Assessment of physical growth, some oxidative stress biomarkers and vitamin D status in children with Familial Mediterranean Fever
Publication date: September 2018Source: Meta Gene, Volume 17Author(s): Moushira Zaki, Hala T. El-Bassyouni, Hanaa Reyad, Walaa Yousef, Eman Youness, Ghada Mohamed, Abeer RamadanAbstractFamilial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by recurrent fever and inflammatory attacks. The aim of our study is to evaluate the growth parameters in Egyptian children with FMF and to investigate vitamin D status (serum 25-(OH) D) and some oxidative stress biomarkers during the attack free period in relation to the disease severity. Cases were classified into mild and moderate according to disease sever...
Source: Meta Gene - July 10, 2018 Category: Genetics & Stem Cells Source Type: research

Relationship between MTHFR gene polymorphisms (C677T and A1298C) and chronic lymphocytic leukemia in the Turkish population
In conclusion, our results demonstrate for the first time MTHFR gene C677T and A1298C polymorphisms, especially A1298C, have a major effect on the risk of CLL in the Turkish patients. We suggest that considering the first contradictory results in Caucasians, further additional studies are necessary to elucidate the relationship of these polymorphisms with the risk of CLL disease in Caucasian populations. (Source: Meta Gene)
Source: Meta Gene - July 10, 2018 Category: Genetics & Stem Cells Source Type: research

Comparative molecular and chemical fingerprinting found accession “Clone-64” as the best genetic material for jojoba industry
Publication date: September 2018Source: Meta Gene, Volume 17Author(s): Swati Agarwal, Suphiya KhanAbstractJojoba (Simmondsia chinensis) is an important commercial shrub. Concerns have been raised about the availability of the good raw material for various industries to lower down the costs of products. Seed planted populations are highly variable in yields and growth habits. For this reason, there is need to develop a selection programs that improves the crop productivity of good quality seed plants. Jojoba industry, mainly depends on its oil, but the remaining seed meal is also useful for various industries like cosmetics...
Source: Meta Gene - July 10, 2018 Category: Genetics & Stem Cells Source Type: research

Absence of association between TLR4 Thr399Ile polymorphism and cervical cancer susceptibility
ConclusionComplete absence of T allele in our study subjects demonstrate no involvement of TLR4 Thr399Ile polymorphism in cervical cancer susceptibility. However, an association between increased age and late clinical staging was observed. A comprehensive analysis on a larger sample size covering diverse ethnic populations of India is warranted to comprehend the role of TLR4 Thr399Ile polymorphism. (Source: Meta Gene)
Source: Meta Gene - July 10, 2018 Category: Genetics & Stem Cells Source Type: research

Molecular phylogeny unveils hidden diversity of hillstream loaches (Cypriniformes: Cobitoidea) in the northern Western Ghats of India
Publication date: Available online 9 July 2018Source: Meta GeneAuthor(s): Ashwini Keskar, Rajeev Raghavan, Mandar S. Paingankar, Pradeep Kumkar, Unmesh Katwate, Shrikant Jadhav, Anand Padhye, Neelesh DahanukarAbstractThe diversity of hillstream loaches in the northern part of the Western Ghats region of India was studied for the first time using two mitochondrial genes, cytochrome oxidase subunit I and cytochrome b. Phylogenetic analysis revealed monophyletic groups corresponding to the genera Indoreonectes, Paracanthocobitis, Nemacheilus, Schistura and Nemachilichthys (family Nemacheilidae), and Balitora, Lepidocephalicht...
