Cancer —Incidence, prevalence and mortality in the oldest-old. A comprehensive review
Publication date: June 2017 Source:Mechanisms of Ageing and Development, Volume 164 Author(s): Shantell C. Nolen, Marcella A. Evans, Avital Fischer, Maria M. Corrada, Claudia H. Kawas, Daniela A. Bota Chronic health conditions are commonplace in older populations. The process of aging impacts many of the world’s top health concerns. With the average life expectancy continuing to climb, understanding patterns of morbidity in aging populations has become progressively more important. Cancer is an age-related disease, whose risk has been proven to increase with age. Limited information is published about the epidemiolo...
Source: Mechanisms of Ageing and Development - May 21, 2017 Category: Geriatrics Source Type: research

Cancer − Incidence, Prevalence and Mortality in the Oldest-Old. A Comprehensive Review
Publication date: Available online 11 May 2017 Source:Mechanisms of Ageing and Development Author(s): Shantell C. Nolen, Marcella A. Evans, Avital Fischer, Maria M. Corrada, Claudia H. Kawas, Daniela A. Bota Chronic health conditions are commonplace in older populations. The process of aging impacts many of the world’s top health concerns. With the average life expectancy continuing to climb, understanding patterns of morbidity in aging populations has become progressively more important. Cancer is an age-related disease, whose risk has been proven to increase with age. Limited information is published about the epi...
Source: Mechanisms of Ageing and Development - May 12, 2017 Category: Geriatrics Source Type: research

FUNCTIONAL RELEVANCE OF miRNAS IN PREMATURE AGEING
Publication date: Available online 11 May 2017 Source:Mechanisms of Ageing and Development Author(s): Xurde M. Caravia, David Roiz-Valle, Alba Morán-Álvarez, Carlos López-Otín Ageing is a complex biological process characterized by the progressive loss of biological fitness due to the accumulation of macromolecular and cellular damage that affects most living organisms. Moreover, ageing is an important risk factor for many pathologies, including cardiovascular diseases, neurological disorders, and cancer. However, the ageing rate can be modulated by genetic, nutritional, and pharmacological fac...
Source: Mechanisms of Ageing and Development - May 12, 2017 Category: Geriatrics Source Type: research

SASP Regulation by Noncoding RNA
Publication date: Available online 11 May 2017 Source:Mechanisms of Ageing and Development Author(s): Amaresh C. Panda, Kotb Abdelmohsen, Myriam Gorospe Noncoding RNAs (ncRNAs), including micro (mi)RNAs, long noncoding (lnc)RNAs, and circular (circ)RNAs, control specific gene expression programs by regulating transcriptional, post-transcriptional, and post-translational processes. Through their broad influence on protein expression and function, ncRNAs have been implicated in virtually all cellular processes such as proliferation, senescence, quiescence, differentiation, apoptosis, and the stress and immune responses. Sen...
Source: Mechanisms of Ageing and Development - May 12, 2017 Category: Geriatrics Source Type: research

Environmental conditions can modulate the links among oxidative stress, age, and longevity
We examined within-individual changes between early- and mid-adulthood in the circulating levels of four oxidative stress markers linked to ageing, using zebra finches (Taeniopygia guttata): a DNA damage product (8-hydroxy-2′-deoxyguanosine; 8-OHdG), protein carbonyls (PC), non-enzymatic antioxidant capacity (OXY), and superoxide dismutase activity (SOD). We further examined whether such within-individual changes differed among birds living under control (ad lib food) or more challenging environmental conditions (unpredictable food availability), having previously found that the latter increased corticosterone levels...
Source: Mechanisms of Ageing and Development - May 7, 2017 Category: Geriatrics Source Type: research

Editorial: Re-thinking ageing: a cross-disciplinary perspective (A New Era for Ageing)
Publication date: April 2017 Source:Mechanisms of Ageing and Development, Volume 163 Author(s): Marios Kyriazis (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - May 4, 2017 Category: Geriatrics Source Type: research

