An in-silico characterization of Sry-related HMG box C (SOXC) in humans and mouse
Publication date: Available online 28 December 2018Source: Meta GeneAuthor(s): Sunil Kanti Mondal, Madhab Kumar SenAbstractSOX4, SOX11 and SOX12 are the members of group C of Sry-related HMG box proteins. Inspite of being discovered more than 15 years ago, their molecular properties and functions are not completely understood. Humans and mice contain 20 SOX genes and 8 are present in Drosophila. Our phylogenetic tree result shows that SOX4 and SOX12 in Primates and Rodentia are more closely related to each other with a few exceptions. Phylogenetic tree based on the amino acid sequences of HMG box domain showed that SOX4 ...
Source: Meta Gene - December 29, 2018 Category: Genetics & Stem Cells Source Type: research

SNP variation in male pattern hair loss in Russians with different dihydrotestosterone levels
In this study the prediction model proposed by Marcinska et al. (2015) is based on the variability of 5 single-nucleotide polymorphisms (SNPs) that are supposed to be strongly associated with MPHL development has been applied to Russians. The 5 SNPs, namely rs5919324 (upstream of the AR gene region), rs1998076 (20p11 locus), rs929626 (EBF1 gene), rs12565727 (TARDBP gene), and rs756853 (HDAC9 gene), were analyzed in group with MPHL phenotype, following subdivision based on dihydrotestosterone (DHT) level, and healthy control group. Significant differences were not found between separate allele and genotype frequencies at th...
Source: Meta Gene - December 26, 2018 Category: Genetics & Stem Cells Source Type: research

A 24-base pair duplication in exon one of HOXD13 gene linked to synpolydactyly type 1 in a Chinese family
In conclusion, variable expressivity and incomplete penetrance of HOXD13 mutation had been evident in the family and our results also widen the spectrum of HOXD13 mutation responsible for synpolydactyly type 1. (Source: Meta Gene)
Source: Meta Gene - December 20, 2018 Category: Genetics & Stem Cells Source Type: research

Breast cancer susceptibility genes in estrogen metabolizing pathway in a southern Indian population
Publication date: Available online 17 December 2018Source: Meta GeneAuthor(s): Andrea Mary Francis, R. Ramya, Nalini Ganesan, P. Kumarasamy, Solomon F.D. Paul, A.K. Munirajan, M. DivyaAbstractThe most common cancer in women is breast cancer, and it poses serious health issues in women, leading to increased mortality rates. Estrogen and its metabolites have been established as risk factors for breast cancer. Determining the role of genetic variants having functional involvement in regulating the estrogen concentration and detoxifying the toxic estrogen metabolites through estrogen hydroxylation by CYP1A1, CYP1B1, and catech...
Source: Meta Gene - December 18, 2018 Category: Genetics & Stem Cells Source Type: research

Urinary excretion profile of microRNAs related to renal fibrosis in Fabry disease patients. A pilot study
Conclusion: In asymptomatic FD patients with decreased α-gal-A enzymatic activity a microRNA profile indicative of renal fibrosis was found. These patients, at present, are not treated because they do not present clinical criteria to start ERT. In this population, the microRNAs urinary profile excretion could be useful to detect renal fibrosis in early stages. (Source: Meta Gene)
Source: Meta Gene - December 17, 2018 Category: Genetics & Stem Cells Source Type: research

Identification of novel miRNAs with potential role in Gastric Cancer diagnosis: In silico procedure
In this study, we retrieved miRNAs obtained by HTP method from OncoLnc database. Consequently, retrieved miRNAs were compared in literature-based databases such as PubMed. As a result, two lists including experimentally validated and predicted miRNAs were provided. We found 28 predicted miRNAs that so far had not been experimentally validated in GC. In the following, further bioinformatics analyses were performed to obtain the expression profile of both validated and predicted miRNAs in tumor and normal tissues. Also, the role of predicted miRNAs in other cancers, and their possible targets in apoptosis, metastasis and ang...
Source: Meta Gene - December 17, 2018 Category: Genetics & Stem Cells Source Type: research

