Epigenetics in Ageing and Development
Publication date: Available online 17 May 2018 Source:Mechanisms of Ageing and Development Author(s): Rosita Gabbianelli, Marco Malavolta (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - May 18, 2018 Category: Geriatrics Source Type: research

CircRNA accumulation: A new hallmark of aging?
Publication date: Available online 16 May 2018 Source:Mechanisms of Ageing and Development Author(s): David Knupp, Pedro Miura Circular RNAs (circRNAs) are a newly appreciated class of RNAs found across phyla that are generated most commonly from back-splicing of protein-coding exons. Recent profiling of circRNAs genome-wide has shown that hundreds of circRNAs dramatically increase in expression during aging in the brains of multiple organisms. No other class of transcripts has been found to show such a strong correlation with aging as circRNAs—could they be playing a role in the aging process? Here, we discuss the ...
Source: Mechanisms of Ageing and Development - May 17, 2018 Category: Geriatrics Source Type: research

Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE Study
Publication date: Available online 30 April 2018 Source:Mechanisms of Ageing and Development Author(s): M. Liset Rietman, Annemieke M.W. Spijkerman, Albert Wong, Harry van Steeg, Alexander Bürkle, María Moreno-Villanueva, Thilo Sindlinger, Claudio Franceschi, Beatrix Grubeck-Loebenstein, Jürgen Bernhardt, P. Eline Slagboom, Olivier Toussaint, Florence Debacq-Chainiaux, Ewa Sikora, Efstathios S. Gonos, Nicolle Breusing, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Andrea Basso, Francesco Piacenza, Marco Malavolta, Sebastiano Collino, Eugene H.J.M. Jansen, W. M. Monique Verschuren, Martijn E.T. Dollé...
Source: Mechanisms of Ageing and Development - May 15, 2018 Category: Geriatrics Source Type: research

Role of hypothalamus in aging and its underlying cellular mechanisms
Publication date: Available online 2 May 2018 Source:Mechanisms of Ageing and Development Author(s): Keetae Kim, Han Kyoung Choe Aging is characterized by a progressive loss of several physiological functions that can cause various age-related disorders. Several factors have been identified as causes of aging to elucidate the decline in functions. Various aspects of physiological deterioration are controlled by the hypothalamus, a critical brain region that connects the neuroendocrine system to physiological functions. In addition, functional alterations in a set of agouti-related peptide/neuropeptide Y (AgRP/NPY) and pro...
Source: Mechanisms of Ageing and Development - May 15, 2018 Category: Geriatrics Source Type: research

RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting
Publication date: Available online 9 May 2018 Source:Mechanisms of Ageing and Development Author(s): Junko Oshima, Hisaya Kato, Yoshiro Maezawa, Koutaro Yokote Progeroid syndrome is a group of disorders characterized by the early onset of diseases that are associated with aging. Best known examples are Werner syndrome, which is adult onset and results from disease-causing DNA sequence variants in the RecQ helicase gene WRN, and Hutchison-Gilford progeria syndrome, which is childhood-onset and results from unique, recurrent disease-causing DNA sequence variants of the gene LMNA that encodes nuclear intermediate filaments. ...
Source: Mechanisms of Ageing and Development - May 15, 2018 Category: Geriatrics Source Type: research

Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor- γ coactivator-1β deficient (Pgc-1β-/-) murine hearts
Discussion Young and aged Pgc-1β-/- showed higher frequencies and durations of arrhythmic episodes through wider PES coupling-interval ranges than WT. Both young and old, regularly-paced, Pgc-1β-/- hearts showed slowed maximum action potential (AP) upstrokes, (dV/dt)max (~157 vs. 120-130 V s-1), prolonged AP latencies (by ~20%) and shortened refractory periods (~58 vs. 51 ms) but similar AP durations (~50 ms at 90% recovery) compared to WT. However, Pgc-1β-/- genotype and age each influenced extrasystolic AP latencies during PES. Young and aged WT ventricles displayed distinct, but Pgc-1β-/- ventr...
Source: Mechanisms of Ageing and Development - May 15, 2018 Category: Geriatrics Source Type: research

