Melatonin: A hypothesis for Kawasaki disease treatment
Kawasaki disease (KD) is the most common cause of acquired heart disease with unknown etiology among children in developed countries. Acute inflammation of the vasculature, genetic susceptibility and immunopathogenesis based on a transmittable and infectious origin, are the pathologic events involved in the early inflammatory etiology and progression of this disease. However, the exact causes of KD remain unknown. Current proposed recommendations include three therapy lines; firstly, an initial standard therapy with intravenous immunoglobulin (IVIG) followed by aspirin. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 15, 2018 Category: Biomedical Science Authors: Eva Ramos, Paloma Pati ño, Russel J. Reiter, Emilio Gil-Martín, Francisco López-Muñoz, Alejandro Romero Source Type: research
How did Lou Gehrig get Lou Gehrig ’s disease? Mycobacterium avium subspecies paratuberculosis in manure, soil, dirt, dust and grass and amyotrophic lateral sclerosis (motor neurone disease) clusters in football, rugby and soccer players
There are several suspected infectious causes of amyotrophic lateral sclerosis (ALS) or motor neurone disease including HIV-1 and species of Brucella, Cyanobacteria and Schistosoma. The increased rates and clusters of ALS in amateur and professional outdoor sports players including rugby, football and soccer players suggest a microorganism present in the grass, dirt and dust they play on and in may be a causative factor. The probable zoonosis Mycobacterium avium subspecies paratuberculosis (MAP) is heavily excreted in an infected domestic ruminant ’s feces or manure and is extensively distributed throughout the soil in c...
Source: Medical Hypotheses - July 12, 2018 Category: Biomedical Science Authors: Ellen S. Pierce Source Type: research
Asprosin: Possible target in connection with ghrelin and cytokine network expression in the post-burn treatment
Burn injury is a severe form of trauma associated with pain, metabolic abnormalities, susceptibility to infections, muscle loss, mental and emotional distress. Conventional therapies as well as some recent approaches for the treatment of burned patients are currently in use. Nutritional therapy is also suggested as a supplementary option in major burns. Within this context, hormones involved in the regulation of appetite will have a paramount importance. The aim is to evaluate the interactions among ghrelin, some inflammatory parameters and the burn injury. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 6, 2018 Category: Biomedical Science Authors: Mustafa Metin Donma, Orkide Donma Source Type: research
The putative glymphatic signature of chronic fatigue syndrome: a new view on the disease pathogenesis and therapy
The underlying pathophysiology of chronic fatigue syndrome remains incompletely understood and there are no curative treatments for this disorder at present. However, increasing neuroimaging evidence indicates that functional and structural abnormalities exist in the brains of chronic fatigue syndrome patients, suggesting that the central nervous system is involved in this disorder and that at least some chronic fatigue syndrome patients may have an underlying neurological basis for their illness. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 6, 2018 Category: Biomedical Science Authors: Peter Wostyn, Peter Paul De Deyn Source Type: research
Clinical features of a fatal shoulder dystocia: the hypovolemic shock hypothesis
Shoulder dystocia is a r a r e b u t severe obstetric complication associated with an increased risk of brachial plexus palsies, fractures of the clavicle and humerus, hypoxic-ischemic encephalopathy and, rarely, neonatal death.Here we describe a fatal case of shoulder dystocia in a term newborn, although labor was uneventful, fetal heart rate tracing was normal until the delivery of the head and the head- to- body delivery interval (HBDI) occurred within 5 minutes. Full resuscitation was performed for 35 minutes without success. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 5, 2018 Category: Biomedical Science Authors: E. Cesari, S. Ghirardello, G. Brembilla, A. Svelato, A Ragusa Source Type: research
Differential proteomics analysis of bile between Gangrenous cholecystitis and Chronic cholecystitis
To establish human biliary protein expression profiles of gangrenous cholecystitis, chronic cholecystitis, and to discover differently expressed proteins for gangrenous cholecystitis by comparative proteomics, we gathered human gallbladder bile samples from gangrenous cholecystitis and chronic cholecystitis patients, respectively After removing the bile salts and lipid peptide fragments were identified by the iTRAQ-coupled LC-MS/MS technology,then identified in SwissProt with Mascot software. A total of 2251 proteins from chronic cholecystitis patients and 2180 proteins from gangrenous cholecystitis patients were identifie...