Glutathione S-transferase gene polymorphisms (GSTT1 and GSTM1) and risk of cancers; a case-control study in southeast of Iran
Publication date: Available online 17 December 2018Source: Meta GeneAuthor(s): Negin Parsamanesh, Hamid Kabiri Rad, Ahmad Mehrazin, Ali Bazi, Ebrahim Miri-MoghaddamAbstractGlutathione S-Transferases (GSTs)1 are enzymes catalyzing reactive oxygen species which are believed to participate in the carcinogenesis of different cancers. We aimed to assess the distribution and the potential impact of GSTT1 and GSTM1 polymorphisms on the risk of several types of cancers in an Iranian population. In this case–control study, 213 cancer patients along with 213 healthy volunteers were included. GSTM1 and GSTT1 polymorphisms were ...
Source: Meta Gene - December 17, 2018 Category: Genetics & Stem Cells Source Type: research

Expression of hTERT in placenta of IUGR pregnancy in an Iranian population
ConclusionsTo the best of our knowledge, the current investigation is the first study on the association between hTERT gene expression and IUGR in Iran. According to our results, there was no significant correlation between hTERT and IUGR etiology in this study. Surely, using more samples could provide more definite results on this matter in the future. (Source: Meta Gene)
Source: Meta Gene - December 13, 2018 Category: Genetics & Stem Cells Source Type: research

Microbiota and potential opportunistic pathogens associated with male and female fruit flies of Malaysian Bactrocera carambolae (Insecta: Tephritidae)
We report here the bacterial communities associated with field-caught male and female adult flies from University Malaya campus. The microbiota was determined by targeted 16S rRNA gene (V3–V4 region) sequencing using the Illumina MiSeq. At 97% similarity, four bacterial phyla (with relative abundance of ≥1% in at least one specimen) – Bacteroidetes, Firmicutes, Proteobacteria, and Tenericutes – were recovered from the adult flies. Proteobacteria was the predominant phylum in all the samples, with the female flies (86.81 ± 6.57%) having higher mean relative abundance than the male flies (71.5...
Source: Meta Gene - December 11, 2018 Category: Genetics & Stem Cells Source Type: research

MTHFR gene specific and global methylation patterns in normal pregnancy: A pilot study (India)
ConclusionThe present study speculates that pregnancy is associated with decrease in global methylation levels and increase in MTHFR gene specific methylation as compared to non pregnant state. There is an inverse relationship between global and MTHFR gene specific methylation. (Source: Meta Gene)
Source: Meta Gene - December 11, 2018 Category: Genetics & Stem Cells Source Type: research

Consideration of the role of MALAT1 long noncoding RNA and catalytic component of RNA-induced silencing complex (Argonaute 2, AGO2) in autism spectrum disorders: Yes, or no?
Publication date: Available online 7 December 2018Source: Meta GeneAuthor(s): Hamid Fallah, Maziar Ganji, Shahram Arsang-Jang, Arezou Sayad, Mohammad TaheriAbstractAutism spectrum disorders (ASD) are complex neurodevelopmental impairments in which dysregulation of long noncoding RNAs (lncRNAs) has been indicated. LncRNAs tend to play role in constituting comprehensive networks of ribonucleoprotein complexes including argonautes. Here, we aimed to study the expressions of MALAT1, a highly conserved lncRNA, and AGO2 gene, encoding the catalytic component of the RNA-induced silencing complex (RISC), in ASD patients. In this c...
Source: Meta Gene - December 7, 2018 Category: Genetics & Stem Cells Source Type: research

Cross-regulation of non-coding RNAs and their correlations with target protein-coding genes in CRC pathobiology
Publication date: Available online 4 December 2018Source: Meta GeneAuthor(s): Esra Bozgeyik, Ibrahim BozgeyikAbstractIlluminating the correlations between non-coding RNAs and protein-coding genes are of great interest to understand more about the molecular mechanisms that drive malignant transformation and understanding such correlations will enable development of more specific and efficient targeted therapeutics. Accordingly, in this comprehensive meta-analysis study, we tried to determine correlations between long non-coding RNA (lncRNA), microRNA (miRNA) and messenger RNA (mRNA) molecules that are involved in the pathog...
Source: Meta Gene - December 5, 2018 Category: Genetics & Stem Cells Source Type: research