Drosophila pericardial nephrocyte ultrastructure changes during ageing
Publication date: Available online 24 April 2018 Source:Mechanisms of Ageing and Development Author(s): Olympia-Ekaterini Psathaki, Lena Dehnen, Paul Hartley, Achim Paululat Here we show that a labyrinth channel compartment and slit diaphragms, which are the histological structures enabling insect nephrocytes ultrafiltration, are established during embryogenesis first by the garland nephrocytes (GCNs). The later pericardial nephrocytes, which represent the majority of functional nephrocytes in larvae and adults, lack these characteristic features at the embryonic stage. During larval development, a subpopulation of the pe...
Source: Mechanisms of Ageing and Development - April 25, 2018 Category: Geriatrics Source Type: research

Epigenetic and non-epigenetic functions of the RYBP protein in development and disease
Publication date: Available online 14 April 2018 Source:Mechanisms of Ageing and Development Author(s): Carolina J. Simoes da Silva, Rocío Simón, Ana Busturia Over the last decades significant advances have been made in our understanding of the molecular mechanisms controlling organismal development. Among these mechanisms the knowledge gained on the roles played by epigenetic regulation of gene expression is extensive. Epigenetic control of transcription requires the function of protein complexes whose specific biochemical activities, such as histone mono-ubiquitylation, affect chromatin compaction and, con...
Source: Mechanisms of Ageing and Development - April 15, 2018 Category: Geriatrics Source Type: research

Immune signatures associated with mortality differ in elderly populations from different birth cohorts and countries even within northern Europe
Publication date: Available online 11 April 2018 Source:Mechanisms of Ageing and Development Author(s): Graham Pawelec Since associations between lifespan and certain simple immune parameters such as T cell proliferative responses to mitogens were reported in the 1970´s, efforts to dissect out immune parameters correlating with morbidity and mortality have sought to define factors predicting individual longevity. Such “immune signatures” associating with defined clinical outcomes would represent biomarkers of “immunosenescence” that might also provide mechanistic insights into the ageing proc...
Source: Mechanisms of Ageing and Development - April 12, 2018 Category: Geriatrics Source Type: research

NFE2L2, PPARGC1 α, and pesticides and Parkinson’s disease risk and progression
Conclusion Our study provides support for the involvement of both NFE2L2 and PPARGC1α in PD susceptibility and progression, marginally and through pathways involving MB/PQ exposure. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - April 7, 2018 Category: Geriatrics Source Type: research

The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature
Publication date: Available online 4 April 2018 Source:Mechanisms of Ageing and Development Author(s): Maria De Luca The extracellular matrix (ECM) is an intricate network that provides structural and anchoring support to cells in order to stabilize cell morphology and tissue architecture. The ECM also controls many aspects of the cell’s dynamic behavior and fate through its ongoing, bidirectional interaction with cells. These interactions between the cell and components of the surrounding ECM are implicated in several biological processes, including development and adult tissue repair in response to injury, through...
Source: Mechanisms of Ageing and Development - April 5, 2018 Category: Geriatrics Source Type: research

Birth weight predicts aging trajectory: A hypothesis
Publication date: Available online 4 April 2018 Source:Mechanisms of Ageing and Development Author(s): Alexander M. Vaiserman Increasing evidence suggests that risk for age-related disease and longevity can be programmed early in life. In human populations, convincing evidence has been accumulated indicating that intrauterine growth restriction (IUGR) resulting in low birth weight (<2.5 kg) followed by postnatal catch-up growth is associated with various aspects of metabolic syndrome, type 2 diabetes and cardiovascular disease in adulthood. Fetal macrosomia (birth weight >4.5 kg), by contrast, is associa...
Source: Mechanisms of Ageing and Development - April 5, 2018 Category: Geriatrics Source Type: research

Effect of heterochromatin stability on intestinal stem cell aging in Drosophila
Publication date: Available online 3 April 2018 Source:Mechanisms of Ageing and Development Author(s): Ho-Jun Jeon, Young-Shin Kim, Joong-Gook Kim, Kyu Heo, Jung-Hoon Pyo, Masamitsu Yamaguchi, Joung-Sun Park, Mi-Ae Yoo Chromatin change is one of the crucial causes of aging. Specifically, maintenance of heterochromatin stability is critical for cellular integrity, and its loss induces genomic instability and cellular aging. However, the causes and effects of heterochromatin instability in multicellular tissue aging still remain unclear. Here, in the adult Drosophila midgut, we report age-related loss of heterochromatin sta...
Source: Mechanisms of Ageing and Development - April 4, 2018 Category: Geriatrics Source Type: research

