-Rocha, Fátima Ribeiro-Dias, Célia Maria de Almeida SoaresAbstractParacoccidioidomycosis (PCM), caused by thermodimorphic fungi of the Paracoccidioides genus, is a systemic disorder that involves the lungs and other organs. The adherence of pathogenic microorganisms to host tissues is an essential event in the onset of colonization and spread. The host-pathogen interaction is a complex interplay between the defense mechanisms of the host an...
Source: Microbes and Infection - April 3, 2019 Category: Infectious Diseases Source Type: research
IL-17A and IL-17F repair HIV-1 gp140 damaged Caco-2 cell barriers by upregulating tight junction genes
Publication date: Available online 2 April 2019Source: Microbes and InfectionAuthor(s): Fengjie Wang, Yanfang Cui, Xiuli Shen, Shuhui Wang, Gui-bo YangAbstractIt is widely accepted that impairment of the intestinal epithelial barrier from HIV/AIDS contributes significantly to microbial translocation and systemic immune activation. Such factors present potential targets for novel treatments aimed toward a functional cure. However, the extracellular mechanisms of intestinal barrier repair are poorly understood. In the current study, we investigated the abilities of IL-17A and IL-17F to repair the damaged barrier caused by HI...
Source: Microbes and Infection - April 3, 2019 Category: Infectious Diseases Source Type: research
Editorial board
Publication date: March 2019Source: Microbes and Infection, Volume 21, Issue 2Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - March 31, 2019 Category: Infectious Diseases Source Type: research
Culture-attenuated pathogenic Leptospira lose the ability to survive to Complement-mediated-killing due to lower expression of Factor H binding proteins
Publication date: Available online 25 March 2019Source: Microbes and InfectionAuthor(s): Azaf Moreno-Torres, Irving R. Malvido-Jiménez, Alejandro de la Peña-Moctezuma, Luz O. Castillo Sánchez, Tatiana R. Fraga, Angela S. Barbosa, Lourdes Isaac, Alfredo Sahagún-RuizAbstractSeveral pathogens including Gram-negative bacteria hijack complement regulators to escape host’s innate response. Pathogenic Leptospira species bind Factor H, C4b binding protein and vitronectin from the complement system. We evaluated the ability of low passage (LP) and culture-attenuated (CA) pathogenic strains of Leptospira, to bind Factor H. We ...
Source: Microbes and Infection - March 26, 2019 Category: Infectious Diseases Source Type: research
Studies on formulation of a combination heat killed immunogen from diarrheagenic Escherichia coli and Vibrio cholerae in RITARD model
Publication date: Available online 7 March 2019Source: Microbes and InfectionAuthor(s): Priyadarshini Mukherjee, Vivek Mondal, Ushasi Bhaumik, Ritam Sinha, Sounak Sarkar, Soma Mitra, Debaki Ranjan Howlader, Suhrid Maiti, Asish Kumar Mukhopadhyay, Shanta Dutta, Hemanta KoleyAbstractMultiple diarrheagenic enteric bacterial infections cause global morbidity and mortality. A combination vaccine is needed to combat different diarrhea-causing organisms. In our present work, we formulated a combination of antigens from three different diarrheagenic Escherichia coli strains and three different Vibrio cholerae strains. We demonstra...
Source: Microbes and Infection - March 9, 2019 Category: Infectious Diseases Source Type: research
Enterovirus D68 and Acute Flaccid Myelitis: Do We Need a Measles Mentality?
Publication date: Available online 4 March 2019Source: Microbes and InfectionAuthor(s): Jason A. Tetro (Source: Microbes and Infection)
Source: Microbes and Infection - March 5, 2019 Category: Infectious Diseases Source Type: research