Mechanisms of endothelial dysfunction during aging: predisposition to thrombosis
Publication date: Available online 3 May 2017 Source:Mechanisms of Ageing and Development Author(s): Cesar Sepúlveda, Iván Palomo, Eduardo Fuentes One of the risk factors for developing cardiovascular disease (CVD) is aging. In the elderly endothelial dysfunction occurs as altered endothelial ability to regulate hemostasis, vascular tone and cell permeability. In addition, there are changes in the expression and plasma levels of important endothelial components related to endothelial-mediated modulation in hemostasis. These include alterations in the metabolism of nitric oxide and prostanoides, endothelin-1,...
Source: Mechanisms of Ageing and Development - May 4, 2017 Category: Geriatrics Source Type: research

Skin melanocytes and fibroblasts show different changes in choline metabolism during cellular senescence
Publication date: Available online 2 May 2017 Source:Mechanisms of Ageing and Development Author(s): Cordula Windler, Claudia Gey, Karsten Seeger Unmodified cells undergo only a limited number of cell divisions until they enter a state termed cellular senescence. Other triggers like cytotoxic compounds can also induce cell senescence. Since cell senescence represents a major mechanism of tumor suppression this cellular state has attracted increasing attention. Different markers like senescence-associated β-galactosidase (SAβGal), senescence-associated heterochromatic foci (SAHF) or certain metabolic changes have...
Source: Mechanisms of Ageing and Development - May 3, 2017 Category: Geriatrics Source Type: research

Learning of nature: the curious case of the naked mole rat
Publication date: Available online 1 May 2017 Source:Mechanisms of Ageing and Development Author(s): Francisco Alejandro Lagunas-Rangel, Venice Chávez-Valencia Naked mole rats (NMRs) are the longest-living rodents known, living up to approximately 30 years and showing sustained good health. Nowadays, NMRs are considered excellent models for aging and, additionally, for cancer research, due to the evidence of a remarkable cancer resistance demonstrated through thousands of necropsies performed with very few cases that describe this pathology, which is believed to be a disease that unavoidably accompanies aging. Sinc...
Source: Mechanisms of Ageing and Development - May 2, 2017 Category: Geriatrics Source Type: research

The growth differentiation factor 11 (GDF11) and myostatin (MSTN) in tissue specific aging
Publication date: Available online 1 May 2017 Source:Mechanisms of Ageing and Development Author(s): X.L. Fan, U. Gaur, L. Sun, D.Y. Yang, M. Yang Growth differentiation factor 11 (GDF11) and myostatin (MSTN) are evolutionarily conserved homologues proteins which are closely related members of the transforming growth factor β superfamily. They are often perceived to serve similar or overlapping roles. Recently, GDF11 has been identified as playing a role during aging, however there are conflicting reports as to the nature of this role. In this review, we will discuss the literature regarding functions of GDF11 and my...
Source: Mechanisms of Ageing and Development - May 2, 2017 Category: Geriatrics Source Type: research

Demographic, Genetic and Phenotypic Characteristics of Centenarians in Italy: focus on gender differences
Publication date: Available online 29 April 2017 Source:Mechanisms of Ageing and Development Author(s): Alberto Montesanto, Francesco De Rango, Chiara Pirazzini, Giulia Guidarelli, Filippo Domma, Claudio Franceschi, Giuseppe Passarino An impressive and coherent series of epidemiological data from different populations (New England Americans, Mormons, Ashkenazi Jewish, Icelandic, Okinawan Japanese, Italians) suggests that long-lived subjects able to reach the extreme limits of human life, such as centenarians and supercentenarians, represent an extraordinary and informative model to identify the mechanisms responsible for ...
Source: Mechanisms of Ageing and Development - April 30, 2017 Category: Geriatrics Source Type: research

Editorial: DNA Damage & amp; Immunity
Publication date: Available online 23 April 2017 Source:Mechanisms of Ageing and Development Author(s): George A. Garinis, Bjoern Schwer, Björn Schumacher (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - April 24, 2017 Category: Geriatrics Source Type: research

How inflammation underlies physical and organ function in acutely admitted older medical patients
Publication date: Available online 22 April 2017 Source:Mechanisms of Ageing and Development Author(s): Henrik Hedegaard Klausen, Ann Christine Bodilsen, Janne Petersen, Thomas Bandholm, Thomas Haupt, Ditte Maria Sivertsen, Ove Andersen (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - April 23, 2017 Category: Geriatrics Source Type: research