Multivessel analysis of progressive vascular aging in the rat: asynchronous vulnerability among vascular territories
Publication date: Available online 29 March 2018 Source:Mechanisms of Ageing and Development Author(s): Mariam El Assar, Argentina Fernández, Alberto Sánchez-Ferrer, Javier Angulo, Leocadio Rodríguez-Mañas Aging induces vascular dysfunction, representing the major risk factor for cardiovascular disease. Our aim was to ascertain specific vulnerability of vascular territories to aging by evaluating the progressive impact of aging on vascular function in four different vascular beds: aorta, mesenteric artery (MA), coronary artery (CA), and penile corpus cavernosum (CC) from 3, 6, 9, 12, 20 or 24 m...
Source: Mechanisms of Ageing and Development - March 30, 2018 Category: Geriatrics Source Type: research

The impact of oxidative DNA damage and stress on telomere homeostasis
Publication date: Available online 28 March 2018 Source:Mechanisms of Ageing and Development Author(s): Ryan P. Barnes, Elise Fouquerel, Patricia L. Opresko Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear chromosome ends. Because telomeres shorten progressively with each replication, they impose a functional limit on the number of times a cell can divide. Critically short telomeres trigger cellular senescence in normal cells, or genomic instability in pre-malignant cells, which contribute to numerous degenerative and aging-related diseases including cancer. Therefore, a detailed understandin...
Source: Mechanisms of Ageing and Development - March 29, 2018 Category: Geriatrics Source Type: research

PIWI-piRNA Pathway: Setting the Pace of Aging by Reducing DNA Damage
This article discusses the proposed role of the PIWI-piRNA pathway in setting the pace of aging as well as the possible mechanisms underlying this process. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - March 24, 2018 Category: Geriatrics Source Type: research

Protein aggregates and proteostasis in aging: amylin and β-cell function
Publication date: Available online 23 March 2018 Source:Mechanisms of Ageing and Development Author(s): Michaela Press, Tobias Jung, Jeannette König, Tilman Grune, Annika Höhn The ubiquitin-proteasomal-system (UPS) and the autophagy-lysosomal-system (ALS) are both highly susceptible for disturbances leading to the accumulation of cellular damage. A decline of protein degradation during aging results in the formation of oxidatively damaged and aggregated proteins finally, resulting in failure of cellular functionality. Besides protein aggregation in response to oxidative damage, amyloids are a different type of p...
Source: Mechanisms of Ageing and Development - March 24, 2018 Category: Geriatrics Source Type: research

SOX2 expression diminishes with ageing in several tissues in mice and humans
Publication date: Available online 21 March 2018 Source:Mechanisms of Ageing and Development Author(s): Estefania Carrasco-Garcia, Leire Moreno-Cugnon, Idoia Garcia, Consuelo Borras, Miren Revuelta, Ander Izeta, Guillermo Lopez-Lluch, Marian M.de Pancorbo, Itziar Vergara, Jose Vina, Ander Matheu SOX2 (Sex-determining region Y box 2) is a transcription factor expressed in several foetal and adult tissues and its deregulated activity has been linked to chronic diseases associated with ageing. Nevertheless, the level of SOX2 expression in aged individuals at the tissue level has not previously been examined. In this work, we...
Source: Mechanisms of Ageing and Development - March 21, 2018 Category: Geriatrics Source Type: research

Age-related evolutions of the dermis: Clinical signs, fibroblast and extracellular matrix dynamics
Publication date: Available online 13 March 2018 Source:Mechanisms of Ageing and Development Author(s): Valérie Haydont, Bruno A. Bernard, Nicolas O. Fortunel Ageing is today a major societal concern that is intrinsically associated with the increase of life expectancy. Outside the context of severe degenerative diseases that affect the elderly populations, normal visible signs of ageing, notably skin sagging and wrinkles, influence the social and individual perception of peoples. Accordingly, there is a strong demand for researches on skin ageing. Deciphering the cellular and molecular processes of skin evolution ...
Source: Mechanisms of Ageing and Development - March 20, 2018 Category: Geriatrics Source Type: research

Laminin-332 regulates differentiation of human interfollicular epidermal stem cells
Publication date: Available online 16 March 2018 Source:Mechanisms of Ageing and Development Author(s): Takaaki Yamada, Seiji Hasegawa, Katsuma Miyachi, Yasushi Date, Yu Inoue, Akiko Yagami, Masaru Arima, Yohei Iwata, Naoki Yamamoto, Satoru Nakata, Kayoko Matsunaga, Kazumitsu Sugiura, Hirohiko Akamatsu Interfollicular epidermal stem cells (IFE-SCs) have self-renewal and differentiation potentials, and maintain epidermal homeostasis. Stem cells in vivo are regulated by the surrounding environment called niche to function properly, however, IFE-SC niche components are not fully understood. In order to elucidate the mechanis...
Source: Mechanisms of Ageing and Development - March 17, 2018 Category: Geriatrics Source Type: research

Age-related evolutions of the dermis: Clinical signs, cellular and molecular players
Publication date: Available online 13 March 2018 Source:Mechanisms of Ageing and Development Author(s): Valérie Haydont, Bruno A. Bernard, Nicolas O. Fortunel Ageing is today a major societal concern that is intrinsically associated with the increase of life expectancy. Outside the context of severe degenerative diseases that affect the elderly populations, normal visible signs of ageing, notably skin sagging and wrinkles, influence the social and individual perception of peoples. Accordingly, there is a strong demand for researches on skin ageing. Deciphering the cellular and molecular processes of skin evolution ...
Source: Mechanisms of Ageing and Development - March 14, 2018 Category: Geriatrics Source Type: research

Epigenetic mechanisms in amyotrophic lateral sclerosis: a short review
Publication date: Available online 12 March 2018 Source:Mechanisms of Ageing and Development Author(s): Ana Dolinar, Metka Ravnik-Glavač, Damjan Glavač Amyotrophic lateral sclerosis is a rapidly progressing neurodegenerative disease. Decades of research show that the etiology of this disease is affected by genetic, epigenetic and environmental factors rather than limited by a patient's genotype. The interaction between these factors is complex, and research has only begun to unravel this issue. The main epigenetic mechanisms, DNA methylation, miRNA, and histone modifications, can explain a portion of the disease complex...
Source: Mechanisms of Ageing and Development - March 13, 2018 Category: Geriatrics Source Type: research

Photoaging and skin cancer: is the inflammasome the missing link?
Publication date: Available online 12 March 2018 Source:Mechanisms of Ageing and Development Author(s): Fawaz Awad, Eman Assrawi, Camille Louvrier, Claire Jumeau, Irina Giurgea, Serge Amselem, Sonia-Athina Karabina Photoaging and epithelial skin tumorigenesis are complex processes triggered mainly by UV radiation from chronic sun exposure. This leads to DNA damage and reactive oxygen species (ROS) production, which initiate an inflammatory response that alters cell structure and function. Changes in cell homeostasis and ROS production activate intracellular multiprotein platforms called inflammasomes. Inflammasomes nuclea...
Source: Mechanisms of Ageing and Development - March 12, 2018 Category: Geriatrics Source Type: research

Altered ureteral contractility with ageing: Role of the rho-kinase pathway
This study investigated the role of calcium sensitisation in the regulation of ureteral contractility with ageing. Isolated ureteral strips from young (6-month old) and older (3-year old) pigs were mounted in Krebs bicarbonate solution and contractility induced by the α1-adrenoceptor agonist phenylephrine (30 and 300 μM) and 5-HT (10 and 100 μM), recorded in the absence and presence of the rho-kinase inhibitors Y-27632 (10 μM) and fasudil (30 μM). Ureteral strips developed bursts of contractile activity which was measured as area under the curve (AUC) and frequency. Maximum contraction to phenylep...
Source: Mechanisms of Ageing and Development - March 10, 2018 Category: Geriatrics Source Type: research

Longevity promoting efficacies of different plant extracts in lower model organisms
Publication date: Available online 8 March 2018 Source:Mechanisms of Ageing and Development Author(s): Debarati Chattopadhyay, Kavitha Thirumurugan Past investigations have shown that various plant extracts are capable of promoting longevity in lower model organisms like Caenorhabditis elegans, Drosophila melanogaster, Saccharomyces cerevisiae, Bombyx mori etc. Longevity studies on such organisms provide a foundation to explore anti-aging efficacies of such plant extracts in higher organisms. Plant extracts of acai palm, apple, asparagus, blueberry, cinnamon, cocoa, Damnacanthus, maize, mistletoe, peach, pomegranate, Rhod...
Source: Mechanisms of Ageing and Development - March 9, 2018 Category: Geriatrics Source Type: research

Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity
In conclusion, Tpm2 may be important in maintaining lens physiology and morphology. However, Tpm2 is involved in the progression of EMT during the wound healing process of mouse LECs, suggesting that inhibition of Tpm2 may suppress PCO. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - March 4, 2018 Category: Geriatrics Source Type: research

Stress and Senescence: A Special Issue dedicated to Olivier Toussaint
Publication date: March 2018 Source:Mechanisms of Ageing and Development, Volume 170 Author(s): Florence Debacq-Chainiaux, Efstathios S. Gonos (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - March 1, 2018 Category: Geriatrics Source Type: research

Studying microRNAs in osteoarthritis: critical overview of different analytical approaches
Publication date: Available online 27 February 2018 Source:Mechanisms of Ageing and Development Author(s): Varvara Trachana, Eleni Ntoumou, Lydia Anastasopoulou, Aspasia Tsezou MicroRNAs are small non-coding RNA species with the ability to post-transcriptionally control the expression of multiple genes, that have gained substantial interest because of their expression alterations that accompanies aging and possible age-related pathologies. Given the constant rise in the number of patients suffering from age-related diseases –due to the increase of the aging population in the western world- the exploration of the rol...
Source: Mechanisms of Ageing and Development - February 28, 2018 Category: Geriatrics Source Type: research

Aging and nutrition induce tissue-specific changes on global DNA methylation status in rats
We examined global DNA methylation profiles in tissues from rats of different age, fed with standard or low-calorie diet, and evaluated their association with aging and nutrition. Tissue-specific variations occur during aging with hyper-methylation taking place in all tissues except for liver. The expression of enzymes involved in methylation reactions (DNMTs and TETs) was consistent with the methylation patterns. Nutrition affects global DNA methylation status throughout lifespan. Interestingly, the differences among different tissues are magnified in 96 weeks old rats fed with low calorie diet. Moreover, the low-calorie ...
Source: Mechanisms of Ageing and Development - February 26, 2018 Category: Geriatrics Source Type: research

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution
Publication date: Available online 25 February 2018 Source:Mechanisms of Ageing and Development Author(s): Alexandra Barbouti, Konstantinos Evangelou, Ioannis S. Pateras, Alexandra Papoudou-Bai, Amalia Patereli, Kalliopi Stefanaki, Dimitra Rontogianni, Daniel Muñoz-Espín, Panagiotis Kanavaros, Vassilis G. Gorgoulis Cellular senescence, an age-related process in response to damage and stress, also occurs during normal development and adult life. The thymus is a central lymphoepithelial organ of the immune system that exhibits age-related changes termed thymic involution. Since the mechanisms regulating thymic...
Source: Mechanisms of Ageing and Development - February 26, 2018 Category: Geriatrics Source Type: research

Exposure of human neurons to silver nanoparticles induces similar pattern of ABC transporters gene expression as differentiation: Study on proliferating and post-mitotic LUHMES cells
In this study we analysed expression of 42 genes from ABC transporter superfamily in both proliferating cells and differentiated neurons after treatment with silver nanoparticles. ABC transporter superfamily is especially known due to the involvement in multidrug resistance phenomenon, but also involvement in transport through blood-brain barrier. Our results indicate that in neurons silver nanoparticles mainly attenuate transporters responsible for maintaining asymmetry of cellular membrane and homeostasis of lipids and cholesterol. Our results revealed also that proliferating foetal brain cells are by far more susceptibl...
Source: Mechanisms of Ageing and Development - February 25, 2018 Category: Geriatrics Source Type: research

The epigenetic alterations of endogenous retroelements in aging
Publication date: Available online 16 February 2018 Source:Mechanisms of Ageing and Development Author(s): Maurizio Cardelli Endogenous retroelements, transposons that mobilize through RNA intermediates, include some of the most abundant repetitive sequences of the human genome, such as Alu and LINE-1 sequences, and human endogenous retroviruses. Recent discoveries demonstrate that these mobile genetic elements not only act as intragenomic parasites, but also exert regulatory roles in living cells. The risk of genomic instability represented by endogenous retroelements is normally counteracted by a series of epigenetic co...
Source: Mechanisms of Ageing and Development - February 17, 2018 Category: Geriatrics Source Type: research

The role of Snf5 in the osteogenic differentiation potential during replicative senescence of rat mesenchymal stromal cells
In this study, we sought to explore the molecular mechanisms underlying the osteogenic differentiation capacities that occur during replicative senescence. It is well known that Oct4 is a key transcription factor essential for maintaining differentiation capacities of the stem cells. In this study, we found that BMSCs at passage 6 (replicative senescent BMSCs) showed marked decreases in the osteogenic differentiation potential and the level of Oct4. These were accompanied by reduced levels of Snf5 and histone H3 lysine-4 trimethylation (H3K4me3) in the Oct4 promoter. In BMSCs at passage 2, knockdown of Snf5 diminished expr...
Source: Mechanisms of Ageing and Development - February 3, 2018 Category: Geriatrics Source Type: research

Back to the future: epigenetic clock plasticity towards healthy aging
Publication date: Available online 11 January 2018 Source:Mechanisms of Ageing and Development Author(s): Ken Declerck, Wim Vanden Berghe Aging is the most important risk factor for major human lifestyle diseases, including cancer, neurological and cardiometabolic disorders. Due to the complex interplay between genetics, lifestyle and environmental factors, some individuals seem to age faster than others, whereas centenarians seem to have a slower aging process. Therefore, a biochemical biomarker reflecting the relative biological age would be helpful to predict an individual’s health status and aging disease risk. ...
Source: Mechanisms of Ageing and Development - January 26, 2018 Category: Geriatrics Source Type: research

The role of epigenetics in cardiovascular health and ageing: A focus on physical activity and nutrition
Publication date: Available online 16 November 2017 Source:Mechanisms of Ageing and Development Author(s): Robert G. Wallace, Laura C. Twomey, Marc-Antoine Custaud, Jonathan D. Turner, Niall Moyna, Philip M. Cummins, Ronan P. Murphy The cardiovascular system is responsible for transport of blood and nutrients to tissues, and is pivotal to the physiological health and longevity. Epigenetic modification is a natural, age-associated process resulting in highly contextualised gene expression with clear implications for cell differentiation and disease onset. Biological/epigenetic age is independent of chronological age, const...
Source: Mechanisms of Ageing and Development - January 10, 2018 Category: Geriatrics Source Type: research

Integrated study on comparative transcriptome and skeletal muscle function in aged rats
Publication date: Available online 8 January 2018 Source:Mechanisms of Ageing and Development Author(s): Jing Zhou, Zhiyin Liao, Jinliang Chen, Kexiang Zhao, Qian Xiao The present study aimed to reveal aging-related changes in the skeletal muscle of SD rats by comparing transcriptome analysis, integrated with muscle physiological parameters. Ten rats aged 25 months were set as the old group (OG) and ten rats aged 6 months were set as the young group (YG). After 6 weeks of feeding, the body mass, grip strength, and gastrocnemius muscle mass were determined, and the differentially expressed genes were analyzed by transcript...
Source: Mechanisms of Ageing and Development - January 9, 2018 Category: Geriatrics Source Type: research

Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3
Conclusion our data suggested that SAL decreased the expression of inflammatory cytokines and up-regulated the expression of SIRT3, which might be the underlying mechanism of SAL on preventing endothelial cells from premature senescence. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - December 28, 2017 Category: Geriatrics Source Type: research

Mechanisms of Aging and Development —A New Understanding of Environmental Damage to the Skin and Prevention with Topical Antioxidants
Publication date: Available online 26 December 2017 Source:Mechanisms of Ageing and Development Author(s): Karen E. Burke Recent research has given us new insights into the molecular biology of extrinsic aging of the skin. Not only does UV irradiation directly cause photoaging of the skin, but also environmental pollutants significantly damage exposed skin by several mechanisms. Exposure to the noxious gases of air pollution with simultaneous exposure to UVA can act synergistically to initiate skin cancer. Also ozone generated from pollutants reacting with UV induces oxidative stress of the skin’s surface via format...
Source: Mechanisms of Ageing and Development - December 26, 2017 Category: Geriatrics Source Type: research

Cortical control of upright stance in elderly
This study examined differences between young and elderly volunteers in cortical involvement to human posture control during quiet stance with normal and altered sensory stimulation (Experiment-1), and biomechanical perturbations (Experiment-2). The primary focus of the first part was to monitor changes in cortical activity when unexpectedly altering the sensory conditions of upright stance, such as switching from stable (eyes open, fixed support surface) to less-stable (eyes closed, sway-referenced support surface) conditions. Our results demonstrate increased cortical activations in delta (0.2–4 Hz) and gamma (30...
Source: Mechanisms of Ageing and Development - December 22, 2017 Category: Geriatrics Source Type: research

DNA methylation dynamics in aging: how far are we from understanding the mechanisms?
Publication date: Available online 18 December 2017 Source:Mechanisms of Ageing and Development Author(s): Fabio Ciccarone, Stefano Tagliatesta, Paola Caiafa, Michele Zampieri DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered. Here we discuss the current knowledge of the dynamic nature of DNA epigenome landscape in mammals, and propose putative molecular mechanisms for aging-associated DNA epigenetic changes. Specifically, we describe age-related variations o...
Source: Mechanisms of Ageing and Development - December 18, 2017 Category: Geriatrics Source Type: research

Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p
This study aims to explore whether atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats or ox-LDL-treated HUVECs through a mechanism involving suppress of miR-21-5p/203a-3p expression and their downstream pathway. The rats were fed with high-fat diet to establish a hyperlipidemic model, which showed an increase in plasma lipids and endothelial senescence, accompanied by the elevation in plasma levels of miR-21-5p/203a-3p, down-regulation of Drp1 and up-regulation of p53 in the aorta of hyperlipidemic rats; these phenomena were reversed by atorvastatin. Next, HUVECs were incubated with ox-L...
Source: Mechanisms of Ageing and Development - December 16, 2017 Category: Geriatrics Source Type: research

Editorial: Non-coding RNA in aging and age-associated diseases – from intracellular regulators to hormone like actions
Publication date: December 2017 Source:Mechanisms of Ageing and Development, Volume 168 Author(s): Matthias Hackl, Yousin Suh, Johannes Grillari (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - December 14, 2017 Category: Geriatrics Source Type: research

OLR1 scavenger receptor knockdown affects mitotic gene expression but is dispensable for oxidized phospholipid- mediated stress signaling in SZ 95 sebocytes
Publication date: Available online 2 November 2017 Source:Mechanisms of Ageing and Development Author(s): Ionela-Mariana Nagelreiter, Masomeh Parvardeh, Marie-Sophie Narzt, Lucian Beer, Christopher Kremslehner, Ximena Maria Muresan, Johannes Grillari, Christos C. Zouboulis, Erwin Tschachler, Florian Gruber Phospholipid oxidation products (OxPL) are versatile stress signaling mediators in the skin. These lipid signaling molecules can be generated non-enzymatically or enzymatically by ultraviolet light, the major extrinsic skin aging factor. OxPL regulate cytoprotective, immunological and metabolic adaptation of the skin to...
Source: Mechanisms of Ageing and Development - December 11, 2017 Category: Geriatrics Source Type: research

Age influences the skin reaction pattern to mechanical stress and its repair level through skin care products
Publication date: Available online 15 November 2017 Source:Mechanisms of Ageing and Development Author(s): Christos C. Zouboulis, Rana Elewa, Monica Ottaviani, Joachim Fluhr, Mauro Picardo, Armand Bernois, Catherine Heusèle, Emanuela Camera Skin aging is associated with alterations of surface texture, sebum composition and immune response. Mechanical stress induces repair mechanisms, which may be dependent on the age and quality of the skin. The response to mechanical stress in young and aged individuals, their subjective opinion and the objective effectiveness of skin care products were evaluated by biophysical sk...
Source: Mechanisms of Ageing and Development - December 11, 2017 Category: Geriatrics Source Type: research

Effects of different hypoxia degrees on endothelial cell cultures —Time course study
Publication date: Available online 15 November 2017 Source:Mechanisms of Ageing and Development Author(s): Ioana Baldea, Ioana Teacoe, Diana Elena Olteanu, Cristina Vaida-Voievod, Andra Clichici, Alexandru Sirbu, Gabriela Adriana Filip, Simona Clichici Introduction Exposure of the endothelial cells to hypoxia, the decrease in oxygen supply can trigger an endothelial response. This response is involved in inflammatory diseases, tumorigenesis, and also with the micro vascular damage associated with aging. The aim of our study was to determine the hypoxia/re-oxygenation induced response in vitro, using human umbilical vein e...
Source: Mechanisms of Ageing and Development - December 11, 2017 Category: Geriatrics Source Type: research

The role of epigenetics in cardiovascular health and aging: a focus on physical activity and nutrition
Publication date: Available online 16 November 2017 Source:Mechanisms of Ageing and Development Author(s): Robert G. Wallace, Laura C. Twomey, Marc-Antoine Custaud, Jonathan Turner, Niall Moyna, Philip M. Cummins, Ronan P. Murphy The cardiovascular system is responsible for transport of blood and nutrients to tissues, and is pivotal to the physiological health and longevity. Epigenetic modification is a natural, age-associated process resulting in highly contextualised gene expression with clear implications for cell differentiation and disease onset. Biological/epigenetic age is independent of chronological age, constitu...
Source: Mechanisms of Ageing and Development - December 11, 2017 Category: Geriatrics Source Type: research

Effect of polyphenols from coffee and grape on gene expression in myoblasts
Publication date: Available online 23 November 2017 Source:Mechanisms of Ageing and Development Author(s): Alexandros Priftis, Nikolaos Goutzourelas, Maria Chalabalaki, Georgia Ntasi, Dimitrios Stagos, Grigorios D. Amoutzias, Leandros A. Skaltsounis, Dimitrios Kouretas Coffee and grape contain various bioactive compounds like polyphenols that may exert beneficial effects, especially antioxidant activity, on human health upon consumption. However, the molecular mechanisms through which these effects are achieved are not fully elucidated. Thus, in the present study in order to investigate these mechanisms, a whole genome ex...
Source: Mechanisms of Ageing and Development - December 11, 2017 Category: Geriatrics Source Type: research

Ferrosenescence: The iron age of neurodegeneration?
Publication date: Available online 24 November 2017 Source:Mechanisms of Ageing and Development Author(s): Adonis Sfera, Kelsey Bullock, Amy Price, Luzmin Inderias, Carolina Osorio Aging has been associated with iron retention in many cell types, including the neurons, promoting neurodegeneration by ferroptosis. Excess intracellular iron accelerates aging by damaging the DNA and blocking genomic repair systems, a process we define as ferrosenescence. Novel neuroimaging and proteomic techniques have pinpointed indicators of both iron retention and ferrosenescence, allowing for their early correction, potentially bringing p...
Source: Mechanisms of Ageing and Development - December 11, 2017 Category: Geriatrics Source Type: research

Cardiomyocyte ionic currents in intact young and aged murine Pgc-1 β−/− atrial preparations
Publication date: January 2018 Source:Mechanisms of Ageing and Development, Volume 169 Author(s): Haseeb Valli, Shiraz Ahmad, Anita Y. Jiang, Robert Smyth, Kamalan Jeevaratnam, Hugh R. Matthews, Christopher L.-H. Huang Introduction Recent studies reported that energetically deficient murine Pgc-1β−/− hearts replicate age-dependent atrial arrhythmic phenotypes associated with their corresponding clinical conditions, implicating action potential (AP) conduction slowing consequent upon reduced AP upstroke rates. Materials and methods We tested a hypothesis implicating Na+ current alterations as a mechanism u...
Source: Mechanisms of Ageing and Development - December 11, 2017 Category: Geriatrics Source Type: research

p38 but not p53 is responsible for UVA-induced MCPIP1 expression
Publication date: Available online 2 November 2017 Source:Mechanisms of Ageing and Development Author(s): Lukasz Skalniak, Marta Smejda, Agnieszka Cierniak, Anna Adamczyk, Piotr Konieczny, Ewelina Madej, Agnieszka Wolnicka-Glubisz MCPIP1 (Monocyte Chemotactic Protein-1 Induced Protein) is an important regulator of inflammation and cell apoptosis, but its role in UVA-induced stress response in the epidermis has never been studied. We have found that moderate apoptosis-inducing dose of UVA (27J/cm2) increases the level of MCPIP1 expression in HaCaT cells and normal human keratinocytes (NHEK) within 6–9h after the trea...
Source: Mechanisms of Ageing and Development - November 17, 2017 Category: Geriatrics Source Type: research