Source: Meta Gene - July 10, 2018 Category: Genetics & Stem Cells Source Type: research

Association study between STAT4 polymorphisms and susceptibility to systemic lupus erythematosus disease: A systematic review and meta-analysis
ConclusionsIn summary, this study reported association between rs7574865 and increased risk of SLE, although rs7601754 indicated association with decreased SLE risk. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of interleukin-18 gene promoter polymorphisms with coronary artery disease in northern Iranian population
This study investigated the association of the IL-18 gene promoter polymorphisms (− 137 and − 607) with CAD in northern Iranian population.MethodsGenomic DNA was extracted from peripheral blood of 314 patients with CAD and 364 healthy controls by a standard protocol. Sequence-Specific Primer-PCR was used for genotyping. Total RNA was extracted from peripheral blood leukocytes from 80 patients with CAD and 80 healthy individuals using Trizol reagent. Real-time PCR was used to measure the level of IL-18 mRNA in the patients and controls.ResultsAnalysis of genotypes revealed that the frequencies of genot...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of Neuregulin-1 gene polymorphisms with neuro-cognitive features of schizophrenia patients from South India: A pilot study
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Smriti Anand, Amudha Govindaraju, Vinithra Vairavan, Suresh Kumar Narayanan, Rashmi Rajagopal, Anirudh Chellappa, Ashok Ayyappa, Kumanan Thiagarajan, Ananda Krishnan Kumar, GaneshPrasad ArunKumarAbstractNumerous genes have been associated with schizophrenia. In particular, Neuregulin-1 (NRG1) has been widely implicated. Specifically, a 7-marker haplotype called HAPICE in NRG1 is correlated with schizophrenia in many ethnic groups. However, the association of these markers with endophenotypes has shown many contrasting results. India, which harbours one sixth...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Bioenergetic diversity of the human gut microbiome
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Panagiotis Agioutantis, Vassiliki Lila KoumandouAbstractThe human microbiome has lately emerged as an important factor in health and disease. The general patterns that emerge from metagenomics studies of the microbial diversity in the human gut of healthy adults, children and infants, are that (a) the microbiome is less diverse early in life, and gets enriched after infancy, and (b) that it is dominated by organisms from two bacterial phyla: bacteroidetes and firmicutes. However, there is still considerable diversity between individuals, based on age, habita...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Molecular characterization and differential mRNA expression profiling of Toll-like receptor-2 gene in Vechur (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle of Kerala in response to anthrax vaccination
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): P.N. Shivakumara, T.V. Aravindakshan, Thomas Naicy, K. Anilkumar, R. UmaAbstractToll like receptors (TLRs) are type 1 transmembrane proteins expressed in almost all cell types and activate the innate immune system. The present study involved characterization and differential transcriptional expression profiling of Toll-like receptor-2 gene in Vechur (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle of Kerala in response to anthrax vaccination. Sequence analysis revealed 2355 bp long TLR2 open reading frame encoding 784 amino acids with a signal...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Genotypes and haplotypes of ABCB1 contribute to TAC chemotherapy response in Malaysian triple negative breast cancer patients
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Ahmad Aizat Abdul Aziz, Md Salzihan Md Salleh, Ibtisam Mohamad, Venkata Murali Krishna Bhavaraju, Maya Mazuwin Yahya, Andee Dzulkarnaen Zakaria, Siew Hua Gan, Ravindran AnkathilAbstractTriple negative breast cancer (TNBC) which is characterized by absent expression of ER, PR and HER2 receptors, is typically associated with poor treatment response and high recurrence risk rate or metastasis. ABCB1 is a drug efflux enzyme, involved in the drug transport across the membrane. Evidence have shown that, activation (or inactivation) of ABCB1 drug transporter gene m...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Genetic diversity analyses for population structuring in Channa striata using mitochondrial and microsatellite DNA regions with implication to their conservation in Indian waters
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Vishwamitra Singh Baisvar, Ravindra Kumar, Mahender Singh, Ajay Kumar Singh, U.K. Chauhan, Akhilesh Kumar Mishra, Basdeo KushwahaAbstractThe snakehead murrel Channa striata, with extensive distribution in Asia, is important in both culture and capture fisheries. Wild sub-populations of C. striata from Indian waters were analyzed in the present study using mitochondrial cytochrome b gene and nuclear microsatellite loci for genetic diversity assessment and sub-population structuring with the expectations that this fish have resulted in isolated sub-populations...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

A multifactor dimensionality reduction model of gene polymorphisms and an environmental interaction analysis in type 2 diabetes mellitus study among Punjabi, a North India population