Telomere shortening during aging: Attenuation by antioxidants and anti-inflammatory agents
Publication date: June 2017 Source:Mechanisms of Ageing and Development, Volume 164 Author(s): Kedar N. Prasad, Meixia Wu, Stephen C. Bondy Telomeres are a repeated sequence -of bases found at the ends of chromosomes. In humans, this sequence is TTAGGG, which is repeated over 2000 times. Telomeres protect the ends chromosomes from fusion with nearby chromosomes, and allow effective replication of DNA. Each time a cell divides, 25–200 base pairs are lost from the terminal sequence of chromosomes. By becoming truncated during cell division, telomeres protect essential genes from being shortened and thus inactivated. I...
Source: Mechanisms of Ageing and Development - April 23, 2017 Category: Geriatrics Source Type: research

Telomere Shortening During Aging; Attenuation by Antioxidants and Anti-inflammatory Agents
Publication date: Available online 18 April 2017 Source:Mechanisms of Ageing and Development Author(s): Kedar N. Prasad, Meixia Wu, Stephen C. Bondy Telomeres are a repeated sequence of bases found at the ends of chromosomes. In humans, this sequence is TTAGGG, which is repeated over 2000 times. Telomeres protect the ends chromosomes from fusion with nearby chromosomes, and allow effective replication of DNA. Each time a cell divides, 25-200 base pairs are lost from the terminal sequence of chromosomes. By becoming truncated during cell division, telomeres protect essential genes from being shortened and thus inactivated....
Source: Mechanisms of Ageing and Development - April 20, 2017 Category: Geriatrics Source Type: research

Differential menopause- versus aging-induced changes in oxidative stress and circadian rhythm gene markers
Publication date: June 2017 Source:Mechanisms of Ageing and Development, Volume 164 Author(s): Oriol A. Rangel-Zuñiga, Cristina Cruz-Teno, Carmen Haro, Gracia M. Quintana-Navarro, Fernando Camara-Martos, Pablo Perez-Martinez, Antonio Garcia-Rios, Marta Garaulet, Manuel Tena-Sempere, Jose Lopez-Miranda, Francisco Perez-Jimenez, Antonio Camargo Menopause is characterized by the depletion of estrogen that has been proposed to cause oxidative stress. Circadian rhythm is an internal biological clock that controls physiological processes. It was analyzed the gene expression in peripheral blood mononuclear cells and the l...
Source: Mechanisms of Ageing and Development - April 16, 2017 Category: Geriatrics Source Type: research

Alterations of the translation apparatus during aging and stress response
Publication date: Available online 13 April 2017 Source:Mechanisms of Ageing and Development Author(s): Yulia Gonskikh, Norbert Polacek Aging is a biological process characterized by the irreversible and time-dependent deterioration of cell functions, tissues, and organs. Accumulating studies in a wide range of species from yeast to human revealed changes associated with the aging process to be conserved throughout evolution. The main characteristics of aging are (i) genomic instability, (ii) loss of telomere function, (iii) epigenetic changes,(iv) increased cellular senescence, (v) depletion of the stem cell pool, (vi) a...
Source: Mechanisms of Ageing and Development - April 14, 2017 Category: Geriatrics Source Type: research

The genetics of human longevity: an intricacy of genes, environment, culture and microbiome
In conclusion, evidences collected from the latest studies on human longevity provide a support for the collection of life-long genetic and environmental/lifestyle variables with beneficial or detrimental effects on health, to improve our understanding of the determinants of human lifespan. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - April 11, 2017 Category: Geriatrics Source Type: research

Differential menopause- versus ageing-induced changes in oxidative stress and circadian rhythm gene markers
Publication date: Available online 10 April 2017 Source:Mechanisms of Ageing and Development Author(s): Oriol A. Rangel-Zuniga, Cristina Cruz-Teno, Carmen Haro, Gracia M. Quintana-Navarro, Fernando Camara-Martos, Pablo Perez-Martinez, Antonio Garcia-Rios, Marta Garaulet, Manuel Tena-Sempere, Jose Lopez-Miranda, Francisco Perez-Jimenez, Antonio Camargo Menopause is characterized by the depletion of estrogen that has been proposed to cause oxidative stress. Circadian rhythm is an internal biological clock that controls physiological processes. It was analyzed the gene expression in peripheral blood mononuclear cells and the...
Source: Mechanisms of Ageing and Development - April 11, 2017 Category: Geriatrics Source Type: research

