Chlamydia psittaci in fulmars on the Faroe Islands: A causative link to South American psittacines eight decades after a severe epidemic
Publication date: Available online 3 March 2020Source: Microbes and InfectionAuthor(s): Helen Wang, Jens-Kjeld Jensen, Anna Olsson, Fabien Vorimore, Rachid Aaziz, Lionel Guy, Patrik Ellström, Karine Laroucau, Björn Herrmann (Source: Microbes and Infection)
Source: Microbes and Infection - March 3, 2020 Category: Infectious Diseases Source Type: research
The Immunopathogenesis of Tuberculous Pericarditis
Publication date: Available online 21 February 2020Source: Microbes and InfectionAuthor(s): Patrick Howlett, Elsa Du Bruyn, Hazel Morrison, Isiguzo C. Godsent, Katalin A. Wilkinson, Mpiko Ntsekhe, Robert J. WilkinsonAbstractTuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8-34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in ...
Source: Microbes and Infection - February 22, 2020 Category: Infectious Diseases Source Type: research
Is COVID-19 Receiving ADE From Other Coronaviruses?
Publication date: Available online 22 February 2020Source: Microbes and InfectionAuthor(s): Jason A. TetroAbstractOne of the most perplexing questions regarding the current COVID-19 coronavirus epidemic is the discrepancy between the severity of cases observed in the Hubei province of China and those occurring elsewhere in the world. One possible answer is antibody dependent enhancement (ADE) of SARS-CoV-2 due to prior exposure to other coronaviruses. ADE modulates the immune response and can elicit sustained inflammation, lymphopenia, and/or cytokine storm, one or all of which have been documented in severe cases and deat...
Source: Microbes and Infection - February 22, 2020 Category: Infectious Diseases Source Type: research
Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia
Publication date: Available online 22 February 2020Source: Microbes and InfectionAuthor(s): Luiza Carvalho Mourão, Camila Maia Pantuzzo Medeiros, Gustavo Pereira Cardoso-Oliveira, Paula Magda da Silva Roma, Jamila da Silva Sultane Aboobacar, Beatriz Carolina Medeiros Rodrigues, Ubirajara Agero, Cor Jesus Fernandes Fontes, Érika Martins BragaAbstractAutoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here we show that ...
Source: Microbes and Infection - February 22, 2020 Category: Infectious Diseases Source Type: research
Lessons learned from the 2019-nCoV epidemic on prevention of future infectious diseases
Publication date: Available online 20 February 2020Source: Microbes and InfectionAuthor(s): Xingchen Pan, David M. Ojcius, Tianyue Gao, Zhongsheng Li, Chunhua Pan, Chungen PanAbstractOnly a month after the outbreak of pneumonia caused by 2019-nCoV, more than forty-thousand people were infected. This put enormous pressure on the Chinese government, medical healthcare provider, and the general public, but also made the international community deeply nervous. On the 25th day after the outbreak, the Chinese government implemented strict traffic restrictions on the area where the 2019-nCoV had originated—Hubei province, whose...
Source: Microbes and Infection - February 22, 2020 Category: Infectious Diseases Source Type: research
The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future
Publication date: Available online 20 February 2020Source: Microbes and InfectionAuthor(s): Jin-Yan Li, Zhi You, Qiong Wang, Zhi-Jian Zhou, Ye Qiu, Rui Luo, Xing-Yi GeAbstractAt the end of December 2019, a novel coronavirus, 2019-nCoV, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China, which has posed great threats to public health and attracted enormous attention around the world. To date, there are no clinically approved vaccines or antiviral drugs available for these human coronavirus infections. Intensive research on the novel emerging human infectious coronaviruses is ...
Source: Microbes and Infection - February 21, 2020 Category: Infectious Diseases Source Type: research
The Role of MicroRNA-155 in Chlamydia muridarum Infected Lungs
Publication date: Available online 19 February 2020Source: Microbes and InfectionAuthor(s): Jonathon Keck, James P. Chambers, Aravind Kancharla, Dona Haj Bashir, Laura Henley, Katherine Schenkel, Kevin Castillo, M. Neal Guentzel, Rishein Gupta, Bernard P. ArulanandamAbstractOur laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmon...
Source: Microbes and Infection - February 19, 2020 Category: Infectious Diseases Source Type: research
Modulation of Human endogenous retroviruses –H, -W and -K transcription by microbes
Publication date: Available online 6 February 2020Source: Microbes and InfectionAuthor(s): Massimiliano Bergallo, Ilaria Galliano, Paola Montanari, Elena Zaniol, Elisa Graziano, Cristina Calvi, Carla Alliaudi, Valentina Daprà, Francesco SavinoAbstractThe human endogenous retroviruses (HERVs) are endogenous retroviruses that are inserted into the germ cell DNA of humans over 30 million years ago. Using real-time RT-PCR we describe HERV modulation by commensal microbes in the human gut.Infants, exclusively or predominant breast milk feeding, less than 12 weeks of age, during bacteria gut colonization, were assessed for elig...
Source: Microbes and Infection - February 6, 2020 Category: Infectious Diseases Source Type: research
Pathogenicity and Transmissibility of 2019-nCoV—A Quick Overview and Comparison with Other Emerging Viruses
Publication date: Available online 4 February 2020Source: Microbes and InfectionAuthor(s): Jieliang ChenAbstractA zoonotic coronavirus, labeled as 2019-nCoV by The World Health Organization (WHO), has been identified as the causative agent of the viral pneumonia outbreak in Wuhan, China, at the end of 2019. Although 2019-nCoV can cause a severe respiratory illness like SARS and MERS, evidence from clinics suggested that 2019-nCoV is generally less pathogenic than SARS-CoV, and much less than MERS-CoV. The transmissibility of 2019-nCoV is still debated and needs to be further assessed. To avoid the 2019-nCoV outbreak turnin...
Source: Microbes and Infection - February 5, 2020 Category: Infectious Diseases Source Type: research
Sendai virus V protein decreases nitric oxide production by inhibiting RIG-I signaling in infected RAW264.7 macrophages
Publication date: Available online 5 February 2020Source: Microbes and InfectionAuthor(s): Naoko Morita, Yukie Tanaka, Erdenezaya Odkhuu, Yoshikazu Naiki, Takayuki Komatsu, Naoki KoideAbstractSendai virus V protein is a known antagonist of RIG-I-like receptors (RLRs) RIG-I and MDA5, which activate transcription factors IRF3, leading to activation of ISGF3 and NF-κB. These transcription factors are known activators of inducible NO synthase (iNOS) and increase the production of nitric oxide (NO). By inhibiting ISGF3 and NF-κB, the V protein acts as an indirect negative regulator of iNOS and NO. Here we report that the V ge...
Source: Microbes and Infection - February 5, 2020 Category: Infectious Diseases Source Type: research
Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China
Publication date: Available online 1 February 2020Source: Microbes and InfectionAuthor(s): Fei Yu, Lanying Du, David M. Ojcius, Chungen Pan, Shibo JiangAbstractOn 10 January 2020, a new coronavirus causing a pneumonia outbreak in Wuhan City in central China was denoted as 2019-nCoV by the World Health Organization (WHO). As of 24 January 2020, there were 887 confirmed cases of 2019-nCoV infection, including 26 deaths, reported in China and other countries. Therefore, combating this new virus and stopping the epidemic is a matter of urgency. Here, we focus on advances in research and development of fast diagnosis methods, a...
Source: Microbes and Infection - February 1, 2020 Category: Infectious Diseases Source Type: research
Editorial board
Publication date: January–February 2020Source: Microbes and Infection, Volume 22, Issue 1Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - January 31, 2020 Category: Infectious Diseases Source Type: research
A potential tradeoff between feeding rate and aversive learning determines intoxication in a Caenorhabditis elegans host-pathogen system
Publication date: Available online 31 January 2020Source: Microbes and InfectionAuthor(s): Pallavi Velagapudi, Rachel Ghoubrial, Ratnavi Shah, Helana Ghali, Meghan Haas, Krunal S. Patel, Ashleigh Riddell, Christopher A. Blanar, Robert P. SmithAbstractDespite being the first line of defense against infection, little is known about how host-pathogen interactions determine avoidance. Caenorhabditis elegans can become infected by chemoattractant-producing bacteria through ingestion. The worms can learn to associate these chemoattractants with harm through aversive learning. As a result, the worms will avoid the pathogen. Evolu...
Source: Microbes and Infection - January 31, 2020 Category: Infectious Diseases Source Type: research
The amino-terminal region of dense granule protein 6 of Toxoplasma gondii stimulates IFN-γ production by microglia
We examined activities of dense granule proteins (GRAs), which Toxoplasma gondii secretes within infected cells, to stimulate microglial IFN-γ production in vitro. We identified that the N-terminal region (amino acids 41-152) of GRA6 (GRA6Nt) stimulates IFN-γ production by both a microglia cell line and primary microglia purified from the brains of uninfected adult mice. In contrast, neither of GRA1, GRA2, GRA5Nt, nor the carboxyl-terminal (amino acids 174-224) of GRA6 stimulated microglial IFN-γ production. GRA6Nt appears to be a target molecule of the sentinel function of microglia to detect cerebral proliferation of ...
Source: Microbes and Infection - January 21, 2020 Category: Infectious Diseases Source Type: research
Galactosaminogalactan secreted from Aspergillus fumigatus and Aspergillus flavus induces platelet activation
Publication date: Available online 18 January 2020Source: Microbes and InfectionAuthor(s): Hemalata Deshmukh, Günter Rambach, Donald C. Sheppard, Mark Lee, Magdalena Hagleitner, Martin Hermann, Reinhard Würzner, Cornelia Lass-Flörl, Cornelia SpethAbstractPlatelets are meanwhile recognized as versatile elements within the immune system and appear to play a key role in the innate immune response to pathogens including fungi. Previous experiments revealed platelet activation by direct contact with the hyphal-associated polysaccharide galactosaminogalactan (GAG). Since secreted fungal products may also be relevant and trigg...
Source: Microbes and Infection - January 19, 2020 Category: Infectious Diseases Source Type: research