In conclusion, it is suggested that pathogenesis of T2DM, obesity and hypertension involves interplay of a variety of susceptibility alleles and environment. The gene-gene and gene-environment interactions are not only possible, but, are probably ubiquitous in determining the susceptibility of complex human diseases. Further studies on epistatic interactions are warranted to elucidate their possible underlying role in pathogenesis of T2DM. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of IRX3 rs3751723 polymorphism with the risk of overweight and obesity: case-control study and meta-analysis
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Eric Tzyy Jiann Chong, Nur Fathiah Abdul Aziz, Ping-Chin LeeAbstractAssociation of the iroquois homeobox 3 (IRX3) rs3751723 polymorphism has been shown to increase the risk of obesity, but the data are underreported in the Malaysian population. Therefore, this study sought to investigate this association in the Malaysian population using both a case-control study and a meta-analysis. Genotyping of the IRX3 rs3751723 polymorphism was performed for 1030 age-matched Malaysians using hydrolysis probe. Odds ratios were calculated with 95% confidence intervals. A ...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Co-evolving pairs of complementary nucleotide sequence regions as candidates for bundling signals in viruses with segmented genomes
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Yoshiyuki SuzukiAbstractSome of RNA viruses with segmented genomes are believed to undergo selective packaging, in which one copy of each genomic segment is incorporated into a virion. The selective packaging is thought to be mediated by supra-molecular complex formation of genomic RNA segments through inter-segmental base pairing of complementary nucleotide sequence regions termed the bundling signal. Here the nucleotide sequences of 10 genomic segments (large: L1, L2, and L3; medium: M1, M2, and M3; and small: S1, S2, S3, and S4) for 29 avian (ARV) and 8 p...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association between serum microRNA-605 and microRNA-623 expression and essential hypertension in Egyptian patients
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Heba K. Badawy, Dina M. Abo-Elmatty, Noha M. MesbahAbstractEssential hypertension is widespread and has significant morbidity and mortality. However, the genetic basis of the disease is unknown. MicroRNAs are post-transcriptional regulators and have been implicated in development of the disease. The aim of this study was to assess the relationship between serum microRNA-605 and microRNA-623 expression and essential hypertension in Egyptian patients. MicroRNA expression in serum was determined in hypertensive patients and normotensive controls by quantitative...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Cholesterol 7- alpha hydroxylase gene (CYP7A1) promoter polymorphism rs3808607 as a risk factor for pulmonary tuberculosis in Egypt
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Nevein M. Al-sheikh, Sally M. El-Hefnway, Ahlam A. El-ShetahyAbstractBackgroundA major tuberculosis susceptibility locus has been identified by genome wide association study on chromosomal region 8q12-q13. The CYP7A1 gene coding for cholesterol 7a-hydroxylase enzyme is located in this locus, this enzyme is involved in cholesterol catabolism.ObjectiveThe aim of the study is to investigate C/A polymorphism rs3808607 at CYP7A1 gene as a risk factor for pulmonary tuberculosis in Egyptian subjects.Subjects & methodsA total number of 180 subjects divided into ...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Investigation of GRTH gene single nucleotide polymorphism in association with male infertility in Iranian population
ConclusionThe results of our study suggest that positive association of rs551373 SNP probably reveals an important role in azoospermia male infertility. Further studies with larger sample size are required to support our findings. Investigation of association of this SNP with other types of non-obstructive male infertility is also suggested. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Spectrum of GALNS mutations and haplotype study in Brazilian patients with Mucopolysaccharidosis type IVA
In this study, 25 different mutations were identified among 68 unrelated South-American patients with MPS IVA. Of the 25 alterations, 7 were novel, being predicted as probably pathogenic by bioinformatics analysis. The bioinformatics findings together with the lack of observation of these alterations in the existing databases, suggests that they are disease-causing mutations, and were correlated with biochemical findings. Additionally, we performed the analysis using intragenic polymorphisms to identify some association between any particular mutation and specific haplotype in Brazilian patients. We identified 14 different...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Studying association of GTF2H4, SULF1, OAS3, and IFNG genes polymorphism and risk of head and neck cancer in Southern Punjab, Pakistan
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Juweria Khawar, Nighat Fatima, Mehreen Ismail, Syed Aun MuhammadAbstractGenetic variations develop inherited tendency to progress cancer. The incidence rate of head and neck cancer (HNC) is 15–40% of all cancer types worldwide but this ratio is worse in South Asian region of Pakistan. We collected 185 samples and observed variations in IFNG, GTF2H4, OAS3 and SULF1 genes of HNC samples associated with tobacco, betel leaf and nuts, naswar and gutka. We performed the tetra-arm PCR and found significant allelic associations of IFNG rs11177074 (P = 0.00...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Discovering a familial Xp11.4 microduplication: Does the mother matter?