The anti-inflammatory effect of melatonin in SH-SY5Y neuroblastoma cells exposed to sublethal dose of hydrogen peroxide
Publication date: Available online 10 April 2017 Source:Mechanisms of Ageing and Development Author(s): Chutikorn Nopparat, Varunya Chantadul, Kannika Permpoonputtana, Piyarat Govitrapong Brain inflammaging is considered as one of the underlying factors of neurodegenerative diseases. The present study aimed to investigate the effects of melatonin, an endogenous indoleamine mainly synthesized by the pineal gland, on hydrogen peroxide (H2O2)-induced inflammaging state in SH-SY5Y cells. Our data showed that p21Cip1 and p16INK4a, cell cycle arrest markers, and the number of senescence-associated β-galactosidase (SA-&beta...
Source: Mechanisms of Ageing and Development - April 11, 2017 Category: Geriatrics Source Type: research

Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence
Publication date: Available online 1 April 2017 Source:Mechanisms of Ageing and Development Author(s): Melisa Lopez-Anton, András Rudolf, Duncan M. Baird, Laureline Roger, Rhiannon E. Robinson, Janusz Witowski, Donald J. Fraser, Timothy Bowen Mesothelial cell (MC) senescence contributes to malignancy and tissue fibrosis. The role of telomere erosion in MC senescence remains controversial, with evidence for both telomere-dependent and telomere-independent mechanisms reported. Single telomere length analysis revealed considerable telomere length heterogeneity in freshly isolated human peritoneal MCs, reflecting a het...
Source: Mechanisms of Ageing and Development - April 1, 2017 Category: Geriatrics Source Type: research

miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1
This study aims to identify both endothelia-specific/enriched and senescence-associated miRNAs as well as their functions. The rats were fed on high-fat diet to establish a hyperlipidemic model, which showed an increase in plasma lipids and acceleration in endothelial senescence and endothelial dysfunction, accompanied by alterations in 7 endothelia-specific/enriched and senescence-associated miRNAs. Among the 7 selected miRNAs, miR-21-5p and miR-203a-3p were significantly up-regulated in a human umbilical vein endothelial cells (HUVECs) senescent model induced by ox-LDL, consistent with their changes in the hyperlipidemic...
Source: Mechanisms of Ageing and Development - March 26, 2017 Category: Geriatrics Source Type: research

CTT1 overexpression increases the replicative lifespan of MMS-sensitive Saccharomyces cerevisiae deficient in KSP1
Publication date: Available online 25 March 2017 Source:Mechanisms of Ageing and Development Author(s): Wei Zhao, Hua-Zhen Zheng, Tao Zhou, Xiao-Shan Hong, Hong-Jing Cui, Zhi-Wen Jiang, Hui-ji Chen, Zhong-Jun Zhou, Xin-Guang Liu Ksplp is a nuclear-localized Ser/Thr kinase that is not essential for the vegetative growth of yeast. A global gene function analysis in yeast suggested that Ksplp was involved in the oxidative stress response; however, the underlying mechanism remains unclear. Here, we showed that KSP1-deficient yeast cells exhibit hypersensitivity to the DNA alkylating agent methyl methanesulphonate (MMS), and t...
Source: Mechanisms of Ageing and Development - March 26, 2017 Category: Geriatrics Source Type: research

The role of the TOR pathway in mediating the link between nutrition and longevity
Publication date: Available online 16 March 2017 Source:Mechanisms of Ageing and Development Author(s): Oleh Lushchak, Olha Strilbytska, Veronika Piskovatska, Kenneth B. Storey, Alexander Koliada, Alexander Vaiserman The target of rapamycin (TOR) pathway integrates signals from extracellular and intracellular agents, such as growth factors, nutrients, mediators of energy balance, oxygen availability and other environmental cues. It allows the regulation of multiple cellular processes including protein and lipid synthesis, ribosome biogenesis, autophagy and metabolic processes. Being conserved across different phyla, TOR r...
Source: Mechanisms of Ageing and Development - March 24, 2017 Category: Geriatrics Source Type: research