Diagnostic Significance of miR-639 and miR-10b in Βreast Cancer Patients
Publication date: February 2019Source: Meta Gene, Volume 19Author(s): Ahmed Ismail, Ahmed I. Abulsoud, Ossama A. Mansour, Amal Fawzy (Source: Meta Gene)
Source: Meta Gene - December 4, 2018 Category: Genetics & Stem Cells Source Type: research

Quantitative epigenetic analysis reveals significance of lipid metabolism regulatory miRNA-33a in defining different categories of arthritis
Publication date: Available online 30 November 2018Source: Meta GeneAuthor(s): Uroosa Ali, Chandrakala Lakireddy, Shaik Iqbal Ahmed, Syed Khaja Mujtaba Hussain, Yasmeen Owaisi, Minhaj Fatima, I.V.S.V. Raksha, Karne Divya Sree, Asma Khannam, Syed Saad Hussain, Prajakta Kale, Manisha Malini, Mazharuddin Ali Khan, Sandeep Kumar Vishwakarma, Aleem Ahmed KhanAbstractArthritis is one of the leading causes of disabilities and morbidity worldwide. Among various forms of arthritis, osteoporosis, osteoarthritis and rheumatoid arthritis have been considered the most common categories with significant pathophysiology. Although these t...
Source: Meta Gene - December 1, 2018 Category: Genetics & Stem Cells Source Type: research

RECK gene polymorphism in patients with hepatocellular carcinoma
ConclusionsRECK gene rs10814325 is associated with higher HCC susceptibility. (Source: Meta Gene)
Source: Meta Gene - November 30, 2018 Category: Genetics & Stem Cells Source Type: research

Altered expression of survivin and its splice variants ∆Ex3 and 2B contributes to disease development in breast cancer
ConclusionOur data demonstrates that differential expression of survivin splice variants is a key feature of breast cancer. Apart from survivin, targeting survivin splice variants can also be an important diagnostic and therapeutic target in cancer. Our findings may provide novel avenues for development of both diagnostics and biotheraepeutics in cancer. (Source: Meta Gene)
Source: Meta Gene - November 30, 2018 Category: Genetics & Stem Cells Source Type: research

Genetic diversity of 18 male and 18 female accessions of Jojoba [Simmondsia chinensis (link) Schneider] using EST-SSRs
Publication date: Available online 22 November 2018Source: Meta GeneAuthor(s): Swati Agarwal, Suphiya KhanAbstractJojoba [Simmondsia chinensis (Link) Schneider] is native shrub of northern Mexico and the southwestern United States, commercially utilized for the liquid wax stored in their seeds. It has polyploidy, dioecious, perennial producing, highly heterozygous individual seeds. That is a fact which creates a great mixing of genes when the pollens are blown long distances for fertilization. Genetic diversity is the main source of variability in any crop improvement program. The present study is aimed at evaluating the g...
Source: Meta Gene - November 23, 2018 Category: Genetics & Stem Cells Source Type: research

Association of the 17p13.1 region gene variants rs1042522 and rs2287499 with risk of breast cancer in Iranian-Azeri population
In conclusion, the polymorphisms of TP53 at codon 72 and WRAP53 at codon 68 and their haplotype may confer an increased risk of breast cancer in the assessed population. (Source: Meta Gene)
Source: Meta Gene - November 17, 2018 Category: Genetics & Stem Cells Source Type: research

Endothelial nitric oxide synthase gene -922A>G, -786 T>C, 4b/4a, and 894 G>T variants and premature coronary artery disease: An association study with haplotype analysis
Publication date: Available online 15 November 2018Source: Meta GeneAuthor(s): Amirsaeed Sabeti Aghabozorgi, Hossein Farshidi, Zahra Farbood, Najmeh Ahangari, Tasnim Eghbal Eftekhaari, Amirhossein Bahreyni, Azim NejatizadehAbstractBackgroundEndothelium nitric oxide (eNO) deficiency may lead to premature coronary artery disease (pCAD). This defect could be due to the effect of some eNOS gene variants on its gene expression.The aim of the studyThe aim of this study is to investigate the association between four eNOS gene variants, independently and as four-locus haplotypes, with pCAD in the southern population of Iran.Method...
Source: Meta Gene - November 16, 2018 Category: Genetics & Stem Cells Source Type: research