We describe two sons one with a 2q37.3 deletion and a Xp11.4 duplication and the other with Xp11.4 duplication only, identified by array-CGH. They both presented a phenotype characterized by poor growth, mild facial dysmorphisms, autism and developmental delay. The 2q37.3 identified chromosomal anomaly was inherited from the healthy father and included approximately 8 known genes, while the Xp11.4 duplication resulted inherited from the healthy mother and involved 13 known genes. Of these TSPAN7 and CASK, localized on Xp11.4, genes are of special interest. The alteration on the X chromosome could be more related to the cli...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Frequent novel mutations are causative for maple syrup urine disease from Southwest Iran
ConclusionAll variations somewhat can affect the structure, the function and the stability of gene products. The results obtained from this study could be useful to facilitate clinical diagnosis and screening of MSUD patients and partly for at-risk carriers and prenatal detection in the population of southwest of Iran. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Report of three cases with hereditary spastic paraplegia and investigation of the mutations
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Mohammad Miryounesi, Seyed Mohammad Bagher Tabei, Mehdi Dianatpour, Majid Fardaei, Soudeh Ghafouri-FardAbstractHereditary spastic paraplegia (HSP) includes a group of clinically and genetically heterogeneous disorders with multiple genetic loci participating in its pathogenesis. Here we report three Iranian patients with HSP. Molecular analyses revealed that they have mutations in AP4M1 gene (NM_004722:c.802C>T, p.R268X and c.1225T>C, p.F409L) and AP4E1 gene (NM_007347: c.3212_3213delCT, p.L1072Afs*10). All of them were born to consanguineous parents. ...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Role of matrix metalloproteinase-9 polymorphisms in basement membrane degradation and pathogenesis of oral submucous fibrosis
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Atul Katarkar, Chandraday Prodhan, Sanjit Mukherjee, Jay G. Ray, Keya ChaudhuriAbstractOral submucous fibrosis (OSMF) is regarded as a collagen and collagenase metabolic disorder. Aberrant expression of matrix metalloproteinases (especially MMP-9) plays important role in remodeling of extracellular matrix (ECM) during development of OSMF. Single nucleotide polymorphisms (SNPs) in MMP-9 promoter and coding region have been demonstrated to be associated with several diseases. In this case-control study, 196 controls and 189 OSMF patients were genotyped at four...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Significant influence of GSTP1 Gene Ile105Val polymorphic sequence variation for elevated risk in predisposition to malignant glioma
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Iqbal Qasim, Arshad A. Pandith, Dheera Sanadhya, Wani Zahoor, Mir Khurshid Iqbal, Ina Amin, Usma Manzoor, Abdul R. Bhat, Zafar A. ShahAbstractIntroductionMalignant glioma is a brain tumor of very aggressive behavior and tissue invasion. A common polymorphic variant of GSTP1 (Ile105Val: A > G) has been associated with increased risk of various cancers including malignant glioma. Thus aim of this study was to address the association of GSTP1 Ile105Val to malignant glioma with respect to its clinico-pathological parameters.MethodThe frequency of genotype...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Differential expression analysis of JAK/STAT pathway related genes in breast cancer
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Jemmy Christy, L. PriyadharshiniAbstractAberrant activation of intracellular signaling pathways confer malignant properties on cancer cells in humans. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in the regulation of various aspects of the hematological system and immune regulation, and thus the JAK/STAT pathway genes are the important component of cytokine signaling. Their function as activators of various mediators of inflammation and their role in carcinogenesis puts them at important junctures with ot...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Polymorphisms rs2233575 and rs712701 in the paired box 4 gene are not associated with type 1 diabetes in children
In conclusion, the polymorphisms rs2233575 and rs712701 were not associated with T1D in the.studied population. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of KCNJ11(RS5219) gene polymorphism with biochemical markers of glycemic status and insulin resistance in gestational diabetes mellitus