CD34+ cell count predicts long lasting life in the oldest old
Publication date: Available online 16 March 2017 Source:Mechanisms of Ageing and Development Author(s): Giuseppe Mandraffino, Caterina Oriana Aragona, Giorgio Basile, Valentina Cairo, Federica Mamone, Carmela Morace, Angela D’Ascola, Angela Alibrandi, Alberto Lo Gullo, Saverio Loddo, Antonino Saitta, Egidio Imbalzano Circulating progenitor cells (CPCs) represent a pool of cells capable of differentiating into mature cells of different organs and systems, promoting tissue maintenance and repair. Among CPCs, CD34+cells (CD34+CPCs) seem to predict outcome in CV disease, also in elderly people. A decline in CD34+CPCs wa...
Source: Mechanisms of Ageing and Development - March 24, 2017 Category: Geriatrics Source Type: research

Worldwide demography of centenarians
Publication date: Available online 16 March 2017 Source:Mechanisms of Ageing and Development Author(s): Jean-Marie Robine, Sarah Cubaynes The global number of centenarians should strongly increase during the 21 st century. According to the Population Division of the United Nations it should reach more than 25 million people in 2100. To better understand the dynamics of the emergence and growth of the centenarian population, we focused on four European countries having long chronological series and high quality data about centenarians, Denmark, France, Sweden, and Switzerland, and Japan which has had the highest lif...
Source: Mechanisms of Ageing and Development - March 24, 2017 Category: Geriatrics Source Type: research

Telomere length analysis in Down syndrome birth
Publication date: Available online 19 March 2017 Source:Mechanisms of Ageing and Development Author(s): Pranami Bhaumik, Mandar Bhattacharya, Priyanka Ghosh, Sujoy Ghosh, Subrata Kumar Dey Human reproductive fitness depends upon telomere chemistry. Maternal age, meiotic nondisjunction error and telomere length of mother of trisomic child are someway associated. Reports exhibiting maternal inheritance of telomere length in Down syndrome child are very scanty. To investigate this, we collected peripheral blood from 170 mothers of Down syndrome child and 186 age matched mothers of euploid child with their newly born babies. ...
Source: Mechanisms of Ageing and Development - March 24, 2017 Category: Geriatrics Source Type: research

Anti-Skin-Aging Effect of Epigallocatechin Gallate by Regulating Epidermal Growth Factor Receptor Pathway on Aging Mouse Model Induced by D-Galactose
In this study, we investigated the anti-aging effect of EGCG, and to clarify underlying mechanism of skin aging in a D-galactose-induced aging mouse model. Forty-five male mice were divided into 5 groups and treated with different dose of EGCG, Vitamin C (VitC) to mice as a positive control. All groups except vehicle were established aging model induced by D-galactose (200mg/kg/day) that was subcutaneously injected to mice for 8 weeks. Two weeks after injection of D-galactose, EGCG and Vit C groups were simultaneously administered once a day by subcutaneously inject after 5hours for injecting D-galactose. The results show ...
Source: Mechanisms of Ageing and Development - March 24, 2017 Category: Geriatrics Source Type: research

Thyroid hormones in extreme longevity
Publication date: Available online 9 March 2017 Source:Mechanisms of Ageing and Development Author(s): Sabrina Garasto, Alberto Montesanto, Andrea Corsonello, Fabrizia Lattanzio, Sergio Fusco, Giuseppe Passarino, Valeria Prestipino Giarritta, Francesco Corica The aim of the present review was to summarize knowledge about thyroid hormones (THs) and longevity. Longevity is a complex multifactorial phenomenon on which specific biological pathways, including hormonal networks involved in the regulation of homeostasis and survival, exert a strong impact. THs are the key responsible for growth, metabolism rate and energy expend...
Source: Mechanisms of Ageing and Development - March 10, 2017 Category: Geriatrics Source Type: research

Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically difficult to assess
Publication date: Available online 9 March 2017 Source:Mechanisms of Ageing and Development Author(s): Beatrice Arosio, Rita Ostan, Daniela Mari, Sarah Damanti, Francesco Ronchetti, Sara Arcudi, Maria Scurti, Claudio Franceschi, Daniela Monti Human life expectancy and the number of the oldest old are rapidly increasing worldwide. Advanced age is the main risk factor for dementia, representing one of the major causes of disability/dependency among older people with a strong impact on their families/caregivers. Centenarians have reached the extreme limits of human life escaping or delaying the major age-related diseases. Th...
Source: Mechanisms of Ageing and Development - March 10, 2017 Category: Geriatrics Source Type: research