Association of PSEN1 rs165932 polymorphism with Alzheimer's disease susceptibility: An extensive meta-analysis
ConclusionsLarge-scale case-control studies from multiple ethnic populations are needed for better understanding of PSEN1 gene polymorphisms in disease pathogenesis. (Source: Meta Gene)
Source: Meta Gene - November 15, 2018 Category: Genetics & Stem Cells Source Type: research

Diagnostic significance of miR-639 and miR-10b in breast cancer patients
Publication date: Available online 12 November 2018Source: Meta GeneAuthor(s): Ahmed Ismail, Ahmed I. Abulsoud, Ossama A. Mansour, Amal Fawzy (Source: Meta Gene)
Source: Meta Gene - November 14, 2018 Category: Genetics & Stem Cells Source Type: research

Cytokine gene variations and their impact on serum levels of IFN-γ, IL-2, IL-4, IL-10 and IL-12 among Iraqi Arabs
In conclusion, a positive influence of IL2+166, IL4−590, and IL4−33 SNP genotypes on IL-2 and IL-4 levels is suggested, and such influence was gender-dependent. (Source: Meta Gene)
Source: Meta Gene - November 11, 2018 Category: Genetics & Stem Cells Source Type: research

No role of 3435C>T and 2677G>T ABCB1 (MDR1) gene single nucleotide polymorphisms in imatinib treatment response: A case control study on CML patients of Kashmir
Publication date: Available online 8 November 2018Source: Meta GeneAuthor(s): Niyaz A. Azad, Zafar A. Shah, Mohsin S. Khan, Roohi RasoolAbstractStudies on polymorphisms in ABCB1 gene have shown importance in CML treatment.42 CML patients comprising 18 males (42.86%) and 24 females (57.14%) aged from 7 to 75 years, of which 19 (45.24%) belonged to age group of ≤45 years and the rest 23 (54.76%) were>45 years of age. A case-control analysis of 3435C>T and 2677G>T ABCB1 single nucleotide polymorphisms (SNPs) with respect to imatinib treatment outcome and evaluation of correlation, if any, with molecular (bot...
Source: Meta Gene - November 9, 2018 Category: Genetics & Stem Cells Source Type: research

FokI polymorphism in vitamin D receptor gene and its association with hepatocellular carcinoma in Egyptian patients with chronic liver disease
ConclusionVDR FokI genotypes and allele frequencies were neither significantly associated with HCC, HCV nor were risk for progression of chronic liver disease into decompensated liver disease. (Source: Meta Gene)
Source: Meta Gene - November 9, 2018 Category: Genetics & Stem Cells Source Type: research

Evaluation of cytogenetic and y chromosome microdeletion analyzes in infertile cases
ConclusionIt is thought that the evaluation of cytogenetics and Y chromosome microdeletion of cases with primary infertility diagnosis in our department between 2011 and 2016 years will contribute to the formation of data for infertility etiology in our country and the literature. (Source: Meta Gene)
Source: Meta Gene - November 8, 2018 Category: Genetics & Stem Cells Source Type: research

Mitochondrial genome sequences reveal the evolutionary relationship among different common carp varieties (Cyprinus carpino L.)
Publication date: Available online 8 November 2018Source: Meta GeneAuthor(s): Xiangjiang Liu, Xiangchen Ye, Hongwei Liang, Lingling Zhou, Xiaoyun Zhou, Guiwei Zou, Guangfu HuAbstractIn China, many common carp varieties have also been developed in the regional distribution and cultivation zones over thousands of years. However, little is known about the evolutionary relationship between these varieties. In the present study, the complete mitochondrial genomes of one wild and three domestic common carp varieties were compared. The results revealed that seven of 63 nucleotide substitutions led to radical amino acid replacemen...
Source: Meta Gene - November 8, 2018 Category: Genetics & Stem Cells Source Type: research

miR-335-5p has an important role in the progression of gastric cancer by down-regulation of CEACAM5
Publication date: Available online 1 November 2018Source: Meta GeneAuthor(s): Alireza Ahadi, Marzieh Sadat SafaviAbstractBackgroundDue to the lack of suitable biomarker to early diagnosis of gastric cancer patients for effective treatment, nowadays there are many experiment acts to use novel biomarker such as miRNAs to early diagnosis of GC.MethodsPeripheral blood specimens were collected before treatment from 113 patients with gastric cancer. The CEACAM5 and miR-335 expression were evaluated by quantitative RT-PCR.ResultCEACAM5 mRNA expression was significantly lower in patients with AGC than patients with EGC (P 
Source: Meta Gene - November 2, 2018 Category: Genetics & Stem Cells Source Type: research