ConclusionThe Polymorphism of KCNJ11 (rs5219) gene is associated with glycemic status and IR (Insulin Resistance) and pregnant women with T allele were at higher risk of developing GDM. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of MicroRNA related single nucleotide polymorphisms 196A-2 and 499 with the risk of hepatocellular carcinoma in Egyptian patients
ConclusionsMIR-SNP-499 might affect the susceptibility of Egyptians to HCC while, MIR-SNP-196A-2 may affect the HCC risk in Egyptians with HCV infection. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

A simulations approach for meta-analysis of genetic association studies based on additive genetic model
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Majnu John, Todd Lencz, Anil K Malhotra, Christoph U Correll, Jian-Ping ZhangAbstractMeta-analysis of genetic association studies is being increasingly used to assess phenotypic differences between genotype groups. When the underlying genetic model is assumed to be dominant or recessive, assessing the phenotype differences based on summary statistics, reported for individual studies in a meta-analysis, is a valid strategy. However, when the genetic model is additive, a similar strategy based on summary statistics will lead to biased results. This fact about ...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of interleukin-8 polymorphism (+781 C/T) with the risk of ovarian cancer
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Mohamad-Kian Zarafshani, Azin Shahmohammadi, Asad Vaisi-Raygani, Hoda Bashiri, Kheirollah YariAbstractIL-8 is a chemokine which plays an essential role in tumorigenesis, specifically in tumor growth, angiogenesis and invasion. Recent studies have determined that IL-8 +781C/T polymorphism correlates with some human cancers. The purpose of current study was to clarify the association of interleukin-8 polymorphism (+781 C/T) with the risk of ovarian cancer. In this case-control study, 150 samples including 50 specimens of ovarian tissue from female patients and...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

OncomiR-27a rs895819 variant and breast cancer risk: An updated meta-analysis
In conclusion overall miR-27a (rs895819) polymorphism was not associated with BC risk. However, the rs895819*G variant may confer protection against cancer in Caucasian and familial BC. Well-designed studies with larger cohorts in diverse ethnic populations are warranted. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Differential expression profiles of miRNAs and correlation with clinical outcomes in acute myeloid leukemia
ConclusionsDeregulated expressions of miRNAs pose significant impact on the clinical outcomes in AML patients. MicroRNA therapeutics indeed has a tremendous potential in the treatment of AML. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

A potential association between mutations in the iNOS cDNA 3′ stretch and oral squamous cell carcinoma - A preliminary study
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Sapna Khowal, Swatantra Kumar Jain, Saima WajidAbstractOral cancers are linked with tobacco, areca nut and alcohol addictive proclivities. The oral squamous cell carcinoma (OSCC) comprises more than 90% cases of oral cancers. The Homo sapiens inducible nitric oxide synthase (iNOS) gene plays crucial role in OSCC pathologies. The given study analyzed the nucleotide mutations existent within two targets of interest namely iNOS cDNA 5′ stretch and iNOS cDNA 3′ stretch, using cDNA pool of cancer and pre-cancer oral biopsies employing Q PCR-Tm calling...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

A new mutation in steroidogenic acute regulatory protein (StAR) is segregated in an Iranian family
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Soudeh Ghafouri-Fard, Vahid Reza Yassaee, Nasrin Alipour, Zeinab Ravesh, Mohammad MiryounesiAbstractLipoid congenital adrenal hyperplasia (LCAH) is the most fatal form of defects in steroid hormone biosynthesis presented with in 46,XY sex reversal and severe fatal salt-losing crisis in the infancy. The disease is caused by mutation in the steroidogenic acute regulatory protein (StAR) coding gene. Several mutations have been found in this gene in different populations with the possible existence of a founder effect. In the current study, we present a novel mu...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of genetic variants with macronutrient intake in Circassian and Chechan populations in relation to diabetes