Strain specificities in cellular and molecular immunopathogenic mechanisms underlying development of experimental autoimmune encephalomyelitis in aged rats
Publication date: Available online 8 March 2017 Source:Mechanisms of Ageing and Development Author(s): Mirjana Nacka-Aleksić, Zorica Stojić-Vukanić, Ivan Pilipović, Ivana Vujnović, Biljana Bufan, Mirjana Dimitrijević, Gordana Leposavić To understand strain-specificities of immune system in aged rats and their immunopathological implications, CD4+ T lymphocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis (EAE) was studied in two strains. Upon immunization for EAE, 22-24-month-old Albino Oxford (AO) rats developed milder neurological deficit of prolonged duration compared with their Dark Ag...
Source: Mechanisms of Ageing and Development - March 9, 2017 Category: Geriatrics Source Type: research

Aging and Efficiency in Living Systems: Complexity, Adaptation and Self-organization
Publication date: Available online 4 March 2017 Source:Mechanisms of Ageing and Development Author(s): Atanu Chatterjee, Georgi Georgiev, Germano Iannacchione Living systems are open, out-of-equilibrium thermodynamic entities, that maintain order by locally reducing their entropy. Aging is a process by which these systems gradually lose their ability to maintain their out-of-equilibrium state, as measured by their free-energy rate density, and hence, their order. Thus, the process of aging reduces the efficiency of those systems, making them fragile and less adaptive to the environmental fluctuations, gradually driving th...
Source: Mechanisms of Ageing and Development - March 5, 2017 Category: Geriatrics Source Type: research

Exosome-based immunomodulation during aging: a nano-perspective on inflamm-aging
Publication date: Available online 1 March 2017 Source:Mechanisms of Ageing and Development Author(s): Francesco Prattichizzo, Luigina Micolucci, Monica Cricca, Sabrina De Carolis, Emanuela Mensà, Antonio Ceriello, Antonio Domenico Procopio, Massimiliano Bonafè, Fabiola Olivieri Exosomes are nanovesicles formed by inward budding of endosomal membranes. They exert complex immunomodulatory effects on target cells, acting both as antigen-presenting vesicles and as shuttles for packets of information like proteins, coding and non-coding RNA, and nuclear and mitochondrial DNA fragments. Albeit different, all such...
Source: Mechanisms of Ageing and Development - March 2, 2017 Category: Geriatrics Source Type: research

Centenarians as extreme phenotypes: an ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases
In conclusion we illustrate recent findings emerged from whole genome sequencing of long-lived individuals and future perspectives for interpreting the huge amount of genetic data that will be generated in the next future. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 28, 2017 Category: Geriatrics Source Type: research

Conserved effect of aging on DNA methylation and association with EZH2 polycomb protein in mice and humans
Publication date: Available online 27 February 2017 Source:Mechanisms of Ageing and Development Author(s): Khyobeni Mozhui, Ashutosh K. Pandey In humans, DNA methylation at specific CpG sites can be used to estimate the ‘epigenetic clock’, a biomarker of aging and health. The mechanisms that regulate the aging epigenome and level of conservation are not entirely clear. We performed affinity-based enrichment with methyl-CpG binding domain protein followed by high-throughput sequencing (MBD-seq) to assay DNA methylation in mouse samples. Consistent with previous reports, aging is associated with increase in meth...
Source: Mechanisms of Ageing and Development - February 28, 2017 Category: Geriatrics Source Type: research

Glycation stimulates cutaneous monocyte differentiation in reconstructed skin in vitro
Publication date: March 2017 Source:Mechanisms of Ageing and Development, Volume 162 Author(s): H. Pageon, H. Zucchi, F. Rousset, S. Girardeau-Hubert, E. Tancrede, D. Asselineau Glycation reaction is a recognized mechanism related to chronological aging. Previous investigations in cutaneous biology have considered the effect of glycation on the dermal matrix molecules, involved in tissue stiffening during skin aging. However, little is known about a possible direct effect of glycation upon cell differentiation. To address such issue, the effect of glycation has been re-investigated in a reconstructed skin model integratin...
Source: Mechanisms of Ageing and Development - February 28, 2017 Category: Geriatrics Source Type: research