A preliminary study of fatty acid synthase gene and the risk of uterine leiomyoma in an Afro-Caribbean female population
ConclusionsThis is the first measure of rs4247357 in a Caribbean population and coincides with a recent study in African- American women where no association was also found. (Source: Meta Gene)
Source: Meta Gene - November 2, 2018 Category: Genetics & Stem Cells Source Type: research

Expression of brain-derived neurotrophic factor (BDNF) and its naturally occurring antisense in breast cancer samples
ConclusionWe provided evidences for participation of BDNF and its naturally occurring anti-sense in the pathogenesis of breast cancer. (Source: Meta Gene)
Source: Meta Gene - November 2, 2018 Category: Genetics & Stem Cells Source Type: research

Analysis of association between cytokine gene polymorphisms and psoriatic disease in Russians of East Siberia
Publication date: Available online 29 October 2018Source: Meta GeneAuthor(s): Marina V. Smolnikova, Maxim B. Freidin, Anna A. Barilo, Svetlana V. SmirnovaAbstractPsoriasis (PS) and psoriatic arthritis (PsA) are subtypes of psoriatic disease (PD), a chronic inflammatory disorder with predominantly cutaneous manifestations. PsA is developed in approximately one third of patients with PS. These two phenotypes are immune-mediated diseases with different heredity that might in part be explained by different genetic factors. We carried out an analysis of association between haplotypes of cytokine genes (TNFA, IL4 and IL10) and P...
Source: Meta Gene - October 30, 2018 Category: Genetics & Stem Cells Source Type: research

Lack of association between sirtuin gene variants and endometrial cancer
This study took paraffin-embedded endometrium specimens from 48 endometrial cancer patients and 53 healthy control subjects. SIRT1 gene variants were determined with the PCR-CCTP method. The result of the single-nucleotide polymorphism (SNP) analysis indicated no significant relationship with endometrial cancer. Recent studies have shown that SIRT has had a positive effect on endometrial tumors. Our study analyzed, for the first time, the association between SIRT1 gene polymorphisms and endometrial cancer. Because of the low population our results are not reflecting the exact contribution of the polymorphism to the develop...
Source: Meta Gene - October 26, 2018 Category: Genetics & Stem Cells Source Type: research

Investigation of antibiotic resistance and the presence of integron genes among ESBL producing Klebsiella isolates
This study aimed to determine the prevalence of antibiotic resistance pattern, and class 1–3 integrons in clinical isolates of Klebsiella among Iranian patients. From March to September 2016, plasmid DNA of 169 Klebsiella isolates was extracted after determining their resistance pattern and ESBL production by disk diffusion method. The presence of class 1–3 integrons was detected by targeting integrase genes with polymerase chain reaction (PCR) method. Out of 169 Klebsiella, 41.1% of Klebsiella pneumoniae and 18.2% of Klebsiella oxytoca isolates were ESBL-positive. The most resistance rate in both species was a...
Source: Meta Gene - October 26, 2018 Category: Genetics & Stem Cells Source Type: research

Association of interleukin-6 rs1800796 polymorphism with reduced cognitive performance in healthy older adults
Publication date: Available online 25 October 2018Source: Meta GeneAuthor(s): Natalia Ewa Bezuch, Steven Bradburn, Sarianna Sipilä, Mati Pääsuke, Helena Gapeyeva, Andrea B. Maier, Jean-Yves Hogrel, Yoann Barnouin, Gillian Butler-Browne, Marco Narici, Jamie McPhee, Chris MurgatroydAbstractWith increasing life expectancy, age-associated cognitive impairment is an escalating problem worldwide. Inflammation is one of the features that characterises cognitive decline and can stimulate neurodegeneration. Interleukin 6 (IL-6) is a cytokine frequently associated with a pro-inflammatory phenotype and increased levels...
Source: Meta Gene - October 25, 2018 Category: Genetics & Stem Cells Source Type: research