Conclusionwe have identified a genetic association between intake of carbohydrate, calorie, vitamin B2 and caffeine in the Circassian population and calorie intake in the Chechan population. Three of these intake traits (carbohydrate, calorie and vitamin B2) were correlated with T2D development in Circassians. The association between macronutrient intake and diabetes development can shed light on causative variants for the pathogenesis of T2D. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Absence of APE1 (Asp148Glu) gene polymorphism in North-West Indian population: A comparison with world population
In this study, we evaluated genotype and allele frequencies of the APE1 (rs 1130409, Asp148Glu; T2197G) gene polymorphism in 450 subjects from North-West India and compared it with other Indian and world populations. Genomic DNA extraction was carried out using standard Phenol-chloroform method and ethanol precipitation. Genotyping was carried out by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) and run on 10% PAGE. Genotyping results were confirmed by direct DNA sequencing and running 10% of the samples in duplicate. It was found that APE1 (rs 1130409; Asp148Glu; T2197G) gene polymorphism ...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Neuropeptide Y Leu7Pro polymorphism is not associated with risk of developing obesity in Pakistani population
ConclusionThe NPY SNP Leu7Pro is found to be extremely rare in Pakistani population and does not contribute towards risk of developing obesity. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Phylogeny based on 16S rRNA sequence and morphology of selected mosses of Mount Abu, Rajasthan (India)
We examined data set that comprises of ten moss species and four outgroup taxa drawn from liverworts. The molecular data contain nucleotide sequences derived from plastid DNA regions, i.e. partial 16S rRNA sequences and the morphological data included 18 characters derived from own observations and published literature. Congruence between the two data sets was investigated by computing several indices. The morphological data set contains poor phylogenetic signals. The results suggest that 1) the mosses, including Sphagnum and Takakia, are monophyletic, 2) Sphagnum and Takakia are placed together and sister to remaining mos...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association between interleukin-17 gene polymorphism and rheumatoid arthritis among Egyptians
ConclusionThe results of this study suggested that the IL-17A and IL-17F gene polymorphisms may not be associated with the susceptibility to RA among Egyptian population. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of Human Leucocyte Antigen (HLA) class II with systemic lupus erythematosis (SLE) patients from western India
ConclusionsOur data suggest an association between HLA class II with susceptibility to SLE in the Indian population. DQB1*05 and DQA1*01 are strongly positively associated with SLE in western Indian SLE patients. DRB1*04, DRB1*11, DQB1*03 and DQA1*03 are negatively associated with SLE in western India. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Elucidation of bacterial species during childhood diarrhea through 16S rRNA Illumina Miseq approach
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Nutan Thakur, Harish Changotra, Neelam Grover, Jitendraa VashisttAbstractDiarrhea causes a debilitating infectious illness among children, especially in developing countries with higher mortality and morbidity rates. Gastrointestinal (GI) tract is occupied by complex microbial-communities structures and the composition of indigenous microbial-consortia gets altered during diseases associated with GI tract. However, effect of microbial imbalance and proliferation in childhood diarrhea severity is less understood. Therefore, present study is focused to compare...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of APOE − 219G > T and −427T > C polymorphic variants in transcriptional regulatory region of APOE gene with gallbladder stone: A north Indian case-control study