Yeast on the corner of life and death decisions
Publication date: January 2017 Source:Mechanisms of Ageing and Development, Volume 161, Part B Author(s): Paula Ludovico, Manuela Côrte-Real (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 21, 2017 Category: Geriatrics Source Type: research

Consumption of protein-enriched milk has minor effects on inflammation in older adults —A 12-week double-blind randomized controlled trial
Conclusion Consumption of a low-fat, protein-enriched milk for 12 weeks had minor effects on inflammatory related markers in older adults compared to an isocaloric carbohydrate drink. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 20, 2017 Category: Geriatrics Source Type: research

Demographic, Phenotypic, and Genetic Characteristics of Centenarians in Okinawa and Honshu, Japan: Part 2 Honshu, Japan
Publication date: Available online 16 February 2017 Source:Mechanisms of Ageing and Development Author(s): Yasumichi Arai, Takashi Sasaki, Nobuyoshi Hirose The scope and purpose of this review was to summarize the aims, methods, findings, and future of centenarian and (semi)-supercentenarian studies in Japan, particularly those from our own interdisciplinary laboratory. Medically, approximately 97% of centenarians contract chronic diseases including hypertension and gastrointestinal disease; however, they present with few cardiovascular risk factors. The low prevalence of diabetes mellitus and carotid atherosclerotic plaq...
Source: Mechanisms of Ageing and Development - February 17, 2017 Category: Geriatrics Source Type: research

DNA damage responses in central nervous system and age-associated neurodegeneration
Publication date: January 2017 Source:Mechanisms of Ageing and Development, Volume 161, Part A Author(s): Muralidhar L. Hegde, Vilhelm A. Bohr, Sankar Mitra (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 15, 2017 Category: Geriatrics Source Type: research

Calorie Restriction Promotes Cardiolipin Biosynthesis and Distribution Between Mitochondrial Membranes
Publication date: Available online 14 February 2017 Source:Mechanisms of Ageing and Development Author(s): Luis Alberto Luévano-Martínez, Maria Fernanda Forni, Julia Peloggia, Ii-Sei Watanabe, Alicia J. Kowaltowski Calorie restriction (CR) has been amply demonstrated to modify mitochondrial function. However, little is known regarding the effects of this dietary regimen on mitochondrial membranes. We isolated phospholipids from rat liver mitochondria from animals on CR or ad libitum diets and found that mitochondria from ad libitum animals present an increased content of lipoperoxides and the content of card...
Source: Mechanisms of Ageing and Development - February 15, 2017 Category: Geriatrics Source Type: research

The Concept of Ageing in Evolutionary Algorithms: Discussion and Inspirations for Human Ageing
Publication date: Available online 4 February 2017 Source:Mechanisms of Ageing and Development Author(s): Christos Dimopoulos, Panagiotis Papageorgis, George Boustras, Christodoulos Efstathiades This paper discusses the concept of ageing as this applies to the operation of Evolutionary Algorithms, and examines its relationship to the concept of ageing as this is understood for human beings. Evolutionary Algorithms constitute a family of search algorithms which base their operation on an analogy from the evolution of species in nature. The paper initially provides the necessary knowledge on the operation of Evolutionary Al...
Source: Mechanisms of Ageing and Development - February 4, 2017 Category: Geriatrics Source Type: research

Consumption of protein-enriched milk has minor effects on inflammation in older adults − a 12-week double-blind randomized controlled trial
Conclusion Consumption of a low-fat, protein-enriched milk for 12 weeks had minor effects on inflammatory related markers in older adults compared to an isocaloric carbohydrate drink. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 3, 2017 Category: Geriatrics Source Type: research

Glycation stimulates cutaneous monocyte differentiation in reconstructed skin in vitro.
Publication date: Available online 3 February 2017 Source:Mechanisms of Ageing and Development Author(s): H. Pageon, H. Zucchi, F. Rousset, S. Hubert, E. Tancrede, D. Asselineau Glycation reaction is a recognized mechanism related to chronological aging. Previous investigations in cutaneous biology have considered the effect of glycation on the dermal matrix molecules, involved in tissue stiffening during skin aging. However, little is known about a possible direct effect of glycation upon cell differentiation. To address such issue, the effect of glycation has been re-investigated in a reconstructed skin model integratin...
Source: Mechanisms of Ageing and Development - February 3, 2017 Category: Geriatrics Source Type: research

Tracking senescent cells: A new biomarker assay opens new avenues in senescence research
Publication date: Available online 1 February 2017 Source:Mechanisms of Ageing and Development Author(s): Arturo Bujarrabal, Björn Schumacher (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 2, 2017 Category: Geriatrics Source Type: research

Limitations and risks of meta-analyses of longevity studies
Publication date: Available online 28 January 2017 Source:Mechanisms of Ageing and Development Author(s): Paola Sebastiani, Harold Bae, Anastasia Gurinovich, Mette Soerensen, Annibale Puca, Thomas T. Perls Searching for genetic determinants of human longevity has been challenged by the rarity of data sets with large numbers of individuals who have reached extreme old age, inconsistent definitions of the phenotype, and the difficulty of defining appropriate controls. Meta-analysis – a statistical method to summarize results from different studies – has become a common tool in genetic epidemiology to accrue larg...
Source: Mechanisms of Ageing and Development - January 28, 2017 Category: Geriatrics Source Type: research

MicroRNAs in Brain Aging
Publication date: Available online 22 January 2017 Source:Mechanisms of Ageing and Development Author(s): Chand Parvez Danka Mohammed, Jun Soo Park, Hong Gil Nam, Keetae Kim Brain aging is one of the most crucial biological processes that affect the physiological balance between health and disease. Age-associated dysfunction of brain leads to severe health problems in current aging society. MicroRNAs (miRNAs) have emerged as important regulators in most physiological processes including fine-tuning of the short-term, cellular regulatory functions as well as modulation of long-term organismal lifespan. In this review, we d...
Source: Mechanisms of Ageing and Development - January 22, 2017 Category: Geriatrics Source Type: research

Obesity induces pro-inflammatory B cells and impairs B cell function in old mice
Publication date: Available online 19 January 2017 Source:Mechanisms of Ageing and Development Author(s): Daniela Frasca, Alain Diaz, Maria Romero, Thomas Vazquez, Bonnie B. Blomberg We analyzed B cells infiltrating the Visceral Adipose Tissue (VAT) of young and old mice to identify contributors to the phenotypic and functional changes observed in aged B cells. We found higher percentages of pro-inflammatory (age-associated B cells, ABC) and less Follicular (FO) B cells in VAT as compared to spleen. VAT B cells express higher pro-adipogenic and inflammatory markers, including NF-kB, as compared to splenic B cells, and als...
Source: Mechanisms of Ageing and Development - January 20, 2017 Category: Geriatrics Source Type: research

The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity
Publication date: Available online 20 January 2017 Source:Mechanisms of Ageing and Development Author(s): Maria Giulia Bacalini, Patrizia D’Aquila, Elena Marasco, Christine Nardini, Alberto Montesanto, Claudio Franceschi, Giuseppe Passarino, Paolo Garagnani, Dina Bellizzi An increasing body of data is progressively indicating that the comprehension of the epigenetic landscape, actively integrated with the genetic elements, is crucial to delineate the molecular basis of the inter-individual complexity of ageing process. Indeed, it has emerged that DNA methylation changes occur during ageing, consisting mainly in a pr...
Source: Mechanisms of Ageing and Development - January 20, 2017 Category: Geriatrics Source Type: research

Periodontal disease level-butyric acid putatively contributes to the ageing blood: A proposed link between periodontal diseases and the ageing process
Publication date: Available online 17 January 2017 Source:Mechanisms of Ageing and Development Author(s): Marni E. Cueno, Keisuke Seki, Kuniyasu Ochiai, Kenichi Imai Periodontal diseases are partly attributable to periodontopathic bacteria found in the host, whereas,butyric acid (BA) is a common secondary metabolite produced by periodontopathic bacterial pathogens.BA has been linked to oxidative stress induction while oxidative stress has long been associated with the ageing process. However, the possible link between BA-induced oxidative stress and the ageingprocess has never been elucidated. Here, we attempted to show t...
Source: Mechanisms of Ageing and Development - January 18, 2017 Category: Geriatrics Source Type: research