Significant associations between prolactin gene polymorphisms and growth traits in the channel catfish (Ictalurus punctatus Rafinesque, 1818) core breeding population
Publication date: Available online 18 October 2018Source: Meta GeneAuthor(s): Shiyong Zhang, Xiang Li, Xiaohui Chen, Jianlin Pan, Minghua Wang, Liqiang Zhong, Qin Qin, Wenji BianAbstractThe aim of this study was to analyze the effects of the prolactin gene (PRL) on growth traits in channel catfish (Ictalurus punctatus). We sequenced pooled DNA samples from channel catfish to identify single nucleotide polymorphisms (SNPs) in the PRL gene. The identified SNPs were then genotyped in 176 individuals from the G1 core breeding population of catfish using the multiplex SNaPshot method. SNP genotypes and diplotypes of the PRL gen...
Source: Meta Gene - October 19, 2018 Category: Genetics & Stem Cells Source Type: research

Definition of an oxidative stress status by combined assessment of Malondialdehyde and Oxidized-LDL: A study in patients with type2 diabetes and control
ConclusionsWe attempted to investigate applicability of MDA and ox-LDL in predicting T2DM related oxidative stress. Present data strongly suggest that using both of MDA and ox-LDL increases their specificity in predicting oxidative milieu and diabetic nephropathy. Moreover, we showed that HDL levels above 35 mg/dl might have beneficial effect on oxidative reactions. (Source: Meta Gene)
Source: Meta Gene - October 17, 2018 Category: Genetics & Stem Cells Source Type: research

Genetic association study of C5178A and G10398A mitochondrial DNA variants with type 2 diabetes in Bangladeshi population
This study aims to explore the relationship of mtDNA C5178A and G10398A variations with T2D in Bangladeshi population. A total of 249 unrelated Bangladeshi populations (127 T2D and 122 healthy controls) were enrolled in this study. Specific DNA sequences within mitochondria were amplified by PCR followed by digestion at the polymorphic sites using AluI and DdeI restriction enzymes. Analyses revealed that 66.93% T2D and 59.02% healthy individuals carried the major allele ‘G’ at 10398 position of the mtGenome; while the minor allele ‘A’ was present in 33.07% T2D and 40.98% healthy individuals. G10398A...
Source: Meta Gene - October 16, 2018 Category: Genetics & Stem Cells Source Type: research

A novel allele frequency trajectories template to discriminate genetic similarity among populations
Publication date: Available online 13 October 2018Source: Meta GeneAuthor(s): Sagy Elzalabany, Tarek Taha, Sahar Fawzi, Olfat ShakerAbstractPopulations' allele frequency studies are one of the major topics of Population genetics. In this research, an Allele Frequency Quality Control System (AFQCS) is proposed as a verification tool for populations' genetics data. This system visualizes and analyses statistically the allele frequencies of 15 Short Tandem Repeats (STRs) autosomal loci based on 65 previously published population genetics studies. Allele Frequency Trajectories (AFTs) for all addressed populations were plotted....
Source: Meta Gene - October 13, 2018 Category: Genetics & Stem Cells Source Type: research

Evidence for an autosomal recessive pattern of inheritance in Keratitis-ichthyosis-deafness (KID) syndrome: Exome sequencing reveals a novel homozygous GJB2 mutation
We present evidence that KID syndrome can be caused by a homozygous GJB2 mutation and demonstrate an autosomal recessive mode of inheritance for the first time at a molecular level.The spectrum of skin manifestations associated with gap junction gene mutations is still growing, particularly in the case of Cx26. Our findings add to the list of pathogenic variants associated with this condition, and contribute to an insight into the genotype-phenotype correlations of Cx26 mutations, thus elucidating the function of different regions of the protein and further add to the widely diverging associated phenotypes. (Source: Meta Gene)
Source: Meta Gene - October 11, 2018 Category: Genetics & Stem Cells Source Type: research

Are long non-coding RNAs involved in the interaction circuit between estrogen receptor and vitamin D receptor?
Publication date: Available online 5 October 2018Source: Meta GeneAuthor(s): Vahid Kholghi Oskooei, Soudeh Ghafouri-FardAbstractBreast cancer as a molecularly heterogeneous disorder harbors dysregulation of several signaling pathways. Estrogen receptor (ER) and vitamin D receptor (VDR) are tow signaling pathways whose fundamental roles in breast cancer have been documented. The presence of a negative vitamin D response element in the Estrogen receptor 1 (ESR1) gene promoter has provided evidences for interactions between ER and VDR signaling pathways. Moreover, recent data indicate that certain long non-coding RNAs (lncRNA...
Source: Meta Gene - October 7, 2018 Category: Genetics & Stem Cells Source Type: research

Random regression models to explore genetic variation and genetic variability in the growth curve of Baluchi lambs
Publication date: Available online 1 October 2018Source: Meta GeneAuthor(s): Farhad Ghafouri-Kesbi, Mohsen GholizadehAbstractThe aim was to apply Random Regression Model (RRM) to describe growth curve of Baluchi lambs. Data was retrieved from an experimental population of Baluchi sheep and consisted of body weight records from 50 to 400 days of age. Regressions for the direct and maternal random effects in the RRM were modeled using different combinations of legendre polynomials with orders from one (i.e., simple repeatability model, SRM) to four. Mean trends were also modeled through a quadratic regression on orthogonal...
Source: Meta Gene - October 5, 2018 Category: Genetics & Stem Cells Source Type: research

Isolation and identification of culturable bacteria from honeydew of Indian lac insect, Kerria lacca (Kerr) (Hemiptera: Tachardiidae)
Publication date: Available online 1 October 2018Source: Meta GeneAuthor(s): Gulsaz Shamim, Kewal Krishan Sharma, Ranganathan RamaniAbstractIndian lac insect, Kerria lacca belongs to a distinct group of phytosuccivorous insects feeding on sugar-rich phloem sap and excreting excess sugar in the form of large quantities of honeydew, which serves as an excellent medium for microbial growth. This work has made a novel attempt to isolate and identify culturable bacterial species associated with lac insect honeydew, which can be further used to unravel their significance by identifying and characterizing semiochemicals or bacter...
Source: Meta Gene - October 5, 2018 Category: Genetics & Stem Cells Source Type: research

Significance of CCL2 (−2518A/G), CCR2 (190G/A) and TLR4 polymorphisms (896 A/G and 1196C/T) in tuberculosis risk in Indian population
Publication date: December 2018Source: Meta Gene, Volume 18Author(s): Paras Singh, Roopali Rajput, Rohit Sarin, Devika TayalAbstractTuberculosis remains one of the major health burden worldwide; with substantial mortality in Indian population. Several host gene polymorphisms have been studied wherein association between variations in host genes and susceptibility or resistance to tuberculosis have been reported. In the present study, we aimed at investigating the effect of polymorphisms of CCL2, CCR2 and TLR4 genes on risk of acquiring tuberculosis in Indian population. The CCL2 (−2518A/G) and TLR4 (D299G or 896A/G &...
Source: Meta Gene - October 5, 2018 Category: Genetics & Stem Cells Source Type: research

5-bp insertion/deletion polymorphism in the promoter region of LncRNA GAS5 and cancer risk: A meta-analysis of 7005 cases and 8576 controls
Publication date: December 2018Source: Meta Gene, Volume 18Author(s): Mohammad Hashemi, Abdolkarim Moazeni-Roodi, Farhad Tabasi, Saeid GhavamiAbstractSeveral studies investigated the impact of 5-bp insertion/deletion (ins/del) polymorphism in the promoter region of GAS5 LncRNA on cancer risk and the results were inconsistent. So, we performed a meta-analysis to examine the association between GAS5 5-bp ins/del polymorphism and cancer risk. The PubMed, Web of Science, Scopus, and Google scholar databases were searched and 8 relevant studies including 7005 cases and 8576 controls participants were identified. Pooled odds rat...
Source: Meta Gene - October 5, 2018 Category: Genetics & Stem Cells Source Type: research

A novel missense mutation of the HGD gene causes Alkaptonuria
Publication date: December 2018Source: Meta Gene, Volume 18Author(s): Shahab Noorian, Bahareh Dehghan Banadaki, Arya Sotoudeh, Shahram Savad, Mohammad Hossein ModarressiAbstractAlkaptonuria (AKU) is a rare autosomal recessive disease that leads to metabolic disorder, characterized by accumulation of homogentisic acid which is related to HGD gene mutations. In this article, we report the case of a 13-year-old male and his sibling with clinical symptoms of AKU who referred to the clinic. The next generation sequencing of the HGD gene was performed and the detected mutation was confirmed by Sanger sequencing. The results indi...
Source: Meta Gene - October 5, 2018 Category: Genetics & Stem Cells Source Type: research

The association between ACE I/D polymorphism and the risk of Alzheimer's disease in Lebanon
In conclusion, our study suggests that ACE I allele and female gender are associated with increased risk of AD in the Lebanese population. (Source: Meta Gene)
Source: Meta Gene - October 5, 2018 Category: Genetics & Stem Cells Source Type: research

Effect of hypermethylation in ovarian cancer: Computational approach
Publication date: Available online 12 September 2018Source: Meta GeneAuthor(s): Imane Saif, Najwa Hassou, Karam Allali, Moulay Mustapha EnnajiAbstractOvarian cancer in women represents a mortality rate of>4% worldwide. In cancer, CpG islet hypermethylation of some gene promoters often leads to the inactivation of tumor suppressor genes. Ovarian cancer is characterized by a targeted hypermethylation, hence the need to study this hypermethylation. We have adopted the hypothesis that a very high mutation rate can cause the epimutation phenomenon, causing a 5-fold deamination methyl-cytosine in thymine, consequence of the m...
Source: Meta Gene - September 13, 2018 Category: Genetics & Stem Cells Source Type: research

Analysis of occurrence of MTRR gene polymorphism in down syndrome and other intellectually disabled children
Publication date: Available online 12 September 2018Source: Meta GeneAuthor(s): Avani Patel, Mansi Desai, J.B. ChauhanAbstractThe 5-methylenetetrahydrofolate homocysteine methyltransferase reductase (MTRR) is a key enzyme involved in folate metabolism. Defect in folate metabolism can lead to abnormal DNA synthesis, repair and methylation which lead to abnormal DNA replication and segregation. The most common polymorphism of MTRR genec.66A > G was analyzed in 30 Down syndrome (DS), 30 intellectually disabled (ID) and 60 control children of Gujarat using PCR-RFLP. The results of the present study revealed negative ass...
Source: Meta Gene - September 12, 2018 Category: Genetics & Stem Cells Source Type: research

Identification of potential antibiotic targets in the proteome of multi-drug resistant Proteus mirabilis
Publication date: Available online 10 September 2018Source: Meta GeneAuthor(s): Nosheen Ehsan, Sajjad Ahmad, Afifa Navid, Syed Sikander AzamAbstractProteus mirabilis is pathogen of the urinary tract and is resistant to many of the clinically used antibiotics. Computational identification of novel antibiotic targets could not only save time but also in parallel provide an array of opportunities for developing novel antibiotics to treat infections caused by this pathogen. In the current study, a step-wise subtraction of P. mirabilis proteome was achieved in search of potential antibiotic targets. The main objectives were to ...
Source: Meta Gene - September 11, 2018 Category: Genetics & Stem Cells Source Type: research

Gender-specific effects of MMP-2 and MMP-9 gene variants and the risk of aneurysmal subarachnoid haemorrhage
In this study, we have evaluated the association between MMP gene variants and aneurysmal subarachnoid hemorrhage (aSAH). The rs243865 in MMP-2 and rs17576 in MMP-9 genes were genotyped using Taqman allelic discrimination assay. Upon gender stratification, the presence of G allele of MMP-9 gene exon variant was found to increase the risk of aSAH by 1.4 fold (p = 0.032), in men. The GG genotype also showed a trend towards association with the risk of aSAH (OR: 1.785, CI: 0.971–3.283, p = 0.062) in men, after adjusting for the vascular risk factors. In women, no association was observed. The MMP-2 gene variants...
Source: Meta Gene - September 8, 2018 Category: Genetics & Stem Cells Source Type: research

IL27 gene single nucleotide polymorphisms confer susceptibility to rheumatoid arthritis in Iranian population
ConclusionPresent findings indicated that IL27 rs181206 polymorphism was involved in susceptibility to RA in the Iranian population. (Source: Meta Gene)
Source: Meta Gene - September 8, 2018 Category: Genetics & Stem Cells Source Type: research