Publication date: June 2018Source: Meta Gene, Volume 16Author(s): Shipra Dwivedi, Amit Kumar Madeshiya, Shraddha Singh, Abhjeet Chandra, Abbas Ali MahdiAbstractGallbladder stone (GBS) is a major cause of morbidity and mortality throughout the world including India. The significant role of APO E in the regulation of lipid metabolism raises the possibility that APO E promoter gene polymorphisms may be a predisposing factor for GBS formation. In this case control study total 358 subjects (n = 102 GBS subjects and n = 256 healthy control) between the age group of 18 to 70 years were enrolled. Three APO E promoter gen...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Implication of ITS phylogeny for biogeographic analysis, and comparative study of morphological and molecular interspecies diversity in Indian Impatiens
This study gave an idea about interspecies diversity in Indian Impatiens and suggests the suitability of ISSR markers for further interspecies diversity studies in Impatiens.Graphical abstract (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Relationship between MTHFR gene polymorphisms (C677T and A1298C) and chronic lymphocytic leukemia in the Turkish population
In conclusion, our results demonstrate for the first time MTHFR gene C677T and A1298C polymorphisms, especially A1298C, have a major effect on the risk of CLL in the Turkish patients. We suggest that considering the first contradictory results in Caucasians, further additional studies are necessary to elucidate the relationship of these polymorphisms with the risk of CLL disease in Caucasian populations. (Source: Meta Gene)
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of glutathione peroxidase 1 gene polymorphism (rs1050450) with Hashimoto's thyroiditis in Northwest Iran
Publication date: September 2018Source: Meta Gene, Volume 17Author(s): Zafar Gholinejad, Amir Hossein Faghfouri, Rasoul Zarrin, Yousef RasmiAbstractHashimoto's thyroiditis (HT) is an inflammatory and autoimmune thyroid disorder. The oxidative stress and inflammation crosstalk play pivotal role in the pathogenesis of HT. The activity of glutathione peroxidase-1 (GPx-1) enzyme is affected by single nucleotide polymorphism in the rs1050450 position, which influence the risk of several diseases. The aim of this study is to determine the association of rs1050450 genotype variant and the HT risk. A hundred and five patients HT p...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Circulating miR-196a-5p miR-373-3p and miR-375: Novel candidate biomarkers for diagnosis of acute coronary syndrome
In this study, total 135 patients with angina or acute myocardial infarction who underwent coronary angiography were recruited and divided into 3 groups: 45 patients with normal coronary arteries, 45 patients with obstructive CAD and 45 patients with acute STEMI. Serum which was obtained from blood samples were drawn before coronary angiography. After RNA isolation and cDNA synthesis, expressions of miRNAs were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Statistical analysis of qRT-PCR expression results was carried out by using the 2−ΔCt formula.ResultsExpression differences were st...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of BRCA2 variants with breast cancer risk: A meta-analysis
Publication date: September 2018Source: Meta Gene, Volume 17Author(s): Sepideh Faramarzi, Ali Dianatpour, Soudeh Ghafouri-FardAbstractBRCA2 is a tumor suppressor gene involved in repair of double strand breaks in DNA. Germ line mutations within this gene are implicated in familial breast and ovary cancer syndromes. Moreover, several studies have assessed association between single nucleotide polymorphisms (SNPs) within this gene and risk of breast cancer. We performed a meta-analysis to assess the association between rs4987117, rs1799955, rs766173, rs15869 SNPs within BRCA2 gene and risk of breast cancer. The pooled odds r...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association study of six single nucleotide polymorphisms with obesity in two independent Iberian samples
In this study, we investigate the reproducibility in two independent samples of the association and weighted GRS previously proposed for six SNPs as predictors for obesity susceptibility. A case-control study was performed using one sample comprising 346 unrelated Portuguese children [6–12 years-old; 191 controls and 155 obese], and a second sample comprising 332 unrelated Spanish adults [18–60 years-old; 217 controls and 115 obese]. Polymorphisms located on FTO, TFAP2B, SEC16B, ETV5, and SH2B1 genes were genotyped by allelic discrimination TaqMan assays.After Bonferroni corrections we found nominal signifi...
Source: Meta Gene - July 5, 2018 Category: Genetics & Stem Cells Source Type: research