T.B. Blues
Publication date: Available online 17 October 2019Source: Microbes and InfectionAuthor(s): Sophia Häfner (Source: Microbes and Infection)
Source: Microbes and Infection - October 18, 2019 Category: Infectious Diseases Source Type: research
Immunization with the basic membrane protein (BMP) family ABC transporter elicits protection against Enterococcus faecium in a murine infection model
Publication date: Available online 1 October 2019Source: Microbes and InfectionAuthor(s): Sally Waheed Yousief, Mohammed Bahey-El-Din, Taha Ibrahim ZaghloulAbstractEnterococcus faecium is evolving as a multi-resistant pathogen causing infections with high morbidity and mortality. A protective vaccine against E. faecium is lacking up till now. ATP-binding cassette (ABC) transporter proteins have important functions in bacteria to maintain survival and homeostasis. In the present study, we evaluated the basic membrane protein (BMP) family ABC transporter substrate-binding protein, designated herein as BMP, as a potential vac...
Source: Microbes and Infection - October 2, 2019 Category: Infectious Diseases Source Type: research
Coxiella burnetii: International pathogen of mystery
Publication date: Available online 28 September 2019Source: Microbes and InfectionAuthor(s): Amanda L. Dragan, Daniel E. VothAbstractCoxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This unique pathogen has been historically challenging to study due to obstacles in genetically manipulating the organism and the inability of small animal models to fully mimic human Q fever. Here, we review the current state of C. burnetii research, highlighting new approaches that allow the mechanistic study of infection in disease relevant settings. (Source: Microbes and Infection)
Source: Microbes and Infection - September 29, 2019 Category: Infectious Diseases Source Type: research
Editorial board
Publication date: April–May 2019Source: Microbes and Infection, Volume 21, Issues 3–4Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - September 20, 2019 Category: Infectious Diseases Source Type: research
Another Protein in the Wall
Publication date: Available online 17 September 2019Source: Microbes and InfectionAuthor(s): Sophia HäfnerAbstractArticle highlight based on “VraSR has an important role in immune evasion of Staphylococcus aureus with low level vancomycin resistance" by Caihong Gao et al. (Source: Microbes and Infection)
Source: Microbes and Infection - September 19, 2019 Category: Infectious Diseases Source Type: research
Complement mediated Klebsiella pneumoniae capsule changes
Publication date: Available online 29 August 2019Source: Microbes and InfectionAuthor(s): Trine S. Jensen, Katharina V. Opstrup, Gunna Christiansen, Pernille V. Rasmussen, Mikkel E. Thomsen, Daniel L. Justesen, Henrik C. Schønheyder, Mads Lausen, Svend BirkelundAbstractThe Gram-negative bacterium Klebsiella pneumoniae is an opportunistic pathogen, which can cause life-threatening infections such as sepsis. Worldwide, emerging multidrug resistant K. pneumoniae infections are challenging to treat, hence leading to increased mortality. Therefore, understanding the interactions between K. pneumoniae and the immune system is i...
Source: Microbes and Infection - August 30, 2019 Category: Infectious Diseases Source Type: research
Phosphoglycerate mutase affects Stenotrophomonas maltophilia attachment to biotic and abiotic surfaces
Publication date: Available online 17 August 2019Source: Microbes and InfectionAuthor(s): Layla Ramos-Hegazy, Shubham Chakravarty, Gregory G. AndersonAbstractStenotrophomonas maltophilia biofilm formation is of increasing medical concern, particularly for lung infections. However, the molecular mechanisms facilitating the biofilm lifestyle in S. maltophilia are poorly understood. We generated and screened a transposon mutant library for mutations that lead to altered biofilm formation compared to wild type. One of these mutations, in the gene for glycolytic enzyme phosphoglycerate mutase (gpmA), resulted in impaired attach...
Source: Microbes and Infection - August 18, 2019 Category: Infectious Diseases Source Type: research
Ripk3 licenced protection against microbial infection in the absence of Caspase1-11 inflammasome
Publication date: Available online 17 August 2019Source: Microbes and InfectionAuthor(s): Bojan Shutinoski, Rajen Patel, Julianna J. Tomlinson, Michael G. Schlossmacher, Subash SadAbstractReceptor interacting protein kinase 3 (Ripk3) is a signal relay protein involved in initiation of programmed cell death (necroptosis) and modulation of inflammasome activation. While caspase 1 and 11 are pro-inflammatory caspases responsible for unleashing inflammation and cell death by enzymatic activation of the executioners of inflammation and cell death (pyroptosis). Upon Salmonella infection, the host mounts a pro-inflammatory respon...
Source: Microbes and Infection - August 18, 2019 Category: Infectious Diseases Source Type: research
CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana
Publication date: Available online 12 August 2019Source: Microbes and InfectionAuthor(s): Ernest Adankwah, Alptekin Güler, Ertan Mayatepek, Richard Odame Phillips, Norman Nausch, Marc JacobsenAbstractIFN-γ release assays (IGRAs) have suboptimal sensitivity for detection of Mycobacterium tuberculosis (Mtb) infection and cannot discriminate between tuberculosis (TB) patients and healthy -potentially Mtb infected-contacts (HCs). In a case-control study we determined T-cell phenotypes of IGRAs in TB patients (n=20) and HCs (n=20) from Ghana. CD27 expression of T-cells was significantly lower in TB patients as compared to HCs...
Source: Microbes and Infection - August 13, 2019 Category: Infectious Diseases Source Type: research
Symposium report: One Health meets sequencing
Publication date: Available online 8 August 2019Source: Microbes and InfectionAuthor(s): Adrian Egli, Daniel Koch, Jürg Danuser, Rene S. Hendriksen, Susanne Driesen, Diana Coman Schmid, Richard Neher, Mirjam Mäusezahl, Helena MB. Seth-Smith, Guido Bloemberg, Sarah Tschudin-Sutter, Andrea Endimiani, Vincent Perreten, Gilbert Greub, Jacques Schrenzel, Roger StephanAbstractWhole genome sequencing (WGS) has become the new gold standard for typing and characterization of pathogens. WGS enables understanding transmission chains of bacteria, exchange of mobile genetic elements, and variation in viruses with the highest resoluti...
Source: Microbes and Infection - August 9, 2019 Category: Infectious Diseases Source Type: research
The Best of Both Worlds- Bringing together Cell Biology and Infection at the Institut Pasteur
Publication date: Available online 30 July 2019Source: Microbes and InfectionAuthor(s): Chiara Zurzolo, Jost EnningaAbstractOnly a profound understanding of the structure and function of cells - either as single units or in the context of tissues and whole organisms - will allow a comprehension of what happens in pathological conditions and provides the means to fight disease. The Cell Biology and Infection (BCI for Biologie Cellulaire et Infection) department was created in 2002 at the Institut Pasteur in Paris to develop a research program under the umbrella of cell biology, infection biology and microbiology. Its vision...
Source: Microbes and Infection - August 1, 2019 Category: Infectious Diseases Source Type: research
Levels of miR-125a-5p are altered in Mycobacterium avium-infected macrophages and associate with the triggering of an autophagic response
Publication date: Available online 23 July 2019Source: Microbes and InfectionAuthor(s): Yang Wang, Cai Chen, Xiao-dan Xu, Hui Li, Ming-hua Chen, Jing Liu, Li-jun TangAbstractMacrophages are major pathogen-killing cells. Mycobacteria can represent a serious threat to human health, in particular Mycobacterium tuberculosis and, less so, the opportunistic Mycobacterium avium. They can cause disseminated infections because of their capacity to survive and proliferate within macrophage phagolysosomes. Accumulating evidence indicates that the regulation of miRNA expression is implicated in the mechanisms of defense of macrophages...
Source: Microbes and Infection - July 24, 2019 Category: Infectious Diseases Source Type: research
Celebrating 130 years of achievement by the Institut Pasteur
Publication date: Available online 22 July 2019Source: Microbes and InfectionAuthor(s): Stewart T. Cole (Source: Microbes and Infection)
Source: Microbes and Infection - July 23, 2019 Category: Infectious Diseases Source Type: research
Calpain regulates CVB3 induced viral myocarditis by promoting autophagic flux upon infection
In this study, we found that calpain was significantly activated in hearts affected by VMC. However, pharmacologically inhibiting calpain aggravated VMC symptoms in mice due to myocardial inflammation and cardiac dysfunction. The inhibition of calpain activity in vitro led to the accumulation of LC3-II and increased levels of p62/SQSTM1 protein expression, suggesting that autophagic flux was impaired by calpain inhibition. These effects of calpain inhibition were also observed in capn4-specific myocardial knockout mice in vivo. Furthermore, our results provided evidence that calpain inhibition in VMC, unlike other cardiova...
Source: Microbes and Infection - July 17, 2019 Category: Infectious Diseases Source Type: research
The remarkable history of the hepatitis C virus
Publication date: Available online 8 July 2019Source: Microbes and InfectionAuthor(s): Stanislas Pol, Sylvie LagayeSummaryThe infection with the hepatitis C virus (HCV) is an example of the translational research success. The reciprocal interactions between clinicians and scientists have allowed in 30 years the initiation of empirical treatments by interferon, the discovery of the virus, the development of serological and virological tools for diagnosis but also for prognosis (the non-invasive biochemical or morphological fibrosis tests, the predictors of the specific immune response including genetic IL28B polymorphisms)....
Source: Microbes and Infection - July 10, 2019 Category: Infectious Diseases Source Type: research