Source: Medical Hypotheses - July 4, 2018 Category: Biomedical Science Authors: Zhenghui Yi, Linjie Wang, Wei Sun, Yinbin Chang Source Type: research
Vibration as Adjuvant Treatment Modality for Central Poststroke Pain
Central post-stroke pain (CPSP), formerly known as thalamic pain syndrome, is a chronic complex disabling pain syndrome characterized by pain and temperature sensation abnormalities after a cerebrovascular accident, infarct, or hemorrhage. It was first described, with pathophysiologic correlation to a lesion in the thalamus, in 1906 by Dejerine and Roussy as a “severe persistent, paroxysmal, often intolerant pain on the hemiplegic side, not yielding to analgesic treatment” [1,2]. There were previous descriptions of pain after a central lesion by Edinger [3] and others earlier in the 19th century [4]. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 3, 2018 Category: Biomedical Science Authors: Eric L. Altschuler Source Type: research
The potential use of scaffold-mediated local delivery of bone modulators in accelerated orthodontics: A hypotheses
Accelerated orthodontics involves the use of fixed orthodontic appliance with the assistance of surgical and/or non-surgical interventions to reduce the overall treatment duration. The surgical techniques used in accelerated orthodontics include dental-alveolus distraction, periodontal ligament distraction, alveolar decortication, and conticision [1]. The potential complication associated with the ‘surgery assisted orthodontics’ has led to the development of non-surgical modalities of accelerated orthodontics. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 3, 2018 Category: Biomedical Science Authors: Amit Jaisinghani, Archana A. Gupta, A. Thirumal Raj Source Type: research
Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by an accelerated aging phenotype that typically leads to death via stroke or myocardial infarction at approximately 14.6 years of age. Most cases of HGPS have been linked to the extensive use of a cryptic splice donor site located in the LMNA gene due to a de novo mutation, generating a truncated and toxic protein known as progerin. Progerin accumulation in the nuclear membrane and within the nucleus distorts the n uclear architecture and negatively effects nuclear processes including DNA replication and repair, leading to accelerated ...
Source: Medical Hypotheses - July 2, 2018 Category: Biomedical Science Authors: Jahahreeh Finley Source Type: research
Autonomic imbalance in cardiac surgery: a potential determinant of the failure in remote ischemic preconditioning
Remote ischemic preconditioning (RIPC) is a cardioprotective strategy against myocardial damage by ischemia-reperfusion. Many in-vivo and ex-vivo animal researches have demonstrated that RIPC decreases significantly the ischemia-reperfusion myocardial damage, by up to 58% in isolated rat heart. Cardiac artery bypass graft surgery (CABG) is a clinical model of myocardial ischemia-reperfusion and a clinical potential application to RIPC. However, although RIPC has shown successful results in experimental studies, clinical trials on CABG have failed to demonstrate a benefit of RIPC in humans. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 2, 2018 Category: Biomedical Science Authors: Abraham I.J. Gajardo, Lukas Karachon, Pablo Bustamante, Pablo Repullo, Marcelo Llancaqueo, Gina S ánchez, Ramón Rodrigo Source Type: research
Risk of gastric cancer following percutaneous endoscopic gastrostomy: A nationwide population-based cohort study
To investigate whether percutaneous endoscopic gastrostomy (PEG) tube placement is associated with increased risk of gastric cancer. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 2, 2018 Category: Biomedical Science Authors: Chih-Cheng Tsao, Shih-Yu Lee, Wei-Kuo Chang, Kuen-Tze Lin, Sheng-Der Hsu, Chen-Liang Tsai, Chun-Shu Lin Source Type: research
Reconceptualizing Delirium as a Disorder of Complex System Failure
Delirium is conceptually elusive and falls outside of conventional biomedical models. Positivist theoretical paradigms of single linear causality are therefore insufficient to provide mechanistic enlightenment. Delirium does, however, share parallels with features of failure within a complex system. Lessons from complex system theory provide important potential healthcare dividends with respect to delirium. The brain is complex and exhibits emergence, a feature of consciousness, which is crucially impacted in delirium. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 2, 2018 Category: Biomedical Science Authors: E. Eeles, A. Teodorczuk, E. Miteleton-Kelly Source Type: research
Ferulic Acid May Target MyD88-Mediated Pro-Inflammatory Signaling – Implications for the Health Protection Afforded by Whole Grains, Anthocyanins, and Coffee
Higher dietary intakes of anthocyanins have been linked epidemiologically to decreased risk for metabolic syndrome, type 2 diabetes and cardiovascular events; clinical trials and rodent studies evaluating ingestion of anthocyanin-rich extracts confirm favorable effects of these agents on endothelial function and metabolic syndrome. However, these benefits of anthocyanins are lost in rats whose gut microbiome has been eliminated with antibiotic treatment – pointing to bacterial metabolites of anthocyanins as the likely protective agents. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 2, 2018 Category: Biomedical Science Authors: Mark F. McCarty, Simon B. Iloki Assanga Source Type: research
Unified Neural Structured Model: a new Diagnostic Tool in Primary Care Psychiatry
In this report, the relationships between each of the major mental disorders and each neuropsychiatric component like personality, reward system, or reinforcement learning have been comprehensively reviewed to construct a new integrated structured model for assessing the overlapped mental conditions in primary care psychiatry. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 2, 2018 Category: Biomedical Science Authors: Tetsuya Akaishi Source Type: research
Cellular stress and AMPK links the effects of diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by an accelerated aging phenotype that typically leads to death via stroke or myocardial infarction at approximately 14.6 years of age. Most cases of HGPS have been linked to the extensive use of a cryptic splice donor site located in the LMNA gene due to a de novo mutation, generating a truncated and toxic protein known as progerin. Progerin accumulation in the nuclear membrane and within the nucleus distorts the nuclear architecture and negatively effects nuclear processes including DNA replication and repair, leading to accelerated cell...
Source: Medical Hypotheses - July 2, 2018 Category: Biomedical Science Authors: Jahahreeh Finley Source Type